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Classification of Short Time Series in Early Parkinson’s Disease With Deep Learning of Fuzzy Recurrence Plots 被引量:9
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作者 Tuan D.Pham Karin Wardell +1 位作者 Anders Eklund Goran Salerud 《IEEE/CAA Journal of Automatica Sinica》 EI CSCD 2019年第6期1306-1317,共12页
There are many techniques using sensors and wearable devices for detecting and monitoring patients with Parkinson’s disease(PD).A recent development is the utilization of human interaction with computer keyboards for... There are many techniques using sensors and wearable devices for detecting and monitoring patients with Parkinson’s disease(PD).A recent development is the utilization of human interaction with computer keyboards for analyzing and identifying motor signs in the early stages of the disease.Current designs for classification of time series of computer-key hold durations recorded from healthy control and PD subjects require the time series of length to be considerably long.With an attempt to avoid discomfort to participants in performing long physical tasks for data recording,this paper introduces the use of fuzzy recurrence plots of very short time series as input data for the machine training and classification with long short-term memory(LSTM)neural networks.Being an original approach that is able to both significantly increase the feature dimensions and provides the property of deterministic dynamical systems of very short time series for information processing carried out by an LSTM layer architecture,fuzzy recurrence plots provide promising results and outperform the direct input of the time series for the classification of healthy control and early PD subjects. 展开更多
关键词 Deep learning early parkinson’s disease(pd) fuzzy recurrence plots long short-term memory(LsTM) neural networks pattern classification short time series
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益肾逐瘀法治疗强直少动型帕金森病临床观察 被引量:3
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作者 于艳敏 张华 +3 位作者 赵颖 张天琪 谭中建 刘岑 《河南中医》 2018年第3期379-382,共4页
目的:观察益肾逐瘀法对强直少动型帕金森病(parkinson's disease,PD)的临床疗效。方法:选取2014年12月至2016年1月就诊于北京中医药大学东直门医院脑病科门诊的强直少动型帕金森病患者9例,均为右利手,将9例患者设为PD组。正常对照... 目的:观察益肾逐瘀法对强直少动型帕金森病(parkinson's disease,PD)的临床疗效。方法:选取2014年12月至2016年1月就诊于北京中医药大学东直门医院脑病科门诊的强直少动型帕金森病患者9例,均为右利手,将9例患者设为PD组。正常对照组为无神经、精神系统疾病及其他重大疾病的志愿者,均为右利手。PD组给予培元解痉汤加减治疗,正常对照组不作药物干预,比较不同观察时点PD相关量表分值。采集正常对照组及PD组治疗前后的f MRI数据,分析各组间不同脑区之间的FC。结果:PD组入组28 d时中医证候量化分级表评分较疗前显著下降(P<0.05),治疗后中医证候量化分级表、NMSS、PDQ-39评分及入组28 d时UPDRSⅢ评分较疗前均有改善的趋势,差异无统计学意义(P>0.05)。治疗前后对比形成的脑网络中杏仁核是一个重要节点,PD组治疗前右侧杏仁核与右侧壳核的FC大于对照组,而治疗后这两个区域的FC较治疗前减弱。结论:益肾逐瘀法对强直少动型PD具有一定的临床疗效,可能通过调整紊乱的脑功能连接而发挥治疗作用。 展开更多
关键词 强直少动型帕金森病 益肾逐瘀法 功能核磁共振 功能连接
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An optimized Parkinson’s disorder identification through evolutionary fast learning network
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作者 Bouslah Ayoub Taleb Nora 《International Journal of Intelligent Computing and Cybernetics》 EI 2022年第3期383-400,共18页
Purpose-Parkinson’s disease(PD)is a well-known complex neurodegenerative disease.Typically,its identification is based on motor disorders,while the computer estimation of its main symptoms with computational machine ... Purpose-Parkinson’s disease(PD)is a well-known complex neurodegenerative disease.Typically,its identification is based on motor disorders,while the computer estimation of its main symptoms with computational machine learning(ML)has a high exposure which is supported by researches conducted.Nevertheless,ML approaches required first to refine their parameters and then to work with the best model generated.This process often requires an expert user to oversee the performance of the algorithm.Therefore,an attention is required towards new approaches for better forecasting accuracy.Design/methodology/approach-To provide an available identification model for Parkinson disease as an auxiliary function for clinicians,the authors suggest a new evolutionary classification model.The core of the prediction model is a fast learning network(FLN)optimized by a genetic algorithm(GA).To get a better subset of features and parameters,a new coding architecture is introduced to improve GA for obtaining an optimal FLN model.Findings-The proposed model is intensively evaluated through a series of experiments based on Speech and HandPD benchmark datasets.The very popular wrappers induction models such as support vector machine(SVM),K-nearest neighbors(KNN)have been tested in the same condition.The results support that the proposed model can achieve the best performances in terms of accuracy and g-mean.Originality/value-A novel efficient PD detectionmodel is proposed,which is called A-W-FLN.The A-W-FLN utilizes FLN as the base classifier;in order to take its higher generalization ability,and identification capability is alsoembedded to discover themost suitable featuremodel in the detection process.Moreover,the proposedmethod automatically optimizes the FLN’s architecture to a smaller number of hidden nodes and solid connecting weights.This helps the network to train on complex PD datasets with non-linear features and yields superior result. 展开更多
关键词 parkinson’s disease(pd) Fast learning network(FLN) Genetic algorithm(GA) speech and handwriting patterns pd identification system
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