Hepatocellular carcinoma(HCC)remains the sixth most common malignancy and the fourth leading cause of cancer death worldwide.Numerous Chinese herbs have been used to prevent and treat HCC.Periploca forrestii Schltr.,b...Hepatocellular carcinoma(HCC)remains the sixth most common malignancy and the fourth leading cause of cancer death worldwide.Numerous Chinese herbs have been used to prevent and treat HCC.Periploca forrestii Schltr.,belonging to the family of Asclepiadaceae,has been reported to have strong inhibitory efficacy against various types of cancer cells,but the mechanism is unclear.Hence,we utilized the compound-disease target network based on the network pharmacology analysis to find out the active ingredients from P.forrestii and the potential target proteins involved in hepatocellular carcinoma.The results showed that the most effective compounds in this plant might be caffeoylquinic acids and the most potential target might be GMP synthase[glutamine-hydrolyzing](PDB:2vxo).This study is of great significance to the further research of P.forrestii and provides a novel treatment strategy for HCC.展开更多
Periploca forrestii Schltr.belonging to the family of Apocynaceae,is one of the“three treasures of Miao medicine”,which was utilized by the Miao people in China for the treatment of rheumatoid arthritis,fractures an...Periploca forrestii Schltr.belonging to the family of Apocynaceae,is one of the“three treasures of Miao medicine”,which was utilized by the Miao people in China for the treatment of rheumatoid arthritis,fractures and wound.Phytochemical investigations have discovered that the main constituents of Periploca forrestii were steroids,terpenoids,flavonoids and their glycosides,flavanols,quinones and phenylpropanoids.Modern pharmacological studies have shown that it possesses a wide range of biological activities,such as anti-inflammatory,anti-rheumatoid arthritis,anticancer,immunosuppressive,neuroprotective and other properties.This paper summarized the primary chemical constituents and pharmacological effects of Periploca forrestii,hoping to provide a reference for its further development and utilization.展开更多
To analyze the chemical constituents of volatile oils from the fruit of Periploca forrestii Schltr.which were collected in Guizhou province.This volatile oils were extracted by simultaneous distillation extraction (SD...To analyze the chemical constituents of volatile oils from the fruit of Periploca forrestii Schltr.which were collected in Guizhou province.This volatile oils were extracted by simultaneous distillation extraction (SDE)and microwave assistant extraction(MAE) method,and ananlyzed by gas chromatography-mass spectrometry(GC-MS)method.The main chemical compounds were methyl salicylate,β-amyrin and β-amyrin acetate etc.The compounds from the volatile oils extracted with SDE and MAE are quite different.The results provide scientific proof for the further development and utilization of Periploca forrestii Schltr.展开更多
文摘Hepatocellular carcinoma(HCC)remains the sixth most common malignancy and the fourth leading cause of cancer death worldwide.Numerous Chinese herbs have been used to prevent and treat HCC.Periploca forrestii Schltr.,belonging to the family of Asclepiadaceae,has been reported to have strong inhibitory efficacy against various types of cancer cells,but the mechanism is unclear.Hence,we utilized the compound-disease target network based on the network pharmacology analysis to find out the active ingredients from P.forrestii and the potential target proteins involved in hepatocellular carcinoma.The results showed that the most effective compounds in this plant might be caffeoylquinic acids and the most potential target might be GMP synthase[glutamine-hydrolyzing](PDB:2vxo).This study is of great significance to the further research of P.forrestii and provides a novel treatment strategy for HCC.
文摘Periploca forrestii Schltr.belonging to the family of Apocynaceae,is one of the“three treasures of Miao medicine”,which was utilized by the Miao people in China for the treatment of rheumatoid arthritis,fractures and wound.Phytochemical investigations have discovered that the main constituents of Periploca forrestii were steroids,terpenoids,flavonoids and their glycosides,flavanols,quinones and phenylpropanoids.Modern pharmacological studies have shown that it possesses a wide range of biological activities,such as anti-inflammatory,anti-rheumatoid arthritis,anticancer,immunosuppressive,neuroprotective and other properties.This paper summarized the primary chemical constituents and pharmacological effects of Periploca forrestii,hoping to provide a reference for its further development and utilization.
文摘To analyze the chemical constituents of volatile oils from the fruit of Periploca forrestii Schltr.which were collected in Guizhou province.This volatile oils were extracted by simultaneous distillation extraction (SDE)and microwave assistant extraction(MAE) method,and ananlyzed by gas chromatography-mass spectrometry(GC-MS)method.The main chemical compounds were methyl salicylate,β-amyrin and β-amyrin acetate etc.The compounds from the volatile oils extracted with SDE and MAE are quite different.The results provide scientific proof for the further development and utilization of Periploca forrestii Schltr.
