目的探索纳洛酮联合血塞通在治疗急性脑梗死患者中的可行性。方法选取2023年1月至2024年1月于蕲春县人民医院就诊的112例急性脑梗死患者为研究对象,随机分为研究组与对照组,每组各56例。研究组给予纳洛酮联合血塞通进行治疗,对照组给予...目的探索纳洛酮联合血塞通在治疗急性脑梗死患者中的可行性。方法选取2023年1月至2024年1月于蕲春县人民医院就诊的112例急性脑梗死患者为研究对象,随机分为研究组与对照组,每组各56例。研究组给予纳洛酮联合血塞通进行治疗,对照组给予纳洛酮治疗。比较两组患者治疗前后的美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、肢体运动功能(Fugl-Meyer Assessment,FMA)评分及Barthel指数(Barthel Index,BI)评分,以及临床有效率、血浆脑钠肽(Plasma Brain Natriuretic Peptide,BNP)水平及不良反应。结果经过两周治疗后,两组患者临床症状体征和自理能力均好转,但研究组患者临床有效率更高(P<0.05)。治疗前,两组患者NIHSS、FMA和BI评分均无显著差异(P>0.005);治疗后,两组患者NIHSS评分均显著下降(P<0.001),FMA评分和BI评分均显著升高(P<0.001),但研究组NIHSS评分下降程度更明显(P<0.001),FMA评分和BI评分上升程度更明显(P<0.001)。治疗后,两组患者血浆BNP水平均降低,且研究组改善程度优于对照组,差异有统计学意义(P<0.001)。治疗期间,两组患者皮疹、恶心、嗜睡、心动过速等不良反应发生率无显著差异(8.93%vs 12.50%,P>0.541)。结论纳洛酮联合血塞通治疗急性脑梗死,有利于运动功能和神经功能的恢复,可有效提高患者的生活能力,且不良反应少。展开更多
Liposarcoma of the stomach is extremely rare, and only 37 cases have been reported worldwide. We herein report two cases of liposarcoma of the stomach. The first patient was referred to our hospital with upper abdomin...Liposarcoma of the stomach is extremely rare, and only 37 cases have been reported worldwide. We herein report two cases of liposarcoma of the stomach. The first patient was referred to our hospital with upper abdominal discomfort. The endoscopic examination revealed a tumor mass about 3 cm in diameter. The patient underwent a partial gastrectomy and had an uneventful recovery. The histopathological examination revealed a welldifferentiated liposarcoma. The second patient had symptoms of upper abdominal discomfort combined with nausea and anorexia. Several palpable masses were found with endoscopy. Endoscopic submucosal dissection was the treatment used, and the postoperative course was uneventful. The histopathological diagnosis was a well-differentiated liposarcoma. The two patients did not undergo any adjuvant therapy. They are both currently in good condition without recurrence. Therefore, we believe that the outcome of liposarcoma of the stomach is positive, and surgical resection may be the first choice for treatment at present.展开更多
文摘目的探索纳洛酮联合血塞通在治疗急性脑梗死患者中的可行性。方法选取2023年1月至2024年1月于蕲春县人民医院就诊的112例急性脑梗死患者为研究对象,随机分为研究组与对照组,每组各56例。研究组给予纳洛酮联合血塞通进行治疗,对照组给予纳洛酮治疗。比较两组患者治疗前后的美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、肢体运动功能(Fugl-Meyer Assessment,FMA)评分及Barthel指数(Barthel Index,BI)评分,以及临床有效率、血浆脑钠肽(Plasma Brain Natriuretic Peptide,BNP)水平及不良反应。结果经过两周治疗后,两组患者临床症状体征和自理能力均好转,但研究组患者临床有效率更高(P<0.05)。治疗前,两组患者NIHSS、FMA和BI评分均无显著差异(P>0.005);治疗后,两组患者NIHSS评分均显著下降(P<0.001),FMA评分和BI评分均显著升高(P<0.001),但研究组NIHSS评分下降程度更明显(P<0.001),FMA评分和BI评分上升程度更明显(P<0.001)。治疗后,两组患者血浆BNP水平均降低,且研究组改善程度优于对照组,差异有统计学意义(P<0.001)。治疗期间,两组患者皮疹、恶心、嗜睡、心动过速等不良反应发生率无显著差异(8.93%vs 12.50%,P>0.541)。结论纳洛酮联合血塞通治疗急性脑梗死,有利于运动功能和神经功能的恢复,可有效提高患者的生活能力,且不良反应少。
基金Supported by Beijing Municipal Science and Technology Commission,No.Z161100000116045National Natural Science Foundation of China,No.81772642
文摘Liposarcoma of the stomach is extremely rare, and only 37 cases have been reported worldwide. We herein report two cases of liposarcoma of the stomach. The first patient was referred to our hospital with upper abdominal discomfort. The endoscopic examination revealed a tumor mass about 3 cm in diameter. The patient underwent a partial gastrectomy and had an uneventful recovery. The histopathological examination revealed a welldifferentiated liposarcoma. The second patient had symptoms of upper abdominal discomfort combined with nausea and anorexia. Several palpable masses were found with endoscopy. Endoscopic submucosal dissection was the treatment used, and the postoperative course was uneventful. The histopathological diagnosis was a well-differentiated liposarcoma. The two patients did not undergo any adjuvant therapy. They are both currently in good condition without recurrence. Therefore, we believe that the outcome of liposarcoma of the stomach is positive, and surgical resection may be the first choice for treatment at present.
