从番荔枝内生真菌Periconia sp. F-31的次生代谢产物中分离得到3个新化合物,通过多种波谱学方法及计算ECD鉴定了所分离化合物的结构,分别为二氯取代的异香豆素pericochlorosin A (1)、含氯取代苯酚化合物pericochlorosin B (2)和十氢化...从番荔枝内生真菌Periconia sp. F-31的次生代谢产物中分离得到3个新化合物,通过多种波谱学方法及计算ECD鉴定了所分离化合物的结构,分别为二氯取代的异香豆素pericochlorosin A (1)、含氯取代苯酚化合物pericochlorosin B (2)和十氢化萘衍生物pericoannosin G (3)。药理活性评价表明,化合物2具有较强的抗HIV活性,其IC50为2.2μM。展开更多
A new polyketide synthase-nonribosomal peptide synthetase （PKS-NRPS） hybrid metabolite, named pericoannosin B （1）, was isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona rnuricata. Th...A new polyketide synthase-nonribosomal peptide synthetase （PKS-NRPS） hybrid metabolite, named pericoannosin B （1）, was isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona rnuricata. The structure and absolute configuration were elucidated by means of extensive spectroscopic analyses （HRMS, NMR, IR, and CD）.展开更多
基金National Natural Science Foundation of China(Grant No.81773607)CAMS Innovation Fund for Medical Sciences(Grant Nos.CIFMS-2018-I2M-3-005 and CIFMS-2016-I2M-2-002)the Drug Inn ovation Major Project(Grant No.2018ZX09711001-001-001)
文摘从番荔枝内生真菌Periconia sp. F-31的次生代谢产物中分离得到3个新化合物,通过多种波谱学方法及计算ECD鉴定了所分离化合物的结构,分别为二氯取代的异香豆素pericochlorosin A (1)、含氯取代苯酚化合物pericochlorosin B (2)和十氢化萘衍生物pericoannosin G (3)。药理活性评价表明,化合物2具有较强的抗HIV活性,其IC50为2.2μM。
基金financially supported by the National Natural Science Foundation of China (Nos. 31170041 and 81402835)the National High Technology Research and Development Program of China (No. 2012AA091606)The National Infrastructure of Microbial Resources (No. NIMR-2015-3)
文摘A new polyketide synthase-nonribosomal peptide synthetase （PKS-NRPS） hybrid metabolite, named pericoannosin B （1）, was isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona rnuricata. The structure and absolute configuration were elucidated by means of extensive spectroscopic analyses （HRMS, NMR, IR, and CD）.
