Root canal therapy combined with endoscopic sinus surgery for odontogenic sinusitis:Efficacy comparison in a cohort study

BACKGROUND Odontogenic maxillary sinusitis,often triggered by dental issues like periapical periodontitis,significantly contributes to chronic sinusitis,mainly affecting adults around 50 years old,emphasizing the need for a multidisciplinary diagnostic and treatment approach.AIM To investigate the therapeutic effect and clinical value of root canal therapy combined with nasal endoscopic surgery compared with simple root canal the-rapy in the treatment of severe odontogenic maxillary sinusitis caused by peria-pical periodontitis.METHODS The clinical data,diagnosis,and treatment of 200 patients with severe odonto-genic maxillary sinusitis caused by periapical periodontitis from October 2020 to October 2021 were analyzed retrospectively.Among them,63 patients were treated with simple root canal therapy as the control group,and 137 patients were treated with root canal therapy combined with nasal endoscopic surgery as the observation group.The therapeutic effect,Lund-Kennedy endoscopic score,paranasal sinus Lund-Mackay score,complication rate,recurrence rate,and patient satisfaction were compared between the two groups.RESULTS First,we compared the effective rates:23 cases were cured,22 were improved,and 8 were ineffective in the control group,yielding a total effective rate of 84.90%.Meanwhile,97 cases were cured,34 improved,and 6 were ineffective in the observation group,resulting in a total effective rate of 95.62%.The observation group had a higher total effective rate compared with the control group(P<0.05).Second,we compared the Lund–Kennedy endoscopic score.Before treatment,no significant difference(P>0.05)was observed in this score between the two groups.After treatment,the Lund–Kennedy endoscopic score decreased in both groups.The Lund–Kennedy endoscopic score of the observation group at 3 and 6 mo after treatment was lower compared to that of the control group(P<0.05).Third,we compared the Lund–Mackay score of paranasal sinuses.Before treatment,there was no significant difference in this score between the two groups(P>0.05).After treatment,the Lund–Mackay scores of paranasal sinuses decreased in both groups.The Lund–Mackay scores of paranasal sinuses in the observation group at 3 and 6 mo after treatment were lower compared to those of the control group(P<0.05).Fourth,we compared the incidence and recurrence rate of complications.Three months after treatment,no significant difference was found in the incidence and recurrence rate of complications between the observation group(6.56%)and the control group(9.52%)(P>0.05).However,6 mo after treatment,the incidence and recurrence rate of complications in the observation group(2.91%)was significantly higher compared to that of the control group(12.69%)(P<0.05).Fifth,we compared patient satisfaction.Six months after treatment,the patient satisfaction of the observation group(93.43%)was significantly better than that of the control group(84.12%)(P<0.05).CONCLUSION Root canal therapy combined with nasal endoscopic surgery has a good therapeutic effect on severe odontogenic maxillary sinusitis caused by periapical periodontitis,and it can reduce the injury of maxillary sinus mucosa and bone,and significantly reduce the incidence of complications and recurrence rate.Meanwhile,it has high patient satisfaction and remarkable therapeutic effect,which is suggested to be popularized and applied in clinic.

The effect of green tea mouthwash (<i>Camellia sinensis</i>) on wound healing following periodontal crown lengthening surgery;a double blind randomized controlled trial

Green tea has been used as a traditional medicine since 2700 BC and several studies have shown that green tea polyphenols inhibit the growth of oral and periodontal pathogenic bacteria and can improve oral and gingival health. In this clinical study we investigated the effect of green tea mouthwash on microbial dental plaque and gingival inflammation following periodontal surgery. A total of 34 crown lengthening surgeries were included in this study. After removing periodontal dressing, green tea mouthwash for the test group and placebo for the patients in the control group were prescribed, and periodontal parameters were assessed at base line and after 2 weeks. Analysis of the data revealed the significant effect of green tea mouthwash on reducing Plaque index (PI), Gingival Index (GI) and Bleeding on probing (BOP). Therefore it would be recommended as a safe, anti-inflammatory and anti-microbial mouthwash for treating gingival inflammation and maintaining oral and gingival health.

Multi-disciplinary treatment of maxillofacial skeletal deformities by orthognathic surgery combined with periodontal phenotype modification:A case report

BACKGROUND Maxillofacial deformities are skeletal discrepancies that cause occlusal,functional,and esthetic problems,and are managed by multi-disciplinary treatment,including careful orthodontic,surgical,and periodontal evaluations.However,thin periodontal phenotype is often overlooked although it affects the therapeutic outcome.Gingival augmentation and periodontal accelerated osteogenic orthodontics(PAOO)can effectively modify the periodontal phenotype and improve treatment outcome.We describe the multi-disciplinary approaches used to manage a case of skeletal ClassⅢmalocclusion and facial asymmetry,with thin periodontal phenotype limiting the correction of deformity.CASE SUMMARY A patient with facial asymmetry and weakness in chewing had been treated with orthodontic camouflage,but the treatment outcome was not satisfactory.After examination,gingiva augmentation and PAOO were performed to increase the volume of both the gingiva and the alveolar bone to allow further tooth movement.After orthodontic decompensation,double-jaw surgery was performed to reposition the maxilla-mandibular complex.Finally,implant placement and chin molding were performed to restore the dentition and to improve the skeletal profile.The appearance and function were significantly improved,and the periodontal tissue remained healthy and stable.CONCLUSION In patients with dentofacial deformities and a thin periodontal phenotype,multi-disciplinary treatment that includes PAOO could be effective,and could improve both the quality and safety of orthodontic-orthognathic therapy.

Host-derived biomarkers in gingival crevicular fluid for complementary diagnosis of apical periodontitis

Apical periodontitis(AP) develops as a result of the host's immune inflammatory response to pulpal infection of the dental root canals that leads to the generation of an apical lesion of endodontic origin(ALEO) and potentially to systemic metabolic alterations. Misdiagnosed ALEO is not infrequent due to the lack of diagnostic tools to differentiate apical lesions of different natures. Despite the conservative endodontic treatment shows a high success rate, there are refractory cases that can not be identified early enough during follow up. This evidences the need to develop complementary diagnostic tools, such as oral fluid biomarker analysis. Gingival crevicular fluid(GCF) is a serum transudate that becomes an exudate under inflammatory conditions, carrying molecules from local periodontal tissuesand general circulation than can be harvested noninvasively. We aimed to review the available literature analyzing GCF composition in AP patients to evaluate whether GCF has any potential for complementary diagnosis. To the date, only few studies addressing changes of GCF components in AP are available. Most studies support GCF modifications in specific components in APaffected teeth, suggesting that it might reflect periapical inflammation. GCF has potential for diagnostic tool, treatment follow-up and eventually to assess systemic comprise.

3D打印技术在口腔医学、颌面外科修复重建中的作用与优势

背景:3D打印技术独特的优势为口腔医学的发展开拓了新的思路。目的:总结3D打印技术在口腔医学中的应用进展。方法:利用计算机检索中国知网和PubMed数据库,以“3D打印,口腔科学”为中文检索词进行分类检索,以“Three-Dimensional printing,stomatology,Dentistry,prosthodontics,oral implant,orthodontics,oral and maxillofacial surgery,dental pulp disease,periodontitis”为英文检索词进行关键词检索,经阅读初步排除与文章主题不相符的文献,根据纳入标准和排除标准,最终纳入54篇文献进行汇总。结果与结论:在口腔医学领域,3D打印技术的应用范围正迅速拓展,逐步取代传统的临床诊断和治疗方式,通过结合数字化技术和先进的材料科学,3D打印可以精确地创建三维模型,为口腔疾病治疗提供了个性化解决方案,确保医师能够在手术前进行详尽的规划和预览,提高手术的安全性。3D打印技术在定制化义齿制作、个性化种植、无托槽隐形矫治等多方面呈现出了显著优势,基于此项技术,医师可以根据患者口腔结构和需求实行精准设计与制作,为患者带来良好的治疗体验和预后效果。3D打印技术在微创牙髓治疗及牙周组织再生方面也展现出了巨大潜力,3D打印的支架和植入物可为干细胞提供适宜环境,促进牙周组织的再生和修复,但目前3D打印在再生治疗仍处于发展阶段,还需更多的研究和实践来验证其临床应用的效果和安全性。

Use of a new retrograde filling material(Biodentine) for endodontic surgery: two case reports

Mineral trioxide aggregate（MTA） is considered at the present time as the gold standard for root-end filling in endodontic surgery.However, this biocompatible material presents several drawbacks such as a long setting time and handling difficulties. The aim of this article is to present a new commercialized calcium silicate-based material named Biodentine with physical improved properties compared to MTA in a clinical application. Two endodontic microsurgeries were performed by using specific armamentarium（microsurgical instrumentation, ultrasonic tips） under high-power magnification with an operatory microscope. Biodentine was used as a root-end filling in order to seal the root canal system. The two cases were considered completely healed at 1 year and were followed for one more year. The 2-year follow-up consolidated the previous observation with absence of clinical symptoms and radiographic evidence of regeneration of the periapical tissues.

Modified Widman flap procedure: With or without periodontal dressing?

Aim: The purpose of this study was to evaluate the postoperative pain experience and gingival indexes with and without the use of periodontal dressing after Modified Widman flap procedure. Materials and Methods: Twenty patients requiring comparable bilateral flap procedures were selected. One quadrant of each jaw randomly received periodontal dressing after the surgery while the other one didn’t. Plaque Index (PI), Sulcus Bleeding Index (SBI) and Probing Depth (PD) were measured prior to the surgery, one week and 2 weeks after the surgery. Postoperative pain experience also was assessed at the conclusion of study. Results: Results showed no significant differences between dressed and undressed segments regarding changes in probing depth, plaque index or sulcus bleeding index. However patients reported significantly less pain postoperatively when the dressing was used Conclusion: Pain is reduced by periodontal dressing but No significant differences between dressed and undressed segments regarding changes in probing depth, plaque index or sulcus bleeding index.

Cathepsin C promotes the progression of periapical periodontitis

Although the role of cathepsin C (Cat C) in inflammation is gradually being elucidated, its function in periapical periodontitis, which is one of the most common infectious diseases worldwide, has not been studied. This study evaluated a surgically-induced model of periapical periodontitis in cathepsin C (Cat C) knock-down (KD) mice, which was constructed with a tetracycline operator, to evaluate the role of Cat C in the pathogenesis and progression of periapical periodontitis. Our results showed, for the first time, that there was a statistically significant increase in the expression of Cat C as periapical periodontitis progressed;this increase started from 1 week after surgery and reached a peak at 3 weeks after surgery, before gradually decreasing. The volume of periapical bone resorption in Cat C KD mice was significantly smaller than that in wild-type mice at 3 and 4 weeks after surgery (P<0.05). Inflammatory cell infiltration into the apical tissues of wild-type mice was also significantly higher than that of Cat C KD mice. The expression of receptor activator of nuclear factor-j B ligand (RANKL) in wild-type mice was also higher than that in Cat C KD mice. The difference in the number of osteoclasts in the apical area between the two groups was statistically significant after 2 weeks. Correlation analysis showed that there was a significant correlation between Cat C and RANKL expression (r= 0.835). Therefore, our data indicated that Cat C promoted the apical inflammation and bone destruction in mice.

Enhancement of Periodontal Healing by Application of a Novel Ointment Compared with Hyaluronic Acid, Histological Observation in Animal Model

Objectives:?The early healing of the periodontal wound in oral cavity may be critical to the treatment outcome. Thus, we made a novel ointment based on natural constituents that our recent investigation suggested a positive therapeutic effects on gingival wounds. The present study was conducted to evaluate the role of this novel biomaterial on periodontal wound healing including soft as well as hard tissue. Materials and Methods: Experimental periodontitis was induced by wire tied around the cement-enamel junction of I2, P1, P3?and M1?in six adult, healthy beagle dogs. After 3 months, mucoperiostal flap elevated and root surfaced was thoroughly scaled and planed. Randomly, three materials including our ointment with two different ratios including materials A and B and hyluronic acid were applied topically and then the flaps were repositioned and sutured. Three dogs at day 7 and the three remaining ones two weeks post-surgery were sacrificed and histological changes were monitored. Results: The result of this study showed that the local applications of this novel ointment promoted the healing process particularly fibroblast proliferation and collagen density remarkably in comparison with hyaluronic acid and control group. Besides, histological finding of our material revealed that in general terms had all the hallmarks of complete healing two weeks post operatively. Conclusion: Our novel material appeared to have outstanding effect on periodontal wound healing which can improve the periodontal healing consequences and provide better strength of periodontal wound flap. From a clinical standpoint, it could play an important role for better repair in diabetic patients who frequently present difficulties in mucosal and cutanous wound healing.

Application of advanced platelet-rich fibrin for through-and-through bony defect during endodontic surgery:Three case reports and review of the literature

BACKGROUND The use of advanced platelet-rich fibrin(A-PRF)membranes for guided bone and tissue regeneration in through-and-through defects after endodontic surgery was explored in three cases.CASE SUMMARY Herein,three patients presented to the endodontic clinic suffering from apical periodontitis,associated with large bone resorption and related to previously endodontically treated teeth.Periapical surgery was indicated in these cases and the osteotomy site was covered by A-PRF membrane.Cone-beam computed tomography(CBCT)was used to assess the cases before and after the surgery.CONCLUSION Four months post-surgery,the recall CBCT scan showed complete obliteration of the osteotomy with newly formed bone.A-PRF membrane showed promising results and was an advantageous addition to surgical endodontic treatment.

A randomized retrospective clinical study on the choice between endodontic surgery and immediate implantation

Background:Periapical endodontic surgery(PES)for root amputation and tooth replacement by immediate implant placement are two possible treatment options for bone lesions in the root apex of a tooth that has previously undergone endodontic treatment.Treatment methods are performed when the effectiveness of orthograde canal revision is questionable or when such treatment cannot be performed.The effectiveness of these methods varies from study to study.Objective:clinical evaluation of the efficacy of periapical endodontic surgery for root amputation and immediate implant placement with simultaneous tooth extraction in the proximate and long-term treatment.Materials and methods:The study included 183 patients between the ages of 24 and 63.Patients were divided into 2 groups;group I-endodontic surgery was performed to resect the apex of the tooth root(108 patients)and group II-an operation to install an implant with simultaneous tooth extraction(75 patients).In group I,in 36 cases,PES was performed in the area of the first molars and premolars,and 72 cases in the area of incisors and canines.In group II,75 patients received 231 implants.Results:In all 108 patients of group I in the postoperative period and within 1 month,the wounds healed without complications.In none of the 36 operated premolars and molars,there was no definitive elimination of the radiographic bone loss(Rude grade 2 and 3)after 12 months.In the area of incisors and canines,complete healing was observed only in 37.5%of cases(I class according to Rud).In group II,out of 184 implants installed immediately after tooth extraction,one was removed one month after implantation.In other cases,all implants were successfully integrated with the subsequent fabrication of prosthetic construction.Conclusion:The complex“implant(installed in the socket of the tooth immediately after its removal)-bone-soft tissues-prosthetic construction”is stable over time in terms of functional and aesthetic parameters,preservation of bone tissue,and mucous membrane.

重点环节护理模式在慢性根尖周炎患者根管治疗中的临床效果

目的探讨重点环节护理模式应用于慢性根尖周炎患者根管治疗中的临床效果。方法94例慢性根尖周炎行根管治疗的患者随机分为两组,对照组予以常规护理,观察组予以重点环节护理模式,比较两组的焦虑症状、疼痛程度以及并发症。结果干预后,观察组的SAS评分、NRS评分均低于对照组(P<0.05)。观察组的并发症发生率为6.38%,低于对照组的21.28%(P<0.05)。结论重点环节护理模式有利于减轻慢性根尖周炎根管治疗患者的焦虑症状及疼痛程度,降低并发症发生风险。

探讨IL-34在小鼠慢性根尖周炎模型中的动态表达

目的:探讨白介素-34(IL-34)在小鼠慢性根尖周炎模型中的表达及变化情况。方法:选择35只SD小鼠,对其下颌第一磨牙开髓制造根尖周炎的模型,并在0、7、14、21、28 d随机脱颈处死,解剖分离含有第一磨牙的下颌骨,进行影像学检查,了解模型中根尖周的破坏情况。将下颌骨标本制备切片,进行HE染色观察根尖周组织病理学改变以及抗酒石酸酸性磷酸酶(TRAP)染色检测破骨细胞,实时荧光定量PCR(RT-qPCR)检测IL-34与肿瘤坏死因子-α(TNF-α)在根尖周炎模型中的动态表达。结果:影像学检查显示,0~7 d根尖无明显异常,14~21 d开始出现轻度根尖破坏,28 d根尖阴影变大,范围增宽。HE染色显示,0 d根尖周组织正常未见明显改变,7 d炎性因子浸润开始增多,14 d出现明显的骨质破坏以及坏死中心,21 d炎性渗出减少,小范围的骨质破坏区域增多,28 d炎性细胞浸润趋于稳定,小范围的骨质破坏连接成片,大范围的骨质破坏形成。TRAP染色显示,0 d几乎看不到破骨细胞,7~14 d破骨细胞数目明显增加,在21 d时到达高峰,28 d时轻微下降,但7、14、21、28 d时均高于0 d(P<0.05)。RT-qPCR检测显示,7~28 d的IL-34及TNF-α的mRNA表达量均逐渐增高,且在14 d到达顶峰,在21 d呈现下降的趋势,28 d又呈现上升趋势,在7~28 d的表达量均高于0 d(P<0.05),并且呈现正相关关系。结论:IL-34的mRNA表达量随着根尖周炎病变程度发展而改变,尤其是与骨质破坏的程度相关,并与TNF-α有着密切的联系,出现短暂的表达量下降说明其表达受到了抑制,有助于为临床治疗提供方向。

Nd:YAP激光消毒与盐酸米诺环素软膏辅助龈下刮治及根面平整术治疗中重度慢性牙周炎的效果分析

目的探讨Nd:YAP激光治疗机消毒与盐酸米诺环素软膏辅助龈下刮治及根面平整术对中重度慢性牙周炎的治疗效果。方法随机选取2020年1月—2023年6月常州市口腔医院收治的60例中重度慢性牙周炎患者为研究对象,根据治疗方法不同分为对照组和研究组,各30例。对照组进行龈下刮治及根面平整术治疗,研究组进行Nd:YAP激光消毒与盐酸米诺环素软膏配合龈下刮治与根面平整术治疗,比较两组治疗效果、不良反应发生情况、牙周指数评分及牙龈沟探诊深度。结果研究组治疗总有效率为96.67%(29/30),高于对照组的73.33%(22/30),差异有统计学意义(χ^(2)=4.706,P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。研究组牙龈指数评分、龈沟出血指数评分、牙龈沟探诊深度指数、菌斑指数评分均低于对照组,差异有统计学意义(P均<0.05)。结论中重度慢性牙周炎施以Nd:YAP激光消毒与盐酸米诺环素软膏配合龈下刮治与根面平整术治疗的效果更好,能够有效改善患者的牙周指标,并且降低不良反应发生率。

基于MobileNetV3网络的龋病和根尖周炎根尖片的诊断

目的研究深度学习技术智能诊断龋齿和根尖周炎的效果,初步探讨深度学习在口腔疾病诊断中的应用价值。方法以2298张包含健康牙齿、龋病、根尖周炎的根尖片数据集为研究对象,随机划分为1573张训练集图像,233张验证集图像以及492张测试集图像。通过多种神经网络对比验证,选择性能较好的MobileNetV3网络模型应用于牙病诊断,并通过调整网络超参数优化模型。采用精确率、准确率、召回率和F1分数评估模型识别龋齿和根尖周炎的能力,并使用类激活热力图对网络模型性能进行可视化分析。结果基于MobileNetV3网络模型的牙齿病变检测算法对健康牙齿、龋病和根尖周炎进行分类的精确率、召回率和准确率分别为99.42%、99.73%和99.60%,F1分数为99.57%,达到了较为理想的智能诊断效果。可视化类激活热力图也显示出网络模型能够较为准确地提取牙科病变的特征。结论基于MobileNetV3网络模型的牙齿病变检测算法能够排除图像质量和人为因素的干扰,具有较高的诊断准确率,可满足口腔医学教学和临床应用需求。

GTR联合根尖手术治疗牙周牙髓联合病变伴重度牙槽骨缺损上颌磨牙1例

牙周牙髓联合病变涉及牙髓和牙周组织,其诊疗难度较大,预后一般不佳。本文报道1例牙周源性的牙周牙髓联合病变伴重度牙槽骨缺损的上颌第一磨牙,经根管治疗术、牙周基础治疗、引导性组织再生术(guided tissue regeneration, GTR)和同期根尖手术联合治疗,达到意向性保留患牙的目的。

口腔主动健康与肥胖

口腔健康与全身健康息息相关。常见的口腔慢性疾病,如牙周炎和根尖周炎,一方面可影响牙槽骨和牙龈等口腔软硬组织健康,另一方面还可能引起全身慢性低度炎症、氧化应激水平升高和菌群失调等全身症状,而这些全身健康状况的改变可加剧肥胖进展。因此,通过口腔主动健康干预,如保持良好的口腔卫生习惯、改变饮食结构、主动寻求口腔检查等,不仅可有效预防和治疗口腔炎症性疾病,还可能通过改善全身健康状态从而解决肥胖问题。本文深入探讨口腔炎症性疾病对肥胖的影响及其内在机制,定义了“口腔主动健康”概念,并系统总结其对口腔炎症性疾病的防治作用,讨论通过口腔主动健康策略改善肥胖的可能性。

ProTaper Universal、M3镍钛锉结合超声荡洗在慢性根尖周病患者根管治疗中的效果对比

目的探究ProTaper Universal、M3镍钛锉结合超声荡洗在慢性根尖周病患者根管治疗中的治疗效果。方法前瞻性选取2022年1月至12月大同市第五人民医院收治的慢性根尖周病患者106例,所有患者均接受根管治疗,按照随机数字表法将其分为对照组和研究组,每组各53例。对照组进行ProTaper Universal、M3镍钛锉结合注射器冲洗治疗,研究组进行ProTaper Universal、M3镍钛锉结合超声荡洗治疗。比较两组间玷污层评分、术后疼痛情况、根管临床预备时间、充填情况,并对治疗效果进行评价。结果研究组根上段、根中段、根下段的玷污层评分分别为(2.05±0.87)、(2.88±1.05)、(3.66±0.74)分,均低于对照组[(2.66±1.02)、(4.05±0.85)、(4.77±0.41)分],差异均有统计学意义(P<0.05)。研究组和对照组的根管预备疼痛情况比较中,研究组2、3级疼痛占比低于对照组,0、1级疼痛占比高于对照组,且研究组术后疼痛率为41.51%,低于对照组(62.26%),差异均有统计学意义(P<0.05)。研究组与对照组的根管充填合格率比较,差异无统计学意义(P>0.05),研究组的根管预备时间及根管治疗时间分别为(9.11±0.78)、(44.52±2.36)s,均短于对照组[(13.88±2.15)、(51.55±5.48)s],差异均有统计学意义(P<0.05)。研究组的治疗有效率为88.68%,高于对照组(73.58%),差异有统计学意义(P<0.05)。结论ProTaper Universal和M3镍钛锉结合超声荡洗在慢性根尖周病根管治疗中表现出更良好的治疗效果和较低的术后疼痛水平,可改善患者的玷污层清洁情况。

青少年局限性海绵状牙龈增生1例

青少年局限性海绵状牙龈增生(LJSGH)是一种具有独特病理表现的牙龈过度增生性疾病,其临床表现不典型,病因和发病机制尚不明确,在国内尚未有病例报道。该病的诊断主要依靠病理检测,治疗后存在复发可能性,最佳治疗方法仍缺乏一定的循证医学证据。本文报道1例LJSGH,并结合文献复习,对其临床特点、病理学特征和治疗进行总结,为该病的诊治提供参考。

牙周炎患者牙周再生性手术后不同时机正畸治疗的临床效果观察

目的:探究牙周炎患者牙周再生性手术后不同时机正畸治疗的临床效果。方法:选取笔者医院2020年1月-2021年9月收治的90例牙周炎患者,分为研究组(45例)及对照组(45例),两组患者均行牙周再生性手术,对照组术后6个月行正畸治疗,研究组术后4周行正畸治疗。记录两组菌斑指数(Plaque index,PLI)、牙周探诊深度(Periodontal probing depth,PPD)、临床附着丧失(Clinical attachment loss,CAL)、探查时出血(Bleeding on probing,BOP)及牙周闭锁率,炎性因子水平[白介素-1β(Interleukin-1β,IL-1β)、干扰素-γ(Interferon-γ,INF-γ)及白介素-17(Interleukin-17,IL-17)]以及并发症发生情况。结果:两组牙周袋闭锁率对比,差异无统计学意义(χ^(2)=0.932,P=0.334)。正畸治疗后,两组牙周PPD、PLI、CAL及BOP均较治疗前减少(P<0.05),INF-γ、IL-1β及IL-17下降(P<0.05),两组牙周指标、炎性因子水平及并发症比较,差异无统计学意义(P>0.05)。结论:牙周炎患者牙周再生性手术完成4周后行正畸可缩短治疗时间,改善牙周组织状况,减少炎症反应,安全性高。