Infectious diseases are severe public health events that threaten global health.Prophylactic vaccines have been considered as the most effective strategy to train the immune system to recognize and clear pathogenic in...Infectious diseases are severe public health events that threaten global health.Prophylactic vaccines have been considered as the most effective strategy to train the immune system to recognize and clear pathogenic infections.However,the existing vaccines against infectious diseases have several limitations,such as difficulties in mass manufacturing and storage,weak immunogenicity,and low efficiency of available adjuvants.Biomaterials,especially functional polymers,are expected to break through these bottlenecks based on the advantages of biocompatibility,degradability,controlled synthesis,easy modification,precise targeting,and immune modulation,which are excellent carriers and adjuvants of vaccines.This review mainly summarizes the application of immunologically effective polymers-enhanced vaccines against viruses-and bacteria-related infectious diseases and predicted their potential improvements.展开更多
基金the National Key Research and Development Program of China(Nos.2022YFC2603500/2022YFC2603501 and 2021YFC2400600/2021YFC2400603/2021YFC2400604)the National Natural Science Foundation of China(Nos.52273158,U21A2099,52022095,51973216,and 51873207)+3 种基金the Science and Technology Development Program of Jilin Province(Nos.20220204018YY,20210509005RQ,20210504001GH,and 20200404182YY)the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2019230)the Special Project for City–Academy Scientific and Technological Innovation Cooperation of Changchun(No.21SH14)the Fundamental Research Funds for the Central Universities,JLU.
文摘Infectious diseases are severe public health events that threaten global health.Prophylactic vaccines have been considered as the most effective strategy to train the immune system to recognize and clear pathogenic infections.However,the existing vaccines against infectious diseases have several limitations,such as difficulties in mass manufacturing and storage,weak immunogenicity,and low efficiency of available adjuvants.Biomaterials,especially functional polymers,are expected to break through these bottlenecks based on the advantages of biocompatibility,degradability,controlled synthesis,easy modification,precise targeting,and immune modulation,which are excellent carriers and adjuvants of vaccines.This review mainly summarizes the application of immunologically effective polymers-enhanced vaccines against viruses-and bacteria-related infectious diseases and predicted their potential improvements.
