The aim of this work was to study the connection between periodontal diseas of women during their pregnancy and the weight of newborn infants the women gave birth to. Method: It was a case-control study and carried ou...The aim of this work was to study the connection between periodontal diseas of women during their pregnancy and the weight of newborn infants the women gave birth to. Method: It was a case-control study and carried out on the outskirts of Dakar (Senegal). The sample consisted of 129 mothers with infants of weight < 2500 g (case) and 258 mothers with infants of weight ≥ 2500 g (control). The socio-demographic variables, patterns of life, history and outcome of pregnancy were collected. The variables relating to periodontal status included the plaque index, inflammation, bleeding, loss of clinical attachment and pocket depth. Data were analyzed by the R software. Logistic regression had identified associations on the threshold of 5%. Results: The proportions of mothers with periodontitis were 70.6% among cases versus 33% in controls. Periodontitis was significantly associated with low weight (OR = 4 [2.3 - 5.7] 4) adjusted on age, BMI and other periodontal indices. Conclusion: periodontal disease appears to be involved in the occurrence of low birth weight in the African context. The introduction of an oral component in prenatal consultations is therefore necessary for the health of mothers and their children.展开更多
The epidemiological associations between the prenatal perfluoroalkyl substances(PFASs)exposure and the reproductive outcomes remain controversial.A continuous evaluation is needed to combine the inconsistent results.I...The epidemiological associations between the prenatal perfluoroalkyl substances(PFASs)exposure and the reproductive outcomes remain controversial.A continuous evaluation is needed to combine the inconsistent results.In this study,we explored the associations between PFASs exposure and the low birth weight(LBW),preterm birth and small for gestational age(SGA).The quality of selected literature,quantitative estimates,publication bias and subgroup analysis were performed on the basis of 17 retrieved articles published before December 2020.The results showed a significant positive association between the perfluorooctane sulfonate(PFOS)exposure and the risk of LBW[Odds ratio(OR)=1.17;95%confidence interval(CI):1.01,1.36;heterogeneity:P=0.30,I2=17%].The positive association was also observed between the PFOS and the risk of preterm birth(OR=1.19;95%CI:1.01,1.39,P=0.007;I2=62%).There was a paucity of evidence regarding the negative effects of perfluorooctanoic acid(PFOA),perfluorohexanesulfonic acid(PFHxS)and perfluorononanoic acid(PFNA)on the pregnancy outcomes.The findings from the subgroup analysis(the sampling period,the birth gender and biologic specimens)did not substantially altered the results of the overall pooled estimate ORs.The increased prevalence of negative birth outcomes with gestational PFASs exposure warrants further explorations from biological process perspective.展开更多
Several reviews have assessed the relationship between exposure to ambient air pollution and adverse birth outcomes during pregnancy,but the results remain controversial.The objective of this study was to assess this ...Several reviews have assessed the relationship between exposure to ambient air pollution and adverse birth outcomes during pregnancy,but the results remain controversial.The objective of this study was to assess this correlation quantitatively and to explore sources of heterogeneity.We included all published case-control or cohort studies that evaluated the correlation between ambient air pollution and low birth weight(LBW),preterm birth(PTB),and small for gestational age(SGA).Analytical methods and inclusion criteria were provided on the PROSPERO website(CRD42018085816).We evaluated pooled effects and heterogeneity.Subgroup analyses(grouped by exposure period,study settings,study design,exposure types,data source,Newcastle-Ottawa quality score(NOS),and adjustment for smoking or meteorological factors)were also conducted and publication bias was examined.The risk of bias in systematic reviews(ROBIS)tool was used to evaluate the overall risk of bias in this review.Forty studies met the inclusion criteria.We observed pooled odds ratios(ORs)of 1.03–1.21 for LBW and 0.97–1.06 for PTB when mothers were exposed to CO,NO2,NOx,O3,PM2.5,PM10,or SO2 throughout their pregnancy.For SGA,the pooled estimate was 1.02 in relation to NO2 concentrations.Subgroup analysis and sensitivity analysis decreased the heterogeneity to some extent,such as the subgroups of continuous measures(OR=0.98(0.97–0.99),I2=0.0%)and NOS>7(OR=0.98(0.97–0.99),I2=0.0%)in evaluating the association between PTB and NO2.This review was completed with a low risk of bias.High concentrations of air pollution were significantly related to the higher risk of adverse birth outcomes.However,the sources of heterogeneity among studies should be further explored.展开更多
Background The survival rate of preterm infants with critical congenital heart disease （P-CCHD） has been improved by medicine advances. The aims of this study were to investigate the contemporary treatments for shor...Background The survival rate of preterm infants with critical congenital heart disease （P-CCHD） has been improved by medicine advances. The aims of this study were to investigate the contemporary treatments for short-term outcomes of P-CCHD and to evaluate risk factors associated with the outcomes. Methods Sixty-four P-CCHD patients admitted to Guangdong General Hospital between 2011 and 2015 were included in this study. De-mographic characteristics and patient records were reviewed. Logistic regression was used to analyze the risk fac-tors of P-CCHD outcome. Results Thirty-six patients underwent surgical treatments for cardiac anomalies. Moreover, 31.25% of the P-CCHD infants did not receive surgery because these parents refused further treat-ment. The in-hospital mortality rate was 8.3% for the patients who underwent surgeries. During a median follow-up of 1.2 years, the survivors were basically healthy. However, mental and physical growth retardation remained. Conclusions Compared to infants in developed Western countries, the treatments and short-term outcomes of P-CCHD infants were satisfactory. However, the long-term outcomes remain to be determined.展开更多
目的分析极低/超低出生体重(very/extremely low birth weight,VLBW/ELBW)早产儿代谢性骨病(metabolic bone disease of prematurity,MBDP)的发生率及危险因素。方法回顾性调查2013年9月1日至2016年8月31日全国多中心61 786例新生儿资料...目的分析极低/超低出生体重(very/extremely low birth weight,VLBW/ELBW)早产儿代谢性骨病(metabolic bone disease of prematurity,MBDP)的发生率及危险因素。方法回顾性调查2013年9月1日至2016年8月31日全国多中心61 786例新生儿资料,符合纳入标准的VLBW/ELBW早产儿504例,其中诊断MBDP 108例,纳入MBDP组,其余396例纳入非MBDP组。收集两组孕母及早产儿基本资料、住院期间主要疾病、营养支持策略和其他治疗情况并进行统计学比较分析;采用多因素logistic回归分析MBDP发生的危险因素。结果 VLBW早产儿MBDP发生率为19.5%(88/452),ELBW早产儿MBDP发生率为38.5%(20/52)。极早产儿、超早产儿MBDP发生率分别为21.7%和45.5%。单因素分析结果显示,MBDP组患儿胎龄、出生体重均小于非MBDP组,住院时间更长,出院时宫外发育迟缓发生率更高(P<0.05);MBDP组新生儿呼吸窘迫综合征、败血症、贫血、低钙血症、早产儿视网膜病变发生率较非MBDP组高(P<0.05);MBDP组较非MBDP组平均加奶速度更慢、达全肠内喂养日龄更大、肠外营养使用时间更长(P<0.05);MBDP组患儿枸橼酸咖啡因使用比例高于非MBDP组、促红细胞生成素使用比例低于非MBDP组(P<0.05)。多因素logistic回归分析结果显示,胎龄<32周、低钙血症、出院时宫外发育迟缓、败血症是MBDP发生的危险因素(P<0.05)。结论低胎龄、低钙血症、出院时宫外发育迟缓、新生儿败血症可能增加VLBW/ELBW早产儿MBDP发生的风险,应加强围生期孕期保健,避免早产,提高新生儿科医师对MBDP的防治意识,对早产儿采取积极合理的营养策略和综合管理措施,以改善VLBW/ELBW早产儿的近远期临床结局。[中国当代儿科杂志,2021,23 (6):555-562]展开更多
文摘The aim of this work was to study the connection between periodontal diseas of women during their pregnancy and the weight of newborn infants the women gave birth to. Method: It was a case-control study and carried out on the outskirts of Dakar (Senegal). The sample consisted of 129 mothers with infants of weight < 2500 g (case) and 258 mothers with infants of weight ≥ 2500 g (control). The socio-demographic variables, patterns of life, history and outcome of pregnancy were collected. The variables relating to periodontal status included the plaque index, inflammation, bleeding, loss of clinical attachment and pocket depth. Data were analyzed by the R software. Logistic regression had identified associations on the threshold of 5%. Results: The proportions of mothers with periodontitis were 70.6% among cases versus 33% in controls. Periodontitis was significantly associated with low weight (OR = 4 [2.3 - 5.7] 4) adjusted on age, BMI and other periodontal indices. Conclusion: periodontal disease appears to be involved in the occurrence of low birth weight in the African context. The introduction of an oral component in prenatal consultations is therefore necessary for the health of mothers and their children.
基金National Natural Science Foundation of China(No.22006010)Shanghai Sailing Program,China(No.19YF1400500)。
文摘The epidemiological associations between the prenatal perfluoroalkyl substances(PFASs)exposure and the reproductive outcomes remain controversial.A continuous evaluation is needed to combine the inconsistent results.In this study,we explored the associations between PFASs exposure and the low birth weight(LBW),preterm birth and small for gestational age(SGA).The quality of selected literature,quantitative estimates,publication bias and subgroup analysis were performed on the basis of 17 retrieved articles published before December 2020.The results showed a significant positive association between the perfluorooctane sulfonate(PFOS)exposure and the risk of LBW[Odds ratio(OR)=1.17;95%confidence interval(CI):1.01,1.36;heterogeneity:P=0.30,I2=17%].The positive association was also observed between the PFOS and the risk of preterm birth(OR=1.19;95%CI:1.01,1.39,P=0.007;I2=62%).There was a paucity of evidence regarding the negative effects of perfluorooctanoic acid(PFOA),perfluorohexanesulfonic acid(PFHxS)and perfluorononanoic acid(PFNA)on the pregnancy outcomes.The findings from the subgroup analysis(the sampling period,the birth gender and biologic specimens)did not substantially altered the results of the overall pooled estimate ORs.The increased prevalence of negative birth outcomes with gestational PFASs exposure warrants further explorations from biological process perspective.
基金Project supported by the National Natural Science Foundation of China(No.81230016)the Birth Defect Control and Prevention Project of Shaanxi Commission of Health and Family Planning(No.sxwsjs wzfcght2016-013),China
文摘Several reviews have assessed the relationship between exposure to ambient air pollution and adverse birth outcomes during pregnancy,but the results remain controversial.The objective of this study was to assess this correlation quantitatively and to explore sources of heterogeneity.We included all published case-control or cohort studies that evaluated the correlation between ambient air pollution and low birth weight(LBW),preterm birth(PTB),and small for gestational age(SGA).Analytical methods and inclusion criteria were provided on the PROSPERO website(CRD42018085816).We evaluated pooled effects and heterogeneity.Subgroup analyses(grouped by exposure period,study settings,study design,exposure types,data source,Newcastle-Ottawa quality score(NOS),and adjustment for smoking or meteorological factors)were also conducted and publication bias was examined.The risk of bias in systematic reviews(ROBIS)tool was used to evaluate the overall risk of bias in this review.Forty studies met the inclusion criteria.We observed pooled odds ratios(ORs)of 1.03–1.21 for LBW and 0.97–1.06 for PTB when mothers were exposed to CO,NO2,NOx,O3,PM2.5,PM10,or SO2 throughout their pregnancy.For SGA,the pooled estimate was 1.02 in relation to NO2 concentrations.Subgroup analysis and sensitivity analysis decreased the heterogeneity to some extent,such as the subgroups of continuous measures(OR=0.98(0.97–0.99),I2=0.0%)and NOS>7(OR=0.98(0.97–0.99),I2=0.0%)in evaluating the association between PTB and NO2.This review was completed with a low risk of bias.High concentrations of air pollution were significantly related to the higher risk of adverse birth outcomes.However,the sources of heterogeneity among studies should be further explored.
基金supported by the National Natural Science Foundation of China(No.8167060825)
文摘Background The survival rate of preterm infants with critical congenital heart disease （P-CCHD） has been improved by medicine advances. The aims of this study were to investigate the contemporary treatments for short-term outcomes of P-CCHD and to evaluate risk factors associated with the outcomes. Methods Sixty-four P-CCHD patients admitted to Guangdong General Hospital between 2011 and 2015 were included in this study. De-mographic characteristics and patient records were reviewed. Logistic regression was used to analyze the risk fac-tors of P-CCHD outcome. Results Thirty-six patients underwent surgical treatments for cardiac anomalies. Moreover, 31.25% of the P-CCHD infants did not receive surgery because these parents refused further treat-ment. The in-hospital mortality rate was 8.3% for the patients who underwent surgeries. During a median follow-up of 1.2 years, the survivors were basically healthy. However, mental and physical growth retardation remained. Conclusions Compared to infants in developed Western countries, the treatments and short-term outcomes of P-CCHD infants were satisfactory. However, the long-term outcomes remain to be determined.
