三种PT试剂对不同病因引起凝血障碍疾病的临床价值探讨

Ｔｈｒｏｍｂｏｔｅｓｔ，Ｎｙｃｏｔｅｓｔ和Ｎｙｃｏｐｌａｓｔｉｎ三种ＰＴ试剂同时检测了６０例口服抗凝治疗和６０例肝脏疾病患者，比较它们之间的敏感性和相关性，从结果可以看出，Ｔｈｒｏｍｂｏｔｅｓｔ其对口服抗凝治疗的监测最敏感，Ｎｙｃｏｔｅｓｔ对肝脏疾病的监测最敏感，Ｎｙｃｏｐｌａｓｔｉｎ虽然能够反映出异常的ＰＴ，但它对两组患者的敏感性不如前两种试剂。Ｔｈｒｏｍｂｏｔｅｓｔ（口服抗凝治疗ＩＮＲ＝３．３２±０．９６，肝脏疾病ＩＮＲ＝２．９３±１．６９）和Ｎｙ－ｃｏｔｅｓｔ（口服抗凝治疗ＩＮＲ＝２．９５±１．３２，肝脏疾病ＩＮＲ＝３．３８±１．７６）与Ｎｙｃｏｐｌａｓｔｉｎ（口服抗凝治疗ＩＮＲ＝２．５３±１．０７，肝脏疾病ＩＮＲ＝２．３８±１．００）的相关性分别为０．７４，０．７８和０．７２，０．７８。

Nanomagnetic CoPt truncated octahedrons:facile synthesis,superior electrocatalytic activity and stability for methanol oxidation

Nanomagnetic CoPt truncated octahedral nanoparticles （TONPs） were successfully synthesised through a facile one-pot strategy. These single crystal CoPt TONPs with an average size of about 8 nm exhibit excellent electrocatalytic performance of both activity and stability for methanol oxidation reaction （MOR）. The mass and specific activities of CoPt TONPs is 8 and 6 times higher than that of standard commercial Pt/C, respectively. After accelerated durability test （ADT）, the loss of electrochemical surface area （ECSA） for CoPt TONPs is only 18.5%, which is significantly less than that of commercial Pt/C （68.2%）, indicating that CoPt TONPs possess much better stability than commercial Pt/C in the prolonged operation. The Curie temperature of CoPt TONPs down to 8 nm is as high as 350 K with weak ferromagntism at room temperature （RT）, which is greatly valuable for recycling in the eletrocatalytic applications.

宽体金线蛭抗凝血活性物质的提取方法

目的:比较不同提取方法对宽体金线蛭提取物抗凝活性的影响,确定抗凝活性物质的较佳提取方法。方法:应用凝血酶滴定法、APTT试剂盒法、PT试剂盒法等3种检测方法比较干品冷提、干品热提、干品脱脂后热提及鲜品冷提等提取物中抗凝活性的差异。结果:与空白对照组比较,各种提取方法所得提取物均具有明显的抗凝活性,各种检测方法所得结果一致。其中,水蛭鲜品和干品脱脂后提取物中抗凝活性较强。结论:水蛭提取物的抗凝活性强弱与原料的处理和提取方法有关。水蛭干品脱脂有利于提高提取物的抗凝活性。凝血酶滴定法可作为提取物抗凝活性的初步检测方法,其结果稳定,易于操作。APTT、PT试剂盒法可作为抗凝活性进一步检测的方法。