We report the first known case of both Noonan syndrome and Whipple's disease occurring in the same patient.A 36-year-old female with history of Noonan syndrome developed fatigue,anorexia,arthritis of the knees and...We report the first known case of both Noonan syndrome and Whipple's disease occurring in the same patient.A 36-year-old female with history of Noonan syndrome developed fatigue,anorexia,arthritis of the knees and hands with a diffuse hyperpigmented rash,night sweats,and an unintentional fifteen pound weight loss over 4 mo.Small bowel enteroscopy demonstrated mild edematous yellowish mucosa without friability.Random small bowel biopsies revealed extensive periodic acid-Schiff positive material within the foamy macrophages.She was treated with a 12 mo course of trimethoprim-sulfamethoxazole DS with clinical improvement to baseline status.展开更多
文摘We report the first known case of both Noonan syndrome and Whipple's disease occurring in the same patient.A 36-year-old female with history of Noonan syndrome developed fatigue,anorexia,arthritis of the knees and hands with a diffuse hyperpigmented rash,night sweats,and an unintentional fifteen pound weight loss over 4 mo.Small bowel enteroscopy demonstrated mild edematous yellowish mucosa without friability.Random small bowel biopsies revealed extensive periodic acid-Schiff positive material within the foamy macrophages.She was treated with a 12 mo course of trimethoprim-sulfamethoxazole DS with clinical improvement to baseline status.
