Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after diagnosis.Given that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic pathway.First,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal denervation.Four weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 weeks.During this period,the animals had access to a running wheel,which they could use or not.Docosahexaenoic acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars compacta.However,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned striatum.Compared to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned striatum.The present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

Exercise and exerkine upregulation:Brain-derived neurotrophic factor as a potential non-pharmacological therapeutic strategy for Parkinson’s disease

Physical activity and exercise have several beneficial roles in enhancing both physiological and psychological well-being of an individual.In addition to aiding the regulation of aerobic and anaerobic metabolism,exercise can stimulate the synthesis of exerkine hormones in the circulatory system.Among several exerkines that have been investigated for their therapeutic potential,Brain-derived neurotrophic factor(BDNF)is considered the most promising candidate,especially in the management of neurodegenerative diseases.Owing to the ability of physical activity to enhance BDNF synthesis,several experimental studies conducted so far have validated this hypothesis and produced satisfactory results at the pre-clinical level.This review highlights some of the recent animal model studies that have evaluated the efficiency of exercise in enhancing BDNF synthesis and promoting neuroprotective effects.Further,this review focuses on understanding the therapeutic benefits of exercise-induced exerkine synthesis as a non-pharmacological strategy in Parkinson’s disease(PD).Regarding physical activity and exerkine induction,the neuromuscular electrical stimulation(NMES)strategy could be considered as an alternate treatment modality for patients affected with PD.

Effectiveness of aerobic exercise interventions on balance,gait,functional mobility and quality of life in Parkinson’s disease:an umbrella review

Introduction Parkinson’s disease(PD)is a neurodegenerative disorder with increasing prevalence into older age.Aerobic exercise(AE)is the most commonly prescribed exercise for PD,although an optimal protocol is undefined.This umbrella review aimed to summarise and synthesize existent evidence regarding the effectiveness of AE on balance,gait,functional mobility,and QoL in people with PD.Content Six databases were searched for systematic reviews reporting the effects of AE on balance,gait,functional mobility,and QoL in people with PD from inception to June 2024.Quality of evidence was assessed using the AMSTAR-2 tool.From 4182 records,17 systematic reviews were included for qualitative analysis.Most(n=12)were rated as critically low for methodological quality,with four rated low and one high.Moderate intensity was the most commonly investigated AE intensity(n=4),although almost half of the reviews(n=8)did not report intensity.AE protocols lasted from 1 to 64 weeks and 1 to 7 days per week.Session length was between 20 and 120 minutes.Reported outcomes included gait(n=15),QoL(n=14),balance(n=12),and functional mobility(n=7).AE does improve aspects of gait,balance,and functional mobility in PD;however it does not appear to improve QoL.Summary and Outlook AE is recommended as part of rehabilitation for people with PD.However,research exploring the efficacy of AE assesses multiple modalities with varied protocols.Further research is needed to identify AE protocols that will best alleviate the symptoms of PD,providing an evidence base for effective clinical translation.

The Effects of Exercise on People with Parkinson’s Disease—Review

Quality of life encompasses physical, psychological and social aspects of health. Apart from motor symptoms (physical aspects), Parkinson’s disease (PD) is also closely related with various non-motor symptoms (psychological and social aspects) that can undermine quality of life greatly, even in early stages of the disease. Most research studies in this field focus on analysis of motor symptoms in PD sufferers. Although benefits of physical activity for the psychosocial quality of life are well-known, they have been mostly neglected in case of the people suffering from PD. Numerous studies clearly show that training programs can ameliorate the quality of life as far as non-motor functions in PD sufferers are concerned. The only psychological aspects of the disease related to the effects of exercise that have been researched so far are depression and cognitive functions. Depression is the most common denominator of poor quality of life, while dementia often accompanies the Parkinson’s disease. Studies have shown positive effects of exercise on the social life of those suffering from the disease, especially in case of group exercise. Studying psychological and social aspects of such chronic conditions as PD is of utmost importance for monitoring the patient’s adjustment to the disease, functioning with it, as well as the overall well-being and satisfaction with life. Thus far, the results have been pointing towards improvement of the quality of life. Exercise is a readily available method of treatment in case of PD, especially if applied in the early stages of the disease. In addition to reviewing the existing studies on the relation between exercise and quality of life of the patients, this paper will also focus on the way the psychological and social aspects of PD are influenced by exercise.

Evaluating rehabilitation interventionsin Parkinson's disease with functional MRI:a promising neuroprotective strategy

Parkinson＇s disease （PD） is a progressive neurodegenerative disorder affecting approximately 10 million people world- wide （Planetta et al., 2014; Zigmond and Smeyne, 2014）. The principal clinical features of PD are bradykinesia, rigidity, tremor at rest and postural instability （Planetta et al., 2014）. It is known that both PD itself and the use of anti-parkinson drugs are associated with several non-motor symptoms such as cognitive impairment, neuropsychiatric disturbances and sleep, autonomic, and sensory disorders （Park and Stacy, 2009; Foster et al., 2014）. The histopathological hallmark of PD is the reduction of dopaminergic cells in the substantia nigra pars compacta, causing dopamine deficiency in spe- cific nuclei of the basal ganglia such as the dorsal striatum （Fearnley and Lees, 1991; Planetta et al., 2014）. The disrup- tion of the dopaminergic system has long been regarded as the major cause of PD; however, it has been shown that a widespread involvement of several non-dopaminergic path- ways also contribute to the clinical manifestations of PD （Park et al., 2014）.

Efficacy of cognitive rehabilitation in Parkinson's disease

Cognitive rehabilitation is a potential and promising treatment for cognitive impairment in Parkinson＇s disease （PD） that has shown efficacy in diverse studies. In addition, some few studies have found brain changes after cognitive rehabilitation in PD, which supports the existence of brain plasticity associated to cognitive training in a degen- erative disease.

Diagnostics, rehabilitation and models of Parkinson’s disease

Diagnostics and rehabilitation of Parkinson’s disease (PD) presents the current information pertaining to etiology, early biomarkers for diagnostics, novel methods to evaluate symptoms, multidisciplinary rehabilitation, new applications of brain imaging and invasive methods to the study of PD. Researchers have only recently begun to focus on the non-motor symptoms of PD, which are poorly recognized and inadequately treated by clinicians. The non-motor symptoms of PD have a significant impact on patient quality of life and mortality, and include cognitive impairments, autonomic, gastrointestinal, and sensory symptoms. Indepth discussion of the use of imaging tools to study disease mechanisms is also provided, with emphasis on the abnormal network organization in parkinsonism. Deep brain stimulation management is a paradigm-shifting therapy for PD, essential tremor and dystonia. In the recent years, new approaches of early diagnostics, training programmes and treatments have vastly improved the lives of people with PD, substantially reducing symptoms and significantly delaying disability. PD results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms;none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction and oxidative stress, may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cas-cade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.

The effect of conduction exercise and selfacupressure in treatment of Parkinson’s disease:Protocol for a pilot study

Objective:Parkinson’s disease(PD)is the second most common neurodegenerative disease in the world.In 2004,approximately 13,000 individuals in Hong Kong,China,had PD.PD greatly affects quality of life and conventional medication can produce severe side effects.The traditional Chinese medicine(TCM)practices of conduction exercise(CE)and selfacupressure(SA)may relieve PD symptoms.This paper presents a protocol for a randomized controlled trial to determine the effectiveness of CE and SA in treating PD.Methods:Patients with primary PD were recruited.Eligible patients were randomly assigned to either a treatment or control group.The assessor and data analysts were blind.The treatment phase duration was 8 weeks,with 8 weekly sessions of CE and SA practice.Baseline,midpoint,and final assessments were carried out during the treatment phase.The primary outcome is scores on the 39-item Parkinson’s Disease Questionnaire(PDQ-39),and the secondary outcome is scores on a custom-designed questionnaire based on TCM“Deficiency of Spleen Qi”scores and scores on a non-motor PD symptoms scale.Discussion:This trial is the first rigorous study of the effectiveness of CE and SA in relieving PD symptoms.The aim is to examine the effectiveness of CE and SA in treating a disease that is difficult to treat conventionally.The data obtained will form the foundation for future related studies.Trial registration:Chinese Clinical Trial Registry(ChiCTR-IPR-17011987,Date of registration:14 July,2017).

Effects of COVID-19 on Outpatient Visitation of Japanese Parkinson’s Disease and Parkinsonism Patients Receiving Rehabilitation

Background: Rehabilitation is effective for preventing progression of Parkinson’s disease (PD) and parkinsonism, but access to services during the COVID-19 pandemic was difficult. The Japanese already practice high levels of social distancing and personal restraint and are keenly aware of dangers related to infectious disease. We therefore presume that many patients discontinued rehabilitation due to behavioral restraint. Objectives: We investigated whether PD patients and parkinsonism patients attending outpatient rehabilitation facilities in Japan initiated rehabilitation interruptions and their associated reasons before and during the COVID-19 pandemic. Methods: Subjects were PD and parkinsonism patients attending a neurology clinic outpatient rehabilitation department in Japan before and during the first year of the COVID-19 pandemic (February 1, 2019, to January 31, 2021). Patients lost to follow-up were investigated as to how long they attended rehabilitation until interruption. We classified factors causing rehabilitation interruption into COVID-19-related factors, disease factors and social reasons. Results: Among 259 subjects (125 men, 134 women, mean age: 76.6 ± 8.5 years), 133 patients (51.4%) initiated interruption of rehabilitation therapy. Cumulative incidence of interruption events was significantly higher during than before the COVID-19 pandemic (p Conclusions: Cumulative incidence of interruption events increased in Japanese PD and parkinsonian patients attending an outpatient rehabilitation facility during the COVID-19 pandemic, primarily due to COVID-19-related factors. Patients and their families need education and guidance to facilitate continuous rehabilitation.

The Impact and Intervention of Handheld Tai Chi Water-Resistance Fitness Ball on Middle-Aged and Elderly Patients with Parkinson’s Disease

Through the use of a survey and statistical methods, this study explores the effects and interventions of handheld Tai Chi water resistance fitness balls on the elderly with Parkinson’s disease. Firstly, a questionnaire on exercise compliance for patients with Parkinson’s disease was developed, and its reliability and validity were tested. Then, a survey was conducted to investigate the current status of exercise compliance among Parkinson’s disease patients, including general information, scoring status, and single and multiple factor analyses of influencing factors [1]. The results of the study show that through qualitative research, the dimensions and item pools of the questionnaire were initially constructed, and the reliability analysis of the questionnaire was conducted through Delphi expert consultation, with favorable results in terms of its reliability and validity [2]. Regarding the current status of exercise compliance among Parkinson’s disease patients, the study found that the level of exercise compliance needs improvement, and there are significant differences in exercise compliance levels among patients under different circumstances. Finally, the research results were discussed and conclusions were drawn. The innovation of this study lies in the development of a questionnaire on exercise compliance for patients with Parkinson’s disease and the preliminary qualitative research and Delphi expert consultation conducted on it, providing new ideas and methods for the study of exercise compliance. However, the study also has limitations as it did not examine the effects of other interventions on Parkinson’s disease, so further research should be conducted [3].

Virtual games and quality of life in Parkinson’s disease: A randomised controlled trial

Objective: To evaluate the efficacy of Nintendo Wii training in quality of life in Parkinson’s disease (PD) patients when compared to traditional physical therapy (PT). Methods: A randomized, single-blinded trial with 2 parallel arms was performed in a referral center for movement disorders in North-eastern, Brazil. Forty-four PD outpatients that fulfilled the eligibility criteria with mild to moderate motor impairment were randomized. Both groups executed a warm up session for 10 minutes that consisted of trunk flexion, extension and rotation, associated with upper and lower limbs stretching. The PT group followed a program that consisted of trunk and limb mobilisation, balance, muscle strengthening, rhythmic movement, postural alignment, double-task execution, bimanual tasks, and gait training. The Nintendo Wii group executed a sequence of tasks according to a previously established protocol, with similar training exercises. Duration of exercises was 40 minutes per session, 3 days per week for 4 weeks. The primary endpoint was the total score obtained in the Parkinson’s disease quality of life questionnaire (PDQ-39) translated from English to Brazilian Portuguese by Oxford outcomes. Secondary endpoints were the scores achieved by each group in the following domains of PDQ-39 scale: mobility, activities of daily living (ADL), emotional well-being, stigma, social support, cognition, communication and bodily discomfort. Assessments were performed before and after intervention in both groups with subjects in the “on” period. Results: Subjects in the Nintendo Wii group showed greater improvement in the PDQ-39 total score when compared to PT group (p = 0.01). Also, significant differences were observed in ADL, stigma, social support and communication when comparing subjects before and after intervention in the Nintendo Wii group (p < 0.05). Conclusions: The results achieved in this trial suggest that rehabilitation using Nintendo Wii may have beneficial effects in quality of life of PD subjects, when compared to traditional PT. Further larger randomised controlled-trials are necessary to reassure these results.

The International Classification of Functioning, Disability and Health as Applied to Parkinson’s Disease: A Literature Review

Objective: The objective was to describe and quantify the development of the use of the International Classification of Functioning, Disability and Health (ICF), and portray the different components that have been used in the case of Parkinson’s disease (PD). Method: A literature review was carried out as from articles published in the electronic databases PubMed, Cochrane, SciELO (Scientific Electronic Library Online) and PEDro (Physiotherapy Evidence Database). The following descriptors were used: “Parkinson disease”, “ICF”, “Doença de Parkinson” and “CIF”, combining them by the use of “and”. The search covered the period from October 2014 to March 2015. Results: 50 scientific articles were found, which were evaluated by means of a thematic interpretive reading of the title and summary, finally arriving at 4 articles which related ICF to PD. In sequence the contents of the 4 articles were evaluated: organizing the author, year published, type of study, objective, methodology, ICF domains described, sample, main results and conclusions with respect to the use of ICF in PD patients, into a frame. Conclusions: The choice of ICF items provides an exact description of the functionality and incapacity domains in PD. However, it was evident that ICF had been little used to classify PD patients and help in the elaboration of intervention programs for these patients.

Aquatic Physiotherapy and Parkinson’s Disease: Effects on Functional Motor Skills

Parkinson’s Disease (PD) is a progressive disease with motor impairment, and as such requires a multidisciplinary team that includes physiotherapy. Physiotherapy can stimulate learning ability, motor recovery, neuroplasticity and neuroprotection. The aquatic physiotherapy (AP) for PD enables movements to be progressively and safely executed, reducing the risk of falls. Hence, the objective of this study is to analyze the effects of an AP program on the functional motor skills of people with PD. This is a controlled quasi-experimental clinical trial, with blind assessor. The participants were male and female, diagnosed with PD, Hoehn and Yahr stages 1 to 4 and medical certificate for AP. The exclusion criteria were: not presenting independent walking;sensorial deficit;contraindications for attending a heated pool;alterations in levodopa ingestion. The functional assessments conducted on land were: walking speed test;Five Times Sit to Stand Test;Mini BESTest, Unified Parkinson’s Disease Rating Scale (UPDRS) for activities of daily living (ADL);and motor skill parts, evaluated before, after and 4 months after AP. The aquatic assessment was conducted through the Aquatic Functional Assessment Scale (AFAS). The participants were allocated in two groups: Control Group (CG), which did not take part in the pool activities, and Experimental Group (EG), which was submitted to AP, throughout 32 twice-a-week, 50-minute-long appointments. Functional exercises were proposed to respect the principles of specificity and progression regarding complexity in the aquatic activities through aquatic motor skills learning phases. Groups and times were compared statistically. At the end of the study, the EG was composed of 11 participants and the CG 7. There were no differences between the groups at the beginning of the study. A difference was observed between groups for gait speed in evaluation 2;difference between assessment 1 and 2 for GE in the ADL and motor, as well as between assessment 2 and 3 for GE in the motor assessment. CG presented a decline from assessment 1 and 3. In the aquatic assessment, the EG had a statistical difference after the intervention. It was observed that the AP program can modify the aquatic motor skills and the land motor skills of walking speed, the UPDRS ADL and the UPDRS motor.

Body Balance and Core Training in Parkinson’s Disease: A Longitudinal Crossover Study

Objective: The objective of this study was to verify the effects of two different training protocols based on Core Stability and Body Balance exercises in subjects with Parkinsons’s Disease. Methods: Eight elderly men with PD (age of 73 ± 9 years, weight 69 ± 16 kg, height 164 ± 13 cm, 2 ± 1 of Disability Score according to Hoehn and Yahr scale). The disability score was evaluated using Hoehn and Yahr scale. This study was 12-month-long organized in 3 blocks of 4 months each. The sample was divided in two groups formed by 4 subjects each group. During the first four months, one group performed core stability exercises (CSG) while the other group exercised itself through a Balance Exercises Program (BG). After this first part of the study both protocols were stopped for the following 4 months. Finally, the group were reversed (counter balance design) for the last 4 months of physical activity. The two groups were measured twice, before (T0) and after the treatment (T1). Both treatments were designed in order to investigate the improvement in core muscles performance in order to grant a better balance control and to reduce the risk of falling. Results: statistically significant variations were found in the flight time of Sit-to-Stand (p < 0.05, +27%) and in the step length (p < 0.05, ?3%). In the CSG group, statistically significant variations were detected in Speed of Steps (p < 0.05, +5%), Step Cadence (p < 0.05, +3%), and Left Stride Duration (p < 0.05, ?3%) (Table 1). Conclusion: Both Body Balance and Core training can be considered two good physical exercise methods for people with PD. This study highlights the positive effects of this training protocol on legs strength improvements and on the balance control while walking.

Exercise-induced increase in brain-derived neurotrophic factor in human Parkinson's disease:a systematic review and metaanalysis

Background:Animal models of exercise and Parkinson’s disease(PD)have found that the physiologic use of exercise may interact with the neurodegenerative disease process,likely mediated by brain derived neurotrophic factor(BDNF).No reviews so far have assessed the methodologic quality of available intervention studies or have bundled the effect sizes of individual studies on exercise-induced effects on BDNF blood levels in human PD.Research design and methods:We searched MEDLINE,EMBASE,Cochrane Library,PsycINFO and PubMed from inception to June 2017.Results:Data aggregated from two randomized controlled trials and four pre-experimental studies with a total of 100 ambulatory patients with idiopathic PD(Hoehn/Yahr≤3)found improvements in BDNF blood concentration levels in all 6 studies(two RCTs and 4 pre-experimental studies).Pooled BDNF level change scores from the 2 RCTs resulted in a significant homogeneous summary effect size(Standardized Mean Difference 2.06,95% CI 1.36 to 2.76),and a significant heterogeneous SES for the motor part of the UPDRS-Ⅲ examination(MD-5.53,95% CI-10.42 to-0.64).Clinical improvements were noted in all studies using a variety of outcome measures.Limitations:The evidence-base consists primarily of small studies with low to moderate methodological quality.Conclusions:This review provides preliminary evidence for the effectiveness of physical exercise treatments for persons with PD on BDNF blood levels.Further research is needed.

The effects of exercise on cognition in Parkinson’s disease: a systematic review

Cognitive impairments are highly prevalent in Parkinson’s disease(PD)and can substantially affect a patient’s quality of life.These impairments remain difficult to manage with current clinical therapies,but exercise has been identified as a possible treatment.The objective of this systematic review was to accumulate and analyze evidence for the effects of exercise on cognition in both animal models of PD and human disease.This systematic review was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses(PRISMA)statement.Fourteen original reports were identified,including six pre-clinical animal studies and eight human clinical studies.These studies used various exercise interventions and evaluated many different outcome measures;therefore,only a qualitative synthesis was performed.The evidence from animal studies supports the role of exercise to improve cognition in humans through the promotion of neuronal proliferation,neuroprotection and neurogenesis.These findings warrant more research to determine what roles these neural mechanisms play in clinical populations.The reports on cognitive changes in clinical studies demonstrate that a range of exercise programs can improve cognition in humans.While each clinical study demonstrated improvements in a marker of cognition,there were limitations in each study,including non-randomized designs and risk of bias.The Grading of Recommendations Assessment,Development and Evaluation(GRADE)system was used and the quality of the evidence for human studies were rated from“low”to“moderate”and the strength of the recommendations were rated from“weak”to“strong”.Studies that assessed executive function,compared to general cognitive abilities,received a higher GRADE rating.Overall,this systematic review found that in animal models exercise results in behavioral and corresponding neurobiological changes in the basal ganglia related to cognition.The clinical studies showed that various types of exercise,including aerobic,resistance and dance can improve cognitive function,although the optimal type,amount,mechanisms,and duration of exercise are unclear.With growing support for exercise to improve not only motor symptoms,but also cognitive impairments in PD,health care providers and policy makers should recommend exercise as part of routine management and neurorehabilitation for this disorder.

Shaker训练法联合摄食训练治疗帕金森病吞咽障碍效果观察

目的:探讨Shaker训练法联合摄食训练对帕金森病(Parkinson′s disease,PD)所致吞咽障碍的疗效。方法:选取2017年5月—2018年7月伴吞咽障碍的PD患者42例,随机分为两组,各21例。对照组进行常规吞咽康复训练,观察组在常规训练基础上进行Shaker训练法和摄食训练,为期4周,训练前后用进食评估问卷调查工具-10(eating assessment tools-10,EAT-10)和反复唾液吞咽试验(the repetitive saliva swallowing test,RSST)进行效果评价。结果:干预前两组EAT-10和RSST评估结果差异无统计学意义(P>0.05),干预后两组EAT-10和RSST结果皆优于治疗前(P<0.05),且观察组优于对照组(P<0.05)。结论:Shaker训练法联合摄食训练对PD吞咽障碍有效,能提高患者生活质量,减少误吸。

基于生态系统理论的帕金森病患者及照护者居家康复运动影响因素的质性研究

目的探讨帕金森病患者及其照护者对居家康复锻炼的真实体验,深入挖掘居家康复的影响因素,为提高帕金森病患者居家康复质量提供参考依据。方法采用描述性质性研究,选取16对居家康复锻炼的帕金森病患者及其主要照护者进行半结构式访谈,基于Bronfenbrenner生态系统理论模型、利用主题分析法和配对分析法对访谈资料进行分析和提炼主题。结果提炼出微系统——帕金森病患者个体特质(疾病现状与进展、心理弹性与应对方式、创伤后成长、运动自我效能与动机)、中系统——家庭抗逆力系统(主要照护者微系统特质、家庭信念系统、家庭组织模式、家庭沟通过程)、外系统——相关社会领域及宏系统——文化环境4个主题。结论帕金森病患者居家康复运动受多种因素的影响,患者及其家庭应充分激发个体主观能动性、重视主要照护者照护功能、调动家庭抗逆力实现家庭复原、合理利用社会资源,医疗教育等社会领域应充分聚焦专科性发展、建立支持系统协同实现帕金森病患者居家康复。

基于信息框架效应的运动干预在帕金森病病人跌倒恐惧中的应用

目的:探讨基于信息框架效应的运动干预在帕金森病人跌倒恐惧中的应用效果。方法:采用便利抽样法选取2023年8月—10月在某三级甲等医院确诊的108例帕金森病人为研究对象,按照入住不同病区分为对照组、积极信息框架组和消极信息框架组,各36例,对照组给予常规护理,积极信息框架组和消极信息框架组分别给予基于信息框架效应的运动干预方案,比较3组病人干预前后的跌倒效能及平衡能力。结果:共103例病人完成干预,积极信息框架组和消极信息框架组病人干预后平衡能力及跌倒效能得分高于对照组,差异均有统计学意义(P<0.05)。结论:基于信息框架效应的运动干预能有效提高帕金森病人的平衡能力和跌倒效能,降低其跌倒恐惧。

Cox健康行为互动模式对COPD稳定期患者肺康复的影响研究

目的探讨Cox健康行为互动模式对慢性阻塞性肺疾病(COPD)稳定期患者肺康复的影响。方法选取2023年1-10月在该院呼吸内科就诊的COPD患者90例,按随机数字表法分为干预组和对照组,各45例。对照组患者给予常规肺康复护理,干预组患者在此基础上实施Cox健康行为互动模式的肺康复护理,比较2组患者的肺康复指标[第1秒用力呼气容积(FEV_(1))、第1秒用力呼气容积占预计值百分比(FEV_(1)%)、FEV_(1)/用力肺活量(FVC)]、运动功能(6 min步行距离)、生活质量[COPD评估测试(CAT)]和出院后肺康复运动依从性。结果干预后,干预组患者FEV_(1)、FEV_(1)%、FEV_(1)/FVC较对照组明显升高,6 min步行距离较对照组明显延长,CAT评分较对照组明显降低,出院后康复运动依从性较对照组明显提高,差异均有统计学意义(P<0.05)。结论基于Cox健康行为互动模式的肺康复护理有助于提高COPD患者的肺功能,增强其运动能力和生活质量,改善其肺康复运动依从性。