Intelligent penetration testing is of great significance for the improvement of the security of information systems,and the critical issue is the planning of penetration test paths.In view of the difficulty for attack...Intelligent penetration testing is of great significance for the improvement of the security of information systems,and the critical issue is the planning of penetration test paths.In view of the difficulty for attackers to obtain complete network information in realistic network scenarios,Reinforcement Learning(RL)is a promising solution to discover the optimal penetration path under incomplete information about the target network.Existing RL-based methods are challenged by the sizeable discrete action space,which leads to difficulties in the convergence.Moreover,most methods still rely on experts’knowledge.To address these issues,this paper proposes a penetration path planning method based on reinforcement learning with episodic memory.First,the penetration testing problem is formally described in terms of reinforcement learning.To speed up the training process without specific prior knowledge,the proposed algorithm introduces episodic memory to store experienced advantageous strategies for the first time.Furthermore,the method offers an exploration strategy based on episodic memory to guide the agents in learning.The design makes full use of historical experience to achieve the purpose of reducing blind exploration and improving planning efficiency.Ultimately,comparison experiments are carried out with the existing RL-based methods.The results reveal that the proposed method has better convergence performance.The running time is reduced by more than 20%.展开更多
This paper proposes a type of double-layer charge liner fabricated using chemical vapor deposition(CVD)that has tungsten as its inner liner.The feasibility of this design was evaluated through penetration tests.Double...This paper proposes a type of double-layer charge liner fabricated using chemical vapor deposition(CVD)that has tungsten as its inner liner.The feasibility of this design was evaluated through penetration tests.Double-layer charge liners were fabricated by using CVD to deposit tungsten layers on the inner surfaces of pure T2 copper liners.The microstructures of the tungsten layers were analyzed using a scanning electron microscope(SEM).The feasibility analysis was carried out by pulsed X-rays,slug-retrieval test and static penetration tests.The shaped charge jet forming and penetration law of inner tungsten-coated double-layer liner were studied by numerical simulation method.The results showed that the double-layer liners could form well-shaped jets.The errors between the X-ray test results and the numerical results were within 11.07%.A slug-retrieval test was found that the retrieved slug was similar to a numerically simulated slug.Compared with the traditional pure copper shaped charge jet,the penetration depth of the double-layer shaped charge liner increased by 11.4% and>10.8% respectively.In summary,the test results are good,and the numerical simulation is in good agreement with the test,which verified the feasibility of using the CVD method to fabricate double-layer charge liners with a high-density and high-strength refractory metal as the inner liner.展开更多
The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytic...The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytical study of the evolution of the nose shape of larger hollow projectiles under hypersonic penetration.In the hypersonic penetration test,eight ogive-nose AerMet100 steel projectiles with a diameter of 40 mm were launched to hit concrete targets with impact velocities that ranged from 1351 to 1877 m/s.Severe erosion of the projectiles was observed during high-speed penetration of heterogeneous targets,and apparent localized mushrooming occurred in the front nose of recovered projectiles.By examining the damage to projectiles,a linear relationship was found between the relative length reduction rate and the initial kinetic energy of projectiles in different penetration tests.Furthermore,microscopic analysis revealed the forming mechanism of the localized mushrooming phenomenon for eroding penetration,i.e.,material spall erosion abrasion mechanism,material flow and redistribution abrasion mechanism and localized radial upsetting deformation mechanism.Finally,a model of highspeed penetration that included erosion was established on the basis of a model of the evolution of the projectile nose that considers radial upsetting;the model was validated by test data from the literature and the present study.Depending upon the impact velocity,v0,the projectile nose may behave as undistorted,radially distorted or hemispherical.Due to the effects of abrasion of the projectile and enhancement of radial upsetting on the duration and amplitude of the secondary rising segment in the pulse shape of projectile deceleration,the predicted DOP had an upper limit.展开更多
Shaped charge liner(SCL)has been extensively applied in oil recovery and defense industries.Achieving superior penetration capability through optimizing SCL structures presents a substantial challenge due to intricate...Shaped charge liner(SCL)has been extensively applied in oil recovery and defense industries.Achieving superior penetration capability through optimizing SCL structures presents a substantial challenge due to intricate rate-dependent processes involving detonation-driven liner collapse,high-speed jet stretching,and penetration.This study introduces an innovative optimization strategy for SCL structures that employs jet penetration efficiency as the primary objective function.The strategy combines experimentally validated finite element method with machine learning(FEM-ML).We propose a novel jet penetration efficiency index derived from enhanced cutoff velocity and shape characteristics of the jet via machine learning.This index effectively evaluates the jet penetration performance.Furthermore,a multi-model fusion based on a machine learning optimization method,called XGBOOST-MFO,is put forward to optimize SCL structure over a large input space.The strategy's feasibility is demonstrated through the optimization of copper SCL implemented via the FEM-ML strategy.Finally,this strategy is extended to optimize the structure of the recently emerging CrMnFeCoNi high-entropy alloy conical liners and hemispherical copper liners.Therefore,the strategy can provide helpful guidance for the engineering design of SCL.展开更多
Catalysis of molecular radicals is often performed in interesting experimental configurations.One possible configuration is tubular geometry.The radicals are introduced into the tubes on one side,and stable molecules ...Catalysis of molecular radicals is often performed in interesting experimental configurations.One possible configuration is tubular geometry.The radicals are introduced into the tubes on one side,and stable molecules are exhausted on the other side.The penetration depth of radicals depends on numerous parameters,so it is not always feasible to calculate it.This article presents systematic measurements of the penetration depth of oxygen atoms along tubes made from nickel,cobalt,and copper.The source of O atoms was a surfatron-type microwave plasma.The initial density of O atoms depended on the gas flow and was 0.7×10^(21)m^(-3),2.4×10^(21)m^(-3),and 4.2×10^(21)m^(-3)at the flow rates of 50,300,and 600 sccm,and pressures of 10,35,and 60 Pa,respectively.The gas temperature remained at room temperature throughout the experiments.The dissociation fraction decreased exponentially along the length of the tubes in all cases.The penetration depths for well-oxidized nickel were 1.2,1.7,and 2.4 cm,respectively.For cobalt,they were slightly lower at 1.0,1.3,and 1.6 cm,respectively,while for copper,they were 1.1,1.3,and 1.7 cm,respectively.The results were explained by gas dynamics and heterogeneous surface association.These data are useful in any attempt to estimate the loss of molecular fragments along tubes,which serve as catalysts for the association of various radicals to stable molecules.展开更多
Accurate prediction of the rate of penetration(ROP)is significant for drilling optimization.While the intelligent ROP prediction model based on fully connected neural networks(FNN)outperforms traditional ROP equations...Accurate prediction of the rate of penetration(ROP)is significant for drilling optimization.While the intelligent ROP prediction model based on fully connected neural networks(FNN)outperforms traditional ROP equations and machine learning algorithms,its lack of interpretability undermines its credibility.This study proposes a novel interpretation and characterization method for the FNN ROP prediction model using the Rectified Linear Unit(ReLU)activation function.By leveraging the derivative of the ReLU function,the FNN function calculation process is transformed into vector operations.The FNN model is linearly characterized through further simplification,enabling its interpretation and analysis.The proposed method is applied in ROP prediction scenarios using drilling data from three vertical wells in the Tarim Oilfield.The results demonstrate that the FNN ROP prediction model with ReLU as the activation function performs exceptionally well.The relative activation frequency curve of hidden layer neurons aids in analyzing the overfitting of the FNN ROP model and determining drilling data similarity.In the well sections with similar drilling data,averaging the weight parameters enables linear characterization of the FNN ROP prediction model,leading to the establishment of a corresponding linear representation equation.Furthermore,the quantitative analysis of each feature's influence on ROP facilitates the proposal of drilling parameter optimization schemes for the current well section.The established linear characterization equation exhibits high precision,strong stability,and adaptability through the application and validation across multiple well sections.展开更多
This study employs a data-driven methodology that embeds the principle of dimensional invariance into an artificial neural network to automatically identify dominant dimensionless quantities in the penetration of rod ...This study employs a data-driven methodology that embeds the principle of dimensional invariance into an artificial neural network to automatically identify dominant dimensionless quantities in the penetration of rod projectiles into semi-infinite metal targets from experimental measurements.The derived mathematical expressions of dimensionless quantities are simplified by the examination of the exponent matrix and coupling relationships between feature variables.As a physics-based dimension reduction methodology,this way reduces high-dimensional parameter spaces to descriptions involving only a few physically interpretable dimensionless quantities in penetrating cases.Then the relative importance of various dimensionless feature variables on the penetration efficiencies for four impacting conditions is evaluated through feature selection engineering.The results indicate that the selected critical dimensionless feature variables by this synergistic method,without referring to the complex theoretical equations and aiding in the detailed knowledge of penetration mechanics,are in accordance with those reported in the reference.Lastly,the determined dimensionless quantities can be efficiently applied to conduct semi-empirical analysis for the specific penetrating case,and the reliability of regression functions is validated.展开更多
When employing penetration ammunition to strike multi-story buildings,the detection methods using acceleration sensors suffer from signal aliasing,while magnetic detection methods are susceptible to interference from ...When employing penetration ammunition to strike multi-story buildings,the detection methods using acceleration sensors suffer from signal aliasing,while magnetic detection methods are susceptible to interference from ferromagnetic materials,thereby posing challenges in accurately determining the number of layers.To address this issue,this research proposes a layer counting method for penetration fuze that incorporates multi-source information fusion,utilizing both the temporal convolutional network(TCN)and the long short-term memory(LSTM)recurrent network.By leveraging the strengths of these two network structures,the method extracts temporal and high-dimensional features from the multi-source physical field during the penetration process,establishing a relationship between the multi-source physical field and the distance between the fuze and the target plate.A simulation model is developed to simulate the overload and magnetic field of a projectile penetrating multiple layers of target plates,capturing the multi-source physical field signals and their patterns during the penetration process.The analysis reveals that the proposed multi-source fusion layer counting method reduces errors by 60% and 50% compared to single overload layer counting and single magnetic anomaly signal layer counting,respectively.The model's predictive performance is evaluated under various operating conditions,including different ratios of added noise to random sample positions,penetration speeds,and spacing between target plates.The maximum errors in fuze penetration time predicted by the three modes are 0.08 ms,0.12 ms,and 0.16 ms,respectively,confirming the robustness of the proposed model.Moreover,the model's predictions indicate that the fitting degree for large interlayer spacings is superior to that for small interlayer spacings due to the influence of stress waves.展开更多
Extracellular polymeric substances(EPS)constitutes crucial elements within bacterial biofilms,facili-tating accelerated antimicrobial resistance and conferring defense against the host's immune cells.Developing pr...Extracellular polymeric substances(EPS)constitutes crucial elements within bacterial biofilms,facili-tating accelerated antimicrobial resistance and conferring defense against the host's immune cells.Developing precise and effective antibiofilm approaches and strategies,tailored to the specific charac-teristics of EPS composition,can offer valuable insights for the creation of novel antimicrobial drugs.This,in turn,holds the potential to mitigate the alarming issue of bacterial drug resistance.Current analysis of EPS compositions relies heavily on colorimetric approaches with a significant bias,which is likely due to the selection of a standard compound and the cross-interference of various EPS compounds.Considering the pivotal role of EPS in biofilm functionality,it is imperative for EPS research to delve deeper into the analysis of intricate compositions,moving beyond the current focus on polymeric materials.This ne-cessitates a shift from heavy reliance on colorimetric analytic methods to more comprehensive and nuanced analytical approaches.In this study,we have provided a comprehensive summary of existing analytical methods utilized in the characterization of EPS compositions.Additionally,novel strategies aimed at targeting EPS to enhance biofilm penetration were explored,with a specific focus on high-lighting the limitations associated with colorimetric methods.Furthermore,we have outlined the challenges faced in identifying additional components of EPS and propose a prospective research plan to address these challenges.This review has the potential to guide future researchers in the search for novel compounds capable of suppressing EPS,thereby inhibiting biofilm formation.This insight opens up a new avenue for exploration within this research domain.展开更多
An externally generated resonant magnetic perturbation can induce complex non-ideal MHD responses in their resonant surfaces.We have studied the plasma responses using Fitzpatrick's improved two-fluid model and pr...An externally generated resonant magnetic perturbation can induce complex non-ideal MHD responses in their resonant surfaces.We have studied the plasma responses using Fitzpatrick's improved two-fluid model and program LAYER.We calculated the error field penetration threshold for J-TEXT.In addition,we find that the island width increases slightly as the error field amplitude increases when the error field amplitude is below the critical penetration value.However,the island width suddenly jumps to a large value because the shielding effect of the plasma against the error field disappears after the penetration.By scanning the natural mode frequency,we find that the shielding effect of the plasma decreases as the natural mode frequency decreases.Finally,we obtain the m/n=2/1 penetration threshold scaling on density and temperature.展开更多
The projectile penetration process into concrete target is a nonlinear complex problem.With the increase ofexperiment data,the data-driven paradigm has exhibited a new feasible method to solve such complex prob-lem.Ho...The projectile penetration process into concrete target is a nonlinear complex problem.With the increase ofexperiment data,the data-driven paradigm has exhibited a new feasible method to solve such complex prob-lem.However,due to poor quality of experimental data,the traditional machine learning(ML)methods,whichare driven only by experimental data,have poor generalization capabilities and limited prediction accuracy.Therefore,this study intends to exhibit a ML method fusing the prior knowledge with experiment data.The newML method can constrain the fitting to experimental data,improve the generalization ability and the predic-tion accuracy.Experimental results show that integrating domain prior knowledge can effectively improve theperformance of the prediction model for penetration depth into concrete targets.展开更多
In today’s era, where mobile devices have become an integral part of our daily lives, ensuring the security of mobile applications has become increasingly crucial. Mobile penetration testing, a specialized subfield w...In today’s era, where mobile devices have become an integral part of our daily lives, ensuring the security of mobile applications has become increasingly crucial. Mobile penetration testing, a specialized subfield within the realm of cybersecurity, plays a vital role in safeguarding mobile ecosystems against the ever-evolving landscape of threats. The ubiquity of mobile devices has made them a prime target for cybercriminals, and the data and functionality accessed through mobile applications make them valuable assets to protect. Mobile penetration testing is designed to identify vulnerabilities, weaknesses, and potential exploits within mobile applications and the devices themselves. Unlike traditional penetration testing, which often focuses on network and server security, mobile penetration testing zeroes in on the unique challenges posed by mobile platforms. Mobile penetration testing, a specialized field within cybersecurity, is an essential tool in the Cybersecurity specialists’ toolkit to protect mobile ecosystems from emerging threats. This article introduces mobile penetration testing, emphasizing its significance, including comprehensive learning labs for Android and iOS platforms, and highlighting how it distinctly differs from traditional penetration testing methodologies.展开更多
Suction foundations are generally installed with negative pressures to overcome the resistance of soils and complete the penetration,but excessive negative pressures are also avoided to cause seepage damages.In this p...Suction foundations are generally installed with negative pressures to overcome the resistance of soils and complete the penetration,but excessive negative pressures are also avoided to cause seepage damages.In this paper,the model test method was used to analyze the movement characteristics of multi-bucket foundations in the process of sinking in sand,and the common calculation methods of sinking resistances are verified.The critical negative pressure corresponding to the seepage failure of foundation was determined under the action of increasing negative pressure step by step and the characteristics of soil failure were studied.The calculation formula of critical suction in sand was verified in application,and according to the test results,the value of seepage coefficient was modified,which provides an example for the study of suction foundation in sand soils.展开更多
The application of the wellhead suction anchor in the second production test of natural gas hydrates(NGHs)in the South China Sea(SCS)was met with success.This design incorporates a central conductor guide pipe,which d...The application of the wellhead suction anchor in the second production test of natural gas hydrates(NGHs)in the South China Sea(SCS)was met with success.This design incorporates a central conductor guide pipe,which distinguishes it from traditional suction foundations.However,this addition resulted in a relatively high penetration resistance and a shallower penetration depth at the self-weight penetration stage.To mitigate this issue,the current study proposes an optimized design where the end of the suction foundation is sharpened.The installation characteristics of the traditional suction foundation and new suction foundation during self-weight penetration into sand are studied through laboratory tests and theoretical analysis.The flat and sharpened bottom shapes are considered in the traditional and new suction models.The effects of the initial penetration velocity on the initial penetration depth and soil plug and impact cavity characteristics are systematically studied.The results show that the self-weight penetration depth of the foundation with a sharpened bottom is 44.5%deeper than that of the foundation with a flat bottom.There are cavities around the foundation at the self-weight penetration stage,and the penetration depth is overestimated by 15%-30%.Finally,a model for predicting the penetration depth of the new suction foundation is proposed.展开更多
An impact point prediction(IPP) guidance based on supervised learning is proposed to address the problem of precise guidance for the ballistic missile in high maneuver penetration condition.An accurate ballistic traje...An impact point prediction(IPP) guidance based on supervised learning is proposed to address the problem of precise guidance for the ballistic missile in high maneuver penetration condition.An accurate ballistic trajectory model is applied to generate training samples,and ablation experiments are conducted to determine the mapping relationship between the flight state and the impact point.At the same time,the impact point coordinates are decoupled to improve the prediction accuracy,and the sigmoid activation function is improved to ameliorate the prediction efficiency.Therefore,an IPP neural network model,which solves the contradiction between the accuracy and the speed of the IPP,is established.In view of the performance deviation of the divert control system,the mapping relationship between the guidance parameters and the impact deviation is analysed based on the variational principle.In addition,a fast iterative model of guidance parameters is designed for reference to the Newton iteration method,which solves the nonlinear strong coupling problem of the guidance parameter solution.Monte Carlo simulation results show that the prediction accuracy of the impact point is high,with a 3 σ prediction error of 4.5 m,and the guidance method is robust,with a 3 σ error of 7.5 m.On the STM32F407 singlechip microcomputer,a single IPP takes about 2.374 ms,and a single guidance solution takes about9.936 ms,which has a good real-time performance and a certain engineering application value.展开更多
In this paper,the penetration mechanism of reactive jet with non-uniform density distribution is studied.The simulations show that the density deficit occurs in the whole reactive jet,and the density increases from th...In this paper,the penetration mechanism of reactive jet with non-uniform density distribution is studied.The simulations show that the density deficit occurs in the whole reactive jet,and the density increases from the jet tip to tail.The density of jet tip is approximately 1.5 g/cm3,which is lower than that of the reactive liner materials.The X-ray experiments show similar results with the simulations.The density decreasing effect of jet tip has a significant influence on the penetration behavior when the reactive jet impacts steel plate.According to the simulation results,this paper assumes that the density gradient in the jet section has linear distribution.Then,the deflagration pressure generated by each jet element at the bottom of crater is introduced into the Bernoulli equation.Based on the virtual origin model and Szendrei-Held equation,the analytical models for penetration depth and radial cratering of reactive jet with the density reduction are obtained.Moreover,to further prove the validity of analytical models,the penetration experiments of the reactive liner shaped charge against steel plate under different standoffs are carried out.There is a convergence between the analytical crater profiles and experimental results when reactive jets penetrate steel plates under different standoffs,especially at standoff of 1.5 and 2.0charge diameters.展开更多
Fine-grained silt is widely distributed in the Huanghe River Delta(HRD)in China,and the sedimentary structure is complex,meaning that the clay content in the silt is variable.The piezocone penetration test(CPTu)is the...Fine-grained silt is widely distributed in the Huanghe River Delta(HRD)in China,and the sedimentary structure is complex,meaning that the clay content in the silt is variable.The piezocone penetration test(CPTu)is the most widely approved in situ test method.It can be used to invert soil properties and interpret soil behavior.To analyse the strength properties of surface sediments in the HRD,this paper evaluated the friction angle and its inversion formula through the CPTu penetration test and monotonic simple shear test and other soil unit experiments.The evaluation showed that the empirical formula proposed by Kulhawy and Mayne had better prediction and inversion effect.The HRD silts with clay contents of 9.2%,21.4%and 30.3%were selected as samples for the CPTu variable rate penetration test.The results show as follows.(1)The effects of the clay content on the tip resistance and the pore pressure of silt under different penetration rates were summarized.The tip resistance Q_t is strongly dependent on the clay content of the silt,the B_(q)value of the silt tends to 0 and is not significantly affected by the change of the CPTu penetration rate.(2)Five soil behavior type classification charts and three soil behavior type indexes based on CPTu data were evaluated.The results show that the soil behavior type classification chart based on soil behavior type index ISBT,the Robertson 2010 behavior type classification chart are more suitable for the silty soil in the HRD.展开更多
Penetration characteristic(size and shape of penetration craters made in high hardness ARMSTAL 30PM steel) of shaped charge jets formed after detonations of modified PG-7VM warheads was analyzed in the article. Modifi...Penetration characteristic(size and shape of penetration craters made in high hardness ARMSTAL 30PM steel) of shaped charge jets formed after detonations of modified PG-7VM warheads was analyzed in the article. Modifications consisted in removing the frontal part of the grenade(fuse, ballistic cap and conductive cone) and introducing of the liner cavity filling made of polyacetal copolymer POM-C. The filings in the form of solid cones with three different heights(33%, 66% and 100% of H-the height of original PG-7VM liner) were placed inside of the hollow cone shaped charge liner. As opposed to the vast majority of previously published works(in which warhead optimization studies were focused on increasing of the depth of penetration in rolled homogeneous armor steel) the main aim of the presented modifications was to maximize the damage ratio(diameters of craters, inlet and outlet holes) of target perforated by shaped charge jet at the cost of the loss of part of the jet penetration capability. According to the best knowledge of the authors such approach to the use of the old PG-7VM warheads has not been analyzed so far. Taking into consideration high stock levels of PG-7VM warheads, and the fact that they are continuously being replaced by more efficient and more sophisticated high-explosive anti-tank warheads, it seems reasonable to look for alternate applications of the warheads withdrawn from the service. Thanks to the introduction of proposed modifications the warheads could be used by special forces or other assault units as directional mines or statically detonated cutting shaped charges as well as by combat engineers as universal charges used in various types of engineering or sapper works. The research included experimental penetration tests and their numerical reproduction in the LS-Dyna software with the simulation methodology defined and validated in previous works of the authors.Small differences(average error = 10-20%) were identified between the experimental and numerical results(dimensions of craters made in steel targets were compared) what confirmed the reliability of the modelling methodology and enabled its use for further optimization of the shapes of fillings. Within the analyzed variants of warheads modifications maximum diameters of penetration craters were obtained for the filling of the height of h = 2/3H. The diameters of holes in individual steel plates were increased by 164%, 70%, 65%(for the first, second and third plate, respectively) in relation to the variant without filling. The results of the study indicated that with the use of different materials of fillings and their various heights it is possible to control the shape of penetration craters pierced in the steel targets.展开更多
Based on the dynamic shock response of the material and structure,the hypervelocity impact processes and mechanisms of long composite rods with axial density/impedance gradients penetration into fourlayer targets were...Based on the dynamic shock response of the material and structure,the hypervelocity impact processes and mechanisms of long composite rods with axial density/impedance gradients penetration into fourlayer targets were studied through experiments and numerical simulation methods.The propagation law of the shock waves,together with the structural responses of the projectiles and targets,the formation and evolution of the fragment groups formed during the processes and their distributions were described.The damage of each target plate was quantitatively analysed by comparing the results of the experiment and numerical simulation.The results showed that the axial density/impedance gradient projectiles could decrease the impact pressure to a certain extent,and the degree of damage to the target plate decreased layer by layer when the head density/impedance of the projectile was high.When the head density/impedance of the projectile was low,the degree of target damage first increased layer by layer until the projectile was completely eroded and then it decreased.The results can provide a reference for the design and application of long rods with axial composite structure for velocities ranging from 6 to 10 Ma or greater.展开更多
Expanding in the oral care business, being passionately driven by innovative and scientific products, functional toothpaste has recently become more popular for functionality, variety, and efficacy. Many new types of ...Expanding in the oral care business, being passionately driven by innovative and scientific products, functional toothpaste has recently become more popular for functionality, variety, and efficacy. Many new types of toothpaste are commercially manufactured with diverse fragrances, colors, probiotics, and pharmaceutical ingredients to enhance the functionalities of toothpaste. Our study attempted to create a toothpaste formulation that might facilitate the intraoral delivery of vitamin D3 into the bloodstream. Simply brushing our teeth with toothpaste should be easy to take the essential vitamin regularly. In this study, an emulsion-based toothpaste mixed with an azone compound and sodium dodecyl sulfate as penetration enhancers blended thoroughly with other ingredients and then with vitamin D. Multiple toothpaste characteristic tests were performed, such as abrasiveness, scratchiness, spreadability, pH, foaming, cleaning, and antibacterial strength with our vitamin D toothpaste, and compared with those of other commercial brand toothpaste. To confirm the intraoral delivery of vitamin D through the oral cavity, an earthworm transport study and TEER value test were conducted using L. terrestris skin. Our data demonstrated the high feasibility of intraoral delivery of vitamin D based on those two skin studies with various experimental support;our vitamin D toothpaste had comparable characteristics with other commercial toothpaste for cleaning functionality.展开更多
文摘Intelligent penetration testing is of great significance for the improvement of the security of information systems,and the critical issue is the planning of penetration test paths.In view of the difficulty for attackers to obtain complete network information in realistic network scenarios,Reinforcement Learning(RL)is a promising solution to discover the optimal penetration path under incomplete information about the target network.Existing RL-based methods are challenged by the sizeable discrete action space,which leads to difficulties in the convergence.Moreover,most methods still rely on experts’knowledge.To address these issues,this paper proposes a penetration path planning method based on reinforcement learning with episodic memory.First,the penetration testing problem is formally described in terms of reinforcement learning.To speed up the training process without specific prior knowledge,the proposed algorithm introduces episodic memory to store experienced advantageous strategies for the first time.Furthermore,the method offers an exploration strategy based on episodic memory to guide the agents in learning.The design makes full use of historical experience to achieve the purpose of reducing blind exploration and improving planning efficiency.Ultimately,comparison experiments are carried out with the existing RL-based methods.The results reveal that the proposed method has better convergence performance.The running time is reduced by more than 20%.
基金funded by the China Postdoctoral Science Foundation(Grant No.2022M721614)the opening project of State Key Laboratory of Explosion Science and Technology,Beijing Institute of Technology(Grant No.KFJJ23-07M)。
文摘This paper proposes a type of double-layer charge liner fabricated using chemical vapor deposition(CVD)that has tungsten as its inner liner.The feasibility of this design was evaluated through penetration tests.Double-layer charge liners were fabricated by using CVD to deposit tungsten layers on the inner surfaces of pure T2 copper liners.The microstructures of the tungsten layers were analyzed using a scanning electron microscope(SEM).The feasibility analysis was carried out by pulsed X-rays,slug-retrieval test and static penetration tests.The shaped charge jet forming and penetration law of inner tungsten-coated double-layer liner were studied by numerical simulation method.The results showed that the double-layer liners could form well-shaped jets.The errors between the X-ray test results and the numerical results were within 11.07%.A slug-retrieval test was found that the retrieved slug was similar to a numerically simulated slug.Compared with the traditional pure copper shaped charge jet,the penetration depth of the double-layer shaped charge liner increased by 11.4% and>10.8% respectively.In summary,the test results are good,and the numerical simulation is in good agreement with the test,which verified the feasibility of using the CVD method to fabricate double-layer charge liners with a high-density and high-strength refractory metal as the inner liner.
基金the National Natural Science Foundation of China(Grant No.12102050)the Open Fund of State Key Laboratory of Explosion Science and Technology(Grant No.SKLEST-ZZ-21-18).
文摘The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytical study of the evolution of the nose shape of larger hollow projectiles under hypersonic penetration.In the hypersonic penetration test,eight ogive-nose AerMet100 steel projectiles with a diameter of 40 mm were launched to hit concrete targets with impact velocities that ranged from 1351 to 1877 m/s.Severe erosion of the projectiles was observed during high-speed penetration of heterogeneous targets,and apparent localized mushrooming occurred in the front nose of recovered projectiles.By examining the damage to projectiles,a linear relationship was found between the relative length reduction rate and the initial kinetic energy of projectiles in different penetration tests.Furthermore,microscopic analysis revealed the forming mechanism of the localized mushrooming phenomenon for eroding penetration,i.e.,material spall erosion abrasion mechanism,material flow and redistribution abrasion mechanism and localized radial upsetting deformation mechanism.Finally,a model of highspeed penetration that included erosion was established on the basis of a model of the evolution of the projectile nose that considers radial upsetting;the model was validated by test data from the literature and the present study.Depending upon the impact velocity,v0,the projectile nose may behave as undistorted,radially distorted or hemispherical.Due to the effects of abrasion of the projectile and enhancement of radial upsetting on the duration and amplitude of the secondary rising segment in the pulse shape of projectile deceleration,the predicted DOP had an upper limit.
基金supported by the NSFC Basic Science Center Program for"Multi-scale Problems in Nonlinear Mechanics" (Grant No.11988102)the NSFC (Grant Nos.U2141204,12172367)+2 种基金the Key Research Program of the Chinese Academy of Sciences (Grant No.ZDRW-CN-2021-2-3)the National Key Research and Development Program of China (Grant No.2022YFC3320504-02)the opening project of State Key Laboratory of Explosion Science and Technology (Grant No.KFJJ21-01 and No.KFJJ18-14 M)。
文摘Shaped charge liner(SCL)has been extensively applied in oil recovery and defense industries.Achieving superior penetration capability through optimizing SCL structures presents a substantial challenge due to intricate rate-dependent processes involving detonation-driven liner collapse,high-speed jet stretching,and penetration.This study introduces an innovative optimization strategy for SCL structures that employs jet penetration efficiency as the primary objective function.The strategy combines experimentally validated finite element method with machine learning(FEM-ML).We propose a novel jet penetration efficiency index derived from enhanced cutoff velocity and shape characteristics of the jet via machine learning.This index effectively evaluates the jet penetration performance.Furthermore,a multi-model fusion based on a machine learning optimization method,called XGBOOST-MFO,is put forward to optimize SCL structure over a large input space.The strategy's feasibility is demonstrated through the optimization of copper SCL implemented via the FEM-ML strategy.Finally,this strategy is extended to optimize the structure of the recently emerging CrMnFeCoNi high-entropy alloy conical liners and hemispherical copper liners.Therefore,the strategy can provide helpful guidance for the engineering design of SCL.
基金funded by the Slovenian Research Agency,Core Funding(No.P2-0082)and Project(No.L24487)。
文摘Catalysis of molecular radicals is often performed in interesting experimental configurations.One possible configuration is tubular geometry.The radicals are introduced into the tubes on one side,and stable molecules are exhausted on the other side.The penetration depth of radicals depends on numerous parameters,so it is not always feasible to calculate it.This article presents systematic measurements of the penetration depth of oxygen atoms along tubes made from nickel,cobalt,and copper.The source of O atoms was a surfatron-type microwave plasma.The initial density of O atoms depended on the gas flow and was 0.7×10^(21)m^(-3),2.4×10^(21)m^(-3),and 4.2×10^(21)m^(-3)at the flow rates of 50,300,and 600 sccm,and pressures of 10,35,and 60 Pa,respectively.The gas temperature remained at room temperature throughout the experiments.The dissociation fraction decreased exponentially along the length of the tubes in all cases.The penetration depths for well-oxidized nickel were 1.2,1.7,and 2.4 cm,respectively.For cobalt,they were slightly lower at 1.0,1.3,and 1.6 cm,respectively,while for copper,they were 1.1,1.3,and 1.7 cm,respectively.The results were explained by gas dynamics and heterogeneous surface association.These data are useful in any attempt to estimate the loss of molecular fragments along tubes,which serve as catalysts for the association of various radicals to stable molecules.
基金The authors greatly thanked the financial support from the National Key Research and Development Program of China(funded by National Natural Science Foundation of China,No.2019YFA0708300)the Strategic Cooperation Technology Projects of CNPC and CUPB(funded by China National Petroleum Corporation,No.ZLZX2020-03)+1 种基金the National Science Fund for Distinguished Young Scholars(funded by National Natural Science Foundation of China,No.52125401)Science Foundation of China University of Petroleum,Beijing(funded by China University of petroleum,Beijing,No.2462022SZBH002).
文摘Accurate prediction of the rate of penetration(ROP)is significant for drilling optimization.While the intelligent ROP prediction model based on fully connected neural networks(FNN)outperforms traditional ROP equations and machine learning algorithms,its lack of interpretability undermines its credibility.This study proposes a novel interpretation and characterization method for the FNN ROP prediction model using the Rectified Linear Unit(ReLU)activation function.By leveraging the derivative of the ReLU function,the FNN function calculation process is transformed into vector operations.The FNN model is linearly characterized through further simplification,enabling its interpretation and analysis.The proposed method is applied in ROP prediction scenarios using drilling data from three vertical wells in the Tarim Oilfield.The results demonstrate that the FNN ROP prediction model with ReLU as the activation function performs exceptionally well.The relative activation frequency curve of hidden layer neurons aids in analyzing the overfitting of the FNN ROP model and determining drilling data similarity.In the well sections with similar drilling data,averaging the weight parameters enables linear characterization of the FNN ROP prediction model,leading to the establishment of a corresponding linear representation equation.Furthermore,the quantitative analysis of each feature's influence on ROP facilitates the proposal of drilling parameter optimization schemes for the current well section.The established linear characterization equation exhibits high precision,strong stability,and adaptability through the application and validation across multiple well sections.
基金supported by the National Natural Science Foundation of China(Grant Nos.12272257,12102292,12032006)the special fund for Science and Technology Innovation Teams of Shanxi Province(Nos.202204051002006).
文摘This study employs a data-driven methodology that embeds the principle of dimensional invariance into an artificial neural network to automatically identify dominant dimensionless quantities in the penetration of rod projectiles into semi-infinite metal targets from experimental measurements.The derived mathematical expressions of dimensionless quantities are simplified by the examination of the exponent matrix and coupling relationships between feature variables.As a physics-based dimension reduction methodology,this way reduces high-dimensional parameter spaces to descriptions involving only a few physically interpretable dimensionless quantities in penetrating cases.Then the relative importance of various dimensionless feature variables on the penetration efficiencies for four impacting conditions is evaluated through feature selection engineering.The results indicate that the selected critical dimensionless feature variables by this synergistic method,without referring to the complex theoretical equations and aiding in the detailed knowledge of penetration mechanics,are in accordance with those reported in the reference.Lastly,the determined dimensionless quantities can be efficiently applied to conduct semi-empirical analysis for the specific penetrating case,and the reliability of regression functions is validated.
文摘When employing penetration ammunition to strike multi-story buildings,the detection methods using acceleration sensors suffer from signal aliasing,while magnetic detection methods are susceptible to interference from ferromagnetic materials,thereby posing challenges in accurately determining the number of layers.To address this issue,this research proposes a layer counting method for penetration fuze that incorporates multi-source information fusion,utilizing both the temporal convolutional network(TCN)and the long short-term memory(LSTM)recurrent network.By leveraging the strengths of these two network structures,the method extracts temporal and high-dimensional features from the multi-source physical field during the penetration process,establishing a relationship between the multi-source physical field and the distance between the fuze and the target plate.A simulation model is developed to simulate the overload and magnetic field of a projectile penetrating multiple layers of target plates,capturing the multi-source physical field signals and their patterns during the penetration process.The analysis reveals that the proposed multi-source fusion layer counting method reduces errors by 60% and 50% compared to single overload layer counting and single magnetic anomaly signal layer counting,respectively.The model's predictive performance is evaluated under various operating conditions,including different ratios of added noise to random sample positions,penetration speeds,and spacing between target plates.The maximum errors in fuze penetration time predicted by the three modes are 0.08 ms,0.12 ms,and 0.16 ms,respectively,confirming the robustness of the proposed model.Moreover,the model's predictions indicate that the fitting degree for large interlayer spacings is superior to that for small interlayer spacings due to the influence of stress waves.
基金funded by the National Natural Science Foundation of China(Grant Nos.:81803812,81803237).
文摘Extracellular polymeric substances(EPS)constitutes crucial elements within bacterial biofilms,facili-tating accelerated antimicrobial resistance and conferring defense against the host's immune cells.Developing precise and effective antibiofilm approaches and strategies,tailored to the specific charac-teristics of EPS composition,can offer valuable insights for the creation of novel antimicrobial drugs.This,in turn,holds the potential to mitigate the alarming issue of bacterial drug resistance.Current analysis of EPS compositions relies heavily on colorimetric approaches with a significant bias,which is likely due to the selection of a standard compound and the cross-interference of various EPS compounds.Considering the pivotal role of EPS in biofilm functionality,it is imperative for EPS research to delve deeper into the analysis of intricate compositions,moving beyond the current focus on polymeric materials.This ne-cessitates a shift from heavy reliance on colorimetric analytic methods to more comprehensive and nuanced analytical approaches.In this study,we have provided a comprehensive summary of existing analytical methods utilized in the characterization of EPS compositions.Additionally,novel strategies aimed at targeting EPS to enhance biofilm penetration were explored,with a specific focus on high-lighting the limitations associated with colorimetric methods.Furthermore,we have outlined the challenges faced in identifying additional components of EPS and propose a prospective research plan to address these challenges.This review has the potential to guide future researchers in the search for novel compounds capable of suppressing EPS,thereby inhibiting biofilm formation.This insight opens up a new avenue for exploration within this research domain.
基金Project supported by the National Natural Science Foundation of China (Grant No.51821005)。
文摘An externally generated resonant magnetic perturbation can induce complex non-ideal MHD responses in their resonant surfaces.We have studied the plasma responses using Fitzpatrick's improved two-fluid model and program LAYER.We calculated the error field penetration threshold for J-TEXT.In addition,we find that the island width increases slightly as the error field amplitude increases when the error field amplitude is below the critical penetration value.However,the island width suddenly jumps to a large value because the shielding effect of the plasma against the error field disappears after the penetration.By scanning the natural mode frequency,we find that the shielding effect of the plasma decreases as the natural mode frequency decreases.Finally,we obtain the m/n=2/1 penetration threshold scaling on density and temperature.
基金supported by the National Natural Science Founda-tion of China(Grant No.12172381)Leading Talents of Science and Technology in the Central Plain of China(Grant No.234200510016).
文摘The projectile penetration process into concrete target is a nonlinear complex problem.With the increase ofexperiment data,the data-driven paradigm has exhibited a new feasible method to solve such complex prob-lem.However,due to poor quality of experimental data,the traditional machine learning(ML)methods,whichare driven only by experimental data,have poor generalization capabilities and limited prediction accuracy.Therefore,this study intends to exhibit a ML method fusing the prior knowledge with experiment data.The newML method can constrain the fitting to experimental data,improve the generalization ability and the predic-tion accuracy.Experimental results show that integrating domain prior knowledge can effectively improve theperformance of the prediction model for penetration depth into concrete targets.
文摘In today’s era, where mobile devices have become an integral part of our daily lives, ensuring the security of mobile applications has become increasingly crucial. Mobile penetration testing, a specialized subfield within the realm of cybersecurity, plays a vital role in safeguarding mobile ecosystems against the ever-evolving landscape of threats. The ubiquity of mobile devices has made them a prime target for cybercriminals, and the data and functionality accessed through mobile applications make them valuable assets to protect. Mobile penetration testing is designed to identify vulnerabilities, weaknesses, and potential exploits within mobile applications and the devices themselves. Unlike traditional penetration testing, which often focuses on network and server security, mobile penetration testing zeroes in on the unique challenges posed by mobile platforms. Mobile penetration testing, a specialized field within cybersecurity, is an essential tool in the Cybersecurity specialists’ toolkit to protect mobile ecosystems from emerging threats. This article introduces mobile penetration testing, emphasizing its significance, including comprehensive learning labs for Android and iOS platforms, and highlighting how it distinctly differs from traditional penetration testing methodologies.
基金The authors would like to acknowledge the support from the National Natural Science Foundation of China(No.52171274).
文摘Suction foundations are generally installed with negative pressures to overcome the resistance of soils and complete the penetration,but excessive negative pressures are also avoided to cause seepage damages.In this paper,the model test method was used to analyze the movement characteristics of multi-bucket foundations in the process of sinking in sand,and the common calculation methods of sinking resistances are verified.The critical negative pressure corresponding to the seepage failure of foundation was determined under the action of increasing negative pressure step by step and the characteristics of soil failure were studied.The calculation formula of critical suction in sand was verified in application,and according to the test results,the value of seepage coefficient was modified,which provides an example for the study of suction foundation in sand soils.
基金financially supported by the Key-Area Research and Development Program of Guangdong ProvinceChina(Grant No.2022B0101100001)+3 种基金the Marine Economic Development Special Program of Guangdong province(Six Major Marine Industries):Research and Demonstration of Critical Technologies for Comprehensive Prevention and Control of Natural Disaster in Offshore Wind FarmsChina(Grant No.29[2023])the Guangxi Key Laboratory of Disaster Prevention and Mitigation and Engineering SafetyChina(Grant No.2020ZDK002)。
文摘The application of the wellhead suction anchor in the second production test of natural gas hydrates(NGHs)in the South China Sea(SCS)was met with success.This design incorporates a central conductor guide pipe,which distinguishes it from traditional suction foundations.However,this addition resulted in a relatively high penetration resistance and a shallower penetration depth at the self-weight penetration stage.To mitigate this issue,the current study proposes an optimized design where the end of the suction foundation is sharpened.The installation characteristics of the traditional suction foundation and new suction foundation during self-weight penetration into sand are studied through laboratory tests and theoretical analysis.The flat and sharpened bottom shapes are considered in the traditional and new suction models.The effects of the initial penetration velocity on the initial penetration depth and soil plug and impact cavity characteristics are systematically studied.The results show that the self-weight penetration depth of the foundation with a sharpened bottom is 44.5%deeper than that of the foundation with a flat bottom.There are cavities around the foundation at the self-weight penetration stage,and the penetration depth is overestimated by 15%-30%.Finally,a model for predicting the penetration depth of the new suction foundation is proposed.
基金supported by the National Natural Science Foundation of China (Grant No.62103432)supported by Young Talent fund of University Association for Science and Technology in Shaanxi, China(Grant No.20210108)。
文摘An impact point prediction(IPP) guidance based on supervised learning is proposed to address the problem of precise guidance for the ballistic missile in high maneuver penetration condition.An accurate ballistic trajectory model is applied to generate training samples,and ablation experiments are conducted to determine the mapping relationship between the flight state and the impact point.At the same time,the impact point coordinates are decoupled to improve the prediction accuracy,and the sigmoid activation function is improved to ameliorate the prediction efficiency.Therefore,an IPP neural network model,which solves the contradiction between the accuracy and the speed of the IPP,is established.In view of the performance deviation of the divert control system,the mapping relationship between the guidance parameters and the impact deviation is analysed based on the variational principle.In addition,a fast iterative model of guidance parameters is designed for reference to the Newton iteration method,which solves the nonlinear strong coupling problem of the guidance parameter solution.Monte Carlo simulation results show that the prediction accuracy of the impact point is high,with a 3 σ prediction error of 4.5 m,and the guidance method is robust,with a 3 σ error of 7.5 m.On the STM32F407 singlechip microcomputer,a single IPP takes about 2.374 ms,and a single guidance solution takes about9.936 ms,which has a good real-time performance and a certain engineering application value.
基金supported by the National Natural Science Foundation of China(No.12002046)the China Postdoctoral Science Foundation(No.2020M680392)。
文摘In this paper,the penetration mechanism of reactive jet with non-uniform density distribution is studied.The simulations show that the density deficit occurs in the whole reactive jet,and the density increases from the jet tip to tail.The density of jet tip is approximately 1.5 g/cm3,which is lower than that of the reactive liner materials.The X-ray experiments show similar results with the simulations.The density decreasing effect of jet tip has a significant influence on the penetration behavior when the reactive jet impacts steel plate.According to the simulation results,this paper assumes that the density gradient in the jet section has linear distribution.Then,the deflagration pressure generated by each jet element at the bottom of crater is introduced into the Bernoulli equation.Based on the virtual origin model and Szendrei-Held equation,the analytical models for penetration depth and radial cratering of reactive jet with the density reduction are obtained.Moreover,to further prove the validity of analytical models,the penetration experiments of the reactive liner shaped charge against steel plate under different standoffs are carried out.There is a convergence between the analytical crater profiles and experimental results when reactive jets penetrate steel plates under different standoffs,especially at standoff of 1.5 and 2.0charge diameters.
基金The National Natural Science Foundation of China under contract No.U2006213。
文摘Fine-grained silt is widely distributed in the Huanghe River Delta(HRD)in China,and the sedimentary structure is complex,meaning that the clay content in the silt is variable.The piezocone penetration test(CPTu)is the most widely approved in situ test method.It can be used to invert soil properties and interpret soil behavior.To analyse the strength properties of surface sediments in the HRD,this paper evaluated the friction angle and its inversion formula through the CPTu penetration test and monotonic simple shear test and other soil unit experiments.The evaluation showed that the empirical formula proposed by Kulhawy and Mayne had better prediction and inversion effect.The HRD silts with clay contents of 9.2%,21.4%and 30.3%were selected as samples for the CPTu variable rate penetration test.The results show as follows.(1)The effects of the clay content on the tip resistance and the pore pressure of silt under different penetration rates were summarized.The tip resistance Q_t is strongly dependent on the clay content of the silt,the B_(q)value of the silt tends to 0 and is not significantly affected by the change of the CPTu penetration rate.(2)Five soil behavior type classification charts and three soil behavior type indexes based on CPTu data were evaluated.The results show that the soil behavior type classification chart based on soil behavior type index ISBT,the Robertson 2010 behavior type classification chart are more suitable for the silty soil in the HRD.
文摘Penetration characteristic(size and shape of penetration craters made in high hardness ARMSTAL 30PM steel) of shaped charge jets formed after detonations of modified PG-7VM warheads was analyzed in the article. Modifications consisted in removing the frontal part of the grenade(fuse, ballistic cap and conductive cone) and introducing of the liner cavity filling made of polyacetal copolymer POM-C. The filings in the form of solid cones with three different heights(33%, 66% and 100% of H-the height of original PG-7VM liner) were placed inside of the hollow cone shaped charge liner. As opposed to the vast majority of previously published works(in which warhead optimization studies were focused on increasing of the depth of penetration in rolled homogeneous armor steel) the main aim of the presented modifications was to maximize the damage ratio(diameters of craters, inlet and outlet holes) of target perforated by shaped charge jet at the cost of the loss of part of the jet penetration capability. According to the best knowledge of the authors such approach to the use of the old PG-7VM warheads has not been analyzed so far. Taking into consideration high stock levels of PG-7VM warheads, and the fact that they are continuously being replaced by more efficient and more sophisticated high-explosive anti-tank warheads, it seems reasonable to look for alternate applications of the warheads withdrawn from the service. Thanks to the introduction of proposed modifications the warheads could be used by special forces or other assault units as directional mines or statically detonated cutting shaped charges as well as by combat engineers as universal charges used in various types of engineering or sapper works. The research included experimental penetration tests and their numerical reproduction in the LS-Dyna software with the simulation methodology defined and validated in previous works of the authors.Small differences(average error = 10-20%) were identified between the experimental and numerical results(dimensions of craters made in steel targets were compared) what confirmed the reliability of the modelling methodology and enabled its use for further optimization of the shapes of fillings. Within the analyzed variants of warheads modifications maximum diameters of penetration craters were obtained for the filling of the height of h = 2/3H. The diameters of holes in individual steel plates were increased by 164%, 70%, 65%(for the first, second and third plate, respectively) in relation to the variant without filling. The results of the study indicated that with the use of different materials of fillings and their various heights it is possible to control the shape of penetration craters pierced in the steel targets.
基金supported by the National Natural Science Foundation of China(Grant No.11772269)。
文摘Based on the dynamic shock response of the material and structure,the hypervelocity impact processes and mechanisms of long composite rods with axial density/impedance gradients penetration into fourlayer targets were studied through experiments and numerical simulation methods.The propagation law of the shock waves,together with the structural responses of the projectiles and targets,the formation and evolution of the fragment groups formed during the processes and their distributions were described.The damage of each target plate was quantitatively analysed by comparing the results of the experiment and numerical simulation.The results showed that the axial density/impedance gradient projectiles could decrease the impact pressure to a certain extent,and the degree of damage to the target plate decreased layer by layer when the head density/impedance of the projectile was high.When the head density/impedance of the projectile was low,the degree of target damage first increased layer by layer until the projectile was completely eroded and then it decreased.The results can provide a reference for the design and application of long rods with axial composite structure for velocities ranging from 6 to 10 Ma or greater.
文摘Expanding in the oral care business, being passionately driven by innovative and scientific products, functional toothpaste has recently become more popular for functionality, variety, and efficacy. Many new types of toothpaste are commercially manufactured with diverse fragrances, colors, probiotics, and pharmaceutical ingredients to enhance the functionalities of toothpaste. Our study attempted to create a toothpaste formulation that might facilitate the intraoral delivery of vitamin D3 into the bloodstream. Simply brushing our teeth with toothpaste should be easy to take the essential vitamin regularly. In this study, an emulsion-based toothpaste mixed with an azone compound and sodium dodecyl sulfate as penetration enhancers blended thoroughly with other ingredients and then with vitamin D. Multiple toothpaste characteristic tests were performed, such as abrasiveness, scratchiness, spreadability, pH, foaming, cleaning, and antibacterial strength with our vitamin D toothpaste, and compared with those of other commercial brand toothpaste. To confirm the intraoral delivery of vitamin D through the oral cavity, an earthworm transport study and TEER value test were conducted using L. terrestris skin. Our data demonstrated the high feasibility of intraoral delivery of vitamin D based on those two skin studies with various experimental support;our vitamin D toothpaste had comparable characteristics with other commercial toothpaste for cleaning functionality.