Effects of vitrectomy combined with internal limiting membrane peeling in patients with diabetic macular edema

BACKGROUND Diabetic macular edema(DME),a chronic microvascular complication of diabetes,is a leading cause of visual impairment and blindness.Pars plana vitrectomy(PPV)can restore the normal macular structure and reduce macular edema,whereas internal limiting membrane(ILM)peeling is used to treat tractional macular diseases.Despite the advantages,there is limited research on the combined effects of PPV with ILM peeling.AIM To observe the effects of PPV combined with ILM peeling on postoperative central macular thickness(CMT),best-corrected visual acuity(BCVA),cystoid macular edema(CME)volume,and complications in patients with DME.METHODS Eighty-one patients(92 eyes)diagnosed with DME at the Beijing Shanqu Liangxiang Hospital between January and December 2022 were randomly divided to undergo PPV alone(control group:41 patients,47 eyes)or PPV+ILM peeling(stripping group:40 patients,45 eyes);a single surgeon performed all surgeries.The two groups were compared preoperatively and 1 and 3 months postoperatively.RESULTS Preoperatively,both groups had comparable values of CMT,BCVA,and CME volume(P>0.05).After surgery(both 1 and 3 months),both groups showed significant reductions in CMT,BCVA,and CME volume compared to preoperative levels,with the stripping group showing more significant reductions compared to the control group(P<0.05).Further repeated-measures ANOVA analysis for within-group differences revealed significant effects of group and time,and interaction effects for CMT,BCVA,and CME volume(P<0.05).There were no significant differences in the incidence of complications between the groups(retinal detachment:control=2,stripping=1;endophthalmitis:Control=4,stripping=1;no cases of secondary glaucoma or macular holes;χ^(2)=0.296,P=0.587).CONCLUSION PPV with ILM peeling can significantly improve the visual acuity of patients with DME,reduce CMT,and improve CME with fewer complications.

Optimization of the Pretreatment of the Mixture of Cassava Peelings and Pineapple Fibers Using Response Surface Methodology and a Process Simulator for the Bioethanol Production

The increase in oil prices and greenhouse gas emissions has led to the search for substitutes for fossil fuels. In Cameroon, the abundance of lignocellulosic resources is inherent to agricultural activity. Production of bioethanol remains a challenge given the crystallinity of cellulose and the presence of the complex. The pretreatment aimed to solubilize the lignin fraction and to make cellulose more accessible to the hydrolytic enzymes, was done using the organosolv process. A mathematical modeling was performed to point out the effect of the temperature on the kinetics of the release of the reducing sugars during the pretreatment. Two mathematical model was used, SAEMAN’s model and Response surface methodology. The first show that the kinetic parameters of the hydrolysis of the cellulose and reducing sugar are: 0.05089 min-1, 5358.1461 J·mol-1, 1383.03691 min-1, 51577.6100 J·mol-1 respectively. The second model was used. Temperature is the factor having the most positive influence whereas, ethanol concentration is not an essential factor. To release the maximum, an organosolv pre-treatment of this sub-strate should be carried out at 209.08°C for 47.60 min with an ethanol-water ratio of 24.02%. Organosolv pre-treatment is an effective process for delignification of the lignocellulosic structure.

Peeling与韦登斯基现象

在房室超常传导受到普遍怀疑之后,韦登斯基现象往往被认为是真正的房室超常传导。这一认识是否符合实验和临床电生理研究的结果?本文作一客观的讨论。韦登斯基现象回顾 1986年韦登斯基在神经—肌肉标本上发现,对神经作阈下刺激,肌肉无反应。然而对神经作强刺激引起肌肉收缩后,原来的阈下刺激此时也能引起肌肉收缩,即所谓韦登斯基效应(Wedensky effect)。

Construction of Renewable Superhydrophobic Surfaces via Thermally Induced Phase Separation and Mechanical Peeling

We report a simple preparation method of a renewable superhydrophobic surface by thermally induced phase separation （TIPS） and mechanical peeling. Porous polyvinylidene fluoride （PVDF） membranes with hierarchical structures were prepared by a TIPS process under different cooling conditions, which were confirmed by scanning electron microscopy and mercury intrusion porosimetry. After peeling off the top layer, rough structures with hundreds of nanometers to several microns were obtained. A digital microscopy determines that the surface roughness of peeled PVDF membranes is much higher than that of the original PVDF membrane, which is important to obtain the superhydrophobicity. Water contact angle and sliding angle measurements demonstrate that the peeled membrane surfaces display super- hydrophobicity with a high contact angle （152°） and a low sliding angle （7.2°）. Moreover, the superhydrophobicity can be easily recovered for many times by a simple mechanical peeling, identical to the original superhydrophobicity. This simple preparation method is low cost, and suitable for large-scale industrialization, which may offer more opportunities for practical applications.

FINITE ELEMENT ANALYSIS ABOUT STRESS AND STRAIN OF SURFACE PEELING IN Cu-Fe-P SHEET

The microstructure of surface peeling in finish rolled Cu-0.1Fe-0.03P sheetis analyzed by scanning electron microscope and energy dispersive spectroscope. Fe-rich areas ofdifferent contents are observed in the matrix. The stress distributions and strain characteristicsat the interface between Cu matrix and Fe particle are studied by elastic-plastic finite elementplane strain model. Larger Fe particles and higher deforming extent of finish rolling are attributedto the intense stress gradient and significant non-homogeneity equivalent strain at the interfaceand accelerate surface peeling of Cu-0.1Fe-0.03P lead frame sheet.

Molecular dynamics simulation of peeling a DNA molecule on substrate

Molecular dynamics （MD） simulations are performed to study adhesion and peeling of a short fragment of single strand DNA （ssDNA） molecule from a graphite surface. The critical peel-off force is found to depend on both the peeling angle and the elasticity of ssDNA. For the short ssDNA strand under investigation, we show that the simulation results can be explained by a continuum model of an adhesive elastic band on substrate. The analysis suggests that it is often the peak value, rather than the mean value, of adhesion energy which determines the peeling of a nanoscale material.

FAILURE ANALYSIS OF PEELING PROCESS FOR TITANIUM ANODES COATINGS

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Displacement of the retina after idiopathic macular hole surgery with different internal limiting membrane peeling patterns

AIM:To explore retinal displacement after surgical treatment for idiopathic macular hole(IMH)with different internal limiting membrane(ILM)peeling patterns.METHODS:Totally 22 eyes from 20 patients with IMH were randomly allocated into two groups,N-T group(11 eyes)and T-N group(11 eyes).For patients in N-T group,ILM was peeled off from nasal to temporal retina.For patients in T-N group,ILM was peeled off from temporal to nasal retina.Preoperative,postoperative 1,3,and 6 mo,autofluorescence fundus images were collected for manual measurement of distances of fixed nasal(N),temporal(T),superior(S),and inferior(I)retinal points(bifurcation or crossing of retinal vessels)around the macula to the optic disc(OD).These were respectively defined as N-OD,T-OD,S-OD,and I-OD.The retinal displacement,macular holeclosure rate,and best corrected visual acuity(BCVA)were compared between the two groups after surgery.RESULTS:At postoperative 1,3,and 6 mo,the macula slipped toward the OD,manifested by the decreased T-OD,N-OD,S-OD,and I-OD(P<0.05).No significant difference was found in the T-OD,N-OD,S-OD,and I-OD between N-T group and T-N group.IMH closure rate was 100%both in N-T group and T-N group.There was no significant difference in BCVA between two groups(P<0.05).CONCLUSION:The macula slips toward the OD after successful macular hole surgery.The two different ILM peeling pattern show similar visual outcome and retinal displacement,which means ILM peeling directions are not the influencing factor of postoperative retinal displacement.

Internal limiting membrane peeling with different dyes in the surgery of idiopathic macular hole: a systematic review of literature and network Meta-analysis

AIM: To evaluate the effect of internal limiting membrane(ILM) peeling with indocyanine green(ICG), brilliant blue G(BBG), triamcinolone acetonide(TA), trypan blue(TB), or without dye for the treatment of idiopathic macular hole(IMH). METHODS: A search was conducted using Pub Med, EMBASE, and CENTRAL(Cochrane Central Register of Controlled Trials) for related studies published before October 2018. RESULTS: A total of 29 studies and 2514 eyes were included in this network Meta-analysis. For IMH closure, the rank from the best to the worse treatment was: BBG, TB, TA, ICG, and no dye. There was a significant difference in postoperative IMH closure rate between BBG and no dye. The rank of the best to the worse treatment to improve visual acuity was: BBG, TB, no dye, TA, and ICG. The improvement rate of visual acuity after using BBG was significantly higher than ICG. The improvement rate of visual acuity was more favorable with TB than ICG, TA, and no dye. CONCLUSION: BBG can contribute to better anatomical and functional outcomes compared to other dyes for ILM peeling in patients with IMH. The results show that the best treatment of ILM peeling with dyes is BBG.

Effect of Fe Particle on the Surface Peeling in Cu-Fe-P Lead Frame

Under the surface peeling of Cu- Fe- P lead frame alloy larger Fe particles were observed by energy dispersive spectroscopy. By using the large strain two-dinension plane strain model and elastic plastic finite element method, the cause for peeling damage of Cu-Fe-P lead frame aUoy was investigated. The results show that when the content of Fe particles is more than 30% at local Fe-rich area the intense stress coacentration in the Fe particle would make the Fe particle broken up. The high equivalent stress mutation and the mismatch of equivalent strain 10% at the two sides of intefrace make it easy to develop the crack and peeling damage on finish rolling. The larger Fe particles in the Cu-Fe-P alloy should be avoided.

Loop Peeling Based on Quasi-Invariance/Induction Variables

Loop optimization plays an important role in compiler optimization and program transformation. Many sophisticated techniques such as loop invariance code motion have been developed. Loop peeling is a technique to assist parallelization of loops by unfolding loops a few times. This paper introduces a novel technique called loop peeling based on quasi invariance/induction variables. It aims at finding a general and automatic method to derive how many times a given loop should be peeled. Our technique allows for a number of iterations before some variables assigned inside a given loop become invariance or induction variables. In this paper we define the notion of quasi invariance/induction variables, present an algorithm for statically computing the optimal peeling length of a given loop. Our technique can increase the accuracy of program analyses, improve the effectiveness of loop peeling and is well suited as supporting other optimization techniques in the context of supercomputers.

Formulations Containing Curcumin or Trans-Resveratrol Increase Dermal Thickness in Rats Submitted to Chemical Peeling

Plant-derived substances such as curcumin and trans-resveratrol, both of which have anti-inflammatory properties, may have a beneficial effect on human skin. The present study analyzed the effects of topical formulations containing curcumin or trans-resveratrol on the recovery and rejuvenation of skin after chemical peeling. The study was performed on rats, randomly divided into seven groups of six animals each. Superficial peeling was performed using a 50% glycolic acid gel, which was applied to the dorsal region of each animal. Rats were then treated with the experimental formulations for 15 days. On the sixteenth day, skin samples were taken and mounted on slides for histological analysis. Statistical analysis showed that the formulation containing trans-resveratrol led to increased dermal and epidermal thickness, while the formulation containing curcumin had no effects on epidermal thickness. The increased epidermal thickness may reflect greater skin vitality, although this was not directly evaluated. The increase in dermal thickness may be attributed to greater collagen production, which may increase skin firmness and elasticity, and lead to skin rejuvenation as well as wrinkle reduction. Formulations containing curcumin or trans-resveratrol may have potential for the topical treatment after peeling and of sensitive skin, in addition to being used for their antiaging properties.

Growth rate of peeling mode in the near separatrix region of diverted tokamak plasma

An analytical expression of the peeling mode in the near separatrix region of diverted tokamak plasma is derived. It is shown that in diverted plasmas both with single and double X points, though the perturbed potential energy of the unstable peeling mode tends to be large, its growth rate becomes very small due to the even larger kinetic energy. Compared to some recent studies that give qualitatively correct results about this growth rate, our result is directly related with the diverted equilibrium quantities suitable for application to realistic experiments.

Effects of Peeling with Flexible Alloy Blade on Naked Oats

This research reported the effect of peeling naked oats with a peeling machine equipped with the flexible alloy blade.Results showed that the flexible alloy blade could achieve the same effect as traditional abrasive rolls. Furthermore, the new peeling method had hardly damage to the oat kernels. The result of scanning electron microscopy indicated the surface of peeled naked oats by the flexible alloy blade is homogeneous. The gap between the flexible alloy blade and the slotted screen could change the particle sizes of the flours obtained, which differed from traditional peeling machines. In addition, peeling for 15 seconds significantly reduced the microbial contaminants. The removal of outer layer decreased the lipase activity. The technological parameters were optimized by orthogonal L_9(3~4) test, the results showed a 30 s peeling time and 2% second-addition of water contributed to the peeling rate. The texture analysis demonstrate that the hardness of cooked groats decreases obviously after peeling treatments.

THE GLOBAL LIPSCHITZ SOLUTION FOR A PEELING MODEL

This paper focusses on a peeling phenomenon governed by a nonlinear wave equation with a free boundary.Under the hypotheses that the total variation of the intial data and the boundary data are small,the global existence of a weak solution to the nonlinear problem(1.1)-(1.3)is proven by a modified Glimm scheme.The regularity of the peeling front is established,and the asymptotic behaviour of the obtained solution and the peeling front at infinity is also studied.