This article gives a general model using specific periodic special functions, which is degenerate elliptic Weierstrass P functions whose presence in the governing equations through the forcing terms simplify the perio...This article gives a general model using specific periodic special functions, which is degenerate elliptic Weierstrass P functions whose presence in the governing equations through the forcing terms simplify the periodic Navier Stokes equations (PNS) at the centers of cells of the 3-Torus. Satisfying a divergence-free vector field and periodic boundary conditions respectively with a general spatio-temporal forcing term which is smooth and spatially periodic, the existence of solutions which have finite time singularities can occur starting with the first derivative and higher with respect to time. The existence of a subspace of the solution space where v<sub>3</sub> is continuous and {C, y<sub>1</sub>, y<sub>1</sub><sup>2</sup>}, is linearly independent in the additive argument of the solution in terms of the Lambert W function, (y<sub>1</sub><sup>2</sup>=y<sub>2</sub>, C∈R) together with the condition v<sub>2</sub>=-2y<sub>1</sub>v<sub>1</sub>. On this subspace, the Biot Savart Law holds exactly [see Section 2 (Equation (13))]. Also on this subspace, an expression X (part of PNS equations) vanishes which contains all the expressions in derivatives of v<sub>1</sub> and v<sub>2</sub> and the forcing terms in the plane which are related as with the cancellation of all such terms in governing PDE. The y<sub>3</sub> component forcing term is arbitrarily small in ε ball where Weierstrass P functions touch the center of the ball both for inviscid and viscous cases. As a result, a significant simplification occurs with a v<sub>3 </sub>only governing PDE resulting. With viscosity present as v changes from zero to the fully viscous case at v =1 the solution for v<sub>3</sub> reaches a peak in the third component y<sub>3</sub>. Consequently, there exists a dipole which is not centered at the center of the cell of the Lattice. Hence since the dipole by definition has an equal in magnitude positive and negative peak in y<sub>3</sub>, then the dipole Riemann cut-off surface is covered by a closed surface which is the sphere and where a given cell of dimensions [-1, 1]<sup>3</sup> is circumscribed on a sphere of radius 1. For such a closed surface containing a dipole it necessarily follows that the flux at the surface of the sphere of v<sub>3</sub> wrt to surface normal n is zero including at the points where the surface of sphere touches the cube walls. At the finite time singularity on the sphere a rotation boundary condition is deduced. It is shown that v<sub>3</sub> is spatially finite on the Riemann Sphere and the forcing is oscillatory in y<sub>3</sub> component if the velocity v3</sub> is. It is true that . A boundary condition on the sphere shows the rotation of a sphere of viscous fluid. Finally on the sphere a solution for v3</sub> is obtained which is proven to be Hölder continuous and it is shown that it is possible to extend Hölder continuity on the sphere uniquely to all of the interior of the ball.展开更多
This article gives a general model using specific periodic special functions, that is, degenerate elliptic Weierstrass P functions composed with the LambertW function, whose presence in the governing equations through...This article gives a general model using specific periodic special functions, that is, degenerate elliptic Weierstrass P functions composed with the LambertW function, whose presence in the governing equations through the forcing terms simplify the periodic Navier Stokes equations (PNS) at the centers of arbitrary r balls of the 3-Torus. The continuity equation is satisfied together with spatially periodic boundary conditions. The yicomponent forcing terms consist of a function F as part of its expression that is arbitrarily small in an r ball where it is associated with a singular forcing expression both for inviscid and viscous cases. As a result, a significant simplification occurs with a v3(vifor all velocity components) only governing PDE resulting. The extension of three restricted subspaces in each of the principal directions in the Cartesian plane is shown as the Cartesian product ℋ=Jx,t×Jy,t×Jz,t. On each of these subspaces vi,i=1,2,3is continuous and there exists a linear independent subspace associated with the argument of the W function. Here the 3-Torus is built up from each compact segment of length 2R on each of the axes on the 3 principal directions x, y, and z. The form of the scaled velocities for non zero scaled δis related to the definition of the W function such that e−W(ξ)=W(ξ)ξwhere ξdepends on t and proportional to δ→0for infinite time t. The ratio Wξis equal to 1, making the limit δ→0finite and well defined. Considering r balls where the function F=(x−ai)2+(y−bi)2+(z−ci)2−ηset equal to −1e+rwhere r>0. is such that the forcing is singular at every distance r of centres of cubes each containing an r-ball. At the centre of the balls, the forcing is infinite. The main idea is that a system of singular initial value problems with infinite forcing is to be solved for where the velocities are shown to be locally Hölder continuous. It is proven that the limit of these singular problems shifts the finite time blowup time ti∗for first and higher derivatives to t=∞thereby indicating that there is no finite time blowup. Results in the literature can provide a systematic approach to study both large space and time behaviour for singular solutions to the Navier Stokes equations. Among the references, it has been shown that mathematical tools can be applied to study the asymptotic properties of solutions.展开更多
The South China Sea (SCS), in particular the northern SCS, is one of ocean areas where energetic internal solitary waves (ISWs)occur most frequently (Cai et al., 2012; Zheng, 2017). Based on the re-appearance pe...The South China Sea (SCS), in particular the northern SCS, is one of ocean areas where energetic internal solitary waves (ISWs)occur most frequently (Cai et al., 2012; Zheng, 2017). Based on the re-appearance period (RP) at an observation station, Ramp et al.(2004) divided the ISWs into two types:Type-a and Type-b. Type-a ISWs arrive regularly at the same time every day, i.e., the RP is about 24 h, and Type-b ISWs arrive about one hour late every day, i.e., the RP is about 25 h.展开更多
During 36 days the motion of two pendulums, which were restarted every hour, was continuously recorded. 869 “runs” were thus made, providing each time the precession during the run, as well as other parameters of th...During 36 days the motion of two pendulums, which were restarted every hour, was continuously recorded. 869 “runs” were thus made, providing each time the precession during the run, as well as other parameters of the motion. Spectral analysis of precession and ellipticity revealed a lunar component of 24 h 50 min, which can only result from an astral action, through mechanisms yet to be discovered. Indeed, an analysis was carried out of the influence of all classical perturbing factors: direct or indirect action of classical gravity, temperature, Earth’s magnetic field, etc.… None of them can explain this component, given its amplitude and phase. Its amplitude excludes also an explanation by general relativity. This is consistent with a major result that Allais claimed to have obtained during each one of the six continuous one-month-long experiments he carried out from 1954 to 1960. The numerous and very precise data provided by an automatic alidade give additional information to those gathered by Allais. All that confirms all the scientific interest that there would be to resume long-duration pendulum observations on a much more important scale: continuous observations for at least 2 years, and if possible more.展开更多
Mr. Chairman, Distinguished Members of the Committee, First of all, I would like to extend, on behalf of the Chinese delegation, our greetings and respects to all the distinguished members of the Committee. The Commit...Mr. Chairman, Distinguished Members of the Committee, First of all, I would like to extend, on behalf of the Chinese delegation, our greetings and respects to all the distinguished members of the Committee. The Committee has made enormous efforts and played an important role in promoting the purposes and principles of the Convention and reinforcing the global efforts to ban and prevent torture. The Chinese Government appreciates your endeavor and will continue to support the work of the Committee.展开更多
Madam Chairwoman, Mr. Rapporteur, Distinguished Members of the Committee, First of all, I would like to extend, on behalf of the Chinese delegation, our heartfelt greetings and respects to all the distinguished membe...Madam Chairwoman, Mr. Rapporteur, Distinguished Members of the Committee, First of all, I would like to extend, on behalf of the Chinese delegation, our heartfelt greetings and respects to all the distinguished members of the Committee. The Committee has made enormous efforts and played an important role in promoting the objectives and principles of the International Convention on Elimination of All Forms of Racial Discrimination. The Chinese Government appreciates your endeavour and will continue to support the work of the Committee.展开更多
In recent years, predictions of damage from earthquakes have been made on a prefectural scale, and expectations exist that more detailed damage forecasts should be made even on a city/town/village scale. It is importa...In recent years, predictions of damage from earthquakes have been made on a prefectural scale, and expectations exist that more detailed damage forecasts should be made even on a city/town/village scale. It is important to know detailed ground characteristics to do damage prediction on a fine scale. Using GIS is the best way to communicate this planar disaster prevention information to the general public. Yokohama City is the second largest city in Japan and developed as part of the capital region of Metropolitan Tokyo. Recently, the population of this city has reached about 3,000,000, and economic and cultural facilities, social infrastructure, and residential complexes are concentrated in this city. The capital region, including Yokohama City, was attacked by the 1923 Great Kanto Earthquake (M7.9) and Yokohama City was devastated by this earthquake. From the research so far, it is known that the H/V spectrum obtained from microtremor observation has a good correlation with the ground characteristics. The authors have been conducting high-density tremor observations that have been ongoing since the 1990s, mainly in Kanagawa Prefecture, Japan. Here, we have organized the predominant periods obtained from the observation results for Yokohama City. The entirety of Yokohama City was divided into 250 m × 250 m meshes and their centers were used as microtremor observation sites. Excluding sites that could not be used due to geographical conditions, observations were made at approximately 5700 sites. So, we compared the data obtained separately, such as the period, terrain classification, and amplification characteristics. The distribution maps of predominant periods in Yokohama City show that the city contains a lot of artificially transformed land, and consequently, the distribution of predominant periods is not uniform. However, it can be seen that the periods become gradually longer, moving from the higher elevation eastern part toward the lower elevation western part. Investigation of the site amplification factors and detailed topographical classifications indicates a clear correlation with the predominant period distribution.展开更多
Si/a-C:H(Ag)multilayer films with different modulation periods are prepared to test their potential applications in human body.The composition,microstructure,mechanical and tribological properties in the simulated bod...Si/a-C:H(Ag)multilayer films with different modulation periods are prepared to test their potential applications in human body.The composition,microstructure,mechanical and tribological properties in the simulated body fluid are investigated.The results show the concentration of Ag first decreases and then increases with the modulation period decreasing from 984 nm to 250 nm.Whereas the C content has an opposite variation trend.Notably,the concentration of Ag plays a more important role than the modulation period in the properties of the multilayer film.The a-C:H sublayer of the film with an appropriate Ag concentration(8.97 at.%)(modulation period of 512 nm)maintains the highest sp3/sp2 ratio,surface roughness and hardness,and excellent tribological property in the stimulated body fluid.An appropriate number of Ag atoms and size of Ag atom allow the Ag atoms to easily enter into the contact interface for load bearing and lubricating.This work proves that the Ag nanoparticles in the a-C:H sublayer plays a more important role in the tribological properties of the composite-multilayer film in stimulated body fluid condition.展开更多
Objective:To evaluate the therapeutic effect of Qinggan Huayu granule on mice with H22 liver cancer ascites tumor.Methods:A H22 liver cancer ascites mouse model was established by intraperitoneally injecting H22 liver...Objective:To evaluate the therapeutic effect of Qinggan Huayu granule on mice with H22 liver cancer ascites tumor.Methods:A H22 liver cancer ascites mouse model was established by intraperitoneally injecting H22 liver cancer cells.Mice were randomly divided into the model group,the Ganfule group(1.35 g/kg),the fluorouracil group(50 mg/kg i.p),the Qinggan Huayu granule groups at low(0.67 g/kg),medium(1.34 g/kg),and high(2.68 g/kg)doses.Then the mice were administered continuously for 10 days and body weight and abdominal circumference were monitored every 3 days.On day 11,eight rats in each group were randomly selected for dissection to detect the amount of peritoneal water,peritoneal permeability and histopathological changes.The remaining mice were observed for survival.In addition,the vascular endothelial growth factor A(VEGFA)and vascular endothelial growth factor receptor 2(VEGFR2)were determined by Western blotting.Results:Compared with the model group,the weight growth of mice in the fluorouracil group and the medium-dose and high-dose Qinggan Huayu granule groups was slower(P<0.05).Moreover,the abdominal circumference of mice in each treatment group was increased slowly.There were significant differences in abdominal circumference between the fluorouracil group,the medium-dose group and the control group from day 6(P<0.05)while the abdominal circumference of the high dose group was significantly smaller than that of the control group from day 12(P<0.05).Moreover,compared with the model group,the amount of ascites in the medium-and high-dose Qinggan Huayu granule groups was decreased significantly(P<0.05).The optical density value of ascites supernatant in medium-and high-dose Qinggan Huayu granule group and the fluorouracil group decreased significantly(P<0.05)and the survival period of the medium-dose Qinggan Huayu granule group and the fluorouracil group was prolonged prominently(P<0.05).There was no significant difference in the low-dose Qinggan Huayu granule group and the Ganfule group.Peritoneal histopathological assay showed more complete peritoneal structure,less edema and less angiogenesis of the peritoneum in the fluorouracil group and the medium-and high-dose Qinggan Huayu granule group,which was better than that of the Ganfule group and the low-dose group.Compared with the model group,the expressions of VEGFA and VEGFR2 in the medium-dose Qinggan Huayu granule group decreased significantly(P<0.05,P<0.01).Conclusion:Qinggan Huayu granule can inhibit ascites production in the mice model with H22 liver cancer ascites tumor,prolong the survival of mice,and reduce peritoneal permeability and suppress the increase of peritoneal neovascularization.The mechanism may be related to the inhibition of VEGF/VEGFR pathway.展开更多
Objective To explore whether age,disease severity,cytokines and lymphocytes in H1N1 influenza A patients correlate with viral load and clearance.Methods Total of 70 mild and 16 severe patients infected with H1N1 influ...Objective To explore whether age,disease severity,cytokines and lymphocytes in H1N1 influenza A patients correlate with viral load and clearance.Methods Total of 70 mild and 16 severe patients infected with H1N1 influenza A virus were enrolled in this study.Results It was found that the patients under 14 years old and severe patients displayed significantly higher viral loads and prolonged viral shedding periods compared with the patients over 14 years old and mild patients,respectively(P < 0.05).Moreover,the patients under 14 years old and severe patients displayed significantly lower Th17 cell frequency than the patients over 14 years old and mild patients(P < 0.01).The viral shedding period inversely correlated with the frequency of IL-17+IFN-γ-CD4+ T cells.Additionally,the decreased concentration of serum TGF-β correlated with the decreased frequency of IL-17+IFN-γ-CD4+ T cells.Conclusions Both younger and severe patients are associated with higher viral loads and longer viral shedding periods,which may partially be attributed to the impaired Th17 cell response.展开更多
Effects of hexametazidine [1,4-di(2,3,4-trimethoxybenzyl)piperazine] on the physiological properties of guinea-pig papillary muscles were investigated. Hexametazidine possesses a concentration-dependent negative inotr...Effects of hexametazidine [1,4-di(2,3,4-trimethoxybenzyl)piperazine] on the physiological properties of guinea-pig papillary muscles were investigated. Hexametazidine possesses a concentration-dependent negative inotropic effect (IC_(50)=81.8±16.9μmol/L).The effect of hexametazidine(30.8μmol/L)was antago- nized completely by increasing the concentration of Ca^(2+)from 1.8 to 5.4mmol/L. Hexametazidine(30.8μmol/L)increased the threshold concentration of adrenaline for inducing the automaticity of the muscles from 3.95±1.80 to 6.67±4.84μmol/L (P<0.05).It prolonged the functional refractory period from 218±14 to 254±20ms (P<0.05)at the concentration of 61.6μmol/L.Hexametazidine(6.2μmol/L)antago- nized the positive inotropic effect of isoprenaline competitively and of histamine non-competitively(pA 2 and pD2′ values were 5.45 and 4.13, respectively).展开更多
文摘This article gives a general model using specific periodic special functions, which is degenerate elliptic Weierstrass P functions whose presence in the governing equations through the forcing terms simplify the periodic Navier Stokes equations (PNS) at the centers of cells of the 3-Torus. Satisfying a divergence-free vector field and periodic boundary conditions respectively with a general spatio-temporal forcing term which is smooth and spatially periodic, the existence of solutions which have finite time singularities can occur starting with the first derivative and higher with respect to time. The existence of a subspace of the solution space where v<sub>3</sub> is continuous and {C, y<sub>1</sub>, y<sub>1</sub><sup>2</sup>}, is linearly independent in the additive argument of the solution in terms of the Lambert W function, (y<sub>1</sub><sup>2</sup>=y<sub>2</sub>, C∈R) together with the condition v<sub>2</sub>=-2y<sub>1</sub>v<sub>1</sub>. On this subspace, the Biot Savart Law holds exactly [see Section 2 (Equation (13))]. Also on this subspace, an expression X (part of PNS equations) vanishes which contains all the expressions in derivatives of v<sub>1</sub> and v<sub>2</sub> and the forcing terms in the plane which are related as with the cancellation of all such terms in governing PDE. The y<sub>3</sub> component forcing term is arbitrarily small in ε ball where Weierstrass P functions touch the center of the ball both for inviscid and viscous cases. As a result, a significant simplification occurs with a v<sub>3 </sub>only governing PDE resulting. With viscosity present as v changes from zero to the fully viscous case at v =1 the solution for v<sub>3</sub> reaches a peak in the third component y<sub>3</sub>. Consequently, there exists a dipole which is not centered at the center of the cell of the Lattice. Hence since the dipole by definition has an equal in magnitude positive and negative peak in y<sub>3</sub>, then the dipole Riemann cut-off surface is covered by a closed surface which is the sphere and where a given cell of dimensions [-1, 1]<sup>3</sup> is circumscribed on a sphere of radius 1. For such a closed surface containing a dipole it necessarily follows that the flux at the surface of the sphere of v<sub>3</sub> wrt to surface normal n is zero including at the points where the surface of sphere touches the cube walls. At the finite time singularity on the sphere a rotation boundary condition is deduced. It is shown that v<sub>3</sub> is spatially finite on the Riemann Sphere and the forcing is oscillatory in y<sub>3</sub> component if the velocity v3</sub> is. It is true that . A boundary condition on the sphere shows the rotation of a sphere of viscous fluid. Finally on the sphere a solution for v3</sub> is obtained which is proven to be Hölder continuous and it is shown that it is possible to extend Hölder continuity on the sphere uniquely to all of the interior of the ball.
文摘This article gives a general model using specific periodic special functions, that is, degenerate elliptic Weierstrass P functions composed with the LambertW function, whose presence in the governing equations through the forcing terms simplify the periodic Navier Stokes equations (PNS) at the centers of arbitrary r balls of the 3-Torus. The continuity equation is satisfied together with spatially periodic boundary conditions. The yicomponent forcing terms consist of a function F as part of its expression that is arbitrarily small in an r ball where it is associated with a singular forcing expression both for inviscid and viscous cases. As a result, a significant simplification occurs with a v3(vifor all velocity components) only governing PDE resulting. The extension of three restricted subspaces in each of the principal directions in the Cartesian plane is shown as the Cartesian product ℋ=Jx,t×Jy,t×Jz,t. On each of these subspaces vi,i=1,2,3is continuous and there exists a linear independent subspace associated with the argument of the W function. Here the 3-Torus is built up from each compact segment of length 2R on each of the axes on the 3 principal directions x, y, and z. The form of the scaled velocities for non zero scaled δis related to the definition of the W function such that e−W(ξ)=W(ξ)ξwhere ξdepends on t and proportional to δ→0for infinite time t. The ratio Wξis equal to 1, making the limit δ→0finite and well defined. Considering r balls where the function F=(x−ai)2+(y−bi)2+(z−ci)2−ηset equal to −1e+rwhere r>0. is such that the forcing is singular at every distance r of centres of cubes each containing an r-ball. At the centre of the balls, the forcing is infinite. The main idea is that a system of singular initial value problems with infinite forcing is to be solved for where the velocities are shown to be locally Hölder continuous. It is proven that the limit of these singular problems shifts the finite time blowup time ti∗for first and higher derivatives to t=∞thereby indicating that there is no finite time blowup. Results in the literature can provide a systematic approach to study both large space and time behaviour for singular solutions to the Navier Stokes equations. Among the references, it has been shown that mathematical tools can be applied to study the asymptotic properties of solutions.
基金The National Science and Technology Major Project of China under contract No.2016ZX05057015the National Natural Science Foundation of China under contract Nos 41376038 and 40406009+3 种基金the NSFC-Shandong Joint Fund for Marine Science Research Centers of China under contract No.U1606405the National Program on Global Change and Air-Sea Interaction of China under contract Nos GASI-03-01-01-02,GASI-02-IND-STSsum and GASI-IPOVAI-01-05the Public Science and Technology Research Funds Projects of Ocean of China under contract No.200905024the National Key Scientific Instrument and Equipment Development Projects of China under contract No.2012YQ12003908
文摘The South China Sea (SCS), in particular the northern SCS, is one of ocean areas where energetic internal solitary waves (ISWs)occur most frequently (Cai et al., 2012; Zheng, 2017). Based on the re-appearance period (RP) at an observation station, Ramp et al.(2004) divided the ISWs into two types:Type-a and Type-b. Type-a ISWs arrive regularly at the same time every day, i.e., the RP is about 24 h, and Type-b ISWs arrive about one hour late every day, i.e., the RP is about 25 h.
文摘During 36 days the motion of two pendulums, which were restarted every hour, was continuously recorded. 869 “runs” were thus made, providing each time the precession during the run, as well as other parameters of the motion. Spectral analysis of precession and ellipticity revealed a lunar component of 24 h 50 min, which can only result from an astral action, through mechanisms yet to be discovered. Indeed, an analysis was carried out of the influence of all classical perturbing factors: direct or indirect action of classical gravity, temperature, Earth’s magnetic field, etc.… None of them can explain this component, given its amplitude and phase. Its amplitude excludes also an explanation by general relativity. This is consistent with a major result that Allais claimed to have obtained during each one of the six continuous one-month-long experiments he carried out from 1954 to 1960. The numerous and very precise data provided by an automatic alidade give additional information to those gathered by Allais. All that confirms all the scientific interest that there would be to resume long-duration pendulum observations on a much more important scale: continuous observations for at least 2 years, and if possible more.
文摘Mr. Chairman, Distinguished Members of the Committee, First of all, I would like to extend, on behalf of the Chinese delegation, our greetings and respects to all the distinguished members of the Committee. The Committee has made enormous efforts and played an important role in promoting the purposes and principles of the Convention and reinforcing the global efforts to ban and prevent torture. The Chinese Government appreciates your endeavor and will continue to support the work of the Committee.
文摘Madam Chairwoman, Mr. Rapporteur, Distinguished Members of the Committee, First of all, I would like to extend, on behalf of the Chinese delegation, our heartfelt greetings and respects to all the distinguished members of the Committee. The Committee has made enormous efforts and played an important role in promoting the objectives and principles of the International Convention on Elimination of All Forms of Racial Discrimination. The Chinese Government appreciates your endeavour and will continue to support the work of the Committee.
文摘In recent years, predictions of damage from earthquakes have been made on a prefectural scale, and expectations exist that more detailed damage forecasts should be made even on a city/town/village scale. It is important to know detailed ground characteristics to do damage prediction on a fine scale. Using GIS is the best way to communicate this planar disaster prevention information to the general public. Yokohama City is the second largest city in Japan and developed as part of the capital region of Metropolitan Tokyo. Recently, the population of this city has reached about 3,000,000, and economic and cultural facilities, social infrastructure, and residential complexes are concentrated in this city. The capital region, including Yokohama City, was attacked by the 1923 Great Kanto Earthquake (M7.9) and Yokohama City was devastated by this earthquake. From the research so far, it is known that the H/V spectrum obtained from microtremor observation has a good correlation with the ground characteristics. The authors have been conducting high-density tremor observations that have been ongoing since the 1990s, mainly in Kanagawa Prefecture, Japan. Here, we have organized the predominant periods obtained from the observation results for Yokohama City. The entirety of Yokohama City was divided into 250 m × 250 m meshes and their centers were used as microtremor observation sites. Excluding sites that could not be used due to geographical conditions, observations were made at approximately 5700 sites. So, we compared the data obtained separately, such as the period, terrain classification, and amplification characteristics. The distribution maps of predominant periods in Yokohama City show that the city contains a lot of artificially transformed land, and consequently, the distribution of predominant periods is not uniform. However, it can be seen that the periods become gradually longer, moving from the higher elevation eastern part toward the lower elevation western part. Investigation of the site amplification factors and detailed topographical classifications indicates a clear correlation with the predominant period distribution.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.51801133,51505318,and 51671140)the Science and Technology Major Project of Shanxi Province,China(Grant No.20181102013)+1 种基金the Shanxi Provincial Youth Fund,China(Grant No.201801D221135)the“1331 Project”Engineering Research Center of Shanxi Province,China(Grant No.PT201801).
文摘Si/a-C:H(Ag)multilayer films with different modulation periods are prepared to test their potential applications in human body.The composition,microstructure,mechanical and tribological properties in the simulated body fluid are investigated.The results show the concentration of Ag first decreases and then increases with the modulation period decreasing from 984 nm to 250 nm.Whereas the C content has an opposite variation trend.Notably,the concentration of Ag plays a more important role than the modulation period in the properties of the multilayer film.The a-C:H sublayer of the film with an appropriate Ag concentration(8.97 at.%)(modulation period of 512 nm)maintains the highest sp3/sp2 ratio,surface roughness and hardness,and excellent tribological property in the stimulated body fluid.An appropriate number of Ag atoms and size of Ag atom allow the Ag atoms to easily enter into the contact interface for load bearing and lubricating.This work proves that the Ag nanoparticles in the a-C:H sublayer plays a more important role in the tribological properties of the composite-multilayer film in stimulated body fluid condition.
基金Fund Project:Beiing Municipal Science and Techoology Commission G20 Engineering Innovation Research for Ten Diseases Ten Drugs Research and Development Projec(N.Z171100001717008)National Key Research and Development Plan for Precision Medicine Research Key Phriject(No.2017YF0910002)。
文摘Objective:To evaluate the therapeutic effect of Qinggan Huayu granule on mice with H22 liver cancer ascites tumor.Methods:A H22 liver cancer ascites mouse model was established by intraperitoneally injecting H22 liver cancer cells.Mice were randomly divided into the model group,the Ganfule group(1.35 g/kg),the fluorouracil group(50 mg/kg i.p),the Qinggan Huayu granule groups at low(0.67 g/kg),medium(1.34 g/kg),and high(2.68 g/kg)doses.Then the mice were administered continuously for 10 days and body weight and abdominal circumference were monitored every 3 days.On day 11,eight rats in each group were randomly selected for dissection to detect the amount of peritoneal water,peritoneal permeability and histopathological changes.The remaining mice were observed for survival.In addition,the vascular endothelial growth factor A(VEGFA)and vascular endothelial growth factor receptor 2(VEGFR2)were determined by Western blotting.Results:Compared with the model group,the weight growth of mice in the fluorouracil group and the medium-dose and high-dose Qinggan Huayu granule groups was slower(P<0.05).Moreover,the abdominal circumference of mice in each treatment group was increased slowly.There were significant differences in abdominal circumference between the fluorouracil group,the medium-dose group and the control group from day 6(P<0.05)while the abdominal circumference of the high dose group was significantly smaller than that of the control group from day 12(P<0.05).Moreover,compared with the model group,the amount of ascites in the medium-and high-dose Qinggan Huayu granule groups was decreased significantly(P<0.05).The optical density value of ascites supernatant in medium-and high-dose Qinggan Huayu granule group and the fluorouracil group decreased significantly(P<0.05)and the survival period of the medium-dose Qinggan Huayu granule group and the fluorouracil group was prolonged prominently(P<0.05).There was no significant difference in the low-dose Qinggan Huayu granule group and the Ganfule group.Peritoneal histopathological assay showed more complete peritoneal structure,less edema and less angiogenesis of the peritoneum in the fluorouracil group and the medium-and high-dose Qinggan Huayu granule group,which was better than that of the Ganfule group and the low-dose group.Compared with the model group,the expressions of VEGFA and VEGFR2 in the medium-dose Qinggan Huayu granule group decreased significantly(P<0.05,P<0.01).Conclusion:Qinggan Huayu granule can inhibit ascites production in the mice model with H22 liver cancer ascites tumor,prolong the survival of mice,and reduce peritoneal permeability and suppress the increase of peritoneal neovascularization.The mechanism may be related to the inhibition of VEGF/VEGFR pathway.
文摘Objective To explore whether age,disease severity,cytokines and lymphocytes in H1N1 influenza A patients correlate with viral load and clearance.Methods Total of 70 mild and 16 severe patients infected with H1N1 influenza A virus were enrolled in this study.Results It was found that the patients under 14 years old and severe patients displayed significantly higher viral loads and prolonged viral shedding periods compared with the patients over 14 years old and mild patients,respectively(P < 0.05).Moreover,the patients under 14 years old and severe patients displayed significantly lower Th17 cell frequency than the patients over 14 years old and mild patients(P < 0.01).The viral shedding period inversely correlated with the frequency of IL-17+IFN-γ-CD4+ T cells.Additionally,the decreased concentration of serum TGF-β correlated with the decreased frequency of IL-17+IFN-γ-CD4+ T cells.Conclusions Both younger and severe patients are associated with higher viral loads and longer viral shedding periods,which may partially be attributed to the impaired Th17 cell response.
文摘Effects of hexametazidine [1,4-di(2,3,4-trimethoxybenzyl)piperazine] on the physiological properties of guinea-pig papillary muscles were investigated. Hexametazidine possesses a concentration-dependent negative inotropic effect (IC_(50)=81.8±16.9μmol/L).The effect of hexametazidine(30.8μmol/L)was antago- nized completely by increasing the concentration of Ca^(2+)from 1.8 to 5.4mmol/L. Hexametazidine(30.8μmol/L)increased the threshold concentration of adrenaline for inducing the automaticity of the muscles from 3.95±1.80 to 6.67±4.84μmol/L (P<0.05).It prolonged the functional refractory period from 218±14 to 254±20ms (P<0.05)at the concentration of 61.6μmol/L.Hexametazidine(6.2μmol/L)antago- nized the positive inotropic effect of isoprenaline competitively and of histamine non-competitively(pA 2 and pD2′ values were 5.45 and 4.13, respectively).