PC-CAR识别肿瘤靶标的结构原理

据Sun Y(Bio Rxiv,2023. doi:10.1101/2023.05.24.542108.)报道,美国费城儿童医院的研究人员解析出一种三维蛋白结构,解释了PC-CAR如何识别这些HLA复合物的“骨架”。这些结构信息将使得人们能够了解嵌合抗原受体(CAR)如何识别不同多态性HLA等位基因中的肿瘤相关抗原,从而为针对更复杂、更难治疗的肿瘤设计精准医疗策略提供更多可能性。

Impacts of automated passenger cars on the capacity of a freeway basic section: applicability in the determination of vehicle adjustment factors in mixed traffic

The highway capacity manual(HCM)provides a formula to calculate the heavy vehicle adjustment factor(fHV)as a function of passenger car equivalent factors for the heavy vehicle(ET).However,a significant drawback is that the methodology was established solely based on human-driven passenger cars(HDPC)and human-driven heavy vehicles(HDHV).Due to automated passenger cars(APCs),a new adjustment factor(fAV)might be expected.This study simulated traffic flows at different percentages of HDHVs and APCs to investigate the impacts of HDHVs and APCs on freeway capacity by analyzing their influence on fHV and fAV values.The simulation determined observed adjustment factors at different percentages of HDHVs and APCs(fobserved).The HCM formula was used to calculate(fHCM).Modifications to the HCM formula are proposed,and vehicle adjustment factors due to HDHVs and APCs were calculated(fproposed).Results showed that,in the presence of APCs,while fobserved and fHCM were statistically significantly different,fobserved and fproposed were statistically equal.Hence,this study recommends using the proposed formula when determining vehicle adjustment factors(fproposed)due to HDHVs and APCs in the traffic stream.

NUMERICAL ANALYSIS OF NONLINEAR STABILITY FOR RAILWAY PASSENGER CARS

The Newton Raphson iteration and QR algorithm are combined to search the Hpf bifurcation point of the vehicle running on straight track and on large radius curved tracks. Limit cycles that are bifurcated from the equilibrium points and the saddle node bifurcation point are computed through employing a variable step Runge Kutta method and the Poincaré map. Finally, numerical simulations are carried out for the stability of a high speed passenger car operating on straight and large radius curved tracks. The influences of the radius of curvature and the superelevation of the track on the stability of the vehicle system are investigated.

Explicit–Implicit Co-Simulation Techniques for Dynamic Responses of a Passenger Car on Arbitrary Road Surfaces

To study the durability of a passenger car, this work investigates numerical simulation techniques. The investigations are based on an explicit implicit approach in which substructure techniques are used to reduce the simulation time, allowing full vehicle dynamic analyses to be performed on a timescale that is dif cult or impossible with the conventional nite element model (FEM). The model used here includes all necessary nonlinearities in order to maintain accuracy. All key components of the car structure are modeled with deformable materials. Tire road interactions are modeled in the explicit package with contact-impact interfaces with arbitrary frictional and geometric properties. Key parameters of the responses of the car driven on six different kinds of test road surfaces are examined and compared with experimental values. It can be concluded that the explicit implicit co-simulation techniques used here are ef cient and accurate enough for engineering purposes. This paper also discusses the limitations of the proposed method and outlines possible improvements for future work.

FAW Technology Strategies of Low-Carbon Passenger Car

Author analyzed the global background of low-carbon technology around the world,a technology & economy analysis model called TOS was developed in the paper,author analyzed technology paths for low-carbon Car in China based on the current technologies available and technologies to be developed in China,3 possible paths are presented based on the analysis,author also explained the FAW BlueWay technology strategies for low carbon cars both for short mid and long term objectives.Author concludes the paper with illustration of powertrain lineup for FAW BlueWay Technologies.

STUDY ON DYNAMIC CURVING BEHAVIOR OF TILTING PASSENGER CARS

By using tilting carbodies, train can negotiate at a higher speed withoutreducing the passenger's ride quality. This is a good method to allow a significant increase inspeed at existing track to improve the railway transportation capability, and to enhance thecompetition ability of railways with other transportation systems. With the increase of the curvenegotiation speed, the wheel-rail lateral forces and wheel-rail wear of the tilting train willincrease. The self-steering radial bogie is an effective way to solve the problem. The dynamic modelof the tilting passenger car with self-steering bogies is established in detail, and the curvingperformance of the car is investigated.

Performance Development Target Setting of Passenger Car Diesel Engine

Setting engine emission targets to meet diesel car requirements is particularly important in engine performance development phase. Many researches are focused on associating vehicle performance with engine targets, but most work is done by testing, which is time and cost consuming, furthermore, the relationship of vehicle and engine will change when either engine or vehicle changes. A GT-Drive model to simulate New European Driving Cycle (NEDC) for passenger car is developed and calibrated by testing data, model precision is controlled within 5%. Time distribution of engine operating conditions when car running NEDC cycle has been analyzed, 10 critical major engine operating points are summarized according to running time proportion. Emission of NOx and smoke control regions containing these 10 points for target engine are set. Vehicle emissions are simulated and evaluated during engine development after engine performance test data are got, and engine combustion system layout and calibration are adjusted until vehicle targets are met. Vehicle is tested in chassis dynamometer finally, the testing results show a good agreement with the simulated results with an error of less than 5%, which proves that the emission value exchange of vehicle and engine is reliable. Performance target decomposition method for passenger car diesel presented can greatly shorten the development cycle and save costs.

Estimation of Passenger Car Equivalents for Basic Freeway Sections at Different Traffic Conditions

Passenger car equivalent (PCE) is an important factor which is used to convert traffic volumes containing proportions of heavy good vehicles (HGVs) to a unify measure containing only passenger cars units (PCU). This paper uses large data base of real traffic raw data extracted from loop detector before being aggregated to estimate PCEs. These detectors are located on the M25 and the M42 motorway sites in the United Kingdom. The selected sites represent basic freeway segments as they are far away from the influence of entrance (on ramp) and exit (off ramp) sections. The data are filtered properly so as to estimate passenger car equivalents (PCEs) using lagging headway method for close following situations at different speed ranges. The results suggest that for the same location, the equivalency factors are varies significantly based traffic speed. However, it is proved that such variation with traffic speed is influenced by the differences in lengths between HGVs and cars. Regression models have also been developed linking the PCEs with traffic speed.

Kinematic and Kinetic Analysis for the Tilting Mechanism of Railway Passenger Cars

The kinematics and kinetics of the tilting mechanism of railway passenger cars are studied. The parameters of the mechanism are given. The motions of the actuator, the center of gravity of the carbody and the center of coupler are calculated. Finally, the maximum driving force, output power and velocity of the actuator are discussed in detail.

基于OPC UA技术的铁路客车蓄电池测试系统设计

文章提出了一套基于OPC UA的标准化架构,可以将各个分散的检测过程数据进行整合,实现实时互通。利用标准的OPC UA架构,实现对各不同种类的蓄电池在不同检修工艺下的统一管理,设计了一套工艺扩展灵活、设备搭配自由的铁路客车蓄电池检修测试标准系统。

基于在线评论的乘用车需求趋势分析方法

提出一种基于在线产品评论的竞争情报挖掘方法,将网络评论文本中的关键信息应用于乘用车设计开发中。结合LDA和TF-IDF算法,从主题特征和情感态度特征获取不同车型评论主题情感倾向性估值,并对应2009—2019年的乘用车销量,构建用户偏好分析的面板数据模型。结果显示:该方法能够有效地提取网络评论情报信息;通过与年份的交互作用分析产品需求趋势,过去11年间消费者只对油耗的关注度降低了8.64%,对动力、空间、外观、内饰和舒适性的关注度分别上升了3.16%,6.80%,89.69%,13.38%和18.47%。其中,与生活品质更加密切的外观、内饰和舒适性等指标的增量远高于传统关注的动力和空间指标。这表明燃油经济性越来越不受关注,已不再成为消费者购买乘用车的决定性因素。

既有铁路客车服役性能研究

我国既有铁路客车保有量大、运用时空环境复杂,其服役性能的演变对运行安全和运维保障带来极大挑战。为系统掌握铁路客车服役状态,调研我国普速客车运营现状,并以车体钢结构为例,开展影响客车服役性能的因素分析。调研发现,大部分普速客车已逐步进入服役中后期,5T等信息化手段实现了对客车的全面监控。不同运用环境下,钢结构腐蚀情况不同,随着运行时间/运行里程的增加,钢结构腐蚀有明显加剧趋势。针对服役期间RW25G车体和209P型转向架疲劳强度开展研究,各关键部位均满足服役寿命30年设计要求;针对服役期间YZ25T车体和CW-200K型转向架开展跟踪测试,发现转向架个别关键承载位置产生损伤值较大。针对服役期间25T型客车动力学性能开展研究,采用TPDS、TCDS和添乘等手段开展跟踪测试,并结合实测车轮磨耗数据和减振器劣化数据开展仿真分析,结果表明,在1个旋修周期内,车辆运行安全性存在一定冗余;随服役时间增加,转向架关键部件的性能劣化或失效会对车辆蛇行稳定性和运行平稳性产生不利影响;开展随机参数的动力学仿真,发现极端工况下轮重减载率上升明显,应予以充分关注。

基于平均车头时距的城市道路PCE算法

为得到一种反映交通流运行情况,适用于各种交通流状态的车辆换算系数(PCE)计算方法,结合车头时距特性分析结论,基于等效车头时距原理,对车头时距法进行改进。通过分析车头时距数据发现,小型车与大型车跟车状态数量差距较大,路段总流量平均车头时距不能体现路段中与大型车有关车辆的平均车头时距,应分跟车状态统计平均车头时距;同一路段不同交通流状态下,同一跟车状态数量相差较大,应分交通流状态分析路段PCE值。因此,用跟车状态平均车头时距代替路段总流量平均车头时距,对车头时距法进行改进。与经典的容量法对比,所提方法在各交通流状态下计算得出的PCE值与容量法计算得出的PCE值差距最大为6.40%,最小为1.57%,证明所提方法适用于各种交通状态。分析PCE影响因素发现,PCE值与大型车比例呈U型曲线关系;公交专用道路段的PCE值在各个时段均高于未设置公交专用道路段相应时段的PCE值。

用于轿车车门内饰板的ABS/PC共混物注塑工艺研究

针对轿车车门内饰板的结构特点,根据丙烯晴-丁二烯-苯乙烯(ABS)/聚碳酸酯(PC)共混物在注射成型过程中所显示的特性,采用正交试验法,选用了合理的注塑工艺参数,解决了车门内饰板注塑生产过程中易产生缺料、亮斑、变形、开裂等缺陷,提高了制品的合格率。

基于事故数据挖掘的乘用车追尾卡车AEB测试规程研究

基于未来出行交通事故场景研究数据库中的乘用车追尾卡车事故,分析并提出了以卡车为目标物的乘用车自动紧急制动系统的典型测试工况。采用K-means聚类算法得出可代表实际卡车的目标物颜色,基于事故数据分析提取卡车目标物尾部特征参数,设计并制作了一种新型的具有与真实车辆反射特性和机器视觉识别特性接近的重型厢式卡车目标物。卡车目标物静止,测试车辆分别以45、50、55、60 km/h的速度进行100%重叠自动紧急制动系统测试,验证了该目标物的可行性和有效性。可为车辆主动安全相关标准法规研究提供数据支撑,推动车辆主动安全测试技术的发展。

铁路客车技术整备所线路配置规模研究

合理确定铁路客车技术整备所的整备线和车底停留线配置规模,对于节约用地和降低工程投资非常重要。TB 10029—2009《铁路客车车辆设备设计规范》第4.3.2条规定,按入所列车数量确定线路数量,并给出相应的计算表。结合规范修订工作,采用线性回归法和概率分析法对线路配置规模进行研究,并对该条规定在当前的适用性进行验证。研究结论如下:(1)按照列车运行图确定客车车底出入客车技术整备所的时间,分析其最大车底停留数量,从而确定整备线和车底停留线数量之和的方法,是确定客车技术整备所线路数量的准确方法。(2)按照入所车底数量和配置系数确定线路数量方法可行,全路客车技术整备所计算平均数量与运行图分析法计算结果的误差为0.3%~7.5%,符合性较好。(3)将3种计算方法应用到具体铁路客车整备所时,全路各所的均方根误差为25%~27%,该误差受运行图编制主客观因素影响,由各客运站列车终到/始发时间分布规律差异造成,可通过运行图调整来适应。

基于三维线形的轻型高速公路纵断面指标研究

为了探究轻型高速公路路线纵断面设计关键参数,基于Carsim/Trucksim软件搭建了人-车-路耦合系统,根据普遍性和不利性原则,选取轿车、面包车和轻型货车作为轻型车辆的代表性车型,开展了代表性车型在直坡路段和弯坡组合路段的行驶仿真。根据轻型车辆在纵断面和弯坡组合路段运行特征,确定了轻型高速公路的控制车型以及路线纵断面的坡度、坡长参数。结果表明:轻型高速公路纵断面设计参数应以轻型货车和面包车作为控制车型;高速行驶下,车辆在弯坡组合路段的速度衰减比在单纵坡路段更为剧烈;根据速度衰减特性和允许速度降幅,轻型高速公路设计速度为100km/h时,若允许轻型货车通行,应以比功率为25W/kg的轻型货车作为控制车辆,路线纵断面最大纵坡为5%,最大坡长为750m,若不允许轻型货车通行,路线纵断面最大纵坡为6%,可不限制最大坡长;设计速度为120km/h和140km/h时,应以比功率为35W/kg的面包车作为控制车辆,路线纵断面最大纵坡分别为6%和5%,对应的最大坡长均为1200m。

铁路客运专线18号道岔装载加固方案研究

道岔是铁路股道转换的重要设备,近年来,随着高速铁路建设规模的不断扩大,对客运专线60-18号道岔需求量大幅增加,全国铁路道岔运输量也随之增加。道岔作为精密的铁路设备,运输质量直接影响道岔的后期使用,为了进一步提高道岔装载质量和装载率,提升运输效率,通过分析货物参数、车辆特点,经过装载加固方案设计和理论计算,研究制定D22A型长大平车运输客运专线60-18号道岔方案,不仅能解决普通木地板平车车源紧张、操作复杂的问题,还能降低运输成本,有效提高道岔的运输效率,保障高速铁路建设的工期和质量,为今后道岔运输提供新的解决方案。