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Pericryptal Fibroblast Sheath in Intestinal Metaplasia,Dysplasia and Carcinoma of the Stomach 被引量:1
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作者 Lu-ying Liu Yu Sun +3 位作者 Zhong-wu Li Guoshuang Feng Wei-cheng You Ji-you Li 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2009年第4期290-294,共5页
Objective: To investigate the existence of pericryptal fibroblasts sheath (PCFS) in normal gastric mucosa, intestinal metaplasia (IM), indefinite for dysplasia (I-Dys), low grade dysplasia (L-Dys), high grade... Objective: To investigate the existence of pericryptal fibroblasts sheath (PCFS) in normal gastric mucosa, intestinal metaplasia (IM), indefinite for dysplasia (I-Dys), low grade dysplasia (L-Dys), high grade dysplasia (H-Dys) and gastric cancer (GC), and its association with gastric carcinogenesis. Methods: In this study, we examined the existence of PCFS in normal gastric mucosa (N=10), IM (N=26), I-Dys (N=16), L-Dys (N=13), H-Dys (N=21) and GC (N=145) using immunohistochemical staining for two smooth muscle markers, alpha smooth muscle actin(α-SMA) and high molecular weight caldesmon (h-CD). The significance of PCFS was discussed, especially in association with gastric carcinogenesis. Results: The PCFS was recognized in 65.4%(17/26) of IM, 62.5%(10/16) of I-Dys and 23.1% (3/13) of L-Dys respectively. No PCFS was detected in H-Dys and GC. The PCFS was gradually reduced in IM, Dys and GC in sequence (P〈0.0001). Conclusion: The PCFS is associated with the differentiation of epithelium and involved in gastric carcinogenesis via epithelial-mesenchymal interaction. 展开更多
关键词 pericryptal fibroblasts sheath (PCFS) Gastric cancer (GC) CARCINOGENESIS Intestinal metaplasia (IM) DYSPLASIA
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胃窦黏膜肠上皮化生类型与程度的关系及其临床意义 被引量:3
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作者 刘杰英 韩艳春 +1 位作者 杨东霞 刘鲁英 《临床与实验病理学杂志》 CAS CSCD 北大核心 2011年第2期134-137,共4页
目的探讨胃窦黏膜肠上皮化生类型与程度的关系及其临床意义,揭示胃黏膜肠化的特性及其发生机制。方法通过光镜观察和免疫组化染色检测99例胃窦黏膜肠化的类型、程度、肠化腺体周围pericryptal fibroblast sheath(PCFs)、同源异形盒基因C... 目的探讨胃窦黏膜肠上皮化生类型与程度的关系及其临床意义,揭示胃黏膜肠化的特性及其发生机制。方法通过光镜观察和免疫组化染色检测99例胃窦黏膜肠化的类型、程度、肠化腺体周围pericryptal fibroblast sheath(PCFs)、同源异形盒基因CDX2蛋白的表达及其之间的相互关系。结果不同程度胃窦黏膜肠化病变其肠化类型存在显著性差异,轻度肠化病变中Ⅰ型肠化所占的比例显著高于中、重度肠化(P<0.001),肠化的类型与程度密切相关(r=0.540,P<0.001)。肠化腺体周围是否存在PCFs与CDX2蛋白表达显著正相关(r=0.584,P<0.001)。结论肠化的程度间接反映了肠化的类型。在临床工作中,通过对肠化的程度进行分级,粗略判断肠化的类型及其是否需要密切随访是可行的。 展开更多
关键词 胃黏膜 肠上皮化生 同源异形盒基因CDX2 pericryptal FIBROBLAST SHEATH
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