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蛋白S缺乏症的PROS1基因突变并临床异质性表现一例
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作者 魏欣雨 王娟 +1 位作者 谭榜云 李子坚 《中国医学科学院学报》 CAS CSCD 北大核心 2023年第5期863-866,共4页
蛋白S活性降低是静脉血栓栓塞的高危因素之一。遗传性蛋白S缺乏症是由PROS1基因突变引起的常染色体显性遗传病。本文报道1例PROS1基因突变的女性患者,测序发现在PROS1基因第3外显子中c.292 G>T。谱系分析显示该突变可能源自于患者的... 蛋白S活性降低是静脉血栓栓塞的高危因素之一。遗传性蛋白S缺乏症是由PROS1基因突变引起的常染色体显性遗传病。本文报道1例PROS1基因突变的女性患者,测序发现在PROS1基因第3外显子中c.292 G>T。谱系分析显示该突变可能源自于患者的母亲。经查询PROS1基因突变数据库及文献检索,证实这个突变为国际首次报道。 展开更多
关键词 突变 pros1 蛋白S缺乏症
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Pros and Cons of Information Teaching——In the Case of the Design of Container Transport
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作者 张金艳 《海外英语》 2017年第21期58-59,共2页
The article is mainly about the advantages and disadvantages of information teaching in the case of a design of Container Transport.Information teaching did bring some good to the teaching,both to the teachers,and the... The article is mainly about the advantages and disadvantages of information teaching in the case of a design of Container Transport.Information teaching did bring some good to the teaching,both to the teachers,and the students and class.Yet it did have some side effects.And some suggestions are given to the information teaching to make it better used for teachers and students. 展开更多
关键词 pros CONS information teaching teaching method
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伴PROS1基因突变的白色萎缩 被引量:2
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作者 张钰 王文芳 +1 位作者 陈圆芳 张佩莲 《临床皮肤科杂志》 CAS CSCD 北大核心 2019年第2期82-83,共2页
报告1例伴PROS1基因突变的白色萎缩。患儿女,16岁。反复双足瘀斑及溃疡伴疼痛4年。皮肤科检查:双侧足背及踝周可见片状紫红色斑片、点状坏死、色素沉着及结痂,中央可见象牙白色形状不规则的萎缩性瘢痕。皮损组织病理检查:真皮内小血管增... 报告1例伴PROS1基因突变的白色萎缩。患儿女,16岁。反复双足瘀斑及溃疡伴疼痛4年。皮肤科检查:双侧足背及踝周可见片状紫红色斑片、点状坏死、色素沉着及结痂,中央可见象牙白色形状不规则的萎缩性瘢痕。皮损组织病理检查:真皮内小血管增生,管壁增厚伴透明变,管腔内纤维素沉积。基因筛查示PROS1基因突变。诊断:伴PROS1基因突变的白色萎缩。予皮下注射低分子肝素钙及口服华法林等抗凝治疗后,皮损基本痊愈,随访1年未复发。 展开更多
关键词 白色萎缩 pros1基因
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Patient-reported Outcomes (PROs): An Approach to Evaluate Treatment Efficacy of Chinese Medicine or Integrative Medicine 被引量:14
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作者 赵利 陈金泉 《Chinese Journal of Integrated Traditional and Western Medicine》 2005年第2期151-153,共3页
Chinese medicine (CM) has been an experience based practice over the past three thousand years. The safety and efficacy of CM has been practised through experience, rather than nowadays’ modern scientific measurement... Chinese medicine (CM) has been an experience based practice over the past three thousand years. The safety and efficacy of CM has been practised through experience, rather than nowadays’ modern scientific measurements. In this way, the development of CM has not been keeping pace with the advance in science and technology and the progress in orthodox medicine. In order to meet the requirements of modern science and technology, an evidence based approach must be adopted. Reassurance is needed to convince people for safety and efficacy of CM and give confidence to the evidence based demands ——“Tradition is confirmed by Modern Science” (1) . 展开更多
关键词 Patient-reported Outcomes pros An Approach to Evaluate Treatment Efficacy of Chinese Medicine or Integrative Medicine
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ProSeal喉罩联合舒芬太尼在妇科腹腔镜手术中的应用效果分析 被引量:4
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作者 张惠 《中国医学创新》 CAS 2015年第3期50-53,共4页
目的:探讨Pro Seal喉罩联合舒芬太尼在妇科腹腔镜手术中的应用效果。方法:将90例妇科腹腔镜患者按随机数字表法分成Pro Seal喉罩联合舒芬太尼麻醉组(喉罩联合组)和气管插管联合舒芬太尼麻醉组(插管联合组)各45例。记录两组T0、T1、T2、T... 目的:探讨Pro Seal喉罩联合舒芬太尼在妇科腹腔镜手术中的应用效果。方法:将90例妇科腹腔镜患者按随机数字表法分成Pro Seal喉罩联合舒芬太尼麻醉组(喉罩联合组)和气管插管联合舒芬太尼麻醉组(插管联合组)各45例。记录两组T0、T1、T2、T3、T4、T5的平均动脉压(MAP)和心率(HR)、气腹前后5 min的气道峰压(Ppeak)和呼气末二氧化碳分压(PETCO2)、手术结束后的苏醒时间;同时比较两组患者相关的并发症。结果:两组T1时点MAP、HR低于T0时(P<0.05),插管联合组在T2、T3、T5时点MAP、HR高于喉罩联合组(P<0.05);两组在间歇正压通气期间Ppeak、PETCO2变化比较差异有统计学意义(P<0.05);喉罩联合组苏醒时间短于插管联合组(P<0.05);喉罩联合组的并发症少于插管联合组(P<0.05)。结论:Pro Seal喉罩联合舒芬太尼麻醉用于腹腔镜妇科手术的临床效果优于气管插管联合舒芬太尼麻醉,具有安全性好,血流动力学平稳,苏醒时间短,并发症少的优点,操作简单,值得推广应用。 展开更多
关键词 Pro Seal喉罩 妇科腹腔镜手术 舒芬太尼 气管插管
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Pros and cons of climate change in China
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作者 Shaohong Wu Jikun Huang +6 位作者 Yanhua Liu Jiangbo Gao Jun Yang Wentao Wang Yunhe Yin Hao Luan Wanlu Dong 《Chinese Journal of Population,Resources and Environment》 2014年第2期95-102,共8页
Climate change strongly affected the structure and functions of natural ecosystems,e.g.the vegetation productivity decreased in the Northeast permafrost region due to the higher temperature and less precipitation,wher... Climate change strongly affected the structure and functions of natural ecosystems,e.g.the vegetation productivity decreased in the Northeast permafrost region due to the higher temperature and less precipitation,whereas in the Tibetan Plateau,the vegetation productivity increased,owing to the improved thermal resource.Climate change led to reduced precipitation in North and Northeast China and thus the reduced surface runoff.The public needs for energy were changed because of climate change,e.g.the shorter heating period in winter.Climate change profoundly influenced human health,pathophoresis and major projects by increasing extreme events,including frequency and magnitude,and causing more serious water shortage.Under the background of climate change,although the improved thermal resources can be helpful for extending the crop growth period,more extreme events may resulted in more instability in agricultural productivity.Not only did climate change indirectly affect the secondary and tertiary industries through the impacts on agriculture and natural resources,but also climate change mitigation measures,such as carbon tax,tariff and trading,had extensive and profound influences on the socioeconomic system.Further analysis indicated that the impact of climate change presented significant regional differences.The impact had its pros and cons,while the advantages outweighed the disadvantages.Based on the above analysis on the impacts of climate change,we put forward suggestions on coping with climate change.First,scientifically dealing with climate change will need to seek advantages while avoiding the disadvantages of climate change in order to achieve the orderly adaptation to climate change,which is characterized with"Overall best,long-term benefit."Second,quantitative adaptation should be given more attention,e.g.proposing operational schemes and predictable goals and using uncertainty analysis on adaptation measures.Third,more active coping strategy should be adopted to enhance China's future comprehensive competitiveness.The strategies include but are not limited to gradually adjusting the industrial structure,intensifying the research and development(R&D)of emission reduction technology and actively responding to the influence of carbon tax,tariff and trading on socioeconomic development in China. 展开更多
关键词 CLIMATE CHANGE pros and CONS orderly and quantitat
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Rich Prospects for China's Green Foods Development
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作者 Zong Shu 《China's Foreign Trade》 1997年第7期38-39,共2页
Green foods, also known as biologic foods or environmental protective foods, are healthy, quality and nutritional foods without pollutants or public hazard. There are four standards for producing green foods in China:... Green foods, also known as biologic foods or environmental protective foods, are healthy, quality and nutritional foods without pollutants or public hazard. There are four standards for producing green foods in China: 1. The origin of the products or the raw materials of products must conform with the ecological environment standards for the production of green foods. 2. Planting of farming crops, the raising of animals and poultry and the farming of aquatic products and 展开更多
关键词 Rich prospects for China’s Green Foods Development PRO
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基于DG4Pros全画幅倾斜航摄系统的地表实景模型获取研究
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作者 吴晓培 童宗凯 +1 位作者 高雅丽 孙俊飞 《现代测绘》 2021年第S02期103-106,共4页
无人机倾斜摄影技术是近年来兴起的一项新型测量技术,具有灵活、快速和高效的特点.基于DG4Pros全画幅倾斜航摄系统,解决了采用无人机倾斜摄影技术获取地表实景模型过程中精度、效果和效率无法兼顾的问题.实验对比证明:该系统在保证模型... 无人机倾斜摄影技术是近年来兴起的一项新型测量技术,具有灵活、快速和高效的特点.基于DG4Pros全画幅倾斜航摄系统,解决了采用无人机倾斜摄影技术获取地表实景模型过程中精度、效果和效率无法兼顾的问题.实验对比证明:该系统在保证模型精度和效果情况下,还能极大程度的提高作业效率. 展开更多
关键词 无人机 倾斜摄影 DG4pros 实景模型 模型精度
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Pros & Cons
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《ChinAfrica》 2013年第9期12-13,共2页
PRO Chen Wei University student Civil servants deserve job security and more career options.Many current civil servants are well-educated and hold master's or even doctorate degrees.If they are offered other career o... PRO Chen Wei University student Civil servants deserve job security and more career options.Many current civil servants are well-educated and hold master's or even doctorate degrees.If they are offered other career opportunities, they may achieve greater success.It is often the case that capable graduates working in civil service can't get promoted despite putting in years of hard work. These individuals are passed over for promotion not because they are incompetent or not dedicated to their jobs. 展开更多
关键词 pros CONS
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THE PRESENT STATUS AND PROSPECTS OF S&T DEVELOP-MENT IN PETROCHEMICAL INDUSTRY IN CHINA
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作者 Hou Xianglin CAS and CAE member 《Bulletin of the Chinese Academy of Sciences》 1997年第4期312-318,共7页
Ⅰ. GENERAL SITUATION The petrochemical industry is a technology and capital-intensive industry. The United States took the lead in the development of the petrochemical industry and started launching petrochemical pro... Ⅰ. GENERAL SITUATION The petrochemical industry is a technology and capital-intensive industry. The United States took the lead in the development of the petrochemical industry and started launching petrochemical projects in the 1930s and 1940s. The petrochemical industry in other developed countries, such as Germany, the United kingdom, France, Italy and Japan, began their development in the 1960s and 1970s.The petrochemical industry in these countries has played 展开更多
关键词 FCC PRO THE PRESENT STATUS AND prosPECTS OF S&T DEVELOP-MENT IN PETROCHEMICAL INDUSTRY IN CHINA
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A Review and Prospect for Scientific and Engineering Computing in China
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作者 Yu Dehao(CAS Institute of Computational Mathematics & Scientific/Engineering Computing) 《Bulletin of the Chinese Academy of Sciences》 2002年第1期49-52,共4页
The rise of scientific computing was one of the most important advances in the S&T progress during the second half of the 20th century. Parallel with theoretical exploration and scientific experiments,scientific c... The rise of scientific computing was one of the most important advances in the S&T progress during the second half of the 20th century. Parallel with theoretical exploration and scientific experiments,scientific computing has become the 'third means' for scientific activities in the world today. The article gives a panoramic review of the subject during the past 50 years in China and lists the contributions made by Chinese scientists in this field. In addition, it reveals some key contents of related projects in the national research plan and looks into the development vista for the subject in China at the dawning years of the new century. 展开更多
关键词 PRO A Review and prospect for Scientific and Engineering Computing in China
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High Hopes Being tall has its pros and cons
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作者 Francisco Little 《ChinAfrica》 2014年第3期61-61,共1页
In China the desire to be taller is high (excuse the pun), despite people's genetic make-up. It's a desire driven by the sheer volume of folk competing for partners, promotions and prime job offerings, where any a... In China the desire to be taller is high (excuse the pun), despite people's genetic make-up. It's a desire driven by the sheer volume of folk competing for partners, promotions and prime job offerings, where any advantage is sought in order to get a foot in the door. And with the vast numbers of job seekers competing for positions, recruiters behind those doors can afford to be picky. The word on the street is height means rapid advancement through the ranks. Many young professionals hold the common belief that taller people have more opportunity for promotion in the desperate climb up the corporate ladder. 展开更多
关键词 High Hopes Being tall has its pros and cons
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ProStrakan在美国扩大Gelclair业务
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《国外药讯》 2009年第5期27-28,共2页
ProStrakan公司将与EKR Therapeutics公司在美国共同销售减轻口腔黏膜炎疼痛的口腔用凝胶Gelclair(Ⅰ),以扩大那里的业务。
关键词 Therapeutics公司 业务 美国 Strakan公司 口腔黏膜炎 PRO
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Defnitfive Technology(狄芬尼提)PROSUB 60有源低音炮原理剖析及维修实例(上)
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作者 方位 《家电维修》 2022年第4期42-45,共4页
成立仅二十几年的美国狄芬尼提品牌作为音箱界的新贵,有音箱界的特斯拉之美誉,其音箱在欧美中高端音响市场占有较大份额。PROSUB 60有源低音炮采用8英寸扬声器,箱体体积小巧,但其功率强劲,低音深潜,笔者实绘其电路(元件号为笔者自编,元... 成立仅二十几年的美国狄芬尼提品牌作为音箱界的新贵,有音箱界的特斯拉之美誉,其音箱在欧美中高端音响市场占有较大份额。PROSUB 60有源低音炮采用8英寸扬声器,箱体体积小巧,但其功率强劲,低音深潜,笔者实绘其电路(元件号为笔者自编,元件值为实测值),分析其工作原理,供同行参考。 展开更多
关键词 音响市场 扬声器 特斯拉 维修实例 元件值 SUB 芬尼 PRO
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Work in Unison to Achieve Prosperity for All——An interview with Li Dezhu,minister in charge of the State Ethnic Affairs Commission
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作者 OUR STAFF REPORTER 《The Journal of Human Rights》 2008年第1期2-8,共7页
Following is transcript of an interview given by Li Dezhu, minister in charge of the State Ethnic Affairs Commission of China, on measures taken by the Chinese Government in recent years to promote the economic, polit... Following is transcript of an interview given by Li Dezhu, minister in charge of the State Ethnic Affairs Commission of China, on measures taken by the Chinese Government in recent years to promote the economic, political, cultural and educational development in the interest of China's ethnic minority groups and of the areas they live in compact communities. The minister also talked about how China's ethnic minorities' lawful rights and interests are protected and what the Chinese Government has been doing to ensure development and prosperity for all the ethnic groups in the country. 展开更多
关键词 Pro LI
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Bayer与ProStrakan公司签订Tostrex的研发协议
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《国外药讯》 2009年第2期22-22,共1页
德国Bayer Schering Pharma公司已与苏格兰的ProStrakan公司签订协议,在加拿大、拉丁美洲、中东、非洲、亚洲太平洋地区开发和商业化后者的Tostrex(Ⅰ)。
关键词 Strakan公司 Tostrex PRO 协议 Pharma公司 亚洲太平洋地区 拉丁美洲 苏格兰
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PROS1基因新同义突变致以脑梗死起病的遗传性蛋白S缺陷症家系调查
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作者 赵瑾莹 潘蓉蓉 +4 位作者 金慧慧 刘春梅 黄婷 张颖冬 田有勇 《临床神经病学杂志》 CAS 2024年第3期184-187,共4页
目的调查一个以急性脑梗死起病的遗传性蛋白S缺陷症家系的临床特征,分析其PROS1基因的突变特点。方法收集先证者及其直系亲属的临床资料,采集血标本,检测蛋白S活性水平并对PROS1基因进行测序。结果该家系直系亲属三代8人,其中3名确诊为... 目的调查一个以急性脑梗死起病的遗传性蛋白S缺陷症家系的临床特征,分析其PROS1基因的突变特点。方法收集先证者及其直系亲属的临床资料,采集血标本,检测蛋白S活性水平并对PROS1基因进行测序。结果该家系直系亲属三代8人,其中3名确诊为遗传性蛋白S缺陷症,先证者及其兄均表现为急性脑梗死,余家系成员尚未发生血栓事件。检测蛋白S活性:先证者、先证者之兄、先证者母亲分别为16.8%、38.0%、31.8%,父亲正常。基因分析发现先证者、先证者之兄、先证者母亲PROS1基因第11外显子均存在c.1323G>A杂合变异,父亲为野生型。结论本家系为一个新发现的由PROS1基因c.1323G>A同义突变引起的遗传性蛋白S缺陷症家系;此突变可能导致青年缺血性脑卒中的发生。 展开更多
关键词 青年缺血性脑卒中 pros1基因 同义突变 遗传性蛋白S缺陷症
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FN1、PROS1在甲状腺乳头状癌合并桥本甲状腺炎中的表达意义
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作者 贾宁 赛顺海 赵棋 《诊断病理学杂志》 2024年第4期313-317,共5页
目的探讨FN1、PROS1在甲状腺乳头状癌(PTC)合并桥本甲状腺炎(HT)中的表达意义。方法应用免疫组化方法检测FN1、PROS1在114例PTC合并HT组织与81例仅为HT组织中表达情况、临床病理特征关系及二者表达相关性。采用受试者工作特性(ROC)曲线... 目的探讨FN1、PROS1在甲状腺乳头状癌(PTC)合并桥本甲状腺炎(HT)中的表达意义。方法应用免疫组化方法检测FN1、PROS1在114例PTC合并HT组织与81例仅为HT组织中表达情况、临床病理特征关系及二者表达相关性。采用受试者工作特性(ROC)曲线分析FN1、PROS1及二者联合对合并HT的PTC诊断价值。结果在合并HT的PTC组织中,FN1、PROS1表达阳性率显著高于HT组织(P<0.001)。FN1、PROS1表达均与淋巴结转移相关(均P<0.05)。Spearman分析结果示,在合并HT的PTC组织中FN1、PROS1表达水平成正相关(r=0.398,P<0.001)。ROC曲线分析显示,FN1、PROS1及二者联合检测合并HT的PTC敏感度分别为95.06%、88.89%和90.12%,特异度分别为91.23%、92.11%和95.61%。结论FN1、PROS1在合并HT的PTC组织中高表达,且阳性表达与淋巴结转移有关,对合并HT的PTC具有较高的辅助诊断价值。 展开更多
关键词 甲状腺乳头状癌 诊断效能 免疫组化 FN1 pros1
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基于ProE的联合收割机二级齿轮减速器仿真分析 被引量:1
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作者 靳峰峰 唐光胤 《农机化研究》 北大核心 2024年第2期255-259,共5页
针对联合收割机二级齿轮减速器总体结构进行了设计,基于Pro/E建立了二级齿轮减速器模型并完成了产品的装配,最后利用Pro/E Mechanism仿真模块对所设计产品进行了运动仿真。结果表明:模型满足设计需求,具有较好的稳定性,对二级齿轮减速... 针对联合收割机二级齿轮减速器总体结构进行了设计,基于Pro/E建立了二级齿轮减速器模型并完成了产品的装配,最后利用Pro/E Mechanism仿真模块对所设计产品进行了运动仿真。结果表明:模型满足设计需求,具有较好的稳定性,对二级齿轮减速器进一步的优化设计具有一定参考作用。 展开更多
关键词 联合收割机 二级齿轮减速器 PRO/E 运动仿真 MECHANISM
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基于ArcGIS Pro实现OSGB三维模型转换关键技术研究
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作者 邵瀚 苟胜国 李永铭 《测绘与空间地理信息》 2024年第6期27-29,共3页
为解决实景三维模型OSGB格式文件碎、数量多,不符合三维模型I3S标准规范,难以形成高效、标准的网络发布方案的问题,本文阐述了I3S标准SLPK三维格式的特点及优势,制定了OSGB格式到SLPK格式的转换流程,基于Python语言和XML.DOM类库对OGSB... 为解决实景三维模型OSGB格式文件碎、数量多,不符合三维模型I3S标准规范,难以形成高效、标准的网络发布方案的问题,本文阐述了I3S标准SLPK三维格式的特点及优势,制定了OSGB格式到SLPK格式的转换流程,基于Python语言和XML.DOM类库对OGSB模型的元数据文件解析,自动获取模型空间参考系统和原点坐标,并利用ArcGIS Pro ModelBuilder模型构建器参数化建模,实现三维实景模型自动格式转换,最后以四川某水电工程实景三维模型转换为例对该方法进行试验。试验表明,该方法普适、高效,能够为当前三维实景模型高效率、高准确性格式转换提供一定的经验参考。 展开更多
关键词 模型 OSGB SLPK 格式转换 ArcGIS Pro ModelBuilder
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