The choline pathway as a strategy to promote central nervous system(CNS) remyelination

Multiple sclerosis is a chronic companied by demyelination inflammatory disease that is ac- and axonal damage resulting in neurological deficits. Remyelination is the natural endogenous repair mechanism of demyelinated axons and it is supposed to protect axons/neurons from degeneration and thus the patient from progressive disability （Franklin and Ffrench-Constant, 2008）. Current therapeutics for patients with multiple sclerosis are to some extent very effective in inhibiting neuroinflamma- tion and demyelination. However, to date there are no substanc- es available that can enhance remyelination. Remyelination is the result of recruitment/proliferation of new oligodendrocyte precursor cells （OPC） and differentiation into mature myelin producing oligodendrocytes （Franklin and Ffrench-Constant, 2008）. These processes are supported by many factors and signals and failure at any stage might lead to repair failure. Strategies to enhance myelin repair are either the promotion of endogenous repair mechanisms via modulation of OPC prolif- eration and oligodendrocyte differentiation or the transplantion of myelinating cells into lesions. Due to the multiloculated pro- cess in multiple sclerosis and the ethical problems with the cell source, the latter is less favoured. The endogenous promotion of remvelination could be achieved by several approaches such as：

Oncogenic Ras/PI3K/Her2 share a common pathway in promoting cancer metastasis via inhibiting expression of p53-related ΔNp63α

Subject Code:H16With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Xiao Zhixiong(肖智雄)from the College of Life Science,Sichuan University demonstrates thatΔNp63αis a common inhibitory target in oncogenic PI3K/Ras/Her2-induced

中国县域生态资产损益的影响机制及优化提升路径

Accounting for the gains and losses of ecological assets holds scientific significance in sustaining human well-being.Based on related research on ecological assets,we established a county-scale ecological asset accounting technology system by analyzing the temporal and spatial variations of county-level ecological assets in China from 1990 to 2018 and clarified the factors which caused the gains and losses of ecological assets.On these bases,optimization and promotion pathways were proposed.The results show that the number of counties dominated by farmland and forest ecological resources accounted for about 45%and 37%of the total counties,respectively.From 1990 to 2018,the quality of county-level ecological stock assets showed an increasing trend,while the water conservation volume decreased in nearly 70%of the counties.The number of counties with the gains(47%)and losses(37%)of ecological flow assets demonstrated spatial patterns which showed the same segmentation characteristics as the“Hu Huanyong Line”,that is,the counties in the vastness of northwest China experienced significant gains,while decreases were widespread in eastern and southern China.The change of ecological assets in more than 70%of the counties was driven by climate change and human activities.The average degree of impact of human activities driving the ecological asset gains in counties was about 80%,while that of climate change causing the ecological asset losses was about 60%.According to various ecological resource types,gain and loss status,and its driving factors,counties in China can be classified into five types:climate change mitigation,climate change adaptation,ecological resources restoration,ecological resources protection,and ecological resources management.Our results indicate that differentiated optimization and promotion pathways can be adopted to achieve desired ecological asset gains.