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Optimization of Fixture Number in Large Thin-Walled Parts Assembly Based on IPSO
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作者 Changhui Liu Jing Wang +3 位作者 Ying Zheng Ke Jin Jianbo Yu Jianfeng Liu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第2期213-227,共15页
There are lots of researches on fixture layout optimization for large thin-walled parts.Current researches focus on the positioning problem,i.e.,optimizing the positions of a constant number of fixtures.However,how to... There are lots of researches on fixture layout optimization for large thin-walled parts.Current researches focus on the positioning problem,i.e.,optimizing the positions of a constant number of fixtures.However,how to determine the number of fixtures is ignored.In most cases,the number of fixtures located on large thin-walled parts is determined based on engineering experience,which leads to huge fixture number and extra waste.Therefore,this paper constructs an optimization model to minimize the number of fixtures.The constraints are set in the optimization model to ensure that the part deformation is within the surface profile tolerance.In addition,the assembly gap between two parts is also controlled.To conduct the optimization,this paper develops an improved particle swarm optimization(IPSO)algorithm by integrating the shrinkage factor and adaptive inertia weight.In the algorithm,particles are encoded according to the fixture position.Each dimension of the particle is assigned to a sub-region by constraining the optional position range of each fixture to improve the optimization efficiency.Finally,a case study on ship curved panel assembly is provided to prove that our method can optimize the number of fixtures while meeting the assembly quality requirements.This research proposes a method to optimize the number of fixtures,which can reduce the number of fixtures and achieve deformation control at the same time. 展开更多
关键词 Assembly quality Large thin-walled parts Fixture layout PSO FEM
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Development of Fixture Layout Optimization for Thin-Walled Parts:A Review
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作者 Changhui Liu Jing Wang +3 位作者 Binghai Zhou Jianbo Yu Ying Zheng Jianfeng Liu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第1期15-39,共25页
An increasing number of researchers have researched fixture layout optimization for thin-walled part assembly during the past decades.However,few papers systematically review these researches.By analyzing existing lit... An increasing number of researchers have researched fixture layout optimization for thin-walled part assembly during the past decades.However,few papers systematically review these researches.By analyzing existing literature,this paper summarizes the process of fixture layout optimization and the methods applied.The process of optimization is made up of optimization objective setting,assembly variation/deformation modeling,and fixture layout optimization.This paper makes a review of the fixture layout for thin-walled parts according to these three steps.First,two different kinds of optimization objectives are introduced.Researchers usually consider in-plane variations or out-of-plane deformations when designing objectives.Then,modeling methods for assembly variation and deformation are divided into two categories:Mechanism-based and data-based methods.Several common methods are discussed respectively.After that,optimization algorithms are reviewed systematically.There are two kinds of optimization algorithms:Traditional nonlinear programming and heuristic algorithms.Finally,discussions on the current situation are provided.The research direction of fixture layout optimization in the future is discussed from three aspects:Objective setting,improving modeling accuracy and optimization algorithms.Also,a new research point for fixture layout optimization is discussed.This paper systematically reviews the research on fixture layout optimization for thin-walled parts,and provides a reference for future research in this field. 展开更多
关键词 Thin-walled parts Assembly quality Fixture layout optimization Modeling methods Optimization algorithms
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A Systematic Review of Computer Vision Techniques for Quality Control in End-of-Line Visual Inspection of Antenna Parts
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作者 Zia Ullah Lin Qi +2 位作者 E.J.Solteiro Pires Arsénio Reis Ricardo Rodrigues Nunes 《Computers, Materials & Continua》 SCIE EI 2024年第8期2387-2421,共35页
The rapid evolution of wireless communication technologies has underscored the critical role of antennas in ensuring seamless connectivity.Antenna defects,ranging from manufacturing imperfections to environmental wear... The rapid evolution of wireless communication technologies has underscored the critical role of antennas in ensuring seamless connectivity.Antenna defects,ranging from manufacturing imperfections to environmental wear,pose significant challenges to the reliability and performance of communication systems.This review paper navigates the landscape of antenna defect detection,emphasizing the need for a nuanced understanding of various defect types and the associated challenges in visual detection.This review paper serves as a valuable resource for researchers,engineers,and practitioners engaged in the design and maintenance of communication systems.The insights presented here pave the way for enhanced reliability in antenna systems through targeted defect detection measures.In this study,a comprehensive literature analysis on computer vision algorithms that are employed in end-of-line visual inspection of antenna parts is presented.The PRISMA principles will be followed throughout the review,and its goals are to provide a summary of recent research,identify relevant computer vision techniques,and evaluate how effective these techniques are in discovering defects during inspections.It contains articles from scholarly journals as well as papers presented at conferences up until June 2023.This research utilized search phrases that were relevant,and papers were chosen based on whether or not they met certain inclusion and exclusion criteria.In this study,several different computer vision approaches,such as feature extraction and defect classification,are broken down and analyzed.Additionally,their applicability and performance are discussed.The review highlights the significance of utilizing a wide variety of datasets and measurement criteria.The findings of this study add to the existing body of knowledge and point researchers in the direction of promising new areas of investigation,such as real-time inspection systems and multispectral imaging.This review,on its whole,offers a complete study of computer vision approaches for quality control in antenna parts.It does so by providing helpful insights and drawing attention to areas that require additional exploration. 展开更多
关键词 Computer vision end-of-line visual inspection of antenna parts machine learning algorithms image processing techniques deep learning models
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“三美论”视角下对比赏析When We Two Parted的汉译本——以查良铮和陈锡麟的译本为例
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作者 哈依霞•赛力克 《现代语言学》 2024年第1期366-372,共7页
“三美论”是许渊冲先生提出的翻译理论,所谓的“三美”指的是意美、音美和形美。本文以许渊冲先生的“三美论”为理论指导,对比赏析查良铮和陈锡麟对乔治•戈登•拜伦诗歌When We Two Parted的两个中译本。从意美、音美和形美三个层面,... “三美论”是许渊冲先生提出的翻译理论,所谓的“三美”指的是意美、音美和形美。本文以许渊冲先生的“三美论”为理论指导,对比赏析查良铮和陈锡麟对乔治•戈登•拜伦诗歌When We Two Parted的两个中译本。从意美、音美和形美三个层面,对比赏析两个中译本对原文意境、诗歌节奏和尾韵以及诗歌形式上的再现。在诗歌汉译中,三美难以兼顾,译者在进行翻译时要分清主次,原则是意美大于音美,音美大于形美。 展开更多
关键词 “三美论” When We Two parted 查良铮 陈锡麟
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DISCRETIZATION APPROACH USING RAY-TESTING MODEL IN PARTING LINE AND PARTING SURFACE GENERATION 被引量:3
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作者 HAN Jianwen JIAN Bin YAN Guangrong LEI Yi 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2007年第1期47-54,共8页
Surface classification, 3D parting line, parting surface generation and demoldability analysis which is helpful to select optimal parting direction and optimal parting line are involved in auto-matic cavity design bas... Surface classification, 3D parting line, parting surface generation and demoldability analysis which is helpful to select optimal parting direction and optimal parting line are involved in auto-matic cavity design based on the my-testing model. A new ray-testing approach is presented to classify the part surfaces to core/cavity surfaces and undercut surfaces by automatic identifying the visibility of surfaces. A simple, direct and efficient algorithm to identify surface visibility is developed. The algorithm is robust and adapted to rather complicated geometry, so it is valuable in computer-aided mold design systems. To validate the efficiency of the approach, an experimental program is implemented. Case studies show that the approach is practical and valuable in automatic parting line and parting surface generation. 展开更多
关键词 Visibility Ray-testing Surface classification parting line Demoldability analysis
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Geochemistry of Sulfur and Hazardous Elements in Late Paleozoic Coals and Partings from Taozao Coalfield, Shandong Province, China 被引量:1
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作者 HuangWenhui CheYao +3 位作者 YangQi TangDazhen ZhaoZhigen TangXiuyi 《Journal of China University of Geosciences》 SCIE CSCD 2004年第1期15-22,共8页
The analyses of different sulfur forms, the trace elements in pyrites using electron microprobe and the trace elements in coal using INAA (instrumental neutron activation analysis) of the Late Paleozoic coals from the... The analyses of different sulfur forms, the trace elements in pyrites using electron microprobe and the trace elements in coal using INAA (instrumental neutron activation analysis) of the Late Paleozoic coals from the Taozao coalfield in Shandong Province, China, conclude that most sulfur (>75 %) in high-sulfur coal of Taiyuan Formation occurred as pyrite, in which many hazardous elements co-existed and their concentrations varied with their geological origin. The concentrations of hazardous elements in high-sulfur coals from Taiyuan Formation, composing mainly of Cu, As, U, Pb, Mo and Co, are much higher than those in the low-sulfur coals from Shanxi Formation and Shihezi Formation, because the influence of seawater during and after coal accumulation in Taiyuan Formation is stronger than those in Shanxi and Shihezi formations. Moreover, the element As is related to Fe, and both elements exist mainly in the form of pyrite. The element U is richer in the coal influenced by seawater. In addition, the coal affected by the magmatism contains more U, too. When high-sulfur coals are processed with heavy media washing to remove sulfur and minerals, the majority of hazardous elements will also be removed from the coals. 展开更多
关键词 Late Paleozoic coals partings GEOCHEMISTRY hazardous elements Shandong Province.
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DESIGN TECHNOLOGY FOR INJECTION MOLD PARTING SURFACE BASED ON CASES AND KNOWLEDGE 被引量:1
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作者 Yu Tongmin Li Guanhua Li Youmin Lan Jian 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2005年第4期609-612,共4页
On the basis of the comprehensive analysis about the automatic generation of the injection mold parting surface, the parting surface design method which introduces knowledge and case-based reasoning (CBR) into the c... On the basis of the comprehensive analysis about the automatic generation of the injection mold parting surface, the parting surface design method which introduces knowledge and case-based reasoning (CBR) into the computer-aided design is described by combining with the actual characteristic in injection mold design, and the design process of case-based reasoning method is also given. A case library including the information of parting surface is built with the index of main shape features, The automatic design of the mold parting surface is realized combined with the forward-reasoning method and the similarity solution procedure. The rule knowledge library is also founded including the knowledge, principles and experiences for parting surface design. An example is used to show the validity of the method, and the quality and the efficiency of the mold design are improved. 展开更多
关键词 Injection mold parting surface design Case-based reasoning (CBR)Similarity solution
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A Ray-Testing Approach to Automatically Identify Surface Visibility in Parting Line Generation 被引量:1
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作者 HAN Jian-wen YAN Guang-rong LEI Yi 《Computer Aided Drafting,Design and Manufacturing》 2005年第2期24-32,共9页
It is critical to identify core/cavity and undercut surfaces of molds in parting line generation. A new Ray-Testing approach is presented to detect these surfaces by identifying the visibility of surfaces. A simple, d... It is critical to identify core/cavity and undercut surfaces of molds in parting line generation. A new Ray-Testing approach is presented to detect these surfaces by identifying the visibility of surfaces. A simple, direct and efficient algorithm to identify surface visibility is developed. Case studies show that the approach is practical and valuable in automated parting line generation. 展开更多
关键词 VISIBILITY ray-testing surface classification parting line
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CAD APPROACH FOR PLASTIC MOULD PARTING DIRECTIONS OPTIMIZATION 被引量:1
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作者 Huang, Canming Luo, Shiwen Liang, Tianpei 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 1998年第1期2-6,共5页
A CAD approach which can optimize and automate the parting direction determination is presented. The approach is based on the geometrical and topological information of the solid modelling of the plastic moulded part ... A CAD approach which can optimize and automate the parting direction determination is presented. The approach is based on the geometrical and topological information of the solid modelling of the plastic moulded part in order to select a pair of optimal parting directions of a two plate mould which minimizes the number of side cores. The shell of a part is divided into inter influential regions and non influential faces in the mould design point of view. Through analyzing and computing the accessibility direction cones of the inter influential regions, the optimal parting directions can be determined automatically. 展开更多
关键词 Accessibility cones CAD Optimal plastic mould parting direction
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AN INTEGRATION BY PARTS FORMULA FOR STOCHASTIC HEAT EQUATIONS WITH FRACTIONAL NOISE
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作者 尹修伟 《Acta Mathematica Scientia》 SCIE CSCD 2023年第1期349-362,共14页
In this paper,we establish the integration by parts formula for the solution of fractional noise driven stochastic heat equations using the method of coupling.As an application,we also obtain the shift Harnack inequal... In this paper,we establish the integration by parts formula for the solution of fractional noise driven stochastic heat equations using the method of coupling.As an application,we also obtain the shift Harnack inequalities. 展开更多
关键词 integration by parts formula stochastic heat equations fractional Brownian motion shift Harnack inequality coupling by change of measures
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The distribution of trace elements and Sr isotopes across the coal and its partings in the Wyodak sea, Powder River Basin, Wyoming, USA
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作者 Baruch F. Spiro Margaret Gomnge +1 位作者 David J Large Chris Somerfield 《Chinese Journal Of Geochemistry》 EI CAS 2006年第B08期48-48,共1页
关键词 煤矿 地质化学 同位素 火山灰
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小尾寒羊不同部位风味物质与风味前体物的相关性分析 被引量:2
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作者 王宇 淑英 +4 位作者 王慧婷 张旭 梁孙硕 焦颖雪 张志胜 《中国食品学报》 EI CAS CSCD 北大核心 2024年第1期263-277,共15页
以6~7月龄、体质量为50 kg的小尾寒羊为实验对象,选取颈肉(NM)、里脊(LLDM)和腿肉(RG),对小尾寒羊挥发性风味物质、脂肪酸和氨基酸进行相关性分析。结果表明:在3个部位共检测到45种挥发性风味物质,其中醛类是最主要的挥发性风味物质,占... 以6~7月龄、体质量为50 kg的小尾寒羊为实验对象,选取颈肉(NM)、里脊(LLDM)和腿肉(RG),对小尾寒羊挥发性风味物质、脂肪酸和氨基酸进行相关性分析。结果表明:在3个部位共检测到45种挥发性风味物质,其中醛类是最主要的挥发性风味物质,占总挥发性风味物质的50%左右。经主成分分析得知,庚醛、壬醛、苯甲醛等24种风味物质是导致不同部位间挥发性风味物质差异的主要影响因素。LLDM中对人体有益的单不饱和脂肪酸和多不饱和脂肪酸含量均为最高,脂肪酸比例更符合人体对羊肉脂肪酸营养价值的需求,对人体健康更有益。氨基酸中以谷氨酸(Glu)和赖氨酸(Lys)为主,约占总氨基酸的17%和10%,其中RG除蛋氨酸(Met)、酪氨酸(Tyr)、赖氨酸(Lys)外含量均为最高,且除谷氨酸(Glu)和脯氨酸(Pro)外与LLDM差异不显著,与NM差异均显著。相关性分析表明,多不饱和脂肪酸与大多数挥发性风味物质呈正相关,且与醛类、醇类和芳香类等挥发性风味物质呈显著正相关,这可能是因为多不饱和脂肪酸极易氧化,在氧化过程中生成醛类、醇类和芳香类等物质。氨基酸与大多数醛类和醇类都呈正相关,这可能是因为氨基酸通过转氨反应等一系列反应,最终生成醛类和醇类等物质。 展开更多
关键词 小尾寒羊 不同部位 挥发性风味物质 脂肪酸 氨基酸 相关性
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基于机器视觉的飞机故障检查系统 被引量:1
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作者 袁忠大 程秀全 王大伟 《机床与液压》 北大核心 2024年第6期196-200,共5页
针对当前飞机维修检查工作以人工目视检查为主、效率低且存在人为因素影响的情况,设计一套基于图像识别与机器深度学习的飞机部件表面无损检测系统。收集并整理了某航空公司一线飞机维修员拍摄的飞机机身及发动机部件图片,对图片集进行... 针对当前飞机维修检查工作以人工目视检查为主、效率低且存在人为因素影响的情况,设计一套基于图像识别与机器深度学习的飞机部件表面无损检测系统。收集并整理了某航空公司一线飞机维修员拍摄的飞机机身及发动机部件图片,对图片集进行预处理,包括通道提取、Sobel滤波处理及二值化;最后用Blob分析对处理后的图像进行特征提取与系统分析。系统运行速度快、准确率高且可连续自动识别图像。利用机器视觉技术对飞机部件表面进行无损检测不仅可以提高生产效率,同时可以去除人为因素对航空器飞行安全的影响,使得飞机的飞行安全得到进一步提升。实践证明,该系统性能稳定可靠,具有极高的推广应用价值。 展开更多
关键词 机器视觉技术 图像处理 飞机部件 无损检测
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存算分离架构下Part元数据的单独管理策略
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作者 刘丹琪 蔡鹏 《华东师范大学学报(自然科学版)》 CAS CSCD 北大核心 2023年第5期40-50,共11页
针对ClickHouse存在的硬件资源无法被充分利用、缺少弹性和节点启动过慢的问题,在存算分离架构下,提出了一套针对描述数据信息的元数据(Part元数据)的管理策略. Part元数据是元数据中最重要的组成成分.为了能够有效管理远程共享存储上... 针对ClickHouse存在的硬件资源无法被充分利用、缺少弹性和节点启动过慢的问题,在存算分离架构下,提出了一套针对描述数据信息的元数据(Part元数据)的管理策略. Part元数据是元数据中最重要的组成成分.为了能够有效管理远程共享存储上的数据,采集了所有Part元数据文件,并将其合并后,经过键值映射、序列化和反序列化,存入分布式键值数据库中.此外,还设计了一套同步策略,以确保远程共享存储上的数据与分布式键值数据库中的元数据的一致性.利用Part元数据管理策略及相关的同步策略,实现了一个针对Part元数据的管理系统,解决了ClickHouse节点启动过慢的问题,并支持高效的节点动态扩缩容. 展开更多
关键词 数据库系统 存算分离架构 元数据管理
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非理性偏好下动力电池再制造供应链最优决策与协调研究 被引量:2
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作者 刘志 王慧 +2 位作者 刘长义 唐娟 龚本刚 《系统管理学报》 CSCD 北大核心 2024年第1期29-45,共17页
考虑动力电池剩余容量不确定特征,构建由电池供应商和汽车制造商组成的再制造供应链,分别探讨决策双方完全理性、单向非理性偏好和双向非理性偏好等5种决策情形下的均衡解。研究发现:动力电池再制造容量起始点对回收量具有正向作用。在... 考虑动力电池剩余容量不确定特征,构建由电池供应商和汽车制造商组成的再制造供应链,分别探讨决策双方完全理性、单向非理性偏好和双向非理性偏好等5种决策情形下的均衡解。研究发现:动力电池再制造容量起始点对回收量具有正向作用。在双向非理性偏好情形下,供应商的利他(公平)偏好程度增加导致制造商和系统总利润提高(降低),而自身利润总是降低;制造商的非理性偏好对供应链成员及系统利润的影响与供应商的非理性偏好程度有关。在单向非理性情形下,供应链成员的利他(公平)偏好程度增加导致自身利润下降(上升)而对方利润上升(下降)。两部定价契约和收益共享契约能够实现双向非理性偏好情形下再制造供应链的协调。 展开更多
关键词 再制造供应链 废旧动力电池 非理性偏好 两部定价契约 收益共享契约
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盖板件高效铣削表面粗糙度预测与工艺参数优化 被引量:1
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作者 张国政 周元枝 +1 位作者 姜洪辉 彭易杭 《工具技术》 北大核心 2024年第4期116-121,共6页
为了保证7075铝合金盖板件铣削表面质量和提高铣削加工效率,进行工艺参数优化,通过响应曲面法(RSM)构建铣削加工表面粗糙度预测模型,分析铣削工艺参数对表面粗糙度的影响规律。基于表面粗糙度预测模型建立高效铣削工艺参数优化目标方程... 为了保证7075铝合金盖板件铣削表面质量和提高铣削加工效率,进行工艺参数优化,通过响应曲面法(RSM)构建铣削加工表面粗糙度预测模型,分析铣削工艺参数对表面粗糙度的影响规律。基于表面粗糙度预测模型建立高效铣削工艺参数优化目标方程,采用改进的粒子群算法(PSO)对目标方程进行优化,运用优化后的工艺参数对某盖板件进行铣削加工。试验结果表明:采用优化后的工艺参数进行盖板件铣削加工可以满足表面粗糙度要求,验证了预测模型的准确性和改进PSO方法的可行性。 展开更多
关键词 盖板件 高效铣削 表面粗糙度 预测模型 工艺参数优化
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老旧直升机维修中无损检测技术的应用 被引量:1
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作者 张庆 王勇先 王勋 《航空工程进展》 CSCD 2024年第3期135-142,共8页
随着使用年限的增长,老旧直升机结构性故障和偶发性故障逐渐增多,给维护修理带来了诸多困难,维护人员常常不能及时发现和消除故障隐患。针对当前老旧直升机的特点和维修现状,介绍了无损检测技术在航空维修领域中的应用,结合直升机结构... 随着使用年限的增长,老旧直升机结构性故障和偶发性故障逐渐增多,给维护修理带来了诸多困难,维护人员常常不能及时发现和消除故障隐患。针对当前老旧直升机的特点和维修现状,介绍了无损检测技术在航空维修领域中的应用,结合直升机结构特点和使用情况探讨确定老旧直升机无损检测的重点部位和关键部件,围绕不同无损检测技术特点对直升机关键部件检测的具体应用方法进行阐述,并结合老旧直升机维护实践对无损检测技术的使用时机做出探讨和研究,最后对无损检测技术在老旧直升机维修中的应用前景进行了展望。 展开更多
关键词 老旧直升机 维修 无损检测 关键部位 技术应用 使用时机
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大跨越架空输电导线铝部应力分布试验 被引量:1
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作者 汪峰 曾超 +1 位作者 薛春林 温作铭 《重庆大学学报》 CAS CSCD 北大核心 2024年第3期66-74,共9页
为了掌握大跨越架空输电导线铝部应力空间分布特性,以JLHA1/G6A-500/280型特强钢芯铝合金导线为研究对象,采用铝股丝表面激光刻槽,内嵌高灵敏、超大复用容量超弱光纤光栅,搭建了大跨越输电导线铝部应力试验平台,研究了不同张力条件下大... 为了掌握大跨越架空输电导线铝部应力空间分布特性,以JLHA1/G6A-500/280型特强钢芯铝合金导线为研究对象,采用铝股丝表面激光刻槽,内嵌高灵敏、超大复用容量超弱光纤光栅,搭建了大跨越输电导线铝部应力试验平台,研究了不同张力条件下大跨越架空输电导线铝部应力分布规律,建立了大跨越导线实体有限元模型,分析了铝股应力分布特征,并验证了试验结果的正确性。结果表明:导线承受张力作用时,外层铝股和次外层铝股应力不同,外层铝股应力小于次外层铝股应力,导线同层铝股应力基本相同;铝股应力随导线张力的增大呈线性增大趋势,张力每增大1%,铝股应力增大约10%。不同导线张力作用时钢股和铝股应力均呈现环状分层特性,铝股平均应力小于钢股平均应力,铝部和钢股应力比约为3∶7;外层和次外层铝合金股丝应力沿圆周向分布不均匀,建议大跨越导线线型设计时考虑铝股丝分层特性。 展开更多
关键词 大跨越输电导线 超弱光纤光栅 铝部应力 分层特性 试验研究
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基于OBE理念的发电厂电气部分课程建设 被引量:3
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作者 孙丽颖 白锐 赵凤贤 《高教学刊》 2024年第2期71-74,共4页
发电厂电气部分是电气工程及其自动化专业重要的专业课程,对学生工程实践能力的培养起到重要的支撑作用。该文基于成果导向教育理念(OBE),建立MOOC教学平台的“课前-课中-课后”线上线下混合式闭环教学模式,构建丰富的教学资源,课程教... 发电厂电气部分是电气工程及其自动化专业重要的专业课程,对学生工程实践能力的培养起到重要的支撑作用。该文基于成果导向教育理念(OBE),建立MOOC教学平台的“课前-课中-课后”线上线下混合式闭环教学模式,构建丰富的教学资源,课程教学目标支撑毕业要求,构建成果导向的课程考核评价体系,体现以学生学习为中心。在新的教学模式下,学生学习效果明显改善。在OBE理念指导下,通过MOOC平台进行电气类专业课程改革是改进教学方法、提升教学质量的有效手段,也是未来教学改革的方向。 展开更多
关键词 成果导向教育 一流课程 线上线下混合式教学 发电厂电气部分 课程建设
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养心草提取物抗肺癌活性部位筛选
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作者 庄苒 苗航 +1 位作者 郭素华 林珠灿 《辽宁中医药大学学报》 CAS 2024年第9期11-15,共5页
目的筛选养心草抗肺癌活性部位。方法运用系统溶剂法制备养心草各提取部位;体外培养肝癌A549细胞,采用MTT法检测细胞株半数抑制浓度(IC50),以IC50作为评价指标,初步筛选出养心草抗肿瘤的有效部位。同时,建立肺癌LLC细胞移植瘤小鼠模型,... 目的筛选养心草抗肺癌活性部位。方法运用系统溶剂法制备养心草各提取部位;体外培养肝癌A549细胞,采用MTT法检测细胞株半数抑制浓度(IC50),以IC50作为评价指标,初步筛选出养心草抗肿瘤的有效部位。同时,建立肺癌LLC细胞移植瘤小鼠模型,通过观察肿瘤体积、小鼠体质量、脏器指数及瘤体质量的变化,对养心草的抗肿瘤效果进行评价养心草石油醚部位及乙酸乙酯部位的体内抗肺癌作用。结果MTT实验结果表明养心草不同提取部位中石油醚部位和乙酸乙酯部位对肺癌A549细胞的增殖显示较强的抑制作用;体内小鼠肺癌LLC细胞移植瘤实验表明石油醚部位和乙酸乙酯部位可明显抑制小鼠肿瘤的生长(P<0.05),且具有剂量依赖性,并对鼠体质量及脏器指数未产生显著影响(P>0.05)。结论养心草的石油醚部位和乙酸乙酯部位是其抗肺癌的有效部位。 展开更多
关键词 养心草 石油醚部位 乙酸乙酯部位 肿瘤细胞 肺癌
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