This study aimed to compare the acute effect of different fast food types on appetite regulatory hormones. This was a randomized, cross over design study. After ten-hour fasting, sixteen obese participants (Body Mass ...This study aimed to compare the acute effect of different fast food types on appetite regulatory hormones. This was a randomized, cross over design study. After ten-hour fasting, sixteen obese participants (Body Mass Index 33.6 ± 4.8 kg/m2) received Indonesia Fast Food (IFF) followed Western Fast Food (WFF) after 1 week wash out. Both of fast foods have similar energy content but higher fat content on WFF vs IFF. Plasma ghrelin, Peptide YY (PYY) and Cholecystokinin (CCK) were measured at 30, 60 and 120 minutes after ingestions. The investigation revealed that the change of plasma ghrelin level was lower on participant consuming WFF in 120 minutes vs IFF (P < 0.05). The change of plasma PYY showed significantly higher among participant on 60 minutes following WFF vs IFF (P < 0.05). The change of plasma CCK level is lower in 30, 60 and 120 minutes after consuming WFF vs IFF (all, P < 0.001). The appetite response regarding “desire to eat” was higher after consuming IFF vs WFF. This study suggested that IFF induced feeling “want to eat” higher than WFF also induced the increasing orexigenic hormone, ghrelin, but the effects on the anorexigenic hormone (PYY) and CCK were opposite.展开更多
Objective:Expression of PYY, MTL and GAS in serum of IBS patients and their relationship with inflammatory response.Methods: Using 100 IBS patients admitted to our hospital from November 2016 toApril 2018as the observ...Objective:Expression of PYY, MTL and GAS in serum of IBS patients and their relationship with inflammatory response.Methods: Using 100 IBS patients admitted to our hospital from November 2016 toApril 2018as the observation group and 100 normal persons in the same period as the control group, we observed the levels of serum PYY, MTL, GAS and expression of inflammatory factors in the two groups, and the correlation between different clinical symptoms of the disease group and serum PYY, MTL, GAS. The correlation analysis between serum PYY, MTL, GAS and inflammatory response in patients with disease and the influencing factors of patients with disease.Results: The expression levels of PYY, MTL, GAS and inflammatory factors in patients with diarrhea were significantly higher than those in control group, and the expression levels of PYY, MTL, GAS and inflammatory factors in patients with diarrhea were significantly higher than those in patients with constipation. The expression levels of PYY, MTL and GAS in patients with diarrhea and constipation were negatively correlated. There was a negative correlation between serum inflammatory factors and DIARRHEA-TYPE patients, but no correlation between Constipation-Type patients and inflammatory factors. Serum PYY, MTL and GAS were positively correlated with inflammatory reaction factors TNF-a, IL-6 and IL-8 in DIARRHEA-TYPE patients. Serum PYY, MTL and GAS levels in patients with DIARRHEA-TYPE patients could be regarded as independent risk factors for IBS.Conclusion: The serum levels of PYY, MTL and GAS in patients with diarrhea IBS were positively correlated with the expression of inflammatory factors, which had guiding significance for the diagnosis and treatment of IBS.展开更多
文摘This study aimed to compare the acute effect of different fast food types on appetite regulatory hormones. This was a randomized, cross over design study. After ten-hour fasting, sixteen obese participants (Body Mass Index 33.6 ± 4.8 kg/m2) received Indonesia Fast Food (IFF) followed Western Fast Food (WFF) after 1 week wash out. Both of fast foods have similar energy content but higher fat content on WFF vs IFF. Plasma ghrelin, Peptide YY (PYY) and Cholecystokinin (CCK) were measured at 30, 60 and 120 minutes after ingestions. The investigation revealed that the change of plasma ghrelin level was lower on participant consuming WFF in 120 minutes vs IFF (P < 0.05). The change of plasma PYY showed significantly higher among participant on 60 minutes following WFF vs IFF (P < 0.05). The change of plasma CCK level is lower in 30, 60 and 120 minutes after consuming WFF vs IFF (all, P < 0.001). The appetite response regarding “desire to eat” was higher after consuming IFF vs WFF. This study suggested that IFF induced feeling “want to eat” higher than WFF also induced the increasing orexigenic hormone, ghrelin, but the effects on the anorexigenic hormone (PYY) and CCK were opposite.
文摘Objective:Expression of PYY, MTL and GAS in serum of IBS patients and their relationship with inflammatory response.Methods: Using 100 IBS patients admitted to our hospital from November 2016 toApril 2018as the observation group and 100 normal persons in the same period as the control group, we observed the levels of serum PYY, MTL, GAS and expression of inflammatory factors in the two groups, and the correlation between different clinical symptoms of the disease group and serum PYY, MTL, GAS. The correlation analysis between serum PYY, MTL, GAS and inflammatory response in patients with disease and the influencing factors of patients with disease.Results: The expression levels of PYY, MTL, GAS and inflammatory factors in patients with diarrhea were significantly higher than those in control group, and the expression levels of PYY, MTL, GAS and inflammatory factors in patients with diarrhea were significantly higher than those in patients with constipation. The expression levels of PYY, MTL and GAS in patients with diarrhea and constipation were negatively correlated. There was a negative correlation between serum inflammatory factors and DIARRHEA-TYPE patients, but no correlation between Constipation-Type patients and inflammatory factors. Serum PYY, MTL and GAS were positively correlated with inflammatory reaction factors TNF-a, IL-6 and IL-8 in DIARRHEA-TYPE patients. Serum PYY, MTL and GAS levels in patients with DIARRHEA-TYPE patients could be regarded as independent risk factors for IBS.Conclusion: The serum levels of PYY, MTL and GAS in patients with diarrhea IBS were positively correlated with the expression of inflammatory factors, which had guiding significance for the diagnosis and treatment of IBS.
