Chronic total occlusive disease of the coronary artery belongs to the category of"chest palsy"and"true heart pain"in traditional Chinese medicine.Its etiology has two aspects:deficiency of blood,bl...Chronic total occlusive disease of the coronary artery belongs to the category of"chest palsy"and"true heart pain"in traditional Chinese medicine.Its etiology has two aspects:deficiency of blood,blood stasis,qi stagnation,and phlegm.Failure can be caused by deficiency or disease.The pathogenesis of this disease is caused by obstruction of the heart pulse,and its pathogenesis can be transformed into each other.The theory of traditional Chinese medicine believes that the general rule is not painful.Therefore,the treatment of coronary CTO lesions should be based on the combination of Tong and Tong tonic.The chronic complete occlusive disease of the coronary artery can be treated through Xuanbi Tongyang,Huoxue Tongluo,and Aroma Wentong.Based on the Chinese medicine's understanding of the etiology and pathogenesis of coronary CTO lesions,it provides a basis for the diagnosis and treatment of traditional Chinese medicine,solves the problems of interventional medicine in western medicine,and gives play to the unique advantages of traditional Chinese medicine for clinical diagnosis and treatment.展开更多
Acne vulgaris is a common chronic inflammatory disease of pilosebaceous units. And sex hormone level disorder has became a hot research topic in the pathogenesis of acne. Studies show that the biological clock disorde...Acne vulgaris is a common chronic inflammatory disease of pilosebaceous units. And sex hormone level disorder has became a hot research topic in the pathogenesis of acne. Studies show that the biological clock disorder can result in the disorder of sex hormone levels which causes or aggravates acne. Biological clock disorder coincides naturally with "sleep rhythm disorder" in Traditional Chinese Medicine(TCM). In this paper, we will discuss the modern medical mechanism of the biological clock disorder resulting in acne from the angle of sex hormones, and analyze the TCM pathogenesis of the disease caused by the disorder of the biological clock.展开更多
Obesity[1]is a group of common and ancient metabolic diseases.Central obesity is common in clinical practice.Due to the simple constitution of adolescents,their pathogenesis is simple and changeable,or there is a mixt...Obesity[1]is a group of common and ancient metabolic diseases.Central obesity is common in clinical practice.Due to the simple constitution of adolescents,their pathogenesis is simple and changeable,or there is a mixture of cold and heat,or a mixture of cold and heat,or the same disease on the surface,and the pathogenesis of traditional Chinese medicine is complex and changeable.The pathogenesis of TCM pathogenesis of adolescent central obesity is analyzed with examples to provide new theoretical ideas for the treatment of obesity by Chinese medicine.展开更多
目的:通过探讨临床表现为单纯蛋白尿、蛋白尿伴血尿的IgAN患者二者间中医证型差异,阐明血尿证候基础,为IgAN临床辨证分型及指导其治疗提供参考依据。方法:采用流行病学现场调查的方法,收集230例IgAN患者的临床及病理资料,根据有无血尿...目的:通过探讨临床表现为单纯蛋白尿、蛋白尿伴血尿的IgAN患者二者间中医证型差异,阐明血尿证候基础,为IgAN临床辨证分型及指导其治疗提供参考依据。方法:采用流行病学现场调查的方法,收集230例IgAN患者的临床及病理资料,根据有无血尿症状分为单纯蛋白尿组(A组107例)和蛋白尿伴血尿组(B组123例)。观察比较两组间临床指标、病理分型、中医证型的差异,再分别与血尿进行相关性分析。结果:(1)一般资料:两组间年龄、性别、体重指数、病程、血压差异均无统计学意义(P>0.05);(2)生化指标:B组Scr、24 h UTP高于A组(P<0.05),eGFR低于A组(P<0.05);两组UA、BUN、Alb差异无统计学意义(P>0.05)。(3)病理资料:B组系膜增殖评分(M)、毛细血管内增生性病变(E)高于A组(P<0.05);两组肾小球节段性硬化或黏连(S)、肾小管萎缩或间质纤维化(T)差异无统计学意义(P>0.05)。(4)中医证型:本虚证A组以脾肾气虚证多见(36.45%),B组以气阴两虚证多见(42.28%);标实证A组以血瘀证多见(50.94%),B组以湿热证多见(57.39%)。(5)血尿的相关因素分析:将两组患者临床指标、病理资料、中医证型分别与血尿进行logistic回归,肾衰竭、中大量尿蛋白(24 h UTP≥1.0 g)、M1、E1、气阴两虚证、湿热证P<0.05,且OR值>1,与血尿相关。结论:(1)CKD1~4期IgAN患者血尿的证候基础可能为气阴两虚兼湿热,蛋白尿的证候基础可能多为脾肾气虚和血瘀;分布规律尤其在CKD1~2期患者更明显。(2)与单纯蛋白尿的IgAN患者相比,血尿可能是蛋白尿伴血尿患者预后不良的因素之一。在治疗时应充分认识到血尿在病程中的重要性,不能忽略血尿的治疗。展开更多
基金National natural science foundation of China(No.81774247)
文摘Chronic total occlusive disease of the coronary artery belongs to the category of"chest palsy"and"true heart pain"in traditional Chinese medicine.Its etiology has two aspects:deficiency of blood,blood stasis,qi stagnation,and phlegm.Failure can be caused by deficiency or disease.The pathogenesis of this disease is caused by obstruction of the heart pulse,and its pathogenesis can be transformed into each other.The theory of traditional Chinese medicine believes that the general rule is not painful.Therefore,the treatment of coronary CTO lesions should be based on the combination of Tong and Tong tonic.The chronic complete occlusive disease of the coronary artery can be treated through Xuanbi Tongyang,Huoxue Tongluo,and Aroma Wentong.Based on the Chinese medicine's understanding of the etiology and pathogenesis of coronary CTO lesions,it provides a basis for the diagnosis and treatment of traditional Chinese medicine,solves the problems of interventional medicine in western medicine,and gives play to the unique advantages of traditional Chinese medicine for clinical diagnosis and treatment.
文摘Acne vulgaris is a common chronic inflammatory disease of pilosebaceous units. And sex hormone level disorder has became a hot research topic in the pathogenesis of acne. Studies show that the biological clock disorder can result in the disorder of sex hormone levels which causes or aggravates acne. Biological clock disorder coincides naturally with "sleep rhythm disorder" in Traditional Chinese Medicine(TCM). In this paper, we will discuss the modern medical mechanism of the biological clock disorder resulting in acne from the angle of sex hormones, and analyze the TCM pathogenesis of the disease caused by the disorder of the biological clock.
基金National key research and development plan letter of assignment(No.2018YFC1704104)Chongqing health and family planning commission Chinese medicine science and technology project(No.ZY20172019)
文摘Obesity[1]is a group of common and ancient metabolic diseases.Central obesity is common in clinical practice.Due to the simple constitution of adolescents,their pathogenesis is simple and changeable,or there is a mixture of cold and heat,or a mixture of cold and heat,or the same disease on the surface,and the pathogenesis of traditional Chinese medicine is complex and changeable.The pathogenesis of TCM pathogenesis of adolescent central obesity is analyzed with examples to provide new theoretical ideas for the treatment of obesity by Chinese medicine.
文摘目的:探讨在生物信息学方法指导下骨质疏松症(osteoporosis,OP)不同病因病机的治疗要点。方法:以滋补肝肾、益气健脾、活血化瘀代表药物为搜索词,在中药系统药理数据库检索活性成分及预测靶点,借助Cytoscape 3.7.2软件构建药物与靶点之间的网络图。通过基因表达数据库(gene expression omnibus database,GEO)相关芯片分析差异基因,结合疾病数据库获取OP所有疾病靶点并构建药物与疾病的关键靶点韦恩图。通过DAVID数据库对关键靶点进行基因本体及京都基因与基因组百科全书富集,以探讨不同病因病机下OP的防治要点。结果:滋补肝肾、益气健脾及活血化瘀组分别筛选出146个、126个及117个靶点,GEO数据库筛选出1173个差异基因,疾病数据库筛选出靶点336个,去重整合后共获得OP靶点1469个。滋补肝肾、益气健脾组映射出25个相同靶点,活血化瘀组映射出21个关键靶点。基因可视化分析发现肝肾亏虚及脾胃虚弱型OP的治疗要点,且主要集中在肿瘤坏死因子通路、核苷酸结合寡聚化结构域样受体通路等方面;气血瘀阻型的治疗要点主要在血管内皮生长因子通路、缺氧诱导因子1通路等方面。结论:OP具有复杂的病因病机,在对症治疗时,肝肾亏虚及脾胃虚弱型更应注重控制体内炎症水平,气血瘀阻型更应注意体内局部血管构建及纠正缺氧状态。同时,众多病因病机之间存在着相似病理过程,也应注重全面调控及防治。
文摘目的:通过探讨临床表现为单纯蛋白尿、蛋白尿伴血尿的IgAN患者二者间中医证型差异,阐明血尿证候基础,为IgAN临床辨证分型及指导其治疗提供参考依据。方法:采用流行病学现场调查的方法,收集230例IgAN患者的临床及病理资料,根据有无血尿症状分为单纯蛋白尿组(A组107例)和蛋白尿伴血尿组(B组123例)。观察比较两组间临床指标、病理分型、中医证型的差异,再分别与血尿进行相关性分析。结果:(1)一般资料:两组间年龄、性别、体重指数、病程、血压差异均无统计学意义(P>0.05);(2)生化指标:B组Scr、24 h UTP高于A组(P<0.05),eGFR低于A组(P<0.05);两组UA、BUN、Alb差异无统计学意义(P>0.05)。(3)病理资料:B组系膜增殖评分(M)、毛细血管内增生性病变(E)高于A组(P<0.05);两组肾小球节段性硬化或黏连(S)、肾小管萎缩或间质纤维化(T)差异无统计学意义(P>0.05)。(4)中医证型:本虚证A组以脾肾气虚证多见(36.45%),B组以气阴两虚证多见(42.28%);标实证A组以血瘀证多见(50.94%),B组以湿热证多见(57.39%)。(5)血尿的相关因素分析:将两组患者临床指标、病理资料、中医证型分别与血尿进行logistic回归,肾衰竭、中大量尿蛋白(24 h UTP≥1.0 g)、M1、E1、气阴两虚证、湿热证P<0.05,且OR值>1,与血尿相关。结论:(1)CKD1~4期IgAN患者血尿的证候基础可能为气阴两虚兼湿热,蛋白尿的证候基础可能多为脾肾气虚和血瘀;分布规律尤其在CKD1~2期患者更明显。(2)与单纯蛋白尿的IgAN患者相比,血尿可能是蛋白尿伴血尿患者预后不良的因素之一。在治疗时应充分认识到血尿在病程中的重要性,不能忽略血尿的治疗。
