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B超引导下经皮经肝内置PTCT管引流救治胆道感染16例体会
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作者 木拉提 牛建华 +1 位作者 衡明敦 阿不都 《农垦医学》 2002年第3期183-184,共2页
关键词 胆道感染 病人 ptct 经皮经肝
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Oral PTCTS (Particulated Transialidase) Removes Serum Microparticles and Decreases Inflammation in Atherosclerotic Plaques of Rabbits
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作者 Shérrira M. Garavelo Jaqueline J. Pereira +7 位作者 Nilsa S. Y. Wadt Marcia M. Reis Renata N. Ikegami Joyce T. Kawakami Abdelali Agouni Suely A. P. Palomino Dulcinéia Abdalla Maria de Lourdes Higuchi 《Advances in Nanoparticles》 2015年第4期107-115,共9页
Background: Previous studies showed that atherosclerotic plaque vulnerability was related with microparticles (MPs)-vesicles larger than 100 nm, which released MMP9 collagenase. In our previous study, intramuscular in... Background: Previous studies showed that atherosclerotic plaque vulnerability was related with microparticles (MPs)-vesicles larger than 100 nm, which released MMP9 collagenase. In our previous study, intramuscular injection of a new drug (PTCTS) normalized oxidized LDL serum levels and reduced rabbit atherosclerosis. Now, we studied administration of oral PTCTS in order to clarify anti-atherosclerotic mechanism of action, analyzing if the treatment removed MPs containing ox-LDL and Mycoplasma pneumoniae antigens and improved the immune response. Methods: We compared two groups of rabbits. Control group (CG, n = 6)—1% cholesterol enriched diet for 12 weeks;Treated group (TG, n = 8)—1% cholesterol enriched diet for 12 weeks with administration of PTCTS (400 μl/day) during the last 6 weeks of diet. The animals had their blood collected, in three different phases of the protocol before being fed with hypercholesterolemic diet, before being treated with water or PTCTS and at the moment of sacrifice. The serum was submitted to immunofluorescence technique to evaluate the quantity of microparticles marked with antibodies against Mycoplasma pneumoniae and ox-LDL. A fragment of aorta was submitted to immunohistochemical detection of antigens from MMP9, ox-LDL, NF-κB and IL-1β. Results: PTCTS showed significant reduction in MMP-9 (P = 0.001) and a tendency of reducing IL-1β (P = 0.09) in the aortic plaques compared with CG. In the serum, PTCTS was able to remove microparticles containing antigen of ox-LDL (P = 0.004) and Mycoplasma pneumoniae (P β and mycoplasma, as well as a better stabilization of the atheromatous plaque by reducing levels of MMP-9, avoiding plaque rupture, without causing mortality or toxicity. 展开更多
关键词 ATHEROSCLEROSIS INFLAMMATION ptctS MYCOPLASMA NF-κB
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Safety and Efficacy of PTCTS Cosmetic Gel: Study on Human Radiodermatitis Lesions
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作者 Silvia Regina Graziani Brigitte M. Van Eyll +3 位作者 Carlos Elias Fristachi Maria de Lourdes Higuchi Renata Ikegami Jose Antonio Ramires 《Case Reports in Clinical Medicine》 2015年第10期327-333,共7页
Radiodermatitis is a constant complication after radiotherapy with no efficient drug for prevention and treatment. Its physiopathology is complex, possibly related to injury of epidermis and endothelial cells from the... Radiodermatitis is a constant complication after radiotherapy with no efficient drug for prevention and treatment. Its physiopathology is complex, possibly related to injury of epidermis and endothelial cells from the basal layer by radiolysis, overproduction of free radicals, pro-inflammatory cytokines, and inflammation. PTCTS gel is an after sun cosmetic gel composed by anti-oxidative plant extract rich in natural nanoparticles and thermal water (Complex A) and recombinant protein of Trypanosoma cruzi transialidase (Complex B), with high anti-oxidative and anti-apoptotic effects, presenting anti-aging and healing cutaneous properties. Objective: To study the safety and efficacy of PTCTS gel for topic use in volunteer subjects with healthy skin, and in patients with radiodermatitis, in different concentrations of Complexes A and B. Material and Methods: The project was approved by the Ethical Committee of Arnaldo Vieira de Carvalho Institute, Sao Paulo, Brazil. The individuals were submitted to laboratorial toxicity study through tests for liver and kidney function, levels of blood glucose and blood count before and after 7 days of PTCTS application. We studied two groups: GI-22 volunteers with healthy skin, presenting articular or skeletal muscle pain and GII-38 patients in radiotherapy for breast or head and neck cancer, with radiodermatitis grade 2 or 3. The patients were evaluated before and after 1.0 ml/cm2 PTCTS gel application, twice a day. We tested Complex B in four different concentrations, and Complex A concentrations varied inversely. Results: No irritation signs were observed in GI nor GII group, 64% of GI had important decrease in the intensity of the muscular or articular pain, and 99% of GII showed regression of radiodermatitis, all exhibiting relief of pain. No patient presented hematologic, renal or hepatic toxicity. Conclusion: PTCTS cosmetic gel is a safe option for radiodermatitis treatment, with no side effects or laboratorial toxicity in different concentrations. This product presented excellent clinical results even if used diluted 4 times more than the original product and may be a good option for treatment of radiodermatitis. Further studies may show if it is also indicated in the prevention of the lesion, and if it is better than products containing corticoids. 展开更多
关键词 Radiodermatitis NANOPARTICLES Thermal Water Transialidase TOXICITY ptctS COSMETIC GEL
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基于PTCT模式的保密微课堂项目实践与应用研究 被引量:1
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作者 杨秀艳 周鸣 《项目管理技术》 2017年第9期106-110,共5页
"保密就是保安全、保密就是保发展",在"互联网+"开放、合作、共享的背景下,推进互联网信息安全和保密教育是保密工作的重中之重。在日益发展的新媒体环境下,微信应用成为知识传播和推广的新途径。国网天津市电力公... "保密就是保安全、保密就是保发展",在"互联网+"开放、合作、共享的背景下,推进互联网信息安全和保密教育是保密工作的重中之重。在日益发展的新媒体环境下,微信应用成为知识传播和推广的新途径。国网天津市电力公司为加强和改进保密工作,将微信这一新传播媒介融入保密教育,特委托天津滨海供电公司孵化保密微课堂项目,建立以项目经理为核心的PTCT模式,统筹项目、沟通协作、指导与指引、工具与技术等核心要素管理,成功实践项目全程管控,取得良好的宣教效果。 展开更多
关键词 保密教育 ptct模式 项目管理
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“PTCT工作法”创建与应用——基于大型装备制造企业项目实践 被引量:1
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作者 吴志远 梁毅 《项目管理技术》 2013年第4期108-112,共5页
项目成功受诸多因素影响,对团队建设的有效管理是决定项目是否成功的重要因素。基于对团队建设能力提升的需求,论述了团队建设的一种新方法:"PTCT工作法"。对"PTCT工作法"创建背景、内涵及应用实践进行了详细阐述,... 项目成功受诸多因素影响,对团队建设的有效管理是决定项目是否成功的重要因素。基于对团队建设能力提升的需求,论述了团队建设的一种新方法:"PTCT工作法"。对"PTCT工作法"创建背景、内涵及应用实践进行了详细阐述,并以示例形式来体现"PTCT工作法"在团队建设各阶段的工作内容。实践经验表明,"PTCT工作法"能够实现对团队建设的有效管理。 展开更多
关键词 ptct工作法 团队建设 管理
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基于伏邪理论探析冠心病介入术后病机 被引量:5
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作者 丁义 吕仕超 +1 位作者 彭立 张军平 《中华中医药学刊》 CAS 2012年第3期530-531,共2页
通过系统复习文献,回顾冠心病病机认识的变迁,结合现代医学研究进展,提出从伏邪理论诠释冠心病介入术后的病机变化规律,即:邪毒内伏易致疾病反复、心气亏虚为邪毒存在提供内环境、热毒为病情反复的诱发因素,为临床提供新的辨治思路。
关键词 伏邪 冠心病 介入 病机
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枸橼酸钠干粉抗凝管在消除EDTA依赖性假性血小板减少症中的应用研究 被引量:2
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作者 黄江浩 何维娜 +4 位作者 华建江 常帅 刘平 汪奇云 徐志康 《四川医学》 CAS 2014年第12期1530-1534,共5页
目的研究一种能消除EDTA依赖性假性血小板减少症(PTCT)的枸橼酸钠干粉抗凝管,以便准确计数此类患者血液中的血小板。方法 1通过观察枸橼酸钠干粉的不同抗凝浓度、不同抗凝血量对PLT值的影响,选出枸橼酸钠干粉的最佳抗凝浓度和最佳抗凝... 目的研究一种能消除EDTA依赖性假性血小板减少症(PTCT)的枸橼酸钠干粉抗凝管,以便准确计数此类患者血液中的血小板。方法 1通过观察枸橼酸钠干粉的不同抗凝浓度、不同抗凝血量对PLT值的影响,选出枸橼酸钠干粉的最佳抗凝浓度和最佳抗凝血量。2选取对照人群130例,用EDTA-K2、枸橼酸钠干粉和枸橼酸钠水剂三种方式抗凝,用仪器法测血常规各值。3选PTCT患者28例,各采集3份静脉血和一份末稍血样本,1份静脉血(2m L)用EDTA-K2抗凝、1份静脉血(2m L)用109mmol/L枸橼酸钠水剂抗凝管抗凝,另1份静脉血(2m L)用枸橼酸钠干粉抗凝管抗凝,末稍血用许汝氏稀释液稀释作血小板手工计数用。三种抗凝血分别于0min、5min、15min、30min、1h、2h、4h、8h用日本希森美康公司XE-1000仪器进行血小板计数检测并同时用玻片在显微镜下镜检血小板有无凝集现象。结果 1枸橼酸钠干粉抗凝管的最佳抗凝浓度为12.8mg/管,最佳抗凝血量为200~800μL。2经枸橼酸钠干粉抗凝管对130例对照组人群的血常规仪器检测结果与EDTA-K2、枸橼酸钠水剂二种方式抗凝的血常规检测结果比较,各种检测(WBC、RBC、HGB、PLT)值与前者比较差异均无统计学意义(P>0.05),与后者比较差异均有统计学意义(P<0.05),EDTA-K2与枸橼酸钠水剂二法检测值间比较差异亦有统计学意义(P<0.05)。328例PTCT患者的枸橼酸钠干粉抗凝管血放置0min^8h和EDTA-K2抗凝血在放置0min用玻片在显微镜下镜检血小板无凝集现象,枸橼酸钠水剂抗凝管血放置60min内未见明显凝集现象,EDTA-K2抗凝血放置5min^8h、枸橼酸钠水剂抗凝管血放置60min后用玻片在显微镜下镜检血小板有不同程度的凝集现象。枸橼酸钠干粉抗凝管血0min^8h仪器血小板计数值与末稍血手工计数值比较,差异均无统计学意义(P>0.05),EDTA-K2抗凝血放置0min仪器检测的血小板计数值与末稍血手工计数值及枸橼酸钠干粉抗凝血在0min^8h的仪器检测结果比较,差异亦均无统计学意义(P>0.05),而放置5min^8h的仪器血小板计数值,则差异均有统计学意义(P<0.05)。结论枸橼酸钠干粉抗凝管采血可使EDTA依赖性假性血小板减少症患者的血小板计数准确、可靠,可替代EDTA抗凝管进行血小板检测。 展开更多
关键词 枸橼酸钠 血小板计数
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介入治疗的临床应用
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作者 贾秀杰 马文斌 《医学综述》 2001年第5期317-318,共2页
关键词 介入治疗 临床应用 ptct
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基于战略导向的保密本质安全体系建设项目实践研究
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作者 杨秀艳 周鸣 《项目管理技术》 2018年第1期54-57,共4页
大型电力企业的秘密安全不仅关乎企业发展,更影响国家经济和社会稳定。国网天津市电力公司基于战略导向进行保密本质安全体系项目建设,运用项目管理和PTCT(Project Teamwork Coaching Technology)团队建设的方法和工具,显著提升保密管... 大型电力企业的秘密安全不仅关乎企业发展,更影响国家经济和社会稳定。国网天津市电力公司基于战略导向进行保密本质安全体系项目建设,运用项目管理和PTCT(Project Teamwork Coaching Technology)团队建设的方法和工具,显著提升保密管理的固有安全能力。 展开更多
关键词 战略导向 项目管理 ptct团队建设法 保密本质安全
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