Balloon displacement during caesarean section with pernicious placenta previa: A case report

BACKGROUND For the past few years,preventive interventional therapy has been widely used domestically and overseas,bringing great benefits to pregnant women at high-risk for complications,such as pernicious placenta previa(PPP)and placenta accreta.Nevertheless,there are still few reports on surgical complications related to interventional therapy,and its safety should be a concern.CASE SUMMARY We report a 36-year-old pregnant woman with PPP who underwent balloon implantation in the lower segment of the abdominal aorta before caesarean section.However,the balloon shifted during the operation,which damaged the arterial vessels after filling,resulting in severe postpartum haemorrhage in the patient.Fortunately,after emergency interventional stent implantation,the pa-tient was successfully relieved of the massive haemorrhage crisis.CONCLUSION It seems that massive postoperative bleeding has been largely avoided in preventive interventional therapy in high-risk pregnant women with placenta-related diseases,but surgical complications related to intervention therapy can also cause adverse consequences.It is equally important for clinical doctors to learn how to promptly identify and effectively treat these rare complications.

Application of abdominal aortic balloon occlusion followed by uterine artery embolization for the treatment of pernicious placenta previa complicated with placenta accreta during cesarean section

Objective:This study aimed to investigate the clinical effects of abdominal aortic balloon occlusion followed by uterine artery embolization for the treatment of pernicious placenta previa complicated with placenta accreta during cesarean section.Methods:We performed a retrospective analysis of the clinical data for 623 patients who experienced pernicious placenta previa complicated with placenta accreta and received treatment in our hospital from January 2013 to January 2019.All patients underwent abdominal aortic balloon occlusion before their cesarean section.Seventyeight patients received bilateral uterine artery embolization,and among them,placenta accreta was found at the opening of the cervix in 13 patients.Due to suturing difficulty after the removal of the placenta,gauze packing was used to temporarily compress the hemorrhage.As soon as the uterus was sutured,emergent bilateral uterine artery embolization was performed.Active bleeding was noted in the remaining 65 patients when the lower part of the uterus was pressed after the placenta was removed and the uterus was sutured,therefor,bilateral uterine artery embolization was performed urgently.Results:Of the 623 patients,545 patients underwent only abdominal aortic balloon occlusion and 78 patients underwent additional emergent bilateral uterine artery embolization due to hemorrhaging during or after their cesarean section.No hysterectomies were performed.In the 78 patients,the amount of bleeding was 800-3,200 ml with an average of 1,650 ml during the operation;the volume of blood transfused was 360-1,750 ml(average:960 ml).The fetal fluoroscopy time was 3–8 s(average:5 s).The dose of radiation exposure was(4.2±2.9) m Gy.Fetal appearance,pulse,grimace,activity,and respiration(Apgar) score were normal.No serious complications were observed during or after the operation in the follow-up visits.Conclusion:For patients with pernicious placenta previa complicated with placenta accreta who experience active bleeding after cesarean section and abdominal aortic balloon occlusion,bilateral uterine artery embolization can effectively reduce blood loss and requirement of blood transfusion during the operation,and lowers the risk of hysterectomy.

Long-term follow-up of abdominal aortic balloon occlusion for the treatment of pernicious placenta previa with placenta accreta

Objective:To evaluate the efficacy and safety of balloon occlusion of the abdominal aorta for the treatment of pernicious placenta previa with placenta accreta.Methods:The clinical data of 623 patients with pernicious placenta previa combined with placenta accrete,who were admitted to our hospital from January 2013 to January 2019 were retrospectively analyzed.All patients underwent abdominal aortic balloon occlusion combined with cesarean section,and 78 patients underwent sequential bilateral uterine artery embolization.We analyzed the operation time,intraoperative blood loss,blood transfusion volume,intraoperative and postoperative complications,fetal radiation exposure time and dose,and the Apgar score of the newborns.We also performed other evaluations to ascertain the efficacy and safety of abdominal aortic balloon occlusion treatment for dangerous placenta previa with placenta accrete.Results:Of the 623 patients,545 underwent only abdominal aortic balloon occlusion,and 78 underwent uterine artery embolization due to intraoperative or postoperative bleeding.The uterus was successfully preserved in all patients.Except for five cases of right lower extremity arterial thrombosis,the remaining patients did not have postoperative lower extremity arteriovenous thrombosis,renal insufficiency,late postpartum hemorrhage,ectopic embolism,spinal cord or peripheral nerve damage,pelvic infection,or other serious complications.The mean operative time was 65.3(±14.5)min.The mean intraoperative blood loss was620(±570)ml.Ninety-six patients(15.4%,96/623)were treated with blood transfusion,and the average amount of blood transfused was 750(±400)ml.The average number of hospitalization days was 6.8(±3.4)days,the average time of fetal ray exposure was 5.2(±1.6)s,and the average radiation dose was 4.1(±2.7)m Gy.The neonatal Apgar score,was 8.4(±0.6)points at 1 min,and 9.6(±0.4)points at 5 min.In the follow-up to May 31,2019,29 patients were lost to follow-up,96 were lactating,and 498 were menstruating.Except for the cases lost to follow-up,the remaining 596 surviving newborns(including 2 twins)showed no abnormalities at the 42-day postnatal outpatient follow-up examination.Conclusion:Balloon occlusion of the abdominal aorta is a safe and effective method for the treatment of pernicious placenta previa with placenta accreta.

Clinical Analysis of Placenta Previa Complicated with Previous Caesarean Section

Objective To investigate the clinical features and treatment of placenta previa complicated with previous caesarean section. Methods The clinical data of 29 patients with placenta previa complicated with a previous caesarean section (RCS group) admitted in Peking Union Medical College Hospital during a period from 2003 to 2011 were retrospectively reviewed and compared with those of 243 patients with placenta previa without a previous caesarean section (FCS group) during the same period. Results There was no difference in the mean age (28.9±3.6 vs. 28.1±4.5 years) and the average gravidity (2.35±1.48 vs. 2.21±1.53) between RCS group and FCS group (all P>0.05). The RCS group had more preterm births (24.1% vs. 13.2%), complete placenta previa (55.2% vs. 4.9%), placenta accreta (34.5% vs. 2.5%), more blood loss during caesarean section (1412±602 vs. 648±265 mL), blood transfusion (51.7% vs. 4.9%), disseminated intravascular coagulation (13.8% vs. 2.1%), and obstetric hysterectomy (13.8% vs. 0.8%) than the FCS group (all P<0.05). The preterm infant rate (30.0% vs. 13.0%), neonatal asphyxia rate (10.0% vs. 4.9%), and perinatal mortality rate (6.7% vs. 0.4%) of the RCS group were higher than those of the FCS group (all P<0.05). Conclusions More patients had complete placenta previa and placenta accreta, postpartum hemorrhage, transfusion, uterine packing, obstetric hysterectomy, and perinatal morbidity in the placenta previa patients with previous caesarean section. The patient should be informed of the risk and unnecessary first cesarean sections should be avoided.

Clinical Analysis on the Effectiveness of Conservative Compression Suture Technique to Conserve Fertility on Pernicious Placenta Previa

Objective: To evaluate the effectiveness of conservative compression surgical suture techniques used for the management of pernicious placenta previa to conserve fertility in the subsequent pregnancies. Study Design: This was a non-comparative retrospective study of 188 patients diagnosed with pernicious placenta previa who underwent cesarean section in The First Hospital of Jilin University, China, from 1 January 2013 to 1 January 2018. Successful group was defined as those in which the intraoperative bleeding was managed by either modified CHO or by B-lynch suture technique and those who had further intervention including hysterectomy were designated as failure group. Results: Out of 217 patients, 188 met inclusion criteria and 29 patients were excluded. In 188 cases, 183 (97.34%) cases successes and 5 (2.65%) cases had hysterectomy. Among included group, 118 patients (62.76%) had undergone emergency cesarean section and 70 patients (37.23%) underwent elective cesarean section. The emergency group had significantly lesser gestation period of gestation at the time of cesarean section (P = 0.021) and lower neonatal weight (P = 0.001) than that of elective group. The estimated blood loss during surgery was 500 - 3200 ml (mean: 925 ml). Additionally, the amount of bleeding was found to be significantly more in patient with intraoperative complication (P = 0.007) and in patient with implanted placenta (P 0.001). Conclusion: The conservative compression suture technique including modified CHO and B-lynch suture technique during the cesarean delivery is a feasible, safe and effective alternative conservative surgical technique for the management of bleeding in case of pernicious placenta previa. Besides good surgical outcome and proper neonatal result this technique also reduces the rate of hysterectomy, thus conserving the fertility.

Application of ultrasound-guided balloon occlusion in cesarean section in 130 cases of sinister placenta previa

Objective:To investigate the clinical utility of ultrasound-guided balloon occlusion in cesarean section in patients with sinister placenta previa.Methods:The Interventional and Ultrasound Departments of the authors’center assisted obstetrics to complete cesarean section in cases of sinister placenta previa.A total of 130 patients with implanted sinister placenta previa were diagnosed using obstetrical ultrasound and magnetic resonance imaging(MRI).Before cesarean section,the balloon was positioned in the bilateral radial or abdominal aorta.Immediately after delivery of the fetus,the balloon was temporarily filled to transiently seal the target vessel.According to the obstetrician’s assessment of hemostasis,the balloon was withdrawn at the appropriate time.Among the 130 patients,there was one case of abdominal aortic occlusion,with 129 cases blocked by the bilateral common iliac artery.Results:All 130 cases were successfully blocked,with an average blocking time of<15 min,while intraoperative blood loss was 800–1500 ml.Conclusion:Ultrasound-guided balloon blocking treatment before cesarean section can mitigate the dangers of placenta previa and significantly reduce blood loss with no exposure to X-ray radiation.Thus,the technique merits serious consideration.

子宫血管缝扎术及宫颈环状缝扎术联合双侧髂内动脉球囊阻断治疗PPP合并胎盘植入效果

目的:探讨凶险性前置胎盘(PPP)合并胎盘植入治疗效果。方法:选取2019年3月-2023年5月本院就诊治疗的PPP合并胎盘植入患者56例临床资料,根据治疗方式不同分为两组,采用子宫血管缝扎术及宫颈环状缝扎术联合双侧髂内动脉球囊阻断治疗为观察组26例,采用单纯双侧髂内动脉球囊阻断治疗为对照组30例,分析两组相关指标。结果:治疗后两组甲胎蛋白及绒毛膜促性腺激素水平均较术前降低,且观察组(82.6±26.3 ng/ml、122.3±56.3 mIU/ml)低于对照组(113.0±41.1 ng/ml、649.5±86.5 mIU/ml),总并发症发生率观察组(3.8%)低于对照组(23.3%)(均P<0.05);两组新生儿Apgar评分(9.6±0.3分、9.3±0.6分)无差异(P>0.05)。观察组住院时间(6.6±1.2d)及住院费用(3.2±0.6)万元均低于对照组(7.9±1.5d)(4.3±1.0)万元(P<0.05)结论:采取子宫血管缝扎与宫颈环状缝扎术、双侧髂内动脉球囊阻断治疗PPP合并胎盘植入可效果更佳,且可降低术后并发症,术后恢复更快,对新生儿未产生不良影响。

凶险性前置胎盘MRI表现及诊断意义

目的探讨凶险性前置胎盘(PPP)核磁共振(MRI)表现及诊断意义。方法回顾性分析67例前置胎盘患者资料,术前均接受MRI检查,经剖宫产术和病理确诊,分析MRI诊断PPP和伴有胎盘植入的诊断效能,观察PPP合并胎盘植入的不同分型诊断结果。结果手术病理诊断PPP患者有60例,非凶险性前置胎盘(nPPP)患者有7例,PPP并发胎盘植入有59例,“金标准”以手术病理诊断结果为准,分析结果显示,MRI诊断PPP的阳性预测值最高,可达96.43%,其次灵敏度可达90.00%%,特异度、精确率则在71.43%、88.06%,阴性预测值最低,为45.45%;MRI诊断PPP并发胎盘植入的阳性预测值最高,可达97.87%,其次特异度可达87.50%,灵敏度、精确率则在77.97%、79.10%,阴性预测值最低,为35.00%;以手术病理诊断PPP合并胎盘植入结果为金标准,MRI的诊断正确率为79.66%,其中粘黏型、植入型及穿透型胎盘植入的诊断正确率分别为50.00%、87.10%及100.00%。结论术前MRI诊断PPP的诊断价值高,能正确评估PPP伴有胎盘植入程度,充分评估胎盘组织与子宫肌层的关系,为产前检查和制定适合治疗方案提供有效信息。

不同位置动脉球囊阻断在凶险性前置胎盘术中的应用价值

目的评估不同位置动脉球囊阻断术在凶险性前置胎盘合并胎盘植入剖腹产术中应用临床效果及安全性的对比研究。方法本院2015年9月至2022年8月共有57例经多普勒超声和/或核磁共振证实凶险性前置胎盘合并胎盘植入,在剖腹产术前行动脉球囊阻断术,其中腹主动脉球囊阻断术(A组)26例,髂总动脉球囊阻断术(B组)31例。结果A、B两组合计子宫保有率100%(57/57),剖宫产手术时间、新生儿Apgar评分(1 min、5 min)两组之间差异无统计学意义(P>0.05),A组术中出血量显著低于B两组术中出血量(P<0.05),放射防护安全性方面,A组明显优于B组(P<0.05)。A组分别出现1例球囊回撤失败,B组分别出现1例动脉血栓和1例下肢静脉血栓,两组之间差异无统计学意义(P>0.05)。结论腹主动脉球囊阻断术和髂总动脉球囊阻断术均可降低子宫切除率,保留患者生育功能,但是腹主动脉球囊阻断术中出血量及放射防护安全性均优于髂总动脉球囊阻断术。

1例凶险性前置胎盘行双侧骼内动脉球囊封堵联合剖宫产术后并发DIC的护理

总结1例凶险性前置胎盘行双侧骼内动脉球囊封堵联合剖宫产术后并发弥散性血管内凝血(DIC)的护理。通过多学科团队的联合诊治及护理,病人病情平稳出院。随访半年,病人状况良好。

Comparison of cell salvage with one and two suction devices during cesarean section in patients with placenta previa and/or accrete: a randomized controlled trial

Background:Cell salvage has recently been recommended for obstetric use in cases with a high risk of massive hemorrhage during cesarean section(CS).However,limited data are available to support the use of one suction device to collect lost blood.This study aimed to investigate the volume of red blood cells(RBCs)salvaged and the components of amniotic fluid(AF)in blood salvaged by one suction device or two devices during CS in patients with placenta previa and/or accrete.Methods:Thirty patients with placenta previa and/or accrete undergoing elective CS in the Women's Hospital of Zhejiang University School of Medicine were recruited for the present study from November 1,2017 to December 1,2018.The patients were randomly assigned to one of the two groups according to an Excel-generated random number sheet:Group 1(w=15),in which only one suction device was used to aspirate all blood and AF,and Group 2(w=15),in which a second suction device was mainly used to aspirate AF before the delivery of the placenta.Three samples of blood per patient(pre-wash,post-wash,and post-filtration)were collected to measure AF components.The salvaged RBC volumes were recorded.Continuous data of pre-wash,post-wash,and postfiltration samples were analyzed by using one-way analysis of variance with Tukey5s test for multiple comparisons,or Kruskal-Wallis test with Dunn test for multiple comparisons.Comparisons of continuous data between Group 1 and Group 2 were conducted using Student's t test or Mann-Whitney U test.Results:The salvaged RBC volume was significantly higher in Group 1 than that in Group 2(401.6±77.2 mL vs.330.1土53.3 mL,?=4.175,P<0.001).In both groups,squamous cells,lamellar bodies,and fat were significantly reduced by washing(all P<0.001)and squamous cells were further reduced by filtering(P<0.001).Squamous cells were found in six post-filtration samples(three from each group).Lamellar bodies and fat were completely removed by filtering.Insulin-like growth factor binding protein 1,alphafetoprotein,albumin,lactate dehydrogenase,and potassium were significantly reduced post-wash(all P<0.05),with no further significant reduction after filtration in either group(all P>0.05).The mean percentage of fetal RBCs post-filtration was(1.8±0.8)%with a range of 1.0%to 3.5%and(1.9±0.9)%with a range of 0.7%to 4.0%in Groups 1 and 2,respectively,showing no significant difference between the two groups(U=188.5,P=0.651).Conclusion:Cell salvage performed by one suction device could result in higher volume of salvaged RBCs and can be used safely for CS in patients with placenta previa and/or accrete when massive hemorrhage occurs.Trial registration number:ChiCTR-INR-17012926,http://www.chictr.org.cn/Chinese Clinical Trial Registry.

妊娠期宫颈癌临床误诊分析

目的探讨妊娠期宫颈癌临床误诊的原因及防范措施。方法回顾性分析2020年1月—2021年12月收治的曾有误诊经过的妊娠期宫颈癌3例临床资料。结果3例均因妊娠期阴道出血、腹痛或阴道分泌物异常就诊。1例考虑为先兆早产,剖宫产术后行MRI检查发现宫颈明显不规则增厚伴异常信号,经增厚组织病理检查确诊为宫颈低分化鳞状细胞癌(鳞癌);1例考虑为先兆流产,妇科检查发现宫颈有一赘生物,经宫颈活检确诊为宫颈中分化鳞癌;1例考虑为前置胎盘,剖宫产术后宫颈内口触及胎盘样组织,腹部超声示宫颈与宫体结合部占位性病变,病理活检示宫颈鳞癌。误诊时间2 d~4个月。3例确诊后予宫颈癌根治术联合术后放疗,随访半年情况良好。结论妊娠期宫颈癌临床少见,临床对以妊娠期出现不规则阴道出血、腹痛及分泌物异常增多就诊者提高警惕,以减少误诊。

凶险性前置胎盘植入发病危险因素及不同类型妊娠结局分析

目的研究凶险性前置胎盘(PPP)植入发病危险因素及不同类型妊娠结局。方法将医院2018年1月—2020年7月收治的343例PPP患者纳入研究,将其按照是否伴胎盘植入分作植入组(95例)和无植入组(248例)。分析两组各项临床资料的差异,并以多因素Logistic回归分析明确PPP植入和相关影响因素的关系。此外,将所有PPP患者按照类型的差异分为中央型、部分型、边缘型以及低置型,分析不同类型PPP患者的妊娠结局。结果植入组产次>2次、胎盘部位为前壁、剖宫产次≥2次、中央型前置胎盘人数占比均明显高于无植入组,差异有统计学意义(P<0.05)。两组年龄、孕次、妊娠期高血压、妊娠期糖尿病以及前置胎盘病史对比,差异均不明显,无统计学意义(P>0.05)。结论产次、胎盘部位、前置胎盘类型以及剖宫产次数均是PPP植入发病的影响因素,其中中央型PPP妊娠结局较差,值得临床重点关注。

PDCA护理管理模式在凶险性前置胎盘患者中的应用效果

目的观察PDCA护理管理模式在凶险性前置胎盘患者中的应用效果。方法选取2020年6月至2023年6月费县人民医院收治的60例凶险性前置胎盘患者,以随机数字表法分为对照组、观察组,每组30例。对照组给予常规护理,观察组给予PDCA护理管理模式,比较两组的情绪状态和护理满意度。结果护理后,两组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均降低,其中观察组SAS、SDS评分低于对照组(P<0.05);观察组对宣教、态度、服务、消毒灭菌及环境方面的护理满意度高于对照组(P<0.05)。结论PDCA护理管理模式在凶险性前置胎盘患者中应用效果显著,能够缓解负面情绪、提高护理满意度,值得推广。

凶险性前置胎盘孕妇MRI征象与产后出血的关系分析

目的:探讨凶险性前置胎盘(PPP)孕妇磁共振成像(MRI)征象与产后出血的关系分析。方法:回顾性分析2018年1月—2023年8月新余市妇幼保健院收治的76例PPP孕妇的临床资料,根据是否发生产后出血分为产后出血组(n=42)和非产后出血组(n=34)。比较两组MRI征象及与产后出血的相关性。结果:产后出血组胎盘植入比例高于非产后出血组,剖宫产次数多于非产后出血组(P<0.05)。产后出血组MRI征象中子宫局限性膨隆、胎盘信号不均匀、胎盘内异常血管、T_(2)WI低信号带占比均高于非产后出血组,子宫下段胎盘厚度大于非产后出血组,差异均有统计学意义(P<0.05)。两组宫颈管口扩张占比及宫颈长度比较,差异均无统计学意义(P>0.05)。受试者操作特征(ROC)曲线分析显示,PPP孕妇MRI征象子宫局限性膨隆、胎盘信号不均匀、胎盘内异常血管、T_(2)WI低信号带、子宫下段胎盘厚度预测产后出血的曲线下面积分别为0.716、0.695、0.740、0.761、0.931;敏感度分别为78.6%、71.4%、83.3%、78.6%、76.2%;特异度分别为64.7%、67.6%、64.7%、73.5%、91.2%。结论:PPP孕妇MRI征象子宫局限性膨隆、胎盘信号不均匀、胎盘内异常血管、T_(2)WI低信号带、子宫下段胎盘厚度与产后出血存在一定相关性,MRI征象检测有助于提高产后出血的诊断效能。

MRI联合血清MMP-9、AFP在凶险型前置胎盘产前诊断中的应用价值

目的分析磁共振成像(MRI)联合血清基质金属蛋白酶-9(MMP-9)、甲胎蛋白(AFP)在凶险型前置胎盘(PPP)产前诊断中的应用价值。方法选取2017年1月-2022年1月我院收治的疑似PPP患者206例,经产后病理检测为PPP患者的有124例即为PPP组,其中胎盘植入组62例和胎盘未植入组62例。选取同期我院收治的无胎盘前置的健康孕妇60例即为对照组;酶联免疫吸附法(ELISA)检测血清MMP-9、AFP水平;采用受试者工作特征(ROC)曲线分析血清MMP-9、AFP在PPP患者产前诊断中价值;以四格表分析MRI联合血清MMP-9、AFP检测对PPP的诊断效能。结果与对照组相比,PPP组患者血清中MMP-9、AFP水平显著升高(P<0.05)。与对照组相比,胎盘植入组和胎盘未植入组血清中MMP-9、AFP水平显著升高;与胎盘未植入组相比,胎盘植入组MMP-9、AFP水平显著升高(P<0.05)。三组间胎盘内信号混杂、胎盘与子宫肌层分界不清、子宫外突、低T2WI信号、胎盘内血管多、粗和膀胱突起数量比较差异具有显著性(P<0.05)。与对照组相比,胎盘植入组和胎盘未植入组的胎盘厚度显著升高;与胎盘未植入组相比,胎盘植入组的胎盘厚度显著升高(P<0.05)。MMP-9和AFP联合诊断PPP的曲线下面积显著高于MMP-9、AFP单独诊断(P<0.05)。MRI联合血清MMP-9、AFP诊断PPP的灵敏度、准确度均最高(P<0.05)。结论MRI联合血清MMP-9、AFP检测可提高PPP的诊断价值。

D-二聚体/血小板计数比值预测凶险性前置胎盘患者产后出血效能

目的:探讨D-二聚体/血小板计数比值(DPR)对凶险性前置胎盘(PPP)患者产后出血的预测效能。方法:收集2019-2023年本院收治的102例PPP患者临床资料,检测D-二聚体和血小板计数并计算DPR,根据PPP患者是否并发产后出血(阴道分娩产后出血量≥500ml、剖宫产术后24h内出血量≥1000ml)分为出血组(n=27)与未出血组(n=75)。采用受试者工作特性(ROC)曲线评估DPR对PPP患者产后出血的预测效能,采用二分类logistic逐步回归分析PPP患者产后出血影响因素。结果:出血组D-二聚体(0.94±0.41 mg/L)、DPR(0.67±0.24)均高于未出血组(0.36±0.25 mg/L、0.29±0.12),血小板计数(243.96±32.51)×10^(9)/L低于未出血组(301.02±40.39)×10^(9)/L(均P<0.05)。DPR预测PPP患者产后出血的最佳截点值为0.46,曲线下面积0.914。logistic逐步回归分析,患者年龄≥35岁(OR=1.260)、胎盘植入类型为穿透型(OR=3.284)、DPR≥0.56(OR=5.094)是PPP患者产后出血的危险因素(均P<0.05)。结论:发生产后出血的PPP患者DPR呈高表达,且DPR预测PPP患者产后出血有一定临床效能。

腹主动脉球囊阻断术配合剖宫产术在凶险性前置胎盘并胎盘植入中的应用效果

目的分析腹主动脉球囊阻断术(IABO)配合剖宫产术在凶险性前置胎盘(PPP)并胎盘植入(PA)中的应用效果。方法以2021年2月至2022年12月驻马店市中医院收治的120例PPP并AP的剖宫产产妇为研究对象,随机将其分为两组。对照组(60例)接受常规剖宫产手术,观察组(60例)在剖宫产的基础上接受IABO,对比手术指标、产妇结局以及新生儿Apgar评分。结果观察组手术时间较对照组长,手术出血量和手术输血量均少于对照组,且住院时间短于对照组(P<0.05);观察组转入重症监护、子宫切除、产褥感染以及失血性休克的发生率低于对照组(P<0.05);观察组1、5、10 min的Apgar评分均高于对照组(P<0.05)。结论IABO配合剖宫产术可有效降低PPP并胎盘植入产妇在剖宫产中的出血量和子宫切除率,改善产妇结局的同时还可提高新生儿Apgar评分,具有较高的临床价值。

凶险性前置胎盘与新生儿窒息相关的临床分析

目的探讨凶险性前置胎盘与新生儿窒息相关的超声检查、高危因素及妊娠结局。方法回顾性分析2016年5月~2020年7月华中科技大学同济医学院附属同济医院收治的144例凶险性前置胎盘孕产妇的临床资料,根据新生儿情况分为未窒息组(n=91)和窒息组(n=53)。主要通过产前超声检查、术中诊断等方法,采用单因素及多因素Logistic回归分析新生儿窒息的高危因素,并比较两组新生儿的结局。结果与未窒息组比较,窒息组前壁胎盘为主、完全性前置胎盘、早产、羊水过多、胎盘穿透的发生率更高,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,前壁胎盘为主、早产、羊水过多、胎盘穿透是新生儿窒息的的独立危险因素(P<0.05,OR>1)。与未窒息组比较,窒息组出生孕周及出生体重更低,入住新生儿科的发生率更高(P<0.05)。结论凶险性前置胎盘与新生儿窒息相关的高危因素为前壁胎盘为主、早产、羊水过多、胎盘穿透。凶险性前置胎盘与新生儿窒息相关的妊娠结局更差。

腹主动脉预置球囊辅助凶险性前置胎盘伴胎盘植入剖宫产的临床应用研究

目的探讨腹主动脉预置球囊术对凶险性前置胎盘(PPP)伴胎盘植入剖宫产产妇应激反应、凝血功能及母婴结局的影响。方法选取2021年1月至2023年6月三门峡市中心医院收治的62例PPP伴胎盘植入产妇,按照随机数表法分为观察组和对照组各31例。两组产妇均行剖宫产术,对照组行髂内动脉预置球囊术,研究组行腹主动脉预置球囊术。比较两组产妇的手术指标、手术前后的应激反应指标[肾上腺素(E)、促肾上腺皮质激素(ACTH)、皮质醇(Cor)、去甲肾上腺素(NE)]、凝血功能[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)]、血红蛋白(Hb)、红细胞压积(HCT)水平,同时比较两组新生儿的相关情况及产妇的子宫切除率和并发症发生率。结果研究组产妇的手术时间、透视耗时、住院时间分别为(111.63±15.59)min、(15.67±3.27)s、(6.04±0.53)d,明显短于对照组的(128.75±20.03)min、(28.96±5.11)s、(6.65±0.74)d,放射剂量、术中与术后24 h出血量、术中输血量分别为(4.21±0.74)mGy、(752.31±153.66)mL、(135.47±20.37)mL、(357.92±32.40)mL,明显少于对照组的(15.63±2.39)mGy、(1026.47±212.52)mL、(328.19±38.92)mL、(950.30±85.61)mL,差异均有统计学意义(P<0.05);术后24 h,研究组产妇的血清Cor、ACTH、E、NE水平明显低于对照组,APTT、TT、PT、FIB、Hb、HCT明显高于对照组,差异均有统计学意义(P<0.05);出生1 min、5 min,研究组新生儿Apgar评分分别为(9.02±0.27)分、(9.52±0.24)分,明显高于对照组的(8.74±0.33)分、(9.13±0.30)分,新生儿窒息率为0,明显低于对照组的19.35%,差异均有统计学意义(P<0.05);研究组产妇的子宫切除率、并发症发生率分别为6.45%、6.45%,明显低于对照组的29.03%、32.26%,差异均有统计学意义(P<0.05)。结论腹主动脉预置球囊可减少PPP伴胎盘植入剖宫术中放射剂量、出血量及输血量,减少应激反应,改善凝血功能,促进术后早期恢复,同时提高手术安全性,改善新生儿分娩结局,降低窒息与子宫切除风险。