Utilization of multiple "omics" studies in microbial pathogeny for microbiology insights

In the present day,bioinfomiatics becomes the modern science with several advantages.Several new"omics"sciences have been introduced for a few years and those sciences can he applied in biomedical work.Here,the author will summarize and discuss on important applications of omics studies in microbiology focusing on microbial pathogeny.It can be seen that genomics and proteinomics can be well used in this area of biomedical studies.

耳闷胀感的病因及其机制探讨

耳闷胀感是一个可能涉及到从外耳到内耳及听神经任何一部分听觉器官异常的常见症状,可表现为耳胀满感、堵塞感、压迫感,以40岁左右女性多见。本文就耳闷症状的病因及其机制做一综述,为临床更好的认识耳闷这一症状提供帮助。

Identification and Pathogen Characteristics Analysis of a Co-infection with CSFV,PRRSV and PCV2

[Objective] The aim of this study was to identify swine diseases caused by CSFV,PRRSV and PCV2 and thus to analyze its pathogeny chracteristics.[Method] The tissues and viscera of the diseased swine were collected from Xiangtan of Hunan(Code of HN/XT)to extract DNA and RNA for PCR amplification and sequencing.Meanwhile,the virulent strains were isolated and identified by cell separation technology.[Result] The sequencing analysis results showed that the amino acid homology between CSFV,PRRSV,PCV2 and sequen...

Three kinds of new pathogenies of gout in poultry

This paper reported three kinds of new pathogenies of gout： stress condition, inconsistent sexual maturity and relatively high protein feed.

Uterine incision dehiscence 3 mo after cesarean section causing massive bleeding:A case report

BACKGROUND The traditional definition of late postpartum hemorrhage is a massive uterine hemorrhage from 24 h after delivery to the puerperal period.Here,we report a case of late postpartum hemorrhage that occurred 3 mo after cesarean section and endangered the patient's life.The cause of the case we are reporting was poor incision healing.By reporting this case,we hope to make doctors aware that late postpartum hemorrhage due to poor incision healing may happen as late as 3 mo after cesarean section.CASE SUMMARY A 31-year-old woman complained of acute,severe vaginal bleeding for 1 h;the patient had a history of cesarean section 3 mo prior.After receiving antiinflammatory treatment,fluid supplementation,blood transfusion,oxytocin administration,and hemostatic treatment,the vaginal bleeding ceased,and the patient’s clinical status improved.Unfortunately,she experienced recurrent massive vaginal bleeding,and uterine contractile agents did not decrease the persistent bleeding.To save the patient’s life,she was admitted for emergency laparotomy.At exploratory laparotomy,dehiscence and necrosis of the previous cesarean section scar were noted;the dehiscence penetrated through the entire thickness of the uterine muscle wall and extended to the left uterine artery.Ultimately,we performed a total hysterectomy.CONCLUSION Late postpartum hemorrhage due to poor incision healing after cesarean section may occur in the 3 mo after cesarean section or even later.Therefore,obstetricians-gynecologists should monitor for this potential complication in all patients post–cesarean section.Such hemorrhages can be severe enough to endanger the patient's life.

A Single-center Retrospective Cohort Study on Cesarean Section under General Anesthesia

Objective Neuraxial block is the most common anesthesia method for cesarean section(CS).However,for some urgent and high-risk cesarean delivery,general anesthesia(GA)also plays a very important role.We aimed to find out the reasons of choosing GA for CS in our center and the factors that may be related to the maternal and fetal outcomes.Methods We retrospectively selected parturients who had CS procedures under GA in Peking Union Medical College Hospital from January 1,2014 to December 31,2016.Clinical data(baseline maternal status,preoperative status,perioperative information,maternal and fetal outcomes)of parturients and neonates were collected and analyzed.We summarized the common reasons for applying general anesthesia,and compared the back-to-ICU ratio and hospital stay time between parturients with different maternal American Society of Anesthesiologists(ASA)grade,gestational weeks and intraoperative blood loss,as well as the fetal one-minute Apgar score between different maternal ASA grade and gestational weeks.Results There were 98 cases of CS under GA enrolled in the study.Among the maternal and fetal factors,pregnancy with internal or surgical diseases is the most common reason(59 cases,60.2%)for choosing GA,followed by the placenta and fetal membrane abnormalities(38 cases,38.8%)and the pregnancy-specific disorders(36 cases,36.7%).ASA gradeⅢ-Ⅳof parturients(χ2=44.3,P<0.05),gestation period<37 weeks(χ2=23.4,P<0.05),and blood loss>800 ml(χ2=5.5,P<0.05)were related to the higher postoperative intensive care unit(ICU)rate in parturients.ASA gradeⅢ-Ⅳof parturients(t=-2.99,P<0.05),gestation period<37 weeks(t=2.47,P<0.05)were related to the longer hospital stay.ASA gradeⅢ-Ⅳof parturients(t=2.21,P=0.01)and gestation period<37 weeks(t=-3.21,P=0.002)were related to the lower one-minute Apgar score of neonates.Conclusion Pregnancy with internal or surgical diseases is the most common reason for choosing GA for CS.High ASA grade and short gestation period were the related factors of high postoperative ICU ratio for parturients and low one-minute Apgar score for neonates.

Inflammatory myofibroblastic tumor of the central nervous system:A case report

BACKGROUND An inflammatory myofibroblastic tumor(IMT)occurring in the central nervous system is very rare,and thus its pathogenesis is unknown.This case report and literature review aimed to explore the pathogenesis,clinical features,imaging findings,pathological characteristics,immunohistochemical characteristics,diagnoses,treatments,and risks of postoperative recurrence of IMT in the central nervous system.CASE SUMMARY A 67-year-old woman was admitted to the hospital with an exophthalmic protrusion and double vision in the left eye that had persisted for 3 mo.Magnetic resonance imaging(MRI)showed a 2.4 cm×1.3 cm heterogeneous large mass in the bottom of the left anterior cranial fossa,which was closely related to the dura mater.Before surgery,we suspected the mass to be meningioma.The entire mass was successfully removed under neuronavigation and electrophysiological monitoring,and postoperative pathology indicated an IMT with extensive infiltration of chronic inflammatory cells and scattered multinucleated giant cells.Head MRI at the 3-mo follow-up showed that the tumor at the bottom of left anterior cranial fossa had been completely resected without recurrence.CONCLUSION From the histological,immunohistochemical,and genetic analyses,the present case suggests that the pathogenesis of IMT-CNS is related to autoimmunity.

Discussion on pathogenesis of colorectal cancer based on the theory of rheumatic fever in traditional Chinese medicine

Rheumatic fever is a disease according to the theory of traditional Chinese medicine(TCM),and its main clinical manifestations include coma and confusion of eyes and head,severe limb drowsiness,fever without consciousness,sticky and greasy stool,short and blood urine,red tongue with yellow and greasy coating,and slippery rapid pulse.Colorectal cancer is a common malignant tumor in the digestive tract.According to the theory of TCM,rheumatic fever is the main etiology and pathogenesis of colorectal cancer,which is the common syndrome of colorectal cancer.The method of antipyretic and removing dampness has been widely used in TCM treatment for colorectal cancer which is effective.From the perspective of rheumatic fever,the article summarizes the material basis of colorectal cancer from the perspectives of gene,protein,metabolism,and microorganism,discussing the potential mechanism of rheumatic fever in the occurrence and development of colorectal cancer combined with the theory of TCM,summarizing the defects of the research direction at this stage,in order to better guide the prevention and treatment of colorectal cancer.

Survey of the Hypertention Suffered by the Middle-aged from Suburban Areas and Its Related Pathogenesis

Objectives To investigate the related pathogenic factors of hypertension affecting the middle-aged in suburban areas in Mudanjiang City and further popularize health education with regard to hypertension. Methods A survey was conducted on 858 middle-aged people of 35 to 59 years old from such suburban areas as Jinglong village, Bada village and Fengshou village by adopting the hypertensive definition and classifying standard of an WHO/ISH hypertensive treatment guidance in 1999. Results Positive correlation was shown between occurrence of hypertension and such elements as diet in excess salt, drinking, obesity, smoking. Conclusions It is of great clinical significance to combat and prevent the hypertension by regulating one＇s diet and life style.

李氏杆菌性猪流产的病原菌鉴定和防治研究

本文报导了某猪场11.2％的妊娠后期母猪暴发流产。剖检胎儿主要表现脑组织水肿和大面积出血、脑、肝、胃内容物、心血脾等脏器触片、染色、镜检有革兰氏阳性2～3×0.5微米呈“V”型排列,无芽胞荚膜,单端鞭毛的杆菌。通过生化特性、接种小白鼠、豚鼠、家兔和妊娠母兔回归试验以及病愈母猪特异性抗体监测等,确诊为李氏杆菌性猪流产,其病原为单核细胞增生李氏杆菌(L、monocy togtnes)。

Etiology and Pathogenesis of Pericarditis from the Perspective of Traditional Chinese and Western Medicine

Pericarditis is a common clinical pericardial disease with complex etiology,pathogenesis,and high recurrence rate.Interleukin-1 is an important inflammatory cytokine,which regulates the occurrence and development of inflammation by regulating IL-1α,IL-1β,and IL-IRA;it plays an important role in pericarditis.In traditional Chinese medicine,the modem understanding of its etiology and pathogenesis has been improved.In this review,the etiology and pathogenesis of pericarditis are discussed from the perspective of traditional Chinese and Western medicine.

Studies on Pathogenie Fusarium species of rice Bakanae disease and strains

We collected infection plants of rice bakanae desiease from 22 counties (cities) in Hubei Province in 1990-1992. Thirty five isolates of single spore were isolated from the plants. Fusarium species were identified from these isolates based on the method of Booth(1971) and other authors. Six kinds of medium wereused in the experiment. Color and growth rate ofcolonies as well as other characters were determinedfrom cultures grown on PSA. The results showedthat thirty one isolates were Fusarium moniliformevar. zhejiangensis, two isolates were Fusariumgramineum, one was Fusariurn oxysporum, and onewas Fusarium solani.