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Management of lateral pelvic lymph nodes in rectal cancer:Is it time to reach an Agreement?
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作者 Sigfredo E Romero-Zoghbi Fernando López-Campos Felipe Couñago 《World Journal of Clinical Oncology》 2024年第4期472-477,共6页
In this editorial,we proceed to comment on the article by Chua et al,addressing the management of metastatic lateral pelvic lymph nodes(mLLN)in stage II/III rectal cancer patients below the peritoneal reflection.The t... In this editorial,we proceed to comment on the article by Chua et al,addressing the management of metastatic lateral pelvic lymph nodes(mLLN)in stage II/III rectal cancer patients below the peritoneal reflection.The treatment of this nodal area sparks significant controversy due to the strategic differences followed by Eastern and Western physicians,albeit with a higher degree of convergence in recent years.The dissection of lateral pelvic lymph nodes without neoadjuvant therapy is a standard practice in Eastern countries.In contrast,in the West,preference leans towards opting for neoadjuvant therapy with chemoradiotherapy or radiotherapy,that would cover the treatment of this area without the need to add the dissection of these nodes to the total mesorectal excision.In the presence of high-risk nodal characteristics for mLLN related to radiological imaging and lack of response to neoadjuvant therapy,the risk of lateral local recurrence increases,suggesting the appropriate selection of strategies to reduce the risk of recurrence in each patient profile.Despite the heterogeneous and retrospective nature of studies addressing this area,an international consensus is necessary to approach this clinical scenario uniformly. 展开更多
关键词 Rectal cancer Lateral pelvic lymph node metastases pelvic lymph node dissection Total neoadjuvant therapy Selective management of the lateral pelvic nodes Prophylactic management of the lateral pelvic nodes CHEMORADIOTHERAPY Total mesorectal excision
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Current perspectives on the management of lateral pelvic lymph nodes in rectal cancer 被引量:3
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作者 Jonathan Yu Jin Chua James Chi Yong Ngu Nan Zun Teo 《World Journal of Clinical Oncology》 2023年第12期584-592,共9页
Significant controversies exist with regards to the optimal management of lateral pelvic lymph nodes metastases(mLLN)in patients with low rectal cancer.The differing views held by Japanese and Western clinicians on th... Significant controversies exist with regards to the optimal management of lateral pelvic lymph nodes metastases(mLLN)in patients with low rectal cancer.The differing views held by Japanese and Western clinicians on the management of mLLN have been well documented.However,the adequacy of pelvic lymph node dissection(PLND)or neoadjuvant chemoradiation(NACRT)alone in addition to total mesorectal excision(TME)have recently come into question,due to the relatively high incidence of lateral local recurrences following PLND and TME,or NACRT and TME alone.Recently,a more selective approach to PLND has been suggested,involving a combination of neoadjuvant therapy,followed by PLND only to patients in whom the oncological benefit is likely to outweigh the risk of potential adverse events.A number of studies have attempted to retrospectively identify certain nodal characteristics on preoperative imaging,such as nodal size,appearance,and size reduction following neoadjuvant therapy.However,no consensus has been reached regarding the optimal criteria for a selective approach to PLND,partly due to the heterogeneity and retrospective nature of most of these studies.This review aims to provide an overview of recent evidence with regards to the diagnostic challenges,considerations for,and outcomes of the current management strategies for mLLN in rectal cancer patients. 展开更多
关键词 pelvic lymph node dissection Lateral pelvic lymph nodes Diagnostic criteria Short axis diameter RADIOTHERAPY Rectal cancer
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Lateral pelvic lymph nodes for rectal cancer:A review of diagnosis and management 被引量:1
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作者 Shimpei Ogawa Michio Itabashi +9 位作者 Yuji Inoue Takeshi Ohki Yoshiko Bamba Kurodo Koshino Ryosuke Nakagawa Kimitaka Tani Hisako Aihara Hiroka Kondo Shigeki Yamaguchi Masakazu Yamamoto 《World Journal of Gastrointestinal Oncology》 SCIE 2021年第10期1412-1424,共13页
The current status and future prospects for diagnosis and treatment of lateral pelvic lymph node(LPLN)metastasis of rectal cancer are described in this review.Magnetic resonance imaging(MRI)is recommended for the diag... The current status and future prospects for diagnosis and treatment of lateral pelvic lymph node(LPLN)metastasis of rectal cancer are described in this review.Magnetic resonance imaging(MRI)is recommended for the diagnosis of LPLN metastasis.A LPLN-positive status on MRI is a strong risk factor for metastasis,and evaluation by MRI is important for deciding treatment strategy.LPLN dissection(LPLD)has an advantage of reducing recurrence in the lateral pelvis but also has a disadvantage of complications;therefore,LPLD may not be appropriate for cases that are less likely to have LPLN metastasis.Radiation therapy(RT)and chemoradiation therapy(CRT)have limited effects in cases with suspected LPLN metastasis,but a combination of preoperative CRT and LPLD may improve the treatment outcome.Thus,RT and CRT plus selective LPLD may be a rational strategy to omit unnecessary LPLD and produce a favorable treatment outcome. 展开更多
关键词 DIAGNOSIS TREATMENT Rectal cancer Lateral pelvic lymph node metastasis Lateral pelvic lymph node dissection RADIOTHERAPY
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Feasibility and limitations of combined treatment for lateral pelvic lymph node metastases in rectal cancer
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作者 Ying-Zi Zheng Fang-Fang Yan Lian-Xiang Luo 《World Journal of Clinical Oncology》 2024年第5期591-593,共3页
Colorectal cancer ranks among the most commonly diagnosed cancers globally,and is associated with a high rate of pelvic recurrence after surgery.In efforts to mitigate recurrence,pelvic lymph node dissection(PLND)is c... Colorectal cancer ranks among the most commonly diagnosed cancers globally,and is associated with a high rate of pelvic recurrence after surgery.In efforts to mitigate recurrence,pelvic lymph node dissection(PLND)is commonly advocated as an adjunct to radical surgery.Neoadjuvant chemoradiotherapy(NACRT)is a therapeutic approach employed in managing locally advanced rectal cancer,and has been found to increase the survival rates.Chua et al have proposed a combination of NACRT with selective PLND for addressing lateral pelvic lymph node metastases in rectal cancer patients,with the aim of reducing recurrence and improving survival outcomes.Nevertheless,certain studies have indicated that the addition of PLND to NACRT and total mesorectal excision did not yield a significant reduction in local recurrence rates or improvement in survival.Consequently,meticulous patient selection and perioperative chemotherapy may prove indispensable in ensuring the efficacy of PLND. 展开更多
关键词 Rectal cancer Lateral pelvic lymph nodes metastases pelvic lymph node dissection Neoadjuvant chemoradiotherapy Total mesorectal excision
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The Number of Positive Pelvic Lymph Nodes and Multiple Groups of Pelvic Lymph Node Metastasis Influence Prognosis in Stage ⅠA-ⅡB Cervical Squamous Cell Carcinoma 被引量:18
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作者 Yu Liu Li-Jon Zhao Ming-Zho Li Ming-Xia Li Jian-Liu Wang Li-Hui Wei 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第15期2084-2089,共6页
Background:Pelvic lymph node metastasis (LNM) is an important prognostic factor in cervical cancer.Cervical squamous cell carcinoma accounts for approximately 75-80% of all cervical cancers.Analyses of the effects ... Background:Pelvic lymph node metastasis (LNM) is an important prognostic factor in cervical cancer.Cervical squamous cell carcinoma accounts for approximately 75-80% of all cervical cancers.Analyses of the effects of the number of positive lymph nodes (LNs),unilateral vcrsus bilateral pelvic LNM and a single group versus multiple groups of pelvic LNM on survival and recurrence of cervical squamous cell carcinoma are still lacking.The study aimed to analyze the effects of the number of positive pelvic LNs and a single group versus multiple groups of pelvic LNM on survival and recurrence.Methods:We performed a retrospective review of 296 patients diagnosed with Stage ⅠA-ⅡB cervical squamous cell carcinoma who received extensive/sub-extensive hysterectomy with pelvic lymphadenectomy/pelvic LN sampling at Peking University People's Hospital from November 2004 to July 2013.Ten clinicopathological variables were evaluated as risk factors for pelvic LNM:Age at diagnosis,gravidity,clinical stage,histological grade,tumor diameter,lymph-vascular space involvement (LVSI),depth of cervical stromal invasion,uterine invasion,parametrial invasion,and neoadjuvant chemotherapy.Results:The incidence of pelvic LNM was 20.27% (60/296 cases).Pelvic LNM (P =0.00) was significantly correlated with recurrence.Pelvic LNM (P =0.00),the number of positive pelvic LNs (P =0.04) and a single group versus multiple groups of pelvic LNM (P =0.03)had a significant influence on survival.Multivariate analysis revealed that LVSI (P =0.00),depth of cervical stromal invasion (P =0.00)and parametrial invasion (P =0.03) were independently associated with pelvic LNM.Conclusions:Patients with pelvic LNM had a higher recurrence rate and poor survival outcomes.Furthermore,more than 2 positive pelvic LNs and multiple groups of pelvic LNM appeared to identify patients with worse survival outcomes in node-positive ⅠA-ⅡB cervical squamous cell carcinoma.LVSI,parametrial invasion,and depth of cervical stromal invasion were identified as independent clinicopathological risk factors for pelvic LNM. 展开更多
关键词 Cervical Squamous Cell Carcinoma pelvic lymph Node Metastasis PROGNOSIS
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Increasing the accuracy and reproducibility of positron emission tomography radiomics for predicting pelvic lymph node metastasis in patients with cervical cancer using 3D local binary pattern-based texture features
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作者 Yang Yu Xiaoran Li +4 位作者 Tianming Du Md Rahaman Marcin Jerzy Grzegorzek Chen Li Hongzan Sun 《Intelligent Medicine》 EI CSCD 2024年第3期153-160,共8页
Background The reproducibility of positron emission tomography(PET)radiomics features is affected by several factors,such as scanning equipment,drug metabolism time and reconstruction algorithm.We aimed to explore the... Background The reproducibility of positron emission tomography(PET)radiomics features is affected by several factors,such as scanning equipment,drug metabolism time and reconstruction algorithm.We aimed to explore the role of 3D local binary pattern(LBP)-based texture in increasing the accuracy and reproducibility of PET radiomics for predicting pelvic lymph node metastasis(PLNM)in patients with cervical cancer.Methods We retrospectively analysed data from 177 patients with cervical squamous cell carcinoma.They un-derwent18 F-fluorodeoxyglucose(18 F-FDG)whole-body PET/computed tomography(PET/CT),followed by pelvic 18 F-FDG PET/magnetic resonance imaging(PET/MR).We selected reproducible and informative PET radiomics features using Lin’s concordance correlation coefficient,least absolute shrinkage and selection operator algorithm,and established 4 models,PET/CT,PET/CT-fusion,PET/MR and PET/MR-fusion,using the logistic regression al-gorithm.We performed receiver operating characteristic(ROC)curve analysis to evaluate the models in the training data set(65 patients who underwent radical hysterectomy and pelvic lymph node dissection)and test data set(112 patients who received concurrent chemoradiotherapy or no treatment).The DeLong test was used for pairwise comparison of the ROC curves among the models.Results The distribution of age,squamous cell carcinoma(SCC),International Federation of Gynaecology and Obstetrics stage and PLNM between the training and test data sets were different(P<0.05).The LBP-transformed radiomics features(50/379)had higher reproducibility than the original radiomics features(9/107).Accuracy of each model in predicting PLNM was as follows:training data set:PET/CT=PET/CT-fusion=PET/MR-fusion(0.848)and test data set:PET/CT=PET/CT-fusion(0.985)>PET/MR=PET/MR-fusion(0.954).There was no statistical difference between the ROC curve of PET/CT and PET/MR models in both data sets(P>0.05).Conclusions The LBP-transformed radiomics features based on PET images could increase the accuracy and reproducibility of PET radiomics in predicting pelvic lymph node metastasis in cervical cancer to allow the model to be generalised for clinical use across multiple centres. 展开更多
关键词 Positron emission tomography Radiomics Cervical cancer REPRODUCIBILITY pelvic lymph node metastasis
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Fluorescence imaging-guided pelvic lymph node localization and resection of bladder cancer after intracutaneous injection of indocyanine green into the lower limbs and perineum
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作者 Yangbing Wei Chao Liu +10 位作者 Xiaoming Cao Bo Wu Liang Wei Hua Yang Chen Liu Haifeng Hao Qiang Jing Fan Liu Libing Sun Nianzeng Xing Xiaofeng Yang 《UroPrecision》 2024年第3期109-117,I0012,共10页
Background:Pelvic lymph node dissection(PLND)in radical cystectomy(RC)is of great significance,but the method and scope of PLND remain controversial.Based on the principle of indirect lymphadenography,we designed a me... Background:Pelvic lymph node dissection(PLND)in radical cystectomy(RC)is of great significance,but the method and scope of PLND remain controversial.Based on the principle of indirect lymphadenography,we designed a method to localize the whole pelvic lymph nodes by intradermal injection of indocyanine green(ICG)through the lower limbs and perineum,and to evaluate the effectiveness of this method. Methods:In a single center,54 bladder cancer patients who underwent RC and PLND participated in a prospective clinical trial,which began on February 28,2022 and ended on December 30,2022.ICG solution was injected subcutaneously at the medial malleolus of both lower extremities and at both sides of the midline of the perineum.The fluorescent laparoscopy was used to trace,locate,and remove the targeted areas under the image fusion mode.The consistency of lymph node resection was determined by histopathological diagnosis.The impact of ICG guidance on the surgical time of PLND was compared with that of 11 bladder cancer patients who underwent RC and PLND without ICG injection,serving as the control group. Results:Perineal lower limb combined injection can provide comprehensive visualization of pelvic lymph nodes.This technique reduces PLND surgical time and increases the accuracy of PLND. Conclusion:Intracutaneous injection of ICG into the lower limbs and perineum can specifically mark pelvic lymph nodes.Intraoperative fluores-cence imaging can accurately identify,locate,and resect lymph nodes in the pelvic region,reducing PLND surgical time and increasing the accuracy of PLND. 展开更多
关键词 4K fluoroscopic laparoscopy bladder cancer indocyanine green pelvic lymph node dissection radical cystectomy
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Indocyanine Green Fluorescence Imaging-Guided Lymphangiography in Colorectal Oncologic Practice:Current Use and Future Considerations
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作者 Yi Qun Liao Yi Chao Ma +8 位作者 Jia Hao Zhao Yu Ji Chen Bin Zhao Yong Kun Fang Fei Wang Chen Wei Hao Ji Dao Rong Wang Dong Tang 《Journal of Nutritional Oncology》 2022年第3期109-119,共11页
The clearance of lesions during surgery for colorectal cancer encompasses the removal of both the primary tumour and its concomitant lymphatic drainage.Huge strides have been made in identifying the precise location o... The clearance of lesions during surgery for colorectal cancer encompasses the removal of both the primary tumour and its concomitant lymphatic drainage.Huge strides have been made in identifying the precise location of not only the primary tumour,but also the lymph nodes(LNs),owing to the use of intraoperative navigation techniques.Among these techniques,indocyanine green-enhanced fluorescence imaging(ICG-FI)has revolutionized colorectal oncologic surgery by providing clear visualization during lymphangiography.ICG-FI has emerged as a powerful tool for sentinel lymph node procedures that allows for local excision instead of radical D3 lymphadenectomy.It also makes it possible to identify potential metastatic lateral pelvic lymph nodes,which enables simultaneous lymphadenectomy of the pelvic side-wall during the resection of middle-lower rectal cancer.This review provides an update on the current use of and research on ICG-FI-guided LNs mapping for colorectal malignancies,and also discusses its drawbacks and future prospects. 展开更多
关键词 Indocyanine green lymph nodes Navigation Colorectal malignancies Lateral pelvic lymph nodes Sentinel lymph node detection
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Management of synchronous lateral pelvic nodal metastasis in rectal cancer in the era of neoadjuvant chemoradiation: A systemic review
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作者 Jolene Si Min Wong Grace Hwei Ching Tan +2 位作者 Claramae Shulyn Chia Chin-Ann Johnny Ong Melissa Ching Ching Teo 《World Journal of Gastrointestinal Surgery》 SCIE CAS 2020年第5期247-258,共12页
BACKGROUND Lateral pelvic lymph node(LLN)metastasis(LLNM)occur in up to 28%of patients with low rectal tumours.While prophylactic lateral pelvic lymph node dissection(LLND)has been abandoned by most western institutio... BACKGROUND Lateral pelvic lymph node(LLN)metastasis(LLNM)occur in up to 28%of patients with low rectal tumours.While prophylactic lateral pelvic lymph node dissection(LLND)has been abandoned by most western institutions in the era of neoadjuvant chemoradiation therapy(CRT),the role of selective LLND in patients with enlarged LLN on pre-CRT imaging remains unclear.Some studies have shown improved survival and recurrence outcomes when LLNs show"response"to CRT.However,no management algorithm exists to differentiate treatment for"responders"vs"non-responders".AIM To determine if selective LLND in patients with enlarged LLNs results in improved survival and recurrence outcomes.METHODS A systemic search of Pub Med and Embase databases for studies reporting on patients with synchronous radiologically suspicious LLNM(s-LLNM)in rectal cancer receiving preoperative-CRT was performed.RESULTS Fifteen retrospective,single-centre studies were included.793 patients with sLLNM were evaluated:456 underwent TME while 337 underwent TME with7,LLND post-CRT.In the TME group,local recurrence(LR)rates range from 12.5%to 36%.Five-year disease free survival(DFS)was 42%to 75%.In the TME with LLND group,LR rates were 0%to 6%.Five years DFS was 41.2%to 100%.Radiological response was seen in 58%.Pathologically positive LLN was found in up to 94%of non-responders vs 0%to 20%in responders.Young age,low tumour location and radiological non-response were associated with final positive LLNM and lowered DFS.CONCLUSION LLND is associated with local control in patients with s-LLNM.It can be performed in radiological non-responders given a large majority represent true LLNM.Its role in radiological responders should be considered in selected high risk patients. 展开更多
关键词 Lateral pelvic lymph node Colorectal cancer Lateral pelvic lymph node dissection
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Early drainage removal in the management of lymphatic leakage after robotic pelvic lymph node dissection
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作者 Wei Wang Kai Zhang +4 位作者 Hongbo Li Lihua Yuan Yan Hou Derek A.O'Reilly Gang Zhu 《UroPrecision》 2023年第4期185-190,共6页
Background:Radical prostatectomy(RP)and radical cystectomy(RC)with concurrent pelvic lymph node dissection(PLND)are considered as the curative surgical treatment options for localized prostate cancer(PC)or muscle-inva... Background:Radical prostatectomy(RP)and radical cystectomy(RC)with concurrent pelvic lymph node dissection(PLND)are considered as the curative surgical treatment options for localized prostate cancer(PC)or muscle-invasive bladder cancer(BC).Regarding lymphatic leakage management after PLND,there is no standard of care,with different therapeutic approaches having been reported with varying success rates.Methods:Seventy patients underwent pelvic lymphadenectomy during robotic RP and RC with postoperative pelvic drainage volume more than 50 mL/day before the removal of drainage tube,were retrospectively evaluated in this study between August 2015 and June 2023.If the pelvic drainage volume on postoperative Day 2 was more than 50 mL/day,a drainage fluid creatinine was routinely tested to rule out urine leakage.We removed the drainage if the patient had no significant abdominal free fluid collection,no abdominal distension or pain,no fever,and no abdominal tenderness.After 1-day observation of the vital signs and abdominal symptoms,the patient was discharged and followed-up in clinic for 2 weeks after surgery.Results:Forty-one cases underwent the early drainage removal even if the pelvic drainage volume was more than 50mL/day.Among these forty-one cases,twenty-five drainage tubes were removed when drainage volume was more than 100 mL/day.All the forty-one cases with pelvic drainage volume greater than 50mL/day were successfully managed with the early drainage removal.No paracentesis or drainage placement was required.No readmission occured during the follow-up period.Conclusion:It is safe to manage the high-volume pelvic lymphatic leakage by early clamping of the drainage tube,ultrasonography assessment of no significant residual fluid in the abdominal and pelvic cavity,and then the early removal of the drainage tube. 展开更多
关键词 bladder cancer lymphatic leakage pelvic drainage pelvic lymph node dissection prostate cancer robotic surgery
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Differences in rates of pelvic lymph node dissection in National Comprehensive Cancer Network favorable,unfavorable intermediate-and high-risk prostate cancer across United States SEER registries
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作者 Rocco Simone Flammia Benedikt Hoeh +13 位作者 Francesco Chierigo Lukas Hohenhorst Gabriele Sorce Zhen Tian Costantino Leonardo Markus Graefen Carlo Terrone Fred Saad Shahrokh F.Shariat Alberto Briganti Francesco Montorsi Felix K.H.Chun Michele Gallucci Pierre I.Karakiewicz 《Current Urology》 2022年第4期191-196,共6页
Background:The National Comprehensive Cancer Network(NCCN)guidelines recommend pelvic lymph node dissection(PLND)in NCCN high-and intermediate-risk prostate cancer patients.We tested for PLND nonadherence(no-PLND)rate... Background:The National Comprehensive Cancer Network(NCCN)guidelines recommend pelvic lymph node dissection(PLND)in NCCN high-and intermediate-risk prostate cancer patients.We tested for PLND nonadherence(no-PLND)rates within the Surveillance Epidemiology and End Results(2010-2015).Materials and methods:We identified all radical prostatectomy patients who fulfilled the NCCN PLND guideline criteria(n=23,495).Nonadherence rates to PLND were tabulated and further stratified according to NCCN risk subgroups,race/ethnicity,geographic distribution,and year of diagnosis.Results:Overall,the no-PLND rate was 26%;it was 41%,25%,and 11%in the NCCN intermediate favorable,intermediate unfavorable,and high-risk prostate cancer patients,respectively(p<0.001).Overtime,the no-PLND rates declined in the overall cohort and within each NCCN risk subgroup.Georgia exhibited the highest no-PLND rate(49%),whereas New Jersey exhibited the lowest(15%).Finally,no-PLND race/ethnicity differences were recorded only in the NCCN intermediate unfavorable subgroup,where Asians exhibited the lowest no-PLND rate(20%)versus African Americans(27%)versus Whites(26%)versus Hispanic-Latinos(25%).Conclusions:The lowest no-PLND rates were recorded in the NCCN high-risk patients followed by NCCN intermediate unfavorable and favorable risk in that order.Our findings suggest that unexpectedly elevated differences in no-PLND rates warrant further examination.In all the NCCN risk subgroups,the no-PLND rates decreased over time. 展开更多
关键词 lymph node excision pelvic lymph node dissection Prostatectomy Prostatic neoplasms
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Selecting lymph node-positive patients for adjuvant therapy after radical prostatectomy and extended pelvic lymphadenectomy:An outcome analysis of 100 node-positive patients managed without adjuvant therapy
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作者 Ashwin Sunil Tamhankar Saurabh Patil +4 位作者 Shanky Singh Danny Darlington Carbin Smruti Mokal Puneet Ahluwalia Gagan Gautam 《Current Urology》 2022年第4期232-239,共8页
Objective:The aim of the study is to evaluate the effect of deferred androgen deprivation therapy on biochemical recurrence(BCR)and other survival parameters in node-positive prostate cancer patients after robot-assis... Objective:The aim of the study is to evaluate the effect of deferred androgen deprivation therapy on biochemical recurrence(BCR)and other survival parameters in node-positive prostate cancer patients after robot-assisted radical prostatectomy with bilateral extended pelvic lymph node dissection(RARP+EPLND).Materials and methods:Of the 453 consecutive RARP procedures performed from 2011 to 2018,100 patients with no prior use of androgen deprivation therapy were found to be lymph node(LN)positive and were observed,with initiation of salvage treatment at the time of BCR only.Patients were divided into 1 or 2 LNs(67)-and more than 2 LNs(33)-positive groups to assess survival outcomes.Results:At a median follow-up of 21 months(1-70 months),the LN group(p<0.000),preoperative prostate-specific antigen(PSA,p=0.013),tumor volume(TV,p=0.031),and LND(p=0.004)were significantly associated with BCR.In multivariate analysis,only the LN group(p=0.035)and PSA level(p=0.026)were statistically significant.The estimated BCR-free survival rates in the 1/2 LN group were 37.6%(27%-52.2%),26.5%(16.8%-41.7%),and 19.9%(9.6%-41.0%)at 1,3,and 5 years,respectively,with a hazard of developing BCR of 0.462(0.225-0.948)compared with the more than 2 LN-positive group.Estimated 5-year overall survival,cancer-specific,metastasis-free,and local recurrence-free survival rates were 88.4%(73.1%-100%),89.5%(74%-100%),65.1%(46.0%-92.1%),and 94.8%(87.2%-100.0%),respectively,for which none of the factors were significant.Based on cutoff values for PSA,TV,and LND of 30 ng/mL,30%,and 10%,respectively,the 1/2 LN group was substratified,wherein the median BCR-free survival for the low-and intermediate-risk groups was 40 and 12 months,respectively.Conclusions:Nearly one fourth and one fifth of 1/2 node-positive patients were BCR-free at 3 and 5 years after RARP+EPLND.Further substratification using PSA,TV,and LN density may help in providing individualized care regarding the initiation of adjuvant therapy. 展开更多
关键词 Adjuvant therapy Extended pelvic lymph node dissection Prostate cancer Robotic radical prostatectomy
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Briganti’s 2012 nomogram is an independent predictor of prostate cancer progression in EAU intermediate-risk class:results from 527 patients treated with robotic surgery
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作者 Antonio Benito Porcaro Francesca Montanaro +15 位作者 Alberto Baielli Francesco Artoni Claudio Brancelli Sonia Costantino Andrea Franceschini Sebastian Gallina Alberto Bianchi Emanuele Serafin Alessandro Veccia Riccardo Rizzetto Matteo Brunelli Filippo Migliorini Salvatore Siracusano Maria Angela Cerruto Riccardo Giuseppe Bertolo Alessandro Antonelli 《Asian Journal of Andrology》 SCIE CAS CSCD 2024年第6期587-591,共5页
The study aimed to test if Briganti’s 2012 nomogram could be associated with the risk of prostate cancer (PCa) progression in European Association of Urology (EAU) intermediate-risk patients treated with robotic surg... The study aimed to test if Briganti’s 2012 nomogram could be associated with the risk of prostate cancer (PCa) progression in European Association of Urology (EAU) intermediate-risk patients treated with robotic surgery. From January 2013 to December 2021, 527 consecutive patients belonging to the EAU intermediate-risk class were selected. Briganti’s 2012 nomogram, which predicts the risk of pelvic lymph node invasion (PLNI), was assessed as a continuous and dichotomous variable that categorized up to the median of 3.0%. Disease progression defined as biochemical recurrence and/or metastatic progression was evaluated by Cox proportional hazards (univariate and multivariate analysis). After a median follow-up of 95.0 months (95% confidence interval [CI]: 78.5–111.4), PCa progression occurred in 108 (20.5%) patients who were more likely to present with an unfavorable nomogram risk score, independently by the occurrence of unfavorable pathology including tumor upgrading and upstaging as well as PLNI. Accordingly, as Briganti’s 2012 risk score increased, patients were more likely to experience disease progression (hazard ratio [HR] = 1.060;95% CI: 1.021–1.100;P = 0.002);moreover, it also remained significant when dichotomized above a risk score of 3.0% (HR = 2.052;95% CI: 1.298–3.243;P < 0.0001) after adjustment for clinical factors. In the studied risk population, PCa progression was independently predicted by Briganti’s 2012 nomogram. Specifically, we found that patients were more likely to experience disease progression as their risk score increased. Because of the significant association between risk score and tumor behavior, the nomogram can further stratify intermediate-risk PCa patients, who represent a heterogeneous risk category for which different treatment paradigms exist. 展开更多
关键词 biochemical recurrence Briganti’s 2012 nomogram intermediate-risk prostate cancer pelvic lymph node invasion prostate cancer progression robot-assisted radical prostatectomy
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Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer 被引量:1
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作者 Xianxian Li Hui Xing Lin Li Yanli Huang Min Zhou Qiong Liu Xiaomin Qin Min He 《Frontiers of Medicine》 SCIE CAS CSCD 2014年第1期96-100,共5页
Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer. Moreover, the impact of para-aortic lymph node (PAN) removal on patient prognosis is still unclear. In this study, 80 patie... Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer. Moreover, the impact of para-aortic lymph node (PAN) removal on patient prognosis is still unclear. In this study, 80 patients were divided into groups A and B. Group A consisted of 30 patients who underwent PAN + pelvic lymph node (PLN) dissection, whereas group B consisted of 50 patients who only underwent PLN dissection. Analysis of the correlation between PAN clearance and prognosis in epithelial ovarian cancer was conducted. Nineteen cases of lymph node metastasis were found in group A, among whom seven cases were positive for PAN, three cases for PLN, and nine cases for both PAN and PLN. In group B, 13 cases were positive for lymph node metastasis. Our study suggested that the metastatic rate of lymph node is 40.0%. Lymph node metastasis was significantly correlated with FIGO stage, tumor differentiation, and histological type both in groups A and B (P 〈 0.05). In groups A and B, the three-year survival rates were 77.9% and 69.0%, and the five-year survival rates were 46.7% and 39.2%, respectively. However, the difference was not statistically significant (P 〉 0.05). The three-year survival rates of PLN metastasis in groups A and B were 68.5% and 41.4%, and the five-year survival rates were 49.7% and 26.4%, respectively. Furthermore, PLN-positive patients who cleared PAN had significantly higher survival rate (P = 0.044). In group A, the three-year survival rates of positive and negative lymph nodes were 43.5% and 72.7%, and the five-year survival rates were 27.2% and 58.5%, respectively. The difference was statistically significant (P= 0.048). Cox model analysis of single factor suggested that lymph node status affected the survival rate (P 〈 0.01), which was the death risk factor. Consequently, in ovarian carcinoma cytoreductive surgery, resection of the para-aortic lymph node, which has an important function in clinical treatment and prognosis of patients with ovarian cancer, is necessary. 展开更多
关键词 ovarian cancer para-aortic lymph node pelvic lymph node
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