A new alkaloid has been isolated from the root of Patrinia scabra. Its structure was elucidated as 2-acetamido-3-phenyl propyl 2-benzamido-3-phenyl propionate by extensive spectr- oscopic analysis.
AIM: To study the chemical constituents and bioactivity of the roots of Patrinia scabra Bunge. METHODS: The chemical constituents were isolated using various chromatographic methods, and the structures were elucidated...AIM: To study the chemical constituents and bioactivity of the roots of Patrinia scabra Bunge. METHODS: The chemical constituents were isolated using various chromatographic methods, and the structures were elucidated on the basis of spectral analysis and chemical methods. In addition, cytotoxic activities toward HepG2 cells were tested by the MTT method. RESULTS: A new triterpenoid saponin, 3-O-(4'-isovaleryl)-O-β-D-xylose-12,30-dihydroxy-oleanane-28,13-lactone-22-O- β-D-glucoside(1), along with two known triterpenoid saponins, acanthopanax saponin CP3(2) and foetoside C(3), were isolated. CONCLUSION: The aglycone of compound 1 was a new skeleton derivative of oleanolic acid. Compound 2 showed strong cytotoxicity to HePG2 cells(IC50 1.49 μmol?L-1).展开更多
文摘A new alkaloid has been isolated from the root of Patrinia scabra. Its structure was elucidated as 2-acetamido-3-phenyl propyl 2-benzamido-3-phenyl propionate by extensive spectr- oscopic analysis.
文摘AIM: To study the chemical constituents and bioactivity of the roots of Patrinia scabra Bunge. METHODS: The chemical constituents were isolated using various chromatographic methods, and the structures were elucidated on the basis of spectral analysis and chemical methods. In addition, cytotoxic activities toward HepG2 cells were tested by the MTT method. RESULTS: A new triterpenoid saponin, 3-O-(4'-isovaleryl)-O-β-D-xylose-12,30-dihydroxy-oleanane-28,13-lactone-22-O- β-D-glucoside(1), along with two known triterpenoid saponins, acanthopanax saponin CP3(2) and foetoside C(3), were isolated. CONCLUSION: The aglycone of compound 1 was a new skeleton derivative of oleanolic acid. Compound 2 showed strong cytotoxicity to HePG2 cells(IC50 1.49 μmol?L-1).