Objectives: To determine the percentage of women who accepted a LARC after abortion, specify the interval time for the insertion of the LARC and compare such interval time with that of injectable and oral contraceptiv...Objectives: To determine the percentage of women who accepted a LARC after abortion, specify the interval time for the insertion of the LARC and compare such interval time with that of injectable and oral contraceptives. Patients and Methods: This is a prospective, descriptive and comparative study conducted in Libreville (Gabon), from February 1, 2013 to August 31, 2013. After receiving post-abortion care (PAC), all patients with stable general states were counseled about three types of contraceptive methods: combined oral contraceptive pills, LARCs (Jadelle? implants, Copper IUDs) and injectable Medroxyprogesterone Acetate (DMPA). Results: 231 women received PAC and among them 215 (93%) wanted to use one of the three proposed contraceptive methods. At the end of the study, only 193 women (89.7%) used contraception and 22 others (10.3%) abandoned their intentions. LARCs were used by 31 (16.0%) women. The average period for the insertion of LARCs was 15.4 ± 15.5 days with extremes of 1 to 53 days. This period for the insertion of LARCS was significantly longer than that of other methods (p < 0.001). LARCs were inserted more often after the 2nd day than immediately (same day) with a highly significant difference (p < 0.0001). Conclusion: LARCs could constitute an appropriate approach to reducing unintended pregnancies in Gabon. However, in order to increase their rates of use, it is necessary to improve women awareness.展开更多
The concept of the phase shift of triplet periodicity （TP） was used for searching potential DNA insertions in genes from 17 bacterial genomes. A mathematical algorithm for detection of these insertions has been deve...The concept of the phase shift of triplet periodicity （TP） was used for searching potential DNA insertions in genes from 17 bacterial genomes. A mathematical algorithm for detection of these insertions has been developed. This approach can detect potential insertions and deletions with lengths that are not multiples of three bases, especially insertions of relatively large DNA fragments （〉 100 bases）. New similarity measure between triplet matrixes was employed to improve the sensitivity for detecting the TP phase shift. Sequences of 17,220 bacterial genes with each consisting of more than 1,200 bases were analyzed, and the presence of a TP phase shift has been shown in -16% of analysed genes （2,809 genes）, which is about 4 times more than that detected in our previous work. We propose that shifts of the TP phase may indicate the shifts of reading frame in genes after insertions of the DNA fragments with lengths that are not multiples of three bases. A relationship between the phase shifts of TP and the frame shifts in genes is discussed.展开更多
目的:目前关于中心静脉置管相关性血栓预防的内容涉及范围广且尚未形成系统的循证方案。本研究对化学治疗(以下简称“化疗”)患者经外周中心静脉导管(peripherally inserted central catheter,PICC)维持期深静脉血栓预防的相关证据提取...目的:目前关于中心静脉置管相关性血栓预防的内容涉及范围广且尚未形成系统的循证方案。本研究对化学治疗(以下简称“化疗”)患者经外周中心静脉导管(peripherally inserted central catheter,PICC)维持期深静脉血栓预防的相关证据提取汇总,评价后形成最佳证据,为临床护理实践提供循证依据。方法:通过PIPOST(population,intervention,professional,outcome,setting,type of evidence)法构建临床循证问题。检索乔安娜布里格斯研究所(Joanna Briggs Institute、JBI)、UpToDate、CINAHL、Cochrane Library、中国知网、万方、维普、Embase、PubMed、Sinomed、医脉通、美国输液护士协会网站中关于PICC维持期化疗患者相关深静脉血栓的相关指南、系统评价、专家共识、随机对照试验、临床决策、证据总结。检索时限为建库至2023年10月。由研究人员对所纳入的文献进行质量评价、证据等级划分,提取最佳证据。结果:最终纳入13篇文献,包括临床决策1篇、指南2篇、证据总结2篇、系统评价3篇、专家共识1篇、随机对照试验4篇。从评估、置管前中后、物理预防、药物预防、健康教育5个方面总结出36条最佳证据。结论:本研究总结了PICC维持期化疗患者相关深静脉血栓预防的最佳证据。医务人员和决策者可以结合具体的情况选择证据,以形成完整科学的护理管理策略,提升护理质量。展开更多
文摘Objectives: To determine the percentage of women who accepted a LARC after abortion, specify the interval time for the insertion of the LARC and compare such interval time with that of injectable and oral contraceptives. Patients and Methods: This is a prospective, descriptive and comparative study conducted in Libreville (Gabon), from February 1, 2013 to August 31, 2013. After receiving post-abortion care (PAC), all patients with stable general states were counseled about three types of contraceptive methods: combined oral contraceptive pills, LARCs (Jadelle? implants, Copper IUDs) and injectable Medroxyprogesterone Acetate (DMPA). Results: 231 women received PAC and among them 215 (93%) wanted to use one of the three proposed contraceptive methods. At the end of the study, only 193 women (89.7%) used contraception and 22 others (10.3%) abandoned their intentions. LARCs were used by 31 (16.0%) women. The average period for the insertion of LARCs was 15.4 ± 15.5 days with extremes of 1 to 53 days. This period for the insertion of LARCS was significantly longer than that of other methods (p < 0.001). LARCs were inserted more often after the 2nd day than immediately (same day) with a highly significant difference (p < 0.0001). Conclusion: LARCs could constitute an appropriate approach to reducing unintended pregnancies in Gabon. However, in order to increase their rates of use, it is necessary to improve women awareness.
文摘The concept of the phase shift of triplet periodicity （TP） was used for searching potential DNA insertions in genes from 17 bacterial genomes. A mathematical algorithm for detection of these insertions has been developed. This approach can detect potential insertions and deletions with lengths that are not multiples of three bases, especially insertions of relatively large DNA fragments （〉 100 bases）. New similarity measure between triplet matrixes was employed to improve the sensitivity for detecting the TP phase shift. Sequences of 17,220 bacterial genes with each consisting of more than 1,200 bases were analyzed, and the presence of a TP phase shift has been shown in -16% of analysed genes （2,809 genes）, which is about 4 times more than that detected in our previous work. We propose that shifts of the TP phase may indicate the shifts of reading frame in genes after insertions of the DNA fragments with lengths that are not multiples of three bases. A relationship between the phase shifts of TP and the frame shifts in genes is discussed.
文摘目的:目前关于中心静脉置管相关性血栓预防的内容涉及范围广且尚未形成系统的循证方案。本研究对化学治疗(以下简称“化疗”)患者经外周中心静脉导管(peripherally inserted central catheter,PICC)维持期深静脉血栓预防的相关证据提取汇总,评价后形成最佳证据,为临床护理实践提供循证依据。方法:通过PIPOST(population,intervention,professional,outcome,setting,type of evidence)法构建临床循证问题。检索乔安娜布里格斯研究所(Joanna Briggs Institute、JBI)、UpToDate、CINAHL、Cochrane Library、中国知网、万方、维普、Embase、PubMed、Sinomed、医脉通、美国输液护士协会网站中关于PICC维持期化疗患者相关深静脉血栓的相关指南、系统评价、专家共识、随机对照试验、临床决策、证据总结。检索时限为建库至2023年10月。由研究人员对所纳入的文献进行质量评价、证据等级划分,提取最佳证据。结果:最终纳入13篇文献,包括临床决策1篇、指南2篇、证据总结2篇、系统评价3篇、专家共识1篇、随机对照试验4篇。从评估、置管前中后、物理预防、药物预防、健康教育5个方面总结出36条最佳证据。结论:本研究总结了PICC维持期化疗患者相关深静脉血栓预防的最佳证据。医务人员和决策者可以结合具体的情况选择证据,以形成完整科学的护理管理策略,提升护理质量。
