Objective:To explore the effect of"Yingxiang-Hegu"on Th1,Th2-related cytokines and[2]transcription factors T-bet and GATA-3 in rats with allergic rhinitis.Methods:Rats were randomly divided into three groups...Objective:To explore the effect of"Yingxiang-Hegu"on Th1,Th2-related cytokines and[2]transcription factors T-bet and GATA-3 in rats with allergic rhinitis.Methods:Rats were randomly divided into three groups:blank group,model group and acupoint group.The rat model of ovalbumin(OVA)AR was established,and the general condition of the rats was observed and scored.Acupuncture intervention was performed on the acupoint group on the second day after successful modeling,once per day for 20 min for 10 d.After intervention,the general behavior,behavioral score and histomorphological changes of nasal mucosa were observed.Eosinophils(EOS)were counted under microscope after nasal lavage smear staining,and the contents of total IgE,IFN-γ,IL-12,IL-4 and IL-5 in serum were detected by ELISA.Westernblot and IHC were used to detect the protein level and positive protein expression of specific transcription factors T-bet and GATA-3 in rat nasal mucosa.Results:After the establishment of the model,except for the blank group,the behavioral observation scores of rats in the model group and acupoint group were more than 5 points,indicating that the model was successful.After acupuncture intervention on acupoint"Yingxiang-Hegu",the behavioral score of rats in the acupoint group and western medicine group was significantly lower than that in the model group(P<0.05).Microscopic examination showed that the structure of nasal mucosa in the model group was obviously damaged,cilia were arranged discontinuously,uneven,local congestion and swelling,a large number of epithelial cells exfoliated and necrotic,goblet cell proliferation,obvious inflammatory cell infiltration.The pathological degree of nasal mucosa in the pair point group was significantly less than that in the model group.Compared with the model group,the levels of IFN-γ,IL-2 and IL-12 in serum were significantly increased,while IgE,IL-4,IL-5 and IL-6 were significantly decreased,GATA-3 protein and positive expression in nasal mucosa were significantly decreased and T-bet was significantly increased after acupuncture.Conclusion:Acupuncture at"Yingxiang-Hegu"can effectively improve the nasal sensitive symptoms and control nasal inflammation in AR rats.The mechanism may be that acupuncture at Yingxiang-Hegu can up-regulate the expression of T-bet,decrease the level of GATA-3,promote the production of Th1 cytokines and inhibit the synthesis and secretion of Th2 cells,thus restoring the immune balance of Th1 and Th2.展开更多
The improved near crack line analysis method was used to investigate an eccentric cracked plate loaded by two pairs of anti_plane point forces at the crack surface in an elastic_perfectly plastic solid. The analytical...The improved near crack line analysis method was used to investigate an eccentric cracked plate loaded by two pairs of anti_plane point forces at the crack surface in an elastic_perfectly plastic solid. The analytical solutions of the elastic_plastic stress fields and displacements near the crack line have been found without the assumptions of the small scale yielding. The law that the length of the plastic zone along the crack line is varied with an external loads and the bearing capacity of an eccentric cracked plate are obtained.展开更多
Most of the Point Pattern Matching (PPM) algorithm performs poorly when the noise of the point's position and outliers exist. This paper presents a novel and robust PPM algorithm which combined Point Pair Topologi...Most of the Point Pattern Matching (PPM) algorithm performs poorly when the noise of the point's position and outliers exist. This paper presents a novel and robust PPM algorithm which combined Point Pair Topological Characteristics (PPTC) and Spectral Matching (SM) together to solve the afore mentioned issues. In which PPTC, a new shape descriptor, is firstly proposed. A new comparability measurement based on PPTC is defined as the matching probability. Finally, the correct matching results are achieved by the spectral matching method. The synthetic data experiments show its robustness by comparing with the other state-of-art algorithms and the real world data experiments show its effectiveness.展开更多
In this paper, the improved near crack line analysis method proposed in Refs. [1] and [2] is used to investigate a center crack loaded by two pairs of antiplane point forces in a finite plate in an elastic-perfectly p...In this paper, the improved near crack line analysis method proposed in Refs. [1] and [2] is used to investigate a center crack loaded by two pairs of antiplane point forces in a finite plate in an elastic-perfectly plastic solid. And the analytical solutions are obtained, that is elastic-plastic stress fields near the crack line and the law that the length of the plastic zone along the crack line is varied with an external loads tr,ld the bearing capacity of a finite plate with a center crack. The results of this paper are sufficiently precise near the crack line, because the assumptions of the small scale yielding theory have not been used and no other assumptions have been taken.展开更多
The point pair feature(PPF)is widely used for 6D pose estimation.In this paper,we propose an efficient 6D pose estimation method based on the PPF framework.We introduce a well-targeted down-sampling strategy that focu...The point pair feature(PPF)is widely used for 6D pose estimation.In this paper,we propose an efficient 6D pose estimation method based on the PPF framework.We introduce a well-targeted down-sampling strategy that focuses on edge areas for efficient feature extraction for complex geometry.A pose hypothesis validation approach is proposed to resolve ambiguity due to symmetry by calculating the edge matching degree.We perform evaluations on two challenging datasets and one real-world collected dataset,demonstrating the superiority of our method for pose estimation for geometrically complex,occluded,symmetrical objects.We further validate our method by applying it to simulated punctures.展开更多
As early as in 1975, Shamos and Hoey first gave an O（n lg n）-time divide-and-conquer algorithm （Stt algorithm in short） for the problem of finding the closest pair of points. In one process of combination, the Euc...As early as in 1975, Shamos and Hoey first gave an O（n lg n）-time divide-and-conquer algorithm （Stt algorithm in short） for the problem of finding the closest pair of points. In one process of combination, the Euclidean distances between 3n pairs of points need to be computed, so the overall complexity of computing distance is then 3n lgn. Since the computation of distance is more costly compared with other basic operation, how to improve SH algorithm from the aspect of complexity of computing distance is considered. In 1998, Zhou, Xiong and Zhu improved SH algorithm by reducing this complexity to 2n lg n. In this paper, we make further improvement. The overall complexity of computing distances is reduced to （3n lg n）/2, which is only half that of SH algorithm.展开更多
In this paper, some new existence and uniqueness of points of coincidence of weakly compatible pair of mappings is obtained, which does not satisfy continuity and commutativity. The conditions are weaker than the usua...In this paper, some new existence and uniqueness of points of coincidence of weakly compatible pair of mappings is obtained, which does not satisfy continuity and commutativity. The conditions are weaker than the usual conditions in cone metric spaces.展开更多
基金Lv Jingshan Acupuncture and Medicine Combination Technology Innovation Team(No.2019TD-003)Lv Jingshan Acupuncture and Moxibustion and Bioelectronic Medicine Innovation Team(No.2022TD-1006)。
文摘Objective:To explore the effect of"Yingxiang-Hegu"on Th1,Th2-related cytokines and[2]transcription factors T-bet and GATA-3 in rats with allergic rhinitis.Methods:Rats were randomly divided into three groups:blank group,model group and acupoint group.The rat model of ovalbumin(OVA)AR was established,and the general condition of the rats was observed and scored.Acupuncture intervention was performed on the acupoint group on the second day after successful modeling,once per day for 20 min for 10 d.After intervention,the general behavior,behavioral score and histomorphological changes of nasal mucosa were observed.Eosinophils(EOS)were counted under microscope after nasal lavage smear staining,and the contents of total IgE,IFN-γ,IL-12,IL-4 and IL-5 in serum were detected by ELISA.Westernblot and IHC were used to detect the protein level and positive protein expression of specific transcription factors T-bet and GATA-3 in rat nasal mucosa.Results:After the establishment of the model,except for the blank group,the behavioral observation scores of rats in the model group and acupoint group were more than 5 points,indicating that the model was successful.After acupuncture intervention on acupoint"Yingxiang-Hegu",the behavioral score of rats in the acupoint group and western medicine group was significantly lower than that in the model group(P<0.05).Microscopic examination showed that the structure of nasal mucosa in the model group was obviously damaged,cilia were arranged discontinuously,uneven,local congestion and swelling,a large number of epithelial cells exfoliated and necrotic,goblet cell proliferation,obvious inflammatory cell infiltration.The pathological degree of nasal mucosa in the pair point group was significantly less than that in the model group.Compared with the model group,the levels of IFN-γ,IL-2 and IL-12 in serum were significantly increased,while IgE,IL-4,IL-5 and IL-6 were significantly decreased,GATA-3 protein and positive expression in nasal mucosa were significantly decreased and T-bet was significantly increased after acupuncture.Conclusion:Acupuncture at"Yingxiang-Hegu"can effectively improve the nasal sensitive symptoms and control nasal inflammation in AR rats.The mechanism may be that acupuncture at Yingxiang-Hegu can up-regulate the expression of T-bet,decrease the level of GATA-3,promote the production of Th1 cytokines and inhibit the synthesis and secretion of Th2 cells,thus restoring the immune balance of Th1 and Th2.
文摘The improved near crack line analysis method was used to investigate an eccentric cracked plate loaded by two pairs of anti_plane point forces at the crack surface in an elastic_perfectly plastic solid. The analytical solutions of the elastic_plastic stress fields and displacements near the crack line have been found without the assumptions of the small scale yielding. The law that the length of the plastic zone along the crack line is varied with an external loads and the bearing capacity of an eccentric cracked plate are obtained.
文摘Most of the Point Pattern Matching (PPM) algorithm performs poorly when the noise of the point's position and outliers exist. This paper presents a novel and robust PPM algorithm which combined Point Pair Topological Characteristics (PPTC) and Spectral Matching (SM) together to solve the afore mentioned issues. In which PPTC, a new shape descriptor, is firstly proposed. A new comparability measurement based on PPTC is defined as the matching probability. Finally, the correct matching results are achieved by the spectral matching method. The synthetic data experiments show its robustness by comparing with the other state-of-art algorithms and the real world data experiments show its effectiveness.
文摘In this paper, the improved near crack line analysis method proposed in Refs. [1] and [2] is used to investigate a center crack loaded by two pairs of antiplane point forces in a finite plate in an elastic-perfectly plastic solid. And the analytical solutions are obtained, that is elastic-plastic stress fields near the crack line and the law that the length of the plastic zone along the crack line is varied with an external loads tr,ld the bearing capacity of a finite plate with a center crack. The results of this paper are sufficiently precise near the crack line, because the assumptions of the small scale yielding theory have not been used and no other assumptions have been taken.
基金This work was supported in part by the National Key R&D Program of China(2018AAA0102200)National Natural Science Foundation of China(62132021,62102435,61902419,62002375,62002376)+2 种基金Natural Science Foundation of Hunan Province of China(2021JJ40696)Huxiang Youth Talent Support Program(2021RC3071)NUDT Research Grants(ZK19-30,ZK22-52).
文摘The point pair feature(PPF)is widely used for 6D pose estimation.In this paper,we propose an efficient 6D pose estimation method based on the PPF framework.We introduce a well-targeted down-sampling strategy that focuses on edge areas for efficient feature extraction for complex geometry.A pose hypothesis validation approach is proposed to resolve ambiguity due to symmetry by calculating the edge matching degree.We perform evaluations on two challenging datasets and one real-world collected dataset,demonstrating the superiority of our method for pose estimation for geometrically complex,occluded,symmetrical objects.We further validate our method by applying it to simulated punctures.
基金This work is supported by the National Natural Science Foundation of China （Grant No. 60496321） and Shanghai Science and Technology Development Fund （Grant No. 025115032）.
文摘As early as in 1975, Shamos and Hoey first gave an O（n lg n）-time divide-and-conquer algorithm （Stt algorithm in short） for the problem of finding the closest pair of points. In one process of combination, the Euclidean distances between 3n pairs of points need to be computed, so the overall complexity of computing distance is then 3n lgn. Since the computation of distance is more costly compared with other basic operation, how to improve SH algorithm from the aspect of complexity of computing distance is considered. In 1998, Zhou, Xiong and Zhu improved SH algorithm by reducing this complexity to 2n lg n. In this paper, we make further improvement. The overall complexity of computing distances is reduced to （3n lg n）/2, which is only half that of SH algorithm.
基金Supported by the Fundamental Research Fund of Sichuan Provincial Science and Technology Department(2012JYZ019)
文摘In this paper, some new existence and uniqueness of points of coincidence of weakly compatible pair of mappings is obtained, which does not satisfy continuity and commutativity. The conditions are weaker than the usual conditions in cone metric spaces.
