Reconstruction of the Global Economic Governance System and China’s Role under the Profound Changes

The world today is undergoing profound changes unseen in a century.In particular,under the impact of the COVID-19 pandemic and the Ukraine crisis,the global political and economic landscape has undergone unprecedentedly profound changes,and the current global economic governance system is facing multiple crises,such as the lack of legitimacy,effectiveness,and common values.Hence,promoting the reform of the global governance system is becoming the prevailing trend.

A safety evaluation of profound hypothermia-induced suspended animation for delayed resuscitation at 90 or 120min

Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia induced suspended animation for delayed resuscitation(SADR) is a novel approach for inducing cardiac arrest and buying additional time for such injuries. However, the time used to safely administer circulatory arrest(CA) is controversial. The goal of this study was to evaluate the safety of hypothermia-induced SADR over 90 and 120 min time intervals.Methods: Sixteen male BAMA minipigs were randomized into two groups: CA90 group(90 min, n =8) and CA120 group(120 min, n =8). Cannulation of the right common carotid arteries and internal jugular veins was performed to establish cardiopulmonary bypass for each animal. Through the perfusion of cold organ preservation solution(OPS), cardioplegia and profound hypothermia(15℃) were induced. After CA, cardiopumonary bypass(CPB) was restarted, and the animals were gradually re-warmed and resuscitated. The animals were assisted with ventilators until spontaneous breathing was achieved. The index of hemodynamic perioperative serum chemistry values [alanine transaminase(ALT), aspartate aminotransferase(AST), creatinine(CR), lactic dehydrogenase(LDH) and troponin T(TnT)] and survival were observed from pre-operation to 7 days post-operation.Results: Fifteen animals were enrolled in the experiment, while 1 animal in CA120 group died from surgical error. All 8 animals in CA90 group recovered, with only 1 animal displaying mild disability. However, in CA120 group, only 2 animals survived with severe disability, and the other 5 animals died after 2 days post-operation. In CA90 group, the perioperative serum chemistry values increased at 1 day post-operation(ALT 84.43±18.65 U/L; AST 88.99±23.19 U/L; Cr 87.90±24.49μmol/L; LDH 1894.13±322.26 U/L; TnT 0.849±0.135 ng/ml) but decreased to normal or almost normal levels at 7 days post-operation(ALT 52.48±9.04 U/L; AST 75.23±21.46 U/L; Cr 82.69±18.41μmol/L; LDH 944.67±834.32 U/L; TnT 0.336±0.076 ng/ml).Conclusion: Profound hypothermia-induced SADR is an effective method for inducing cardiac arrest. Our results indicate that inducing CA for 90 min(at 15℃) is safer than doing so for 120 min. Our results indicate that 120 min of CA at 15℃ is dangerous and can result in high mortality and severe neurological complications. Further experimentation is needed to determine whether 120 min of CA at temperatures lower than 15℃ can lead to safe recovery.

PROfound研究——前列腺癌精准治疗新希望

转移性去势抵抗性前列腺癌(metastatic castrate-resistant prostate cancer,mCRPC)是前列腺癌发展的终末阶段。患者生存预后很差。尽管不断地有新的治疗手段出现,比如新型内分泌治疗以及紫杉醇类化疗,mCRPC患者的生存期依然很有限。奥拉帕利是一款聚腺苷酸二磷酸核糖基聚合酶(poly ADP-ribose polymerase,PARP)抑制剂,PARP酶在DNA修复中扮演着重要的角色。奥拉帕利已经获批用于卵巢癌和乳腺癌的治疗。目前,奥拉帕利用于mCRPC治疗的Ⅲ期临床研究PROfound的结果在2019年的欧洲肿瘤内科学会(ESMO)年会与2020年的美国临床肿瘤学会-泌尿生殖系统肿瘤研讨会(ASCO-GU)已经发布。本文将带来PROfound研究的结果以及最新的结果更新。

Otolithic organ function in patients with profound sensorineural hearing loss

Profound sensorineural hearing loss (PSHL) is not uncommonly encountered in otology. In clinics, there is a high incidence of otolithic damage in patients with PSHL, but relevant reports are few. Sharing a continuous membranous structure and similar receptor cell ultrastructures, the cochlea and vestibule may be susceptible to the same harmful factors. Disorders of the inner ear may result in a variety of manifestations, including vertigo, spatial disorientation, blurred vision, impaired articulation, and hearing impairment. Considering the diversity of clinical symptoms associated with PSHL with otolithic dysfunction, it may be frequently misdiagnosed, and objective means of testing the function of otolithic organs should be recommended for hearing-impaired patients. Vestibular-evoked myogenic potentials (VEMPs) via air-conducted sound are of great importance for the diagnosis of otolithic function. Hearing devices such as cochlear implants are commonly accepted treatments for PSHL, and early identification and treatment of vestibular disorders may increase the success rate of cochlear implantation. Therefore, it is necessary to increase awareness of otolithic functional states in patients with PSHL.

The Significant and Profound Impacts of Chou’s 5-Steps Rule

In this short review paper, the significant and profound impacts of the 5-steps rule have been briefly recalled with crystal clear convincingness.

The Significant and Profound Impacts of Chou’s Invariance Theorem

In this short review paper, the significant and profound impacts of the Chou’s “invariance theorem” have been briefly presented with crystal clear convincingness.

The Significant and Profound Impacts of Chou’s Pseudo Amino Acid Composition or PseAAC

In this short review paper, the significant and profound impacts of the Pseudo Amino Acid Composition or PseAAC have been briefly presented with crystal clear convincingness.

PSYCHOLOGICAL DEVELOPMENT OF CHILDREN AFTER CARDIAC SURGERY WITH PROFOUND HYPOTHERMIA AND CIRCULATORY ARREST

Fifty-three patients with congenital heart disease were follwed up 14 to 57months after cardiac surgery with profound hypothermia and circulatory arrest.Meanintelligence quotient(IQ)was 88.6±16.1The incidence of psychological underdevelopedwas 13.2(7/53),higher than normal children population,The high incidence may be attri-buted to poor preoperative intellecutual development.The circulatory arrest time weremore than 60 minutes in 9 cases,41-60 minutes in 32 cases and less than 40 minutes inanother 12 cases.The IQ of these three groups were 84.8±11.9,86.2±15.7and 95.3±19.2respctively and incidence of psychological underdeveloped were 11.1%,15.6% and 8.5%respectively,No significant difference existed between groups.The time of circulatory ar-rest also had no obvious correlation with IQ.

Research and Analysis on the Profound Implication of Holland Still Life Images

The 17th century Holland still life drawing mostly all is through the extremely rigorous science manner, concentrates on completely to carry on the description to some lifeless goods. Such as flowers, shells, fruit and other things and of this style is the product of the Dutch culture, which represented by observing depict static objects, record the many realistic scene of eternal charm. Precise visual science and prosperity in the Netherlands, some of the new invention made evidence for its science and technology, such as microscope and camera, like the golden age of fine painting. It has some aspect research also to take compared to the vision, for example the botany, explains the showing plant flowers and plants with the science method in the different growh stage significance. In the philosophy domain, in the visual optics and under the technical development, the epistemology obtained the further development. The Dutch painters also recorded the world in a more detailed and vivid way through their methods.

Effects of hemodilution on neurological injury and cerebral amino acid content after circulatory arrest during profound hypothermia in rats

To investigate the effects of different degrees of hemodilution on neurological injury and amino acid content in different brain areas after deep hypothermic circulatory arrest (DHCA).Methods Forty-eight male adult SD rats weighing 400～450 g were randomly divided into 4 groups (n=12 each):group Ⅰ Hct 10%(H1);group Ⅱ Hct 20% (H2);group Ⅲ Hct 30%(H3) and control group (C).All animals except those in control group underwent DHCA at 18℃ for 90 min (includinhg cooling and rewarming) under general anesthesia with fentanyl,ketamine and droperidol.Different degrees of hemodilution were accomplised by changing the composition and volume of priming solution used in cardiopulmonary bypass (CPB).Hct was determined before,at the initiation of CPB and beginning of rewarming.PaO2,pH and blood lactate of arterial blood and SO2 of venous blood from internal jugular vein (SjvO2) were determined at the beginning and end of cooling and rewarming.The animals were killed and brains removed after recovery of circulatory function for the count of injured neurons and detemination of glutamate (Glu),aspartate (Asp),glycine (Gly),γ-aminobutyric acid (GABA) and taurine (Tau) contents in cortex,hippocampus and thalamus.Results The number of injured neurons in hippocampus and parietal cortex were significantly smaller in Hct 30% group than in the other two groups (P<0.05).The contents of the five amino acids in hippocampus and parietal cortex were all increased after DHCA.The Glu,Asp and Gly contents in hippocampus and parietal cortex were significantly lower in Hct 30% group than in the other 2 groups (P<0.05).There was no significant difference in GABA and Tau contents among the 3 groups.Conclusion Hemodilution at Hct 30% attenuates the neuronal injury after DHCA.The inhibition of the release of the excitatory amino acids in the brain may be involved in the mechanism of neuronal protection.13 refs,1 fig,3 tabs.

The Profound Revelation of Human Social Relations and the Profound Realization of Information Right of Citizens——The social significance of network technique advancement in the perspective of “Entity Cube”

The R＆D group of relationship searching in Microsoft Asia Research Institute explains ＂Entity Cube＂ launched in 2008 as follows：

双侧极重度感音神经性聋患儿人工耳蜗植入效果分析

目的分析双侧极重度感音神经性聋患儿人工耳蜗植入效果。方法选取2018年2月~2022年2月本院接诊的80例双侧极重度感音神经性聋患儿,将40例非对称性听力损失患儿纳入对照组,行单侧人工耳蜗植入;将40例对称性听力损失患儿纳入观察组,行双侧人工耳蜗植入;分析两组开机前和干预6、12、36个月后的听觉行为分级(CAP)、言语可懂度分级(SIR),并建立多因素logistic模型,分析双侧人工耳蜗植入后影响CAP、SIR评分的独立危险因素。结果观察组干预后12、36个月CAP、SIR评分显著高于对照组(P<0.05)。多因素logistic分析显示,年龄>3岁、术前未使用助听器、植入时间<1年、内耳畸形是影响双侧人工耳蜗植入儿童CAP、SIR评分的独立危险因素(P<0.05)。结论双侧人工耳蜗植入是极重度感音神经性聋患儿听觉补偿的有效手段,年龄、植入时间、内耳畸形等因素可能影响患儿的听觉、言语功能康复,尽早为患儿植入双侧人工耳蜗,加强相关干预,才能有效促使患儿听觉言语功能康复。

习近平法治思想中的“大变局”应对方略论

“大变局”应对方略是习近平法治思想立足于“百年未有之大变局”的科学论断,针对积极应对世界大变局的现实需要所彰显之实效导向型共识。其作为一种凸显执行性遵守之行动整合的共同准则与依据,往往围绕建立健全涉外法治体系和营造国际法治新秩序这两种应对方略而具体展开。法治体系应对方略主要表征为建立健全涉外法治体系的原则表达、目标设定与核心要素,法治秩序应对方略则主要表征为营造国际法治新秩序的目标设定、方案要义与路径导向。基于此,全面梳理习近平法治思想中的“大变局”应对方略样态,能够为涉外法治工作的有效推动提供系统的类型化指引。

茶道君子论略

茶为国饮,君子为传统人格楷模,茶与君子相通相融,催生了茶道君子这一高标人格符号。从君子之知而言,仁爱礼敬的品德、中庸清逸的睿智、自强弘毅的精神,蕴育了茶道的内涵;从茶道之行来看,精行俭德之人、恬淡坚贞之士、亲家爱国之子,彰显了君子的风貌;而从知行合一来分析,秉持守正笃行的理念、打造心物合一的美境、共享古今茶德的趣旨,则是茶道君子修炼的基本路径。

Pursuing Excellence in the Biomedical Field:The Inspiring Story of Prof.Dr.Mike Chan——An Interview with Prof.Dr.Mike Chan,Scientist,Author and Founder of European Wellness Biomedical Group

From humble beginnings to global influence,Prof.Dr.Mike K.S.Chan's story is a remarkable tale of passion,perseverance,and groundbreaking innovation in the biomedical field.As the co-owner and founder of the European Wellness Biomedical Group,he has dedicated his life to advancing biotechnology,stem cell research,and regenerative medicine,profoundly impacting lives across the globe.

Disputes are Normal,Arbitration is the Solution

At present,some of the greatest changes that the world has seen in the last century are accelerating.The international political and economic structure is profoundly adjusted,so the economic ties and legal interactions between countries are facing greater challenges.The theme of the second parallel forum of the Global Business and Law Conference 2024 is"Dispute Resolution and Global Economic Win-win",which not only offers a profound insight into the current international economic development needs,but also represents strategic thinking on the future global winwin situation.

“人民美好生活体育需要”:内涵解读、深刻依据与重要保障

满足“人民美好生活体育需要”是新时代新征程促进体育高质量发展、加快体育强国建设的目标所在。运用文献资料法、逻辑分析法等,认为“人民美好生活体育需要”随着人们生活水平的提升和体育发展样态的丰富而持续拓展,具有深刻的学理基础和广泛的实践需求,既以丰富多样的物质性体育需要为基础,又以社会层面的精神性体育需要为提升。满足“人民美好生活体育需要”,是马克思主义体育学说的价值体现,是中国共产党体育观的初心体现,是社会主义体育事业的本质体现,是加快体育强国建设的目标体现,需要以立足人口规模巨大的国情为基础,以推动体育高质量发展为支撑,以打造良好的生态环境为依托,以实现共同富裕取得实质性进展为导向。

Lantern Festival: The New Platform for Cultural Exchanges Between China and the World

Theincreasinglyadvanced lantern technology and the emerging Chinese-style scenes are intertwined so that the lanternfestivals across China show the characteristics of combining traditional culture and modern innovation.As for international cultural exchanges,lantern art has connected different cultures with its unique artistic charm and profound cultural connotation.

世界百年未有之大变局的时代意蕴

世界百年未有之大变局不是一时一地一域之变,而是具有系统性、全局性和长远性的深刻变化。只有坚持正确的历史观、大局观和角色观,站在时代的高度才能准确把握世界百年未有之大变局的基本性质。从时代意蕴看,世界百年未有之大变局是世界历史由一元主导走向多元并存的时代,是资本主义和社会主义竞争格局重塑的时代,是中国发展与世界变局同步交织、相互激荡的时代,是中国为人类文明发展进步作出更大贡献的时代。深刻把握世界百年未有之大变局的时代意蕴,有助于我们更好地利用大势、发挥优势、引领态势。