肿瘤的发生是一种复杂的生物学过程，癌基因激活和抑癌基因失活是肿瘤发生发展的基础。1997年不同的研究小组分别用不同的方法发现了抑癌基因PTEN （gene of phosphate and tension homology deleted on chromsome ten）[1-2]，该基因是...肿瘤的发生是一种复杂的生物学过程，癌基因激活和抑癌基因失活是肿瘤发生发展的基础。1997年不同的研究小组分别用不同的方法发现了抑癌基因PTEN （gene of phosphate and tension homology deleted on chromsome ten）[1-2]，该基因是继p53基因后，另一种与多种系统肿瘤的发生有密切关系的基因[3-5]，被认为是未来基因治疗的潜在途径，自发现以来一直是国内外研究的热点。近年来研究发现，PTEN基因的功能不仅局限于抑癌作用；针对该基因及蛋白的基因型和非基因型调控研究，亦有更深入的发现。本文现对PTEN基因功能及其调控的研究进展作一综述。展开更多
PTEN is a candidate tumor suppressor which has sequence homology with dual-specificity phosphatase. PTEN is a multifunctional protein endowed with a phosphatase activity capable of dephosphorylating both tyrosine phos...PTEN is a candidate tumor suppressor which has sequence homology with dual-specificity phosphatase. PTEN is a multifunctional protein endowed with a phosphatase activity capable of dephosphorylating both tyrosine phosphate, serine/threonine phosphate residues on proteins and phospholipids of the phosphatidylinositol pathway. PTEN appears to be mutated at considerable frequency in several types of human tumors, including those from brain, breast, endometrium, and prostate. PTEN play an important role in pathogenesis of tumor, tumor cell invasion and metastasis. In this review, we will discuss the chemical structure of PTEN, its phosphatase activity, the ability of affecting signal transduction, and its mutational status in cancer.展开更多
文摘肿瘤的发生是一种复杂的生物学过程，癌基因激活和抑癌基因失活是肿瘤发生发展的基础。1997年不同的研究小组分别用不同的方法发现了抑癌基因PTEN （gene of phosphate and tension homology deleted on chromsome ten）[1-2]，该基因是继p53基因后，另一种与多种系统肿瘤的发生有密切关系的基因[3-5]，被认为是未来基因治疗的潜在途径，自发现以来一直是国内外研究的热点。近年来研究发现，PTEN基因的功能不仅局限于抑癌作用；针对该基因及蛋白的基因型和非基因型调控研究，亦有更深入的发现。本文现对PTEN基因功能及其调控的研究进展作一综述。
文摘PTEN is a candidate tumor suppressor which has sequence homology with dual-specificity phosphatase. PTEN is a multifunctional protein endowed with a phosphatase activity capable of dephosphorylating both tyrosine phosphate, serine/threonine phosphate residues on proteins and phospholipids of the phosphatidylinositol pathway. PTEN appears to be mutated at considerable frequency in several types of human tumors, including those from brain, breast, endometrium, and prostate. PTEN play an important role in pathogenesis of tumor, tumor cell invasion and metastasis. In this review, we will discuss the chemical structure of PTEN, its phosphatase activity, the ability of affecting signal transduction, and its mutational status in cancer.
