In this paper,two kinds of PS-PTCs were synthesized using different methods byintroducing cinchonine and quinine to the polymer support. Their catalytic properties forthe alkylation of N-diphenylmethylene glycine t-bu...In this paper,two kinds of PS-PTCs were synthesized using different methods byintroducing cinchonine and quinine to the polymer support. Their catalytic properties forthe alkylation of N-diphenylmethylene glycine t-butyl ester were also compared展开更多
The optical alpha-amino acids were synthesized under room temperature by alkylation of N-(diphenyl methylene) glycine t-butyl ester under polymer-supported phase transfer conditions using polymer-supported cinchonine ...The optical alpha-amino acids were synthesized under room temperature by alkylation of N-(diphenyl methylene) glycine t-butyl ester under polymer-supported phase transfer conditions using polymer-supported cinchonine (or quinine) alkaloids as chiral phase transfer catalysts and dichloromethane as solvent, followed by hydrolysis of the above intermediates introduced to the final products-optical alpha-amino acids. This is a new method for the asymmetric synthesis of alpha-amino acids. The influences of catalyst, temperature, substrates, and organic solvents on the chemical yield and optical purities of products were studied.展开更多
文摘In this paper,two kinds of PS-PTCs were synthesized using different methods byintroducing cinchonine and quinine to the polymer support. Their catalytic properties forthe alkylation of N-diphenylmethylene glycine t-butyl ester were also compared
基金Project supported by State Education Committee Initial Research Crams for Return Scholar and supported by NSFC No 29774012.
文摘The optical alpha-amino acids were synthesized under room temperature by alkylation of N-(diphenyl methylene) glycine t-butyl ester under polymer-supported phase transfer conditions using polymer-supported cinchonine (or quinine) alkaloids as chiral phase transfer catalysts and dichloromethane as solvent, followed by hydrolysis of the above intermediates introduced to the final products-optical alpha-amino acids. This is a new method for the asymmetric synthesis of alpha-amino acids. The influences of catalyst, temperature, substrates, and organic solvents on the chemical yield and optical purities of products were studied.
