The Level-2 probabilistic safety assessment(PSA) of pressurized water reactors studies the possibility of creep rupture for major reactor coolant system components during the course of high pressure severe accident se...The Level-2 probabilistic safety assessment(PSA) of pressurized water reactors studies the possibility of creep rupture for major reactor coolant system components during the course of high pressure severe accident sequences. The present paper covers this technical issue and tries to quantify its associated phenomenological uncertainties for the development of Level-2 PSA. A framework is proposed for the formal quantification of uncertainties in the Level-2 PSA model of a PWR type nuclear power plant using an integrated deterministic and PSA approach. This is demonstrated for estimation of creep rupture failure probability in station blackout severe accident of a 2-loop PWR, which is the representative case for high pressure sequences. MELCOR 1.8.6 code is employed here as the deterministic tool for the assessment of physical phenomena in the course of accident. In addition, a MATLAB code is developed for quantification of the probabilistic part by treating the uncertainties through separation of aleatory and epistemic sources of uncertainty.The probability for steam generator tube creep rupture is estimated at 0.17.展开更多
目的:探析阿比特龙联合多西他赛和醋酸泼尼松治疗去势抵抗性前列腺癌患者的临床效果。方法:选取2019年12月-2020年12月阳江市人民医院收治的80例去势抵抗性前列腺癌患者进行回顾性分析,以治疗方案的不同作为分组依据,对照组(40例)应用...目的:探析阿比特龙联合多西他赛和醋酸泼尼松治疗去势抵抗性前列腺癌患者的临床效果。方法:选取2019年12月-2020年12月阳江市人民医院收治的80例去势抵抗性前列腺癌患者进行回顾性分析,以治疗方案的不同作为分组依据,对照组(40例)应用多西他赛和醋酸泼尼松治疗,观察组(40例)在对照组基础上联合阿比特龙治疗。观察两组临床疗效,并分析两组治疗前后血清前列腺特异性抗原(PSA)水平与卡氏功能状态评分(Karnofsky performance status score,KPS)变化情况。结果:观察组治疗总有效率为80.00%,高于对照组的57.50%(P<0.05)。治疗后,两组血清PSA水平均低于治疗前,KPS评分高于治疗前,且观察组血清PSA水平低于对照组,KPS评分高于对照组(P<0.05)。结论:应用阿比特龙联合多西他赛和醋酸泼尼松治疗去势抵抗性前列腺癌患者,不仅效果理想,而且可改善患者血清PSA水平,提高患者身体健康状况。展开更多
文摘The Level-2 probabilistic safety assessment(PSA) of pressurized water reactors studies the possibility of creep rupture for major reactor coolant system components during the course of high pressure severe accident sequences. The present paper covers this technical issue and tries to quantify its associated phenomenological uncertainties for the development of Level-2 PSA. A framework is proposed for the formal quantification of uncertainties in the Level-2 PSA model of a PWR type nuclear power plant using an integrated deterministic and PSA approach. This is demonstrated for estimation of creep rupture failure probability in station blackout severe accident of a 2-loop PWR, which is the representative case for high pressure sequences. MELCOR 1.8.6 code is employed here as the deterministic tool for the assessment of physical phenomena in the course of accident. In addition, a MATLAB code is developed for quantification of the probabilistic part by treating the uncertainties through separation of aleatory and epistemic sources of uncertainty.The probability for steam generator tube creep rupture is estimated at 0.17.
文摘目的:探析阿比特龙联合多西他赛和醋酸泼尼松治疗去势抵抗性前列腺癌患者的临床效果。方法:选取2019年12月-2020年12月阳江市人民医院收治的80例去势抵抗性前列腺癌患者进行回顾性分析,以治疗方案的不同作为分组依据,对照组(40例)应用多西他赛和醋酸泼尼松治疗,观察组(40例)在对照组基础上联合阿比特龙治疗。观察两组临床疗效,并分析两组治疗前后血清前列腺特异性抗原(PSA)水平与卡氏功能状态评分(Karnofsky performance status score,KPS)变化情况。结果:观察组治疗总有效率为80.00%,高于对照组的57.50%(P<0.05)。治疗后,两组血清PSA水平均低于治疗前,KPS评分高于治疗前,且观察组血清PSA水平低于对照组,KPS评分高于对照组(P<0.05)。结论:应用阿比特龙联合多西他赛和醋酸泼尼松治疗去势抵抗性前列腺癌患者,不仅效果理想,而且可改善患者血清PSA水平,提高患者身体健康状况。
