Pain interventional therapy,known as the most promising medical technology in the 21st century,refers to clinical treatment technology based on neuroanatomy,neuroimaging,and nerve block technology to treat pain diseas...Pain interventional therapy,known as the most promising medical technology in the 21st century,refers to clinical treatment technology based on neuroanatomy,neuroimaging,and nerve block technology to treat pain diseases.Compared with traditional destructive surgery,interventional pain therapy is considered a better and more economical choice of treatment.In recent years,a variety of minimally invasive pain interventional therapy techniques,such as neuroregulation,spinal cord electrical stimulation,intervertebral disc ablation,and intrasheath drug infusion systems,have provided effective solutions for the treatment of patients with post-herpetic neuralgia,complex regional pain syndrome,cervical/lumbar disc herniation,and refractory cancer pain.展开更多
Acute postoperative pain is commonly treated with flurbiprofen(FBP),but conventional delivery methods are suboptimal.This study prepared a new non-burst release microneedles(MNs)using genipin cross-linked gelatin(cGel...Acute postoperative pain is commonly treated with flurbiprofen(FBP),but conventional delivery methods are suboptimal.This study prepared a new non-burst release microneedles(MNs)using genipin cross-linked gelatin(cGel).By adding varying amounts of genipin to modulate the crosslinking degree of cGel,the drug release behavior of the drug-loaded MNs in the skin can be altered.The crosslinking parameters that meet therapeutic requirements are selected,thus providing rapid and longlasting analgesic effects.cGel solutions were successfully cross-linked,altering matrix material microstructure,confirmed by scanning electron microscope imaging and fourier transform infrared spectroscopy.MNs demonstrated increasing mechanical strength with higher crosslinking.Drug release rates were rapid initially,then slowed,exhibiting a characteristic of decreased release rates with increasing degrees of crosslinking.In vivo,FBP/cGel MNs significantly reduced allodynia and hyperalgesia post-surgery,with the greatest effect observed at 2–3 h post-surgery,and can maintain analgesia for up to 6 h.Biosafety tests confirmed good biocompatibility.FBP/cGel MNs effectively penetrate the stratum corneum,safely delivering drugs with significant analgesic effects,excellent mechanical properties,and good biocompatibility,representing a promising strategy for managing acute postoperative pain.展开更多
Phantom limb pain(PLP) is not uncommon after amputation. PLP is described as a painful sensation perceived in the missing limb. Despite of its complicated pathophysiology, high prevalence of PLP has been associated wi...Phantom limb pain(PLP) is not uncommon after amputation. PLP is described as a painful sensation perceived in the missing limb. Despite of its complicated pathophysiology, high prevalence of PLP has been associated with poor health-related quality of life, low daily activity and short walking distances. A prompt and effective management of PLP is essential in caring for the amputee population. Current treatments including physical therapy, psychotherapy, medications, and interventions have been used with limited success. In this review,we provided an updated and evidence-based review of treatment options for PLP.展开更多
Objective:To observe the effect of electroacupuncture plus drug anesthesia on pain and stress response in patients after radical surgery for stomach cancer.Methods:A total of 60 patients were randomized into a control...Objective:To observe the effect of electroacupuncture plus drug anesthesia on pain and stress response in patients after radical surgery for stomach cancer.Methods:A total of 60 patients were randomized into a control group and an observation group by the random number table,with 30 cases in each group.The control group was given conventional drug anesthesia.The observation group was given additional electroacupuncture intervention.Before anesthesia and 2 h,12 h and 24 h after surgery,the visual analog scale(VAS)was scored,the heart rate,the mean arterial pressure,and the levels of serumβ-endorphin(β-EP)and adrenocorticotrophic hormone(ACTH)were measured.Results:Two hours,12 h and 24 h after surgery,the VAS scores of both groups were higher than those before anesthesia(all P<0.05),and the VAS scores in the observation group were lower than those in the control group at the same time points(all P<0.05).Two hours,12 h and 24 h after surgery,the heart rates and mean arterial pressures in the control group were significantly higher than those before anesthesia(all P<0.05),while there were no significant intra-group differences in the observation group(all P>0.05),and the indicators were lower than those in the control group at the same time points(all P<0.05).Two hours,12 h and 24 h after surgery,the serumβ-EP levels in the observation group were significantly higher than those before anesthesia(all P<0.05),and significantly higher than those in the control group at the same time points(all P<0.05).Two hours,12 h and 24 h after surgery,the serum ACTH levels in the control group were significantly higher than those before anesthesia(all P<0.05),and were significantly higher than those in the observation group at the same time points(all P<0.05).Conclusion:Electroacupuncture plus drug anesthesia can significantly relieve pain and stress response in patients after radical surgery for stomach cancer.展开更多
The authors have treated postoperative complication of anus and intestine by usingacupuncture at main point Chengshan(BL 57) with cool-producing needling manipulation. Therapeuticeffects of the treatment on postoperat...The authors have treated postoperative complication of anus and intestine by usingacupuncture at main point Chengshan(BL 57) with cool-producing needling manipulation. Therapeuticeffects of the treatment on postoperative severe pain, retention of urine, constipation, and bleedingwere observed clinically. Results indicated that the cure rate was 97. 6 % and the total effective ratewas 100%. Strong stimulation of Chengshan(BL 57) point improved mainly postoperative edema,spasm, local edema. The improvement of hyperemia and spasm is a ma jor factor of curing various postoperative complication of the anus and intestine. The therapeutic method has advantages of using lesspoints, rapidly producing effects, shorter therapeutic course, suffering little for patients, and no sideeffect.展开更多
目的系统评价音乐疗法对儿童术后疼痛管理的影响。方法计算机检索中国知网、万方数据知识服务平台、维普资讯中文期刊服务平台、中国生物医学文献服务系统、PubMed、Web of Science、Medline等数据库,收集有关音乐疗法对儿童术后疼痛管...目的系统评价音乐疗法对儿童术后疼痛管理的影响。方法计算机检索中国知网、万方数据知识服务平台、维普资讯中文期刊服务平台、中国生物医学文献服务系统、PubMed、Web of Science、Medline等数据库,收集有关音乐疗法对儿童术后疼痛管理的相关文献。对纳入文献进行筛选、资料提取和质量评价后,采用RevMan 5.3软件进行Meta分析。结果共纳入9篇随机对照研究。Meta分析结果显示,与常规护理相比,采用音乐疗法的儿童疼痛行为评估量表评分、Wong-Baker面部表情疼痛量表评分、心率、收缩压更低(P<0.05),但两种护理方法在动脉血氧饱和度的差异无统计学意义(P>0.05)。结论音乐疗法可以缓解儿童术后疼痛,降低心率、收缩压,但对动脉血氧饱和度没有明显的改善作用。展开更多
The urinary, psychosocial, organ-specific, infection, neurological/systemic and tenderness （UPOINT） phenotype system has been validated to be an effective phenotype system in classifying patients with chronic prosta...The urinary, psychosocial, organ-specific, infection, neurological/systemic and tenderness （UPOINT） phenotype system has been validated to be an effective phenotype system in classifying patients with chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS） in western populations. To validate the utility of the UPOINT system and evaluate the effect of multimodal therapy based on the UPOINT system in Chinese patients with CPICPPS, we performed this study. Chinese patients with CP/CPPS were prospectively offered multimodal therapy using the UPOINT system and re-examined after 6 months. A minimum 6-point drop in National Institutes of Health-Chronic Prostatitis Symptoms Index （NIH-CPSI） was set to be the primary endpoint. Finally, 140 patients were enrolled in the study. The percentage of patients with each domain was 59.3%, 45.0%, 49.3%, 22.1%, 37.9%, and 56.4% for the UPOINT, respectively. The number of positive domains significantly correlated with symptom severity, which is measured by total NIH-CPSI scores （r = 0.796, P 〈 0.001）. Symptom duration was associated with a greater number of positive domains （r = 0.589, P〈 0.001）. With 6 months follow-up at least, 75.0% （105/140） had at least a 6-point improvement in NIH-CPSI after taking the therapy. All NIH-CPSI scores were significantly improved from original ones： pain 10.14 ± 4.26 to 6.60 ± 3.39, urinary 6.29 ± 2.42 to 3.63 ± 1.52, quality of life 6.56 ± 2.44 to 4.06 ± 1.98, and total 22.99 ± 7.28 to 14.29 ±5.70 （all P〈 0.0001）. Our study indicates that the UPOINT system is clinically feasible in classifying Chinese patients with CP/CPPS and directing therapy.展开更多
目的评价不同康复锻炼方式改善乳腺癌术后肩关节功能的效果。方法检索中国知网、维普网、万方数据、SinoMed、PubMed、Embase、Cochrane Library、Web of Science数据库中关于锻炼方式改善乳腺癌术后患者肩关节功能的随机对照试验,检索...目的评价不同康复锻炼方式改善乳腺癌术后肩关节功能的效果。方法检索中国知网、维普网、万方数据、SinoMed、PubMed、Embase、Cochrane Library、Web of Science数据库中关于锻炼方式改善乳腺癌术后患者肩关节功能的随机对照试验,检索时限为建库至2024年1月,采用Stata17.0软件进行文献的质量评价与数据分析。结果共纳入13项研究,涉及9种锻炼方式和994例患者。网状Meta分析结果表明,在改善肩部屈曲功能方面,水疗法和渐进式康复操的效果优于常规护理(均P<0.05),其中以水疗法的效果最佳;在改善肩部伸展功能方面,渐进式康复操、本体感觉神经肌肉促进术、推拿的效果优于常规护理(均P<0.05),其中以渐进式康复操的效果最佳;在改善肩部外旋功能方面,渐进式康复操的效果优于常规护理(P<0.05);在改善肩部内旋功能方面,涉及的锻炼方式两两比较均未产生统计学差异;在缓解疼痛方面,抗阻力训练的干预效果优于常规护理(P<0.05)。结论水疗法能更好地改善肩部屈曲功能,渐进式康复操在改善肩部伸展、外旋功能方面更具优势,抗阻力训练改善肩部疼痛的效果最优。展开更多
Objective： To observe the clinical efficacy of Chinese herbal fumigation plus beating with mulberry stick in treating heel pain. Methods： Sixty patients with heel pain were randomized into a treatment group and a c...Objective： To observe the clinical efficacy of Chinese herbal fumigation plus beating with mulberry stick in treating heel pain. Methods： Sixty patients with heel pain were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by Chinese herbal fumigation plus beating with mulberry stick, and the control group was by orally taking Diclofenac Sodium Sustained Release Tablets plus external use of She Xiong Zhen Tong Gao （Moschus Analgesic Plaster）. After one treatment course, the visual analogue scale （VAS） was used to observe the change of pain, and the clinical efficacies were also evaluated. Results： After intervention, the improvement of VAS score in the treatment group was more significant than that in the control group （P〈0.01）. The total effective rate of the treatment group was significantly higher than that of the control group （P〈0.01）. Conclusion： Chinese herbal fumigation plus beating with mulberry stick can produce a higher clinical efficacy than orally taking Diclofenac Sodium Sustained Release Tablets in treating heel pain.展开更多
基金supported by the Lishui Science and Technology Plan Project(Grant Number:2022SJZC020)the Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission(Grant Number:2020KY1084)
文摘Pain interventional therapy,known as the most promising medical technology in the 21st century,refers to clinical treatment technology based on neuroanatomy,neuroimaging,and nerve block technology to treat pain diseases.Compared with traditional destructive surgery,interventional pain therapy is considered a better and more economical choice of treatment.In recent years,a variety of minimally invasive pain interventional therapy techniques,such as neuroregulation,spinal cord electrical stimulation,intervertebral disc ablation,and intrasheath drug infusion systems,have provided effective solutions for the treatment of patients with post-herpetic neuralgia,complex regional pain syndrome,cervical/lumbar disc herniation,and refractory cancer pain.
基金the National Key Research and Development Program of China(Nos.2022YFB3205602 and 2022YFB3804703)the National Natural Science Foundation of China(Nos.52372174,61875015,and T2125003)+2 种基金the Beijing Natural Science Foundation(Nos.L212046 and L212010)the Fundamental Research Funds for the Central Universitiesthe Animal Experimentation Ethics Committee of the Cancer Hospital,Chinese Academy of Medical Sciences(Ethical Approval No.NCC2023A291).
文摘Acute postoperative pain is commonly treated with flurbiprofen(FBP),but conventional delivery methods are suboptimal.This study prepared a new non-burst release microneedles(MNs)using genipin cross-linked gelatin(cGel).By adding varying amounts of genipin to modulate the crosslinking degree of cGel,the drug release behavior of the drug-loaded MNs in the skin can be altered.The crosslinking parameters that meet therapeutic requirements are selected,thus providing rapid and longlasting analgesic effects.cGel solutions were successfully cross-linked,altering matrix material microstructure,confirmed by scanning electron microscope imaging and fourier transform infrared spectroscopy.MNs demonstrated increasing mechanical strength with higher crosslinking.Drug release rates were rapid initially,then slowed,exhibiting a characteristic of decreased release rates with increasing degrees of crosslinking.In vivo,FBP/cGel MNs significantly reduced allodynia and hyperalgesia post-surgery,with the greatest effect observed at 2–3 h post-surgery,and can maintain analgesia for up to 6 h.Biosafety tests confirmed good biocompatibility.FBP/cGel MNs effectively penetrate the stratum corneum,safely delivering drugs with significant analgesic effects,excellent mechanical properties,and good biocompatibility,representing a promising strategy for managing acute postoperative pain.
文摘Phantom limb pain(PLP) is not uncommon after amputation. PLP is described as a painful sensation perceived in the missing limb. Despite of its complicated pathophysiology, high prevalence of PLP has been associated with poor health-related quality of life, low daily activity and short walking distances. A prompt and effective management of PLP is essential in caring for the amputee population. Current treatments including physical therapy, psychotherapy, medications, and interventions have been used with limited success. In this review,we provided an updated and evidence-based review of treatment options for PLP.
文摘Objective:To observe the effect of electroacupuncture plus drug anesthesia on pain and stress response in patients after radical surgery for stomach cancer.Methods:A total of 60 patients were randomized into a control group and an observation group by the random number table,with 30 cases in each group.The control group was given conventional drug anesthesia.The observation group was given additional electroacupuncture intervention.Before anesthesia and 2 h,12 h and 24 h after surgery,the visual analog scale(VAS)was scored,the heart rate,the mean arterial pressure,and the levels of serumβ-endorphin(β-EP)and adrenocorticotrophic hormone(ACTH)were measured.Results:Two hours,12 h and 24 h after surgery,the VAS scores of both groups were higher than those before anesthesia(all P<0.05),and the VAS scores in the observation group were lower than those in the control group at the same time points(all P<0.05).Two hours,12 h and 24 h after surgery,the heart rates and mean arterial pressures in the control group were significantly higher than those before anesthesia(all P<0.05),while there were no significant intra-group differences in the observation group(all P>0.05),and the indicators were lower than those in the control group at the same time points(all P<0.05).Two hours,12 h and 24 h after surgery,the serumβ-EP levels in the observation group were significantly higher than those before anesthesia(all P<0.05),and significantly higher than those in the control group at the same time points(all P<0.05).Two hours,12 h and 24 h after surgery,the serum ACTH levels in the control group were significantly higher than those before anesthesia(all P<0.05),and were significantly higher than those in the observation group at the same time points(all P<0.05).Conclusion:Electroacupuncture plus drug anesthesia can significantly relieve pain and stress response in patients after radical surgery for stomach cancer.
文摘The authors have treated postoperative complication of anus and intestine by usingacupuncture at main point Chengshan(BL 57) with cool-producing needling manipulation. Therapeuticeffects of the treatment on postoperative severe pain, retention of urine, constipation, and bleedingwere observed clinically. Results indicated that the cure rate was 97. 6 % and the total effective ratewas 100%. Strong stimulation of Chengshan(BL 57) point improved mainly postoperative edema,spasm, local edema. The improvement of hyperemia and spasm is a ma jor factor of curing various postoperative complication of the anus and intestine. The therapeutic method has advantages of using lesspoints, rapidly producing effects, shorter therapeutic course, suffering little for patients, and no sideeffect.
文摘目的系统评价音乐疗法对儿童术后疼痛管理的影响。方法计算机检索中国知网、万方数据知识服务平台、维普资讯中文期刊服务平台、中国生物医学文献服务系统、PubMed、Web of Science、Medline等数据库,收集有关音乐疗法对儿童术后疼痛管理的相关文献。对纳入文献进行筛选、资料提取和质量评价后,采用RevMan 5.3软件进行Meta分析。结果共纳入9篇随机对照研究。Meta分析结果显示,与常规护理相比,采用音乐疗法的儿童疼痛行为评估量表评分、Wong-Baker面部表情疼痛量表评分、心率、收缩压更低(P<0.05),但两种护理方法在动脉血氧饱和度的差异无统计学意义(P>0.05)。结论音乐疗法可以缓解儿童术后疼痛,降低心率、收缩压,但对动脉血氧饱和度没有明显的改善作用。
文摘The urinary, psychosocial, organ-specific, infection, neurological/systemic and tenderness （UPOINT） phenotype system has been validated to be an effective phenotype system in classifying patients with chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS） in western populations. To validate the utility of the UPOINT system and evaluate the effect of multimodal therapy based on the UPOINT system in Chinese patients with CPICPPS, we performed this study. Chinese patients with CP/CPPS were prospectively offered multimodal therapy using the UPOINT system and re-examined after 6 months. A minimum 6-point drop in National Institutes of Health-Chronic Prostatitis Symptoms Index （NIH-CPSI） was set to be the primary endpoint. Finally, 140 patients were enrolled in the study. The percentage of patients with each domain was 59.3%, 45.0%, 49.3%, 22.1%, 37.9%, and 56.4% for the UPOINT, respectively. The number of positive domains significantly correlated with symptom severity, which is measured by total NIH-CPSI scores （r = 0.796, P 〈 0.001）. Symptom duration was associated with a greater number of positive domains （r = 0.589, P〈 0.001）. With 6 months follow-up at least, 75.0% （105/140） had at least a 6-point improvement in NIH-CPSI after taking the therapy. All NIH-CPSI scores were significantly improved from original ones： pain 10.14 ± 4.26 to 6.60 ± 3.39, urinary 6.29 ± 2.42 to 3.63 ± 1.52, quality of life 6.56 ± 2.44 to 4.06 ± 1.98, and total 22.99 ± 7.28 to 14.29 ±5.70 （all P〈 0.0001）. Our study indicates that the UPOINT system is clinically feasible in classifying Chinese patients with CP/CPPS and directing therapy.
文摘目的评价不同康复锻炼方式改善乳腺癌术后肩关节功能的效果。方法检索中国知网、维普网、万方数据、SinoMed、PubMed、Embase、Cochrane Library、Web of Science数据库中关于锻炼方式改善乳腺癌术后患者肩关节功能的随机对照试验,检索时限为建库至2024年1月,采用Stata17.0软件进行文献的质量评价与数据分析。结果共纳入13项研究,涉及9种锻炼方式和994例患者。网状Meta分析结果表明,在改善肩部屈曲功能方面,水疗法和渐进式康复操的效果优于常规护理(均P<0.05),其中以水疗法的效果最佳;在改善肩部伸展功能方面,渐进式康复操、本体感觉神经肌肉促进术、推拿的效果优于常规护理(均P<0.05),其中以渐进式康复操的效果最佳;在改善肩部外旋功能方面,渐进式康复操的效果优于常规护理(P<0.05);在改善肩部内旋功能方面,涉及的锻炼方式两两比较均未产生统计学差异;在缓解疼痛方面,抗阻力训练的干预效果优于常规护理(P<0.05)。结论水疗法能更好地改善肩部屈曲功能,渐进式康复操在改善肩部伸展、外旋功能方面更具优势,抗阻力训练改善肩部疼痛的效果最优。
基金supported by Jiaxing Hospital of Chinese Medicine
文摘Objective： To observe the clinical efficacy of Chinese herbal fumigation plus beating with mulberry stick in treating heel pain. Methods： Sixty patients with heel pain were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by Chinese herbal fumigation plus beating with mulberry stick, and the control group was by orally taking Diclofenac Sodium Sustained Release Tablets plus external use of She Xiong Zhen Tong Gao （Moschus Analgesic Plaster）. After one treatment course, the visual analogue scale （VAS） was used to observe the change of pain, and the clinical efficacies were also evaluated. Results： After intervention, the improvement of VAS score in the treatment group was more significant than that in the control group （P〈0.01）. The total effective rate of the treatment group was significantly higher than that of the control group （P〈0.01）. Conclusion： Chinese herbal fumigation plus beating with mulberry stick can produce a higher clinical efficacy than orally taking Diclofenac Sodium Sustained Release Tablets in treating heel pain.
