Objective: To study the effect of early enteral nutrition intervention on nerve function, systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage. Methods: A total of 98 p...Objective: To study the effect of early enteral nutrition intervention on nerve function, systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage. Methods: A total of 98 patients with hypertensive cerebral hemorrhage who received hospitalization in the hospital between April 2015 and February 2017 were collected and divided into control group and observation group by random number table method, 49 cases in each group. Control group received routine enteral nutrition intervention and observation group received early enteral nutrition intervention. The differences in serum levels of nerve function-related indexes, oxidative stress indexes and inflammatory mediators were compared between the two groups of patients before and after intervention. Results: Before intervention, the differences in serum levels of nerve function-related indexes, oxidative stress indexes and inflammatory mediators were not statistically significant between the two groups of patients. After 1 week of intervention, serum S100B, NSE, GFAP, MBP, LPO, MDA, PCT, IL-1β, IL-6 and TNF-α levels of both groups of patients were lower than those before intervention while GSH-PX levels were higher than those before intervention, and serum S100B, NSE, GFAP, MBP, LPO, MDA, PCT, IL-1β, IL-6 and TNF-α levels of observation group were lower than those of control group while GSH-PX level was higher than that of control group. Conclusion:Early enteral nutrition intervention can effectively optimize the nerve function and suppress the systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage.展开更多
Objective: To study the effects of adjuvant ginkgolide injection therapy in perioperative period of hypertensive cerebral hemorrhage on neural functional recovery. Methods: Patients with hypertensive cerebral hemorrha...Objective: To study the effects of adjuvant ginkgolide injection therapy in perioperative period of hypertensive cerebral hemorrhage on neural functional recovery. Methods: Patients with hypertensive cerebral hemorrhage who underwent evacuation of hematoma in Traditional Chinese Medicine Hospital of Shunyi District Beijing between June 2015 and October 2017 were selected and divided into ginkgolide group and normal control group according to the perioperative application of ginkgolide injection or not in the history data. The levels of nerve injury markers and inflammatory stress mediators in serum as well as the expression of inflammatory stress signal molecules in peripheral blood were measured before treatment and 7 d after treatment. Results: Compared with same group before treatment, serum GNS and BDNF levels as well as peripheral blood Wnt1, GSK-3β and β-catenin expression of both groups of patients were significantly higher whereas serum Tau, NSE, OPN, MIF, HMGB1, TNF-α and MDA levels as well as peripheral blood eNOS and p38MAPK expression were significantly lower 7 d after treatment, and serum GNS and BDNF levels as well as peripheral blood Wnt1, GSK-3β and β-catenin expression of ginkgolide group 7 d after treatment were higher than those of normal control group whereas serum Tau, NSE, OPN, MIF, HMGB1, TNF-α and MDA levels as well as peripheral blood eNOS and p38MAPK expression were lower than those of normal control group. Conclusion: Adjuvant ginkgolide injection therapy in perioperative period of hypertensive cerebral hemorrhage can reduce the degree of nerve injury and inhibit the degree of inflammatory stress.展开更多
Objective: To compare the effects of sufentanil/fentanyl combined with propofol on the anesthesia of minimally invasive drainage for hypertensive cerebral hemorrhage. Methods:Patients with hypertensive cerebral hemorr...Objective: To compare the effects of sufentanil/fentanyl combined with propofol on the anesthesia of minimally invasive drainage for hypertensive cerebral hemorrhage. Methods:Patients with hypertensive cerebral hemorrhage who received minimally invasive drainage in Huanggang Cerebrovascular Hospital between June 2014 and February 2017 were selected and randomly divided into two groups, observation group received sufentanil combined with propofol anesthesia, and control group received fentanyl combined with propofol anesthesia. The serum contents of nerve injury, stress response, oxidation reaction and inflammatory response markers were measured during surgery and 12 h after surgery. Results: During surgery and 12 h after surgery, serum TF, NSE, GFAP, GLU, NE, E, ACTH, Cor, Ins, MDA, AOPP, 8-OHdG, NO, ICAM-1, TNF-α, IL-6, IL-17 and IL-23 levels of observation group were significantly lower than those of control group. Conclusion: Sufentanil combined with propofol for minimally invasive drainage of hypertensive cerebral hemorrhage is more effective than fentanyl combined with propofol to reduce the brain damage and inhibit the inflammatory response, stress response and oxidation reaction.展开更多
Objective: To study the effects of mild hypothermia irrigation fluid on nerve function and oxidative stress during intracranial hematoma irrigation. Methods: The patients with hypertensive cerebral hemorrhage who rece...Objective: To study the effects of mild hypothermia irrigation fluid on nerve function and oxidative stress during intracranial hematoma irrigation. Methods: The patients with hypertensive cerebral hemorrhage who received hematoma aspiration in our hospital between August 2014 and November 2017 were chosen and randomly divided into the observation group who received mild hypothermia irrigation fluid and the control group who received room temperature irrigation fluid. Before treatment and 72 h after treatment, the contents of nerve injury markers, cytokines and oxidative stress mediators were measured after peripheral blood extraction and serum separation. Results: Compared with those of control group, serum neuron-specific enolase (NSE), visinin-like protein-1 (VILIP-1), glial fibrillary acidic protein (GFAP), neuropeptide Y (NPY), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), high mobility group protein B1 (HMGB1), macrophage migration inhibitory factor (MIF), interleukin-1β (IL-1β), interleukin-10 (IL-10), malondialdehyde (MDA), 8-OHdG and nitric oxide (NO) contents of observation group were significantly lower whereas serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and total antioxidant capacity (TAOC) contents were significantly higher after treatment (P<0.05). Conclusion: The application of mild hypothermia irrigation fluid during intracranial hematoma irrigation can alleviate the nerve function injury, improve the neurotrophic status and inhibit the oxidative stress response.展开更多
文摘Objective: To study the effect of early enteral nutrition intervention on nerve function, systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage. Methods: A total of 98 patients with hypertensive cerebral hemorrhage who received hospitalization in the hospital between April 2015 and February 2017 were collected and divided into control group and observation group by random number table method, 49 cases in each group. Control group received routine enteral nutrition intervention and observation group received early enteral nutrition intervention. The differences in serum levels of nerve function-related indexes, oxidative stress indexes and inflammatory mediators were compared between the two groups of patients before and after intervention. Results: Before intervention, the differences in serum levels of nerve function-related indexes, oxidative stress indexes and inflammatory mediators were not statistically significant between the two groups of patients. After 1 week of intervention, serum S100B, NSE, GFAP, MBP, LPO, MDA, PCT, IL-1β, IL-6 and TNF-α levels of both groups of patients were lower than those before intervention while GSH-PX levels were higher than those before intervention, and serum S100B, NSE, GFAP, MBP, LPO, MDA, PCT, IL-1β, IL-6 and TNF-α levels of observation group were lower than those of control group while GSH-PX level was higher than that of control group. Conclusion:Early enteral nutrition intervention can effectively optimize the nerve function and suppress the systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage.
文摘Objective: To study the effects of adjuvant ginkgolide injection therapy in perioperative period of hypertensive cerebral hemorrhage on neural functional recovery. Methods: Patients with hypertensive cerebral hemorrhage who underwent evacuation of hematoma in Traditional Chinese Medicine Hospital of Shunyi District Beijing between June 2015 and October 2017 were selected and divided into ginkgolide group and normal control group according to the perioperative application of ginkgolide injection or not in the history data. The levels of nerve injury markers and inflammatory stress mediators in serum as well as the expression of inflammatory stress signal molecules in peripheral blood were measured before treatment and 7 d after treatment. Results: Compared with same group before treatment, serum GNS and BDNF levels as well as peripheral blood Wnt1, GSK-3β and β-catenin expression of both groups of patients were significantly higher whereas serum Tau, NSE, OPN, MIF, HMGB1, TNF-α and MDA levels as well as peripheral blood eNOS and p38MAPK expression were significantly lower 7 d after treatment, and serum GNS and BDNF levels as well as peripheral blood Wnt1, GSK-3β and β-catenin expression of ginkgolide group 7 d after treatment were higher than those of normal control group whereas serum Tau, NSE, OPN, MIF, HMGB1, TNF-α and MDA levels as well as peripheral blood eNOS and p38MAPK expression were lower than those of normal control group. Conclusion: Adjuvant ginkgolide injection therapy in perioperative period of hypertensive cerebral hemorrhage can reduce the degree of nerve injury and inhibit the degree of inflammatory stress.
文摘Objective: To compare the effects of sufentanil/fentanyl combined with propofol on the anesthesia of minimally invasive drainage for hypertensive cerebral hemorrhage. Methods:Patients with hypertensive cerebral hemorrhage who received minimally invasive drainage in Huanggang Cerebrovascular Hospital between June 2014 and February 2017 were selected and randomly divided into two groups, observation group received sufentanil combined with propofol anesthesia, and control group received fentanyl combined with propofol anesthesia. The serum contents of nerve injury, stress response, oxidation reaction and inflammatory response markers were measured during surgery and 12 h after surgery. Results: During surgery and 12 h after surgery, serum TF, NSE, GFAP, GLU, NE, E, ACTH, Cor, Ins, MDA, AOPP, 8-OHdG, NO, ICAM-1, TNF-α, IL-6, IL-17 and IL-23 levels of observation group were significantly lower than those of control group. Conclusion: Sufentanil combined with propofol for minimally invasive drainage of hypertensive cerebral hemorrhage is more effective than fentanyl combined with propofol to reduce the brain damage and inhibit the inflammatory response, stress response and oxidation reaction.
文摘Objective: To study the effects of mild hypothermia irrigation fluid on nerve function and oxidative stress during intracranial hematoma irrigation. Methods: The patients with hypertensive cerebral hemorrhage who received hematoma aspiration in our hospital between August 2014 and November 2017 were chosen and randomly divided into the observation group who received mild hypothermia irrigation fluid and the control group who received room temperature irrigation fluid. Before treatment and 72 h after treatment, the contents of nerve injury markers, cytokines and oxidative stress mediators were measured after peripheral blood extraction and serum separation. Results: Compared with those of control group, serum neuron-specific enolase (NSE), visinin-like protein-1 (VILIP-1), glial fibrillary acidic protein (GFAP), neuropeptide Y (NPY), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), high mobility group protein B1 (HMGB1), macrophage migration inhibitory factor (MIF), interleukin-1β (IL-1β), interleukin-10 (IL-10), malondialdehyde (MDA), 8-OHdG and nitric oxide (NO) contents of observation group were significantly lower whereas serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and total antioxidant capacity (TAOC) contents were significantly higher after treatment (P<0.05). Conclusion: The application of mild hypothermia irrigation fluid during intracranial hematoma irrigation can alleviate the nerve function injury, improve the neurotrophic status and inhibit the oxidative stress response.
