Function and pathway of PTRF in the senescence of human fibroblasts

PTRF was first identified as Pol I and transcript release factor, which enhanced ribosomal RNA synthesis through dissociating the ternary complex of RNA polymerase I. It has

衰老及相关疾病与细胞信号转导的关系

概述了衰老及相关病变与细胞信号转导障碍或异常的密切关系。细胞与细胞间或细胞与环境间无时无刻不在进行着信息联系 ,信号转导途径的任何一个环节出现问题 ,都可引起细胞生长失控 ,进而引起病变。因而了解细胞衰老机理和信号转导途径 ,从分子水平上认识、预防和治疗疾病有着深远的意义。