Objective:To evaluate the protective effect of ethanol extract of Mollugo nudicaulis(M.nudicaulis) against perchloroethylene-induced hepatotoxicity.Methods:The hepatoprotective activity of the ethanol extract of M.nud...Objective:To evaluate the protective effect of ethanol extract of Mollugo nudicaulis(M.nudicaulis) against perchloroethylene-induced hepatotoxicity.Methods:The hepatoprotective activity of the ethanol extract of M.nudicaulis(200 mg/kg body wt) was studied in percholoroethylene (1 000 mg/kg body wt) induced hepatotoxicity in Wistar albino rats.The serum levels of AST, ALT,ALP,bilirubin and the liver content of SOD,CAT,GPx,GST,CSH,vitamin C were assessed to evaluate the hepatoprotective and antioxidant activities of the extract.The activity of the extract was compared with silymarin,a standard reference drug.In addition,serum urea,uric acid and creatinine levels were measured to evaluate the kidney function.The histopathological examination of the liver tissues was observed to support the biochemical parameters.Results: The results revealed that the extract significantly(P【0.05) restored the serum levels of AST,ALT, ALP,bilinibin and significantly(P【0.05) increased the antioxidant enzymes SOD,CAT,GPx,GST, GSH,vitamin C in perchloroethylene-induced rats to its normalcy.The biochemical observations were suppoited by the histopathological studies of the liver tissues.Conclusions:The results led to the conclusion that M.nudicaulis possess hepatoprotective and antioxidant activites against perchloroethylene-induced hepatotoxicity in rats.展开更多
Solubilization of perchloroethylene （PCE） in a nonionic （Triton X-100） and a cationic （cetyltrimethylammonium bromide （CTAB）） surfactant solutions and the degradation of surfactant solubilized PCE using fine t...Solubilization of perchloroethylene （PCE） in a nonionic （Triton X-100） and a cationic （cetyltrimethylammonium bromide （CTAB）） surfactant solutions and the degradation of surfactant solubilized PCE using fine to nanosize Fe and bi-metallic Fe-Ni particles were investigated. Micelle partition coefficients （Kin） and molar solubility ratio （MSR） for PCE in 10 g/L of surfactant solutions have been quantified and the solubility of PCE （100 mg/L in water） in the surfactant solutions increased by about ten fold, Of the two suffactants studied, Triton X-100 solubilized the higher amount of PCE per gram of suffactant. To degrade solubilized PCE, both iron and bimetallic Fe-Ni particles were used in continuously stirred batch reactors. The iron and hi-metallic particles were synthesized using the solution method and the particles were characterized using the SEM, EDS, TEM and XRD. The PCE solubilized up to 500 mg/L in both surfactant solutions were totally degraded at various rates by 200 g/L of hi-metallic Fe-Ni particles in less than 20 hr, which is the highest concentration of PCE degraded in the shortest time compared to data in the literature. The degradations of PCE solubilized in surfactant solutions were represented by nonlinear kinetic relationships which depended on the type of surfactant used for solubilizing the PCE.展开更多
文摘Objective:To evaluate the protective effect of ethanol extract of Mollugo nudicaulis(M.nudicaulis) against perchloroethylene-induced hepatotoxicity.Methods:The hepatoprotective activity of the ethanol extract of M.nudicaulis(200 mg/kg body wt) was studied in percholoroethylene (1 000 mg/kg body wt) induced hepatotoxicity in Wistar albino rats.The serum levels of AST, ALT,ALP,bilirubin and the liver content of SOD,CAT,GPx,GST,CSH,vitamin C were assessed to evaluate the hepatoprotective and antioxidant activities of the extract.The activity of the extract was compared with silymarin,a standard reference drug.In addition,serum urea,uric acid and creatinine levels were measured to evaluate the kidney function.The histopathological examination of the liver tissues was observed to support the biochemical parameters.Results: The results revealed that the extract significantly(P【0.05) restored the serum levels of AST,ALT, ALP,bilinibin and significantly(P【0.05) increased the antioxidant enzymes SOD,CAT,GPx,GST, GSH,vitamin C in perchloroethylene-induced rats to its normalcy.The biochemical observations were suppoited by the histopathological studies of the liver tissues.Conclusions:The results led to the conclusion that M.nudicaulis possess hepatoprotective and antioxidant activites against perchloroethylene-induced hepatotoxicity in rats.
基金supported by the Center for Innovative Grouting Materials and Technology (CIGMAT) at the University of Houston with funding from the Texas Hazardous Waste Research Center and Texas Higher Education Coordinating Board (THECB)
文摘Solubilization of perchloroethylene （PCE） in a nonionic （Triton X-100） and a cationic （cetyltrimethylammonium bromide （CTAB）） surfactant solutions and the degradation of surfactant solubilized PCE using fine to nanosize Fe and bi-metallic Fe-Ni particles were investigated. Micelle partition coefficients （Kin） and molar solubility ratio （MSR） for PCE in 10 g/L of surfactant solutions have been quantified and the solubility of PCE （100 mg/L in water） in the surfactant solutions increased by about ten fold, Of the two suffactants studied, Triton X-100 solubilized the higher amount of PCE per gram of suffactant. To degrade solubilized PCE, both iron and bimetallic Fe-Ni particles were used in continuously stirred batch reactors. The iron and hi-metallic particles were synthesized using the solution method and the particles were characterized using the SEM, EDS, TEM and XRD. The PCE solubilized up to 500 mg/L in both surfactant solutions were totally degraded at various rates by 200 g/L of hi-metallic Fe-Ni particles in less than 20 hr, which is the highest concentration of PCE degraded in the shortest time compared to data in the literature. The degradations of PCE solubilized in surfactant solutions were represented by nonlinear kinetic relationships which depended on the type of surfactant used for solubilizing the PCE.
