Although PI3K/AKT has undoubtedly been one of the most important pathways that impact tumorigenesis and proliferation, PI3K-beta has not been considered as a stand-alone target for potential cancer treatment until the...Although PI3K/AKT has undoubtedly been one of the most important pathways that impact tumorigenesis and proliferation, PI3K-beta has not been considered as a stand-alone target for potential cancer treatment until the re-cent discovery of the key role that PI3K-beta plays in phosphatase and TENsin homolog （PTEN）-deficient tumors. Medicinal chemistry efforts from the pharmaceutical industry and academia in the past few years have led to sig-nificant advancements in understanding beta isoform selectivity and in the development of a clinical drug candidate.展开更多
文摘Although PI3K/AKT has undoubtedly been one of the most important pathways that impact tumorigenesis and proliferation, PI3K-beta has not been considered as a stand-alone target for potential cancer treatment until the re-cent discovery of the key role that PI3K-beta plays in phosphatase and TENsin homolog （PTEN）-deficient tumors. Medicinal chemistry efforts from the pharmaceutical industry and academia in the past few years have led to sig-nificant advancements in understanding beta isoform selectivity and in the development of a clinical drug candidate.
