The conditions in which we live nowadays contribute to exposure of our bodies to harmful factors such as UV radiation, pollution, smoking, poor eating habits, low physical activity, stress, which thereafter lead to th...The conditions in which we live nowadays contribute to exposure of our bodies to harmful factors such as UV radiation, pollution, smoking, poor eating habits, low physical activity, stress, which thereafter lead to the acceleration of skin aging process. In women, the process is additionally dependent on the menopause, as a result of the disappearance of hormones, the process is faster. Physiological changes that occur in women’s body during perimenopausal and menopausal period affect their sexual function: pain during an intercourse, decreased libido, lack of agitation. Deficiency of hormones, besides skin changes, leads to vaginal dryness, accompanied by inflammation, often correlated with discharge and burning. As a result of the loss of hyaluronic acid labia become slack and less moisturized. In addition, there has been observed: a gradual loss of pigment and hair, involution of the clitoris, and involution and sticking of labia minora, lipoatrophy of labia majora with subsequent reduction in their volume and thinning the lining around the vaginal opening. This article presents processes of skin aging. It describes mechanisms of intrinsic and extrinsic aging. It also presents the mechanisms of accelerated aging in women in perimenopausal period—accelerated skin aging dependent on hormonal factors associated with the loss of ovarian function. The research presents how the hormonal loss influences woman’s body, her genitals—its functionality and aesthetic look. It also shows how using filler treatments in gynecology can restore the aesthetic appearance of female genital and improve their functionality.展开更多
Objective: To explore the correlation of menopausal index with sex hormones, lipid metabolism and cytokines in perimenopausal women. Methods: A total of 208 perimenopausal women who were treated in this hospital betwe...Objective: To explore the correlation of menopausal index with sex hormones, lipid metabolism and cytokines in perimenopausal women. Methods: A total of 208 perimenopausal women who were treated in this hospital between September 2015 and March 2018 were selected as the perimenopausal group and 150 healthy young women (20-30 years old) who received physical examination in this hospital during the same period were selected as the control group. The differences in the levels of Kupperman menopausal index as well as the contents of sex hormones, lipid metabolism indexes and inflammatory factors were compared between the two groups. Results: Kupperman menopausal index of perimenopausal group was higher than that of control group;sex hormones E2, P and T contents were lower than those of control group whereas FSH content was higher than that of control group;lipid metabolism indexes TC and LDL-C contents were higher than those of control group whereas HDL-C content was lower than that of control group;inflammatory factors IL-1β, IL-2, IL-18 and IFN-γ contents were higher than those of control group;the Kupperman menopausal index of perimenopausal women was negatively correlated with E2, P, T and HDL-C contents, and positively correlated with FSH, TC, LDL-C, IL-1β, IL-2, IL-18 and IFN-γ contents. Conclusion: The Kupperman menopausal index in perimenopausal women abnormally increases, and the specific level is directly correlated with the female sex hormones, lipid metabolism disorder and systemic microinflammation.展开更多
Objective: The paper aims to investigate the clinical nursing pathway (CNP) in the application of immunosorption therapy in patients with rheumatic immune disease. Methods: Convenience sampling method was used to sele...Objective: The paper aims to investigate the clinical nursing pathway (CNP) in the application of immunosorption therapy in patients with rheumatic immune disease. Methods: Convenience sampling method was used to select inpatients who received immunoadsorption therapy from January 2020 to December 2022 in the rheumatology and Immunology department of a 3A hospital in Jingzhou City. 30 patients from January 2020 to June 2021 were selected as control group, and 30 patients from July 2021 to December 2022 were selected as observation group. The control group was given routine nursing. On the basis of the control group, the observation group used a clinical nursing pathway for intervention during the perioperative period of immunosorbent therapy. The incidence of adverse reactions, patient satisfaction, and nurse satisfaction during immunosorbent therapy between the control group and the observation group were compared. Results: After intervention, the incidence of adverse reactions in the observation group was significantly lower than that in the control group, while patient satisfaction and nurse satisfaction in the observation group were significantly higher than those in the control group. The results are all statistically significant (P Conclusion: Clinical nursing pathway is beneficial to reduce the incidence of adverse reactions in patients with immunoadsorption during peri-treatment and improve the satisfaction of patients and nurses.展开更多
Objective:To observe the effect of Chinese medicine therapy combined with psychological intervention(combined therapy) on the clinical symptoms and levels of blood lipids and sex hormones of patients of peri-menopa...Objective:To observe the effect of Chinese medicine therapy combined with psychological intervention(combined therapy) on the clinical symptoms and levels of blood lipids and sex hormones of patients of peri-menopausal syndrome complicated with hyperlipidemia.Methods:With the use of a randomizing digital table method,185 patients that fit the registration standard were randomly assigned to three groups.The 59 cases in Group A were treated with two Chinese patents,Kunbao Pill(坤宝丸) and Modified Xiaoyao Pill(加味逍遥丸);the 63 in Group B received psychological intervention alone;and the 63 in Group C were treated with both(the combined therapy),with the treatment course for all six months.The items of observation included: (1) scoring by SCL-90 on eight factors and seven symptoms;(2) scoring on Chinese medicine symptoms by Kupermann scale,including anxiety and bad temper,scorching sense ation with sweating,dizziness,tinnitus, soreness and weakness of the loin and knees,palpitation,insomnia,lassitude,weakness,and hyposexuality; (3) blood contents of total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C),apoprotein Al(ApoAl) and B(ApoB);(4) levels of sex hormones, including estradiol(E_2),progesterone(P),pituitary prolactin(PRL),follicular stimulating hormone(FSH),and luteinzing hormone(LH) in some randomly selected patients;(5) adverse reaction;and(6) one-year follow-up study on long-term effect.Results:A total of 21 patients(6,8,and 7 cases in Groups A,B,and C,respectively) dropped out;the drop-out rate was insignificant among groups.(1) The markedly effective rates in Group A, B,and C were 26.42%(14/53),18.18%(10/55),and 53.57%(30/56),respectively,and the total effective rates in them were 64.15%(34/53),50.91%(28/55),and 87.50%(49/56),respectively,suggesting the therapeutic efficacy in Group C was significantly better than that in Groups A and B(P〈0.01).(2) SCL-90 scoring showed that the total scores decreased significantly after treatment in Group C(P〈0.01),but remained unchanged in Groups A and B(P〉0.05).(3) Scoring on Chinese medicine symptoms showed the same results as shown by SCL-90 scoring in terms of total scores and individual symptoms,except that menstrual disorder and amenorrhea were unchanged in all three groups(P〉0.05).(4) Levels of HDL-C,ApoAl,and E_2 increased and those of TG,TC,LDL-C,ApoB,FSH,and LH decreased after treatment in Group C,reaching near normal levels;similar trends of blood lipids were shown in Group A,but the level of sex hormones was unchanged.In Group B all the above-mentioned indices were unchanged(P〉0.05).(5) A one-year follow-up study showed the markedly effective rate and the total effective rate in Group C were higher than those in the other two groups respectively(P〈0.01).(6) No adverse reaction was found.Conclusion:Chinese medicine therapy combined with psychological intervention could not only improve the nervous symptoms,but also regulate the blood levels of lipids and sex hormones in patients of peri-menopausal syndrome complicated with hyperlipidemia.展开更多
文摘The conditions in which we live nowadays contribute to exposure of our bodies to harmful factors such as UV radiation, pollution, smoking, poor eating habits, low physical activity, stress, which thereafter lead to the acceleration of skin aging process. In women, the process is additionally dependent on the menopause, as a result of the disappearance of hormones, the process is faster. Physiological changes that occur in women’s body during perimenopausal and menopausal period affect their sexual function: pain during an intercourse, decreased libido, lack of agitation. Deficiency of hormones, besides skin changes, leads to vaginal dryness, accompanied by inflammation, often correlated with discharge and burning. As a result of the loss of hyaluronic acid labia become slack and less moisturized. In addition, there has been observed: a gradual loss of pigment and hair, involution of the clitoris, and involution and sticking of labia minora, lipoatrophy of labia majora with subsequent reduction in their volume and thinning the lining around the vaginal opening. This article presents processes of skin aging. It describes mechanisms of intrinsic and extrinsic aging. It also presents the mechanisms of accelerated aging in women in perimenopausal period—accelerated skin aging dependent on hormonal factors associated with the loss of ovarian function. The research presents how the hormonal loss influences woman’s body, her genitals—its functionality and aesthetic look. It also shows how using filler treatments in gynecology can restore the aesthetic appearance of female genital and improve their functionality.
文摘Objective: To explore the correlation of menopausal index with sex hormones, lipid metabolism and cytokines in perimenopausal women. Methods: A total of 208 perimenopausal women who were treated in this hospital between September 2015 and March 2018 were selected as the perimenopausal group and 150 healthy young women (20-30 years old) who received physical examination in this hospital during the same period were selected as the control group. The differences in the levels of Kupperman menopausal index as well as the contents of sex hormones, lipid metabolism indexes and inflammatory factors were compared between the two groups. Results: Kupperman menopausal index of perimenopausal group was higher than that of control group;sex hormones E2, P and T contents were lower than those of control group whereas FSH content was higher than that of control group;lipid metabolism indexes TC and LDL-C contents were higher than those of control group whereas HDL-C content was lower than that of control group;inflammatory factors IL-1β, IL-2, IL-18 and IFN-γ contents were higher than those of control group;the Kupperman menopausal index of perimenopausal women was negatively correlated with E2, P, T and HDL-C contents, and positively correlated with FSH, TC, LDL-C, IL-1β, IL-2, IL-18 and IFN-γ contents. Conclusion: The Kupperman menopausal index in perimenopausal women abnormally increases, and the specific level is directly correlated with the female sex hormones, lipid metabolism disorder and systemic microinflammation.
文摘Objective: The paper aims to investigate the clinical nursing pathway (CNP) in the application of immunosorption therapy in patients with rheumatic immune disease. Methods: Convenience sampling method was used to select inpatients who received immunoadsorption therapy from January 2020 to December 2022 in the rheumatology and Immunology department of a 3A hospital in Jingzhou City. 30 patients from January 2020 to June 2021 were selected as control group, and 30 patients from July 2021 to December 2022 were selected as observation group. The control group was given routine nursing. On the basis of the control group, the observation group used a clinical nursing pathway for intervention during the perioperative period of immunosorbent therapy. The incidence of adverse reactions, patient satisfaction, and nurse satisfaction during immunosorbent therapy between the control group and the observation group were compared. Results: After intervention, the incidence of adverse reactions in the observation group was significantly lower than that in the control group, while patient satisfaction and nurse satisfaction in the observation group were significantly higher than those in the control group. The results are all statistically significant (P Conclusion: Clinical nursing pathway is beneficial to reduce the incidence of adverse reactions in patients with immunoadsorption during peri-treatment and improve the satisfaction of patients and nurses.
文摘Objective:To observe the effect of Chinese medicine therapy combined with psychological intervention(combined therapy) on the clinical symptoms and levels of blood lipids and sex hormones of patients of peri-menopausal syndrome complicated with hyperlipidemia.Methods:With the use of a randomizing digital table method,185 patients that fit the registration standard were randomly assigned to three groups.The 59 cases in Group A were treated with two Chinese patents,Kunbao Pill(坤宝丸) and Modified Xiaoyao Pill(加味逍遥丸);the 63 in Group B received psychological intervention alone;and the 63 in Group C were treated with both(the combined therapy),with the treatment course for all six months.The items of observation included: (1) scoring by SCL-90 on eight factors and seven symptoms;(2) scoring on Chinese medicine symptoms by Kupermann scale,including anxiety and bad temper,scorching sense ation with sweating,dizziness,tinnitus, soreness and weakness of the loin and knees,palpitation,insomnia,lassitude,weakness,and hyposexuality; (3) blood contents of total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C),apoprotein Al(ApoAl) and B(ApoB);(4) levels of sex hormones, including estradiol(E_2),progesterone(P),pituitary prolactin(PRL),follicular stimulating hormone(FSH),and luteinzing hormone(LH) in some randomly selected patients;(5) adverse reaction;and(6) one-year follow-up study on long-term effect.Results:A total of 21 patients(6,8,and 7 cases in Groups A,B,and C,respectively) dropped out;the drop-out rate was insignificant among groups.(1) The markedly effective rates in Group A, B,and C were 26.42%(14/53),18.18%(10/55),and 53.57%(30/56),respectively,and the total effective rates in them were 64.15%(34/53),50.91%(28/55),and 87.50%(49/56),respectively,suggesting the therapeutic efficacy in Group C was significantly better than that in Groups A and B(P〈0.01).(2) SCL-90 scoring showed that the total scores decreased significantly after treatment in Group C(P〈0.01),but remained unchanged in Groups A and B(P〉0.05).(3) Scoring on Chinese medicine symptoms showed the same results as shown by SCL-90 scoring in terms of total scores and individual symptoms,except that menstrual disorder and amenorrhea were unchanged in all three groups(P〉0.05).(4) Levels of HDL-C,ApoAl,and E_2 increased and those of TG,TC,LDL-C,ApoB,FSH,and LH decreased after treatment in Group C,reaching near normal levels;similar trends of blood lipids were shown in Group A,but the level of sex hormones was unchanged.In Group B all the above-mentioned indices were unchanged(P〉0.05).(5) A one-year follow-up study showed the markedly effective rate and the total effective rate in Group C were higher than those in the other two groups respectively(P〈0.01).(6) No adverse reaction was found.Conclusion:Chinese medicine therapy combined with psychological intervention could not only improve the nervous symptoms,but also regulate the blood levels of lipids and sex hormones in patients of peri-menopausal syndrome complicated with hyperlipidemia.