XRCC1 Polymorphisms and Pancreatic Cancer:A Meta-Analysis

Objective：To assess the association between X-ray repair cross-complementating group 1 （XRCC1） polymorphisms and pancreatic cancer.Methods：We searched MEDLINE,Web of Science and HuGE Navigator at June 2010,and then quantitatively summarized associations of the XRCC1 polymorphisms with pancreatic cancer risk using meta-analysis.Results：Four studies with 1343 cases and 2302 controls were included.Our analysis found：at codon 194,the Trp allele did not decrease pancreatic cancer risk （Arg/Arg versus Trp/Trp：OR=0.97;95% CI：0.48-1.96;P=0.97;Arg/Arg versus Arg/Trp：OR=0.89;95% CI：0.70-1.13;P=0.55;Arg/Trp versus Trp/Trp：OR=1.06;95% CI：0.52-2.16;P=0.90）;at codon 280,only a study showed a nonsignificant association between single nucleotide polymorphism with pancreatic cancer risk;at codon 399,the Gln allele also showed no signi？cant effect on pancreatic cancer compared to Arg allele （Arg/Arg versus Gln/Gln：OR=0.94;95% CI：0.74-1.18;Arg/Arg versus Arg/Gln：OR=0.97;95% CI：0.83-1.13;Arg/Gln versus Gln/Gln：OR=0.97;95% CI：0.77-1.22）.The shape of the funnel plot and the Egger＇s test did not detect any publication bias.Conclusion：There is no evidence that XRCC1 polymorphisms （Arg194Trp,Arg280His,and Arg399Gln） are associated with pancreatic cancer risk.

中国人与西方人胰腺癌组织中Ki-ras基因第12密码子突变表型的比较

目的探讨中国胰腺癌患者Ki-ras基因第12密码子突变表型的特点及与西方国家胰腺癌的区别。方法采用PCR扩增靶基因片段,Dotblot杂交的方法检测59例中国胰腺癌患者标本中Ki-ras基因第12密码子突变表型。利用Medline检索相关西方国家文献报道的胰腺癌患者Ki-ras基因第12密码子突变表型,并与本组资料进行对比。结果本组患者Ki-ras基因第12密码子突变频繁(76.3%)。与西方国家文献报道的资料比较显示,各国胰腺癌患者中Ki-ras基因第12密码子突变频率差异无统计学意义(P>0.05),但突变的表型及第二碱基突变的转换和颠换比的差异存在统计学意义(P<0.05,P<0.01,P<0.001)。结论Ki-ras基因第12密码子突变在中国胰腺癌患者较频繁,其突变表型在各国胰腺癌患者中可能存在差异。