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Spectrum of Henoch-Schonlein Purpura in Children: A Single-Center Experience from Western Provence of Saudi Arabia 被引量:1
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作者 Esraa M. Bukhari Khouloud A. Al-Sofyani Mohammed Ahmed Muzaffer 《Open Journal of Rheumatology and Autoimmune Diseases》 2015年第1期17-22,共6页
The aim of this study was to describe the common presentation, frequency, and complications of Henoch-Schonlein purpura (HSP) in patients <18 years who were followed up at King Abdulaziz University Hospital, Jeddah... The aim of this study was to describe the common presentation, frequency, and complications of Henoch-Schonlein purpura (HSP) in patients <18 years who were followed up at King Abdulaziz University Hospital, Jeddah over the last 12 years. We performed a retrospective chart review of the medical records of all patients diagnosed as HSP. During this period, only 29 cases were reported (15 males, 14 females), with the mean age at the diagnosis 7.5 years. 82% percent of the patients had joint involvement in the form of arthritis or arthralgia;17.2% had no joint involvement. Abdominal manifestations were reported in 72.4% of the patients, while renal involvement was documented in 24.1% of the cases;two patients had scrotal involvement. Four patients (13.7%) had a recurrence within four months of HSP diagnosis. However, all patients had full recovery within a month. More research is warranted to study the prevalence, clinical manifestations, preceding factors, and complications of HSP in a Saudi-based cohort. 展开更多
关键词 CHILDREN Diagnosis henoch-schonlein purpura pediatricS Presentation RENAL Involvement
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IgA1 from HSP Patients Trigger Apoptosis and Inhibit Cytoskeletal Proteins in HUVEC
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作者 Liping Yuan Wenjun Fei +3 位作者 Lin Wu Ming Gui Qin Zhang Bo Hu 《Open Journal of Pediatrics》 2014年第1期42-46,共5页
Background: Henoch-Schonlein purpura (HSP) is a kind of systemic small vessel vasculitis in children. Endothelium cells injury induced by IgA1 is considered important in the pathogenesis of HSP. Research found that th... Background: Henoch-Schonlein purpura (HSP) is a kind of systemic small vessel vasculitis in children. Endothelium cells injury induced by IgA1 is considered important in the pathogenesis of HSP. Research found that the apoptosis of vein endothelial cells was related to the vasculitis in HSP patients. Purpose: To observe the effect of IgA1 from HSP patients on the apoptosis of HUVEC and firstly analyze the mechanism of the apoptosis of HUVEC induced by IgA1. Methods: HUVECs were cultured in 3 different conditional media with IgA1 from HSP patients, normal healthy children and simply medium (blank control). Serum IgA1 was purified by jacalin affinity chromatography. The rates of apoptosis in HUVEC incubated with IgA1 were determined by TUNEL method and flow cytometry, respectively. The expression of the cytoskeletal proteins, such as FAK, Vinculin and MLCK was detected with the methods of Real-time PCR and Westernblot, respectively. Results: The present study showed that the apoptosis rate of HUVEC by IgA1 isolated from HSP patients was higher than blank control (14.77% ± 2.23% vs 2.25% ± 0.77%) (P < 0.01) and the rate of HUVEC by IgA1 from normal healthy children was higher than blank control (9.97% ± 1.48% vs 2.25% ± 0.77%) (P < 0.01). The cytoskeletal proteins, such as FAK, Vinculin and MLCK expression were down-regulated in HUVEC co-cultured with IgA1 isolated from HSP patients for 24h. Conclusion: These findings firstly on IgA1 from HSP patients may induce apoptosis of vascular endothelial cells through inhibiting the cytoskeletal proteins expression. IgA1 may accelerate progression of HSP by inducing apoptosis of vascular endothelial cells. 展开更多
关键词 henoch-schonlein purpura(hsp) Endothelial Cells Immunoglobulin A APOPTOSIS Cytoskeletal Proteins
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Acute kidney injury due to bilateral ureteral obstruction in children
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作者 Daniele Bianchi Giuseppe Vespasiani Pierluigi Bove 《World Journal of Nephrology》 2014年第4期182-192,共11页
Bilateral ureteral obstruction in children is a rare condition arising from several medical or surgical pictures.It needs to be promptly suspected in order to attempt a quick renal function recovery.In this paper we c... Bilateral ureteral obstruction in children is a rare condition arising from several medical or surgical pictures.It needs to be promptly suspected in order to attempt a quick renal function recovery.In this paper we concentrated on uncommon causes of obstruction,with the aim of giving a summary of such multiple,rare and heterogeneous conditions joint together by the common denominator of sudden bilateral ureteral obstruction,difficult to be suspected at times.Conversely,typical and well-known diseases have been just run over.We considered pediatric cases of ureteral obstruction presenting as bilateral,along with some cases which truly appeared as single-sided,because of their potential bilateral presentation.We performed a review of the literature by a search on Pub Med,Cross Ref Metadata Search,internet and reference lists of single articles updated to May 2014,with no time limits in the past.Given that we deal with rare conditions,we decided to include also papers in non-English languages,published with an English abstract.For the sake of clearness,we divided our research results into 8 categories:(1) urolithiasis;(2) congenital urinary tract malformations;(3) immuno-rheumatologic causes of ureteral obstruction;(4) ureteral localization of infections;(5) other systemic infective causes of ureteral obstructions;(6) neoplastic intrinsic ureteral obstructions;(7) extrinsic ureteralobstructions; and(8) iatrogenic trigonal obstruction or inflammation.Of course,different pathogenic mechanisms underlay those clinical pictures,partly wellknown and partly not completely understood. 展开更多
关键词 Acute kidney injury Bilateral ureteral obstruction HYDRONEPHROSIS Anuria pediatricS Ureteral stenting henoch-schonlein purpura TUBERCULOSIS MASSES Congenital malformations
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张士卿基于“热瘀损络”论治小儿过敏性紫癜经验
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作者 王正平 张弢 +4 位作者 李玉霞 王庆苗 丁繁 翟双庆 张士卿(指导) 《中华中医药杂志》 CAS CSCD 北大核心 2024年第6期2928-2931,共4页
小儿过敏性紫癜因机繁杂,迁延难愈,呈现出“脉络受损”的病证特点。张士卿教授结合五十余年临床经验,认为过敏性紫癜病位在脉络,临证时紧扣热、瘀损络的核心病机,确立“清热凉血,化瘀通络”的基本治法,创制出经验方“四草消斑汤”运用... 小儿过敏性紫癜因机繁杂,迁延难愈,呈现出“脉络受损”的病证特点。张士卿教授结合五十余年临床经验,认为过敏性紫癜病位在脉络,临证时紧扣热、瘀损络的核心病机,确立“清热凉血,化瘀通络”的基本治法,创制出经验方“四草消斑汤”运用于临床,若化裁得当,疗效颇佳。文章整理了张教授从中医学络病之脉络-血管系统病视角,基于“热瘀损络”论治小儿过敏性紫癜的思路及经验,以期为同道提供临床参考和借鉴。 展开更多
关键词 小儿过敏性紫癜 络病 脉络学说 名医经验 张士卿 四草消斑汤
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