期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Trypanosoma cruzi invasion in non-phagocytic cells:an ultrastructural study
1
作者 Juan Agustín CUETO Emile SANTOS BARRIAS +1 位作者 Wanderley de SOUZA Patricia Silvia ROMANO 《BIOCELL》 SCIE 2018年第3期105-108,共4页
Trypanosoma cruzi is the causative agent of Chagas disease.This parasite requires the intracellular niche in order to proliferate and disseminate the infection.After invasion,T.cruzi resides temporarily in an acidic v... Trypanosoma cruzi is the causative agent of Chagas disease.This parasite requires the intracellular niche in order to proliferate and disseminate the infection.After invasion,T.cruzi resides temporarily in an acidic vacuole which is lysed by a not well-understood mechanism.Transmission electron microscopy was used to describe the process of T.cruzi escape from the parasitophorous vacuole over the time.Using HeLa(non-professional phagocytic cells)as host cell,we observed that recently internalized parasites reside in a membrane-bounded vacuole.A few hours later,the first sign of vacuole disruption appeared as membrane discontinuities.This observation was followed by a progressive vacuole swelling as evidenced by an electron-lucent halo between the parasite and the vacuole membrane.Apparently,the vacuole membrane remnants reorganized as small vesicles that eventually disappeared from the vicinity of the parasites.Finally,parasites reach the host cell cytosol where replication takes place.The thorough ultrastructural description of this process set the base for a comprehensive understanding of the parasite-host cell interaction and,thus open the possibility of new therapeutic intervention strategies. 展开更多
关键词 parasitophorous vacuole PATHOGEN Parasites Chagas disease Infectious diseases
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部