Amblyopia is a neurodevelopmental disorder of the visual cortex arising from abnormal visual experience early in life. Amblyopia is a major cause of impaired vision in infants and young children (prevalence around 3.5...Amblyopia is a neurodevelopmental disorder of the visual cortex arising from abnormal visual experience early in life. Amblyopia is a major cause of impaired vision in infants and young children (prevalence around 3.5%). There are different treatment options for amblyopia based on its severity and age of the patient. Traditional treatments include patching or occlusion of the dominant eye and pharmacological penalisation using Atropine (1%). Recent developments in amblyopia management have found success with the use of binocular exercises and certain modifications of glasses and contact lenses. The critical age up to which amblyopia is treatable or reversible is also being pushed up with more research. With newer advancements in amblyopia therapy, the success rate is also improving with multimodal approach.展开更多
Thepenalised least square estimator of non-convex penalties such as the smoothly clipped absolute deviation(SCAD)and the minimax concave penalty(MCP)is highly nonlinear and has many local optima.Finding a local soluti...Thepenalised least square estimator of non-convex penalties such as the smoothly clipped absolute deviation(SCAD)and the minimax concave penalty(MCP)is highly nonlinear and has many local optima.Finding a local solution to achieve the so-called oracle property is a challenging problem.We show that the orthogonalising EM(OEM)algorithm can indeed find such a local solution with the oracle property under some regularity conditions for a moderate but diverging number of variables.展开更多
文摘Amblyopia is a neurodevelopmental disorder of the visual cortex arising from abnormal visual experience early in life. Amblyopia is a major cause of impaired vision in infants and young children (prevalence around 3.5%). There are different treatment options for amblyopia based on its severity and age of the patient. Traditional treatments include patching or occlusion of the dominant eye and pharmacological penalisation using Atropine (1%). Recent developments in amblyopia management have found success with the use of binocular exercises and certain modifications of glasses and contact lenses. The critical age up to which amblyopia is treatable or reversible is also being pushed up with more research. With newer advancements in amblyopia therapy, the success rate is also improving with multimodal approach.
基金Xiong’s research was supported by the National Natural Sci-ence Foundation of China[grant number 11471172],[grant number 11671386].
文摘Thepenalised least square estimator of non-convex penalties such as the smoothly clipped absolute deviation(SCAD)and the minimax concave penalty(MCP)is highly nonlinear and has many local optima.Finding a local solution to achieve the so-called oracle property is a challenging problem.We show that the orthogonalising EM(OEM)algorithm can indeed find such a local solution with the oracle property under some regularity conditions for a moderate but diverging number of variables.
