Laboratory animals and animal experiments are foundations and important support conditions for life sciences, especially for medical research. The animal experiments have drawn extensive attention from the society bec...Laboratory animals and animal experiments are foundations and important support conditions for life sciences, especially for medical research. The animal experiments have drawn extensive attention from the society because of the ethical issue. This paper takes Wenzhou Medical University as an example to give a brief introduction to the ethical review about laboratory animals in the university so as to further draw attention and concerns from the public about the ethical issue of laboratory animals. We successively introduce its scientific projects, nurturing environment and ethical review of laboratory animals.展开更多
The 14th Scientific Congress of the Chinese Association for Laboratory Animal Science was held on October 11‐12,2018 in Qingdao,China.During this congress,an international forum on the development of Laboratory Anima...The 14th Scientific Congress of the Chinese Association for Laboratory Animal Science was held on October 11‐12,2018 in Qingdao,China.During this congress,an international forum on the development of Laboratory Animal Sciences(LAS)worldwide was held in which participants learnt about the development of new LAS resources and technologies,as well as the progress of LAS in China.The main points that were discussed are as follows.After nearly a century of development,there are more than 200 species of experimental animals,and more than 20 000 inbred lines,outbred lines,genetic engineered animals,animal models of diseases,and other resources all over the world,which provide abundant experimental animal resources for scientific research.These resources are widely used in life science research.展开更多
The Second Online Academic Salon on Monkeypox Virus: One Health, monkeypox prevention, and treatment was held online on August 26, 2022, at Beijing, China. The Academic Salon was hosted by the Chinese Association for ...The Second Online Academic Salon on Monkeypox Virus: One Health, monkeypox prevention, and treatment was held online on August 26, 2022, at Beijing, China. The Academic Salon was hosted by the Chinese Association for Laboratory Animal Sciences(CALAS);organized by the Editorial Office of Animal Models and Experimental Medicine( AMEM), Acta Laboratorium Animalis Scientia Sinica, and the Chinese Journal of Comparative Medicine;and co-organized by the China Union of Life Science Societies and Wiley Press. This online salon was simultaneously broadcast live, and attracted more than 2000 participants online from home and abroad.展开更多
Background: With the aim of establishing the most comprehensive database of laboratory animal strains, the "laboratory animal strain resources database"(LasDB)was constructed as a searchable online database ...Background: With the aim of establishing the most comprehensive database of laboratory animal strains, the "laboratory animal strain resources database"(LasDB)was constructed as a searchable online database of all laboratory animal strains,stocks and mutant embryonic stem-cell lines available worldwide, including inbred,outbred, mutant and genetically engineered strains.Methods: MySQL database software was used to construct the LasDB, offering an easy-to-use interface.Results: To date, LasDB has a collection covering data for 21 596 mouse strains,2062 rat strains, 13 monkey strains, 2 hamster strains, 5 dog strains, 5 rabbit strains and more than 50 other laboratory animal strains. LasDB will be continually improved with regular updates of new laboratory animal strains from all over the world.Conclusion: To the best of our knowledge, this is the first database that attempts to systematically integrate all available laboratory animal strain data with the aim of supporting open usage and full resource sharing.展开更多
The First Academic Salon on Monkeypox Virus was held online on June 10th,2022 in Beijing,China.The Academic Salon was hosted by the Chinese Association for Laboratory Animal Sciences (CALAS);organized by the Editorial...The First Academic Salon on Monkeypox Virus was held online on June 10th,2022 in Beijing,China.The Academic Salon was hosted by the Chinese Association for Laboratory Animal Sciences (CALAS);organized by the Editorial Office of Animal Models and Experimental Medicine (AMEM),Acta Laboratorium Animalis Scientia Sinica,and the Chinese Journal of Comparative Medicine,and co-organized by China Union of Life Science Societies.This Academic Salon was also broadcast live on Wiley WeChat Video Channel,and attracted over 2400online attendees home and abroad.展开更多
Genetically heterogenous mouse population served as the basis for experiment designed to select mice for the high levels of extrapolation ability. Extrapolation task (which belongs to the category of cognitive tasks) ...Genetically heterogenous mouse population served as the basis for experiment designed to select mice for the high levels of extrapolation ability. Extrapolation task (which belongs to the category of cognitive tasks) was the following: hungry and thirsty mouse was placed in the experimental box facing the cup with milk which could be reached via the small opening in the frontal wall. After several seconds of drinking the food moved behind this wall to the right or to the left and disappeared from animal view. Mouse can find the food only if it moves in the direction of food movement. The direction could be chosen at random or based on animal apprehension of elementary logic of this task. Mice were selected not only for high scores of this task solution but also for lack of anxiety signs during test performance. Extrapolation task scores in selected strain mice were above the chance levels in F9 but non-significantly different from those of control unselected mouse population. The performance of F9 mice in the “puzzle box” cognitive test, based on animal tendency to avoid the brightly lit area in the dark compartment with increasing “difficulty” of reaching this compartment, was measured as mean escape latencies of the respective group. The latencies of mice from selected strain were significantly shorter than those of control animals. This fact is interpreted as the sign that the selection for one cognitive trait (yet still not efficient) resulted in positive changes in the ability to solve another cognitive task. The relationship of cognitive task solutions success and anxiety behavior scores in F9 is discussed.展开更多
The Faculty of Medicine, University of Colombo(UCFM), is the forerunner in the laboratory animal science(LAS) field in Sri Lanka. Here laboratory animals such as rats, frogs and rabbits were used in medical education ...The Faculty of Medicine, University of Colombo(UCFM), is the forerunner in the laboratory animal science(LAS) field in Sri Lanka. Here laboratory animals such as rats, frogs and rabbits were used in medical education to demonstrate physiological principles in the early 1950 s. The establishment of the first animal house in 1969 at UCFM better facilitated the use of laboratory animals in medical education and research. By 2006, lack of ethical guide lines was an issue and a set of ethical guidelines was developed and published in 2009, which today are followed by researchers and reviewers in many universities and research institutions in the country. With this development, there was a need for an organized system of education for the LAS discipline. This was fulfilled by conducting the first certificate course on LAS in the Asian region in 2011 in collaboration with the Utrecht University,Netherlands. The Sri Lanka Association for LAS has continued LAS education since its establishment in 2012 at UCFM by conducting workshops and short courses.展开更多
The Institute of Laboratory Animal Sciences(ILAS)is a unique research organization dedicated to research on laboratory animals and comparative medicine.It is affi liated with the Chinese Academy of Medical Sciences(CA...The Institute of Laboratory Animal Sciences(ILAS)is a unique research organization dedicated to research on laboratory animals and comparative medicine.It is affi liated with the Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC).It was founded in 1980,when China has just begun to develop laboratory animal sciences.ILAS currently has 478 staff working in four main business areas:scientifi c research;laboratory animal resource development conservation and production;comparative medicine technology services;and teaching and training.展开更多
The Institute of Laboratory Animal Sciences(ILAS)is a unique research organization dedicated to research on laboratory animals and comparative medicine.It is affi liated with the Chinese Academy of Medical Sciences(CA...The Institute of Laboratory Animal Sciences(ILAS)is a unique research organization dedicated to research on laboratory animals and comparative medicine.It is affi liated with the Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC).It was founded in 1980,when China has just begun to develop laboratory animal sciences.ILAS currently has 478 staff working in four main business areas:scientifi c research;laboratory animal resource development conservation and production;comparative medicine technology services;and teaching and training.展开更多
The Chinese Association for Laboratory Animal Sciences(CALAS)was founded in 1987.Qian Xin-zhong,the former minister of the Ministry of Health,was the president of the fi rst session of the Council.CALAS has now comple...The Chinese Association for Laboratory Animal Sciences(CALAS)was founded in 1987.Qian Xin-zhong,the former minister of the Ministry of Health,was the president of the fi rst session of the Council.CALAS has now completed seven sessions of the Council.The current president is Prof.Chuan Qin,the director of the Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).CALAS oversees 16 work Committees,such as the Academic Committee,Journal and Information Committee,International Exchange and Cooperation Committee,as well as 16 professional Committees,e.g.Laboratory Animal Welfare and Ethics Professional Committee and Laboratory Animal Standardization Professional Committee.展开更多
The Chinese Association for Laboratory Animal Sciences(CALAS)was founded in 1987.Qian Xin-zhong,the former minister of the Ministry of Health,was the president of the first session of the Council.CALAS has now complet...The Chinese Association for Laboratory Animal Sciences(CALAS)was founded in 1987.Qian Xin-zhong,the former minister of the Ministry of Health,was the president of the first session of the Council.CALAS has now completed seven sessions of the Council.The current president is Prof.Chuan Qin,the director of the Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).CALAS oversees 16 work Committees,such as the Academic Committee,Journal and Information Committee,International Exchange and Cooperation Committee,as well as 16 professional Committees,e.g.Laboratory Animal Welfare and Ethics Professional Committee and Laboratory Animal Standardization Professional Committee.展开更多
The Chinese Association for Laboratory Animal Sciences(CALAS)was founded in 1987.Qian Xin-zhong,the former minister of the Ministry of Health,was the president of the fi rst session of the Council.CALAS has now comple...The Chinese Association for Laboratory Animal Sciences(CALAS)was founded in 1987.Qian Xin-zhong,the former minister of the Ministry of Health,was the president of the fi rst session of the Council.CALAS has now completed seven sessions of the Council.The current president is Prof.Chuan Qin,the director of the Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).CALAS oversees 16 work Committees,such as the Academic Committee,Journal and Information Committee,International Exchange and Cooperation Committee,as well as 16 professional Committees,e.g.Laboratory Animal Welfare and Ethics Professional Committee and Laboratory Animal Standardization Professional Committee.展开更多
基金supported by fund of science and technology project of Wenzhou(Y20140601)
文摘Laboratory animals and animal experiments are foundations and important support conditions for life sciences, especially for medical research. The animal experiments have drawn extensive attention from the society because of the ethical issue. This paper takes Wenzhou Medical University as an example to give a brief introduction to the ethical review about laboratory animals in the university so as to further draw attention and concerns from the public about the ethical issue of laboratory animals. We successively introduce its scientific projects, nurturing environment and ethical review of laboratory animals.
文摘The 14th Scientific Congress of the Chinese Association for Laboratory Animal Science was held on October 11‐12,2018 in Qingdao,China.During this congress,an international forum on the development of Laboratory Animal Sciences(LAS)worldwide was held in which participants learnt about the development of new LAS resources and technologies,as well as the progress of LAS in China.The main points that were discussed are as follows.After nearly a century of development,there are more than 200 species of experimental animals,and more than 20 000 inbred lines,outbred lines,genetic engineered animals,animal models of diseases,and other resources all over the world,which provide abundant experimental animal resources for scientific research.These resources are widely used in life science research.
文摘The Second Online Academic Salon on Monkeypox Virus: One Health, monkeypox prevention, and treatment was held online on August 26, 2022, at Beijing, China. The Academic Salon was hosted by the Chinese Association for Laboratory Animal Sciences(CALAS);organized by the Editorial Office of Animal Models and Experimental Medicine( AMEM), Acta Laboratorium Animalis Scientia Sinica, and the Chinese Journal of Comparative Medicine;and co-organized by the China Union of Life Science Societies and Wiley Press. This online salon was simultaneously broadcast live, and attracted more than 2000 participants online from home and abroad.
基金the Central Research Institutes Basic Operating Grants,Grant/Award Number:DWS201512CAMS Innovation Fund for Medical Sciences(CIFMS),Grant/Award Number:2016-I2M-2-006-03National Major Scientific and Technological Special Project for Key Infectious Diseases,Grant/Award Number:2017ZX10304402-001
文摘Background: With the aim of establishing the most comprehensive database of laboratory animal strains, the "laboratory animal strain resources database"(LasDB)was constructed as a searchable online database of all laboratory animal strains,stocks and mutant embryonic stem-cell lines available worldwide, including inbred,outbred, mutant and genetically engineered strains.Methods: MySQL database software was used to construct the LasDB, offering an easy-to-use interface.Results: To date, LasDB has a collection covering data for 21 596 mouse strains,2062 rat strains, 13 monkey strains, 2 hamster strains, 5 dog strains, 5 rabbit strains and more than 50 other laboratory animal strains. LasDB will be continually improved with regular updates of new laboratory animal strains from all over the world.Conclusion: To the best of our knowledge, this is the first database that attempts to systematically integrate all available laboratory animal strain data with the aim of supporting open usage and full resource sharing.
文摘The First Academic Salon on Monkeypox Virus was held online on June 10th,2022 in Beijing,China.The Academic Salon was hosted by the Chinese Association for Laboratory Animal Sciences (CALAS);organized by the Editorial Office of Animal Models and Experimental Medicine (AMEM),Acta Laboratorium Animalis Scientia Sinica,and the Chinese Journal of Comparative Medicine,and co-organized by China Union of Life Science Societies.This Academic Salon was also broadcast live on Wiley WeChat Video Channel,and attracted over 2400online attendees home and abroad.
文摘Genetically heterogenous mouse population served as the basis for experiment designed to select mice for the high levels of extrapolation ability. Extrapolation task (which belongs to the category of cognitive tasks) was the following: hungry and thirsty mouse was placed in the experimental box facing the cup with milk which could be reached via the small opening in the frontal wall. After several seconds of drinking the food moved behind this wall to the right or to the left and disappeared from animal view. Mouse can find the food only if it moves in the direction of food movement. The direction could be chosen at random or based on animal apprehension of elementary logic of this task. Mice were selected not only for high scores of this task solution but also for lack of anxiety signs during test performance. Extrapolation task scores in selected strain mice were above the chance levels in F9 but non-significantly different from those of control unselected mouse population. The performance of F9 mice in the “puzzle box” cognitive test, based on animal tendency to avoid the brightly lit area in the dark compartment with increasing “difficulty” of reaching this compartment, was measured as mean escape latencies of the respective group. The latencies of mice from selected strain were significantly shorter than those of control animals. This fact is interpreted as the sign that the selection for one cognitive trait (yet still not efficient) resulted in positive changes in the ability to solve another cognitive task. The relationship of cognitive task solutions success and anxiety behavior scores in F9 is discussed.
基金Grants/funds provided by the National Science Foundation of Sri Lanka,The American Physiological Society,AAALAC International,Laboratory Animals Limited of UK,ICLAS and the AFLAS-ETALAST program for the activities conducted by UCFM and SLALAS leading to the development of the LAS field in Sri Lanka are greatly appreciated
文摘The Faculty of Medicine, University of Colombo(UCFM), is the forerunner in the laboratory animal science(LAS) field in Sri Lanka. Here laboratory animals such as rats, frogs and rabbits were used in medical education to demonstrate physiological principles in the early 1950 s. The establishment of the first animal house in 1969 at UCFM better facilitated the use of laboratory animals in medical education and research. By 2006, lack of ethical guide lines was an issue and a set of ethical guidelines was developed and published in 2009, which today are followed by researchers and reviewers in many universities and research institutions in the country. With this development, there was a need for an organized system of education for the LAS discipline. This was fulfilled by conducting the first certificate course on LAS in the Asian region in 2011 in collaboration with the Utrecht University,Netherlands. The Sri Lanka Association for LAS has continued LAS education since its establishment in 2012 at UCFM by conducting workshops and short courses.
文摘The Institute of Laboratory Animal Sciences(ILAS)is a unique research organization dedicated to research on laboratory animals and comparative medicine.It is affi liated with the Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC).It was founded in 1980,when China has just begun to develop laboratory animal sciences.ILAS currently has 478 staff working in four main business areas:scientifi c research;laboratory animal resource development conservation and production;comparative medicine technology services;and teaching and training.
文摘The Institute of Laboratory Animal Sciences(ILAS)is a unique research organization dedicated to research on laboratory animals and comparative medicine.It is affi liated with the Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC).It was founded in 1980,when China has just begun to develop laboratory animal sciences.ILAS currently has 478 staff working in four main business areas:scientifi c research;laboratory animal resource development conservation and production;comparative medicine technology services;and teaching and training.
文摘The Chinese Association for Laboratory Animal Sciences(CALAS)was founded in 1987.Qian Xin-zhong,the former minister of the Ministry of Health,was the president of the fi rst session of the Council.CALAS has now completed seven sessions of the Council.The current president is Prof.Chuan Qin,the director of the Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).CALAS oversees 16 work Committees,such as the Academic Committee,Journal and Information Committee,International Exchange and Cooperation Committee,as well as 16 professional Committees,e.g.Laboratory Animal Welfare and Ethics Professional Committee and Laboratory Animal Standardization Professional Committee.
文摘The Chinese Association for Laboratory Animal Sciences(CALAS)was founded in 1987.Qian Xin-zhong,the former minister of the Ministry of Health,was the president of the first session of the Council.CALAS has now completed seven sessions of the Council.The current president is Prof.Chuan Qin,the director of the Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).CALAS oversees 16 work Committees,such as the Academic Committee,Journal and Information Committee,International Exchange and Cooperation Committee,as well as 16 professional Committees,e.g.Laboratory Animal Welfare and Ethics Professional Committee and Laboratory Animal Standardization Professional Committee.
文摘The Chinese Association for Laboratory Animal Sciences(CALAS)was founded in 1987.Qian Xin-zhong,the former minister of the Ministry of Health,was the president of the fi rst session of the Council.CALAS has now completed seven sessions of the Council.The current president is Prof.Chuan Qin,the director of the Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).CALAS oversees 16 work Committees,such as the Academic Committee,Journal and Information Committee,International Exchange and Cooperation Committee,as well as 16 professional Committees,e.g.Laboratory Animal Welfare and Ethics Professional Committee and Laboratory Animal Standardization Professional Committee.