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多主体协同开发社区教育课程的PERSONAL模式探索——基于“我爱我家”的个案研究
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作者 陈莉 《继续教育研究》 2024年第3期40-47,共8页
通过对“我爱我家”这一社区自发课程的跟踪调查,发现社区自发课程开发实质上是一个组织学习过程,经过个体直觉、知识解释、知识整合等环节实现组织的制度化学习,在推动学习型无边界组织生成的同时,生成社区教育课程。在这一过程中,政策... 通过对“我爱我家”这一社区自发课程的跟踪调查,发现社区自发课程开发实质上是一个组织学习过程,经过个体直觉、知识解释、知识整合等环节实现组织的制度化学习,在推动学习型无边界组织生成的同时,生成社区教育课程。在这一过程中,政策(policies)支持、专家(expert)指导、区域需求和区域特征(regional)、社区系统(system)、组织化(organization)等多要素叠加发挥作用,通过不断拓展新鲜(new)领域的积极行动(action)整合所有资源,并推动跨越边界的学习(learning)贯穿始终。因此,多主体协同的社区自发课程可以不完全地概括为PERSONAL模式。要以PERSONAL模式发展社区自发课程,需要以学习者为中心,注重发展人际互动,营造有利于跨组织交互学习的教育生态系统。 展开更多
关键词 社区自发课程 组织学习 多主体协同 personal模式
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Personal Thermal Management by Radiative Cooling and Heating
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作者 Shidong Xue Guanghan Huang +3 位作者 Qing Chen Xungai Wang Jintu Fan Dahua Shou 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第8期225-267,共43页
Maintaining thermal comfort within the human body is crucial for optimal health and overall well-being.By merely broadening the setpoint of indoor temperatures,we could significantly slash energy usage in building hea... Maintaining thermal comfort within the human body is crucial for optimal health and overall well-being.By merely broadening the setpoint of indoor temperatures,we could significantly slash energy usage in building heating,ventilation,and air-conditioning systems.In recent years,there has been a surge in advancements in personal thermal management(PTM),aiming to regulate heat and moisture transfer within our immediate surroundings,clothing,and skin.The advent of PTM is driven by the rapid development in nano/micro-materials and energy science and engineering.An emerging research area in PTM is personal radiative thermal management(PRTM),which demonstrates immense potential with its high radiative heat transfer efficiency and ease of regulation.However,it is less taken into account in traditional textiles,and there currently lies a gap in our knowledge and understanding of PRTM.In this review,we aim to present a thorough analysis of advanced textile materials and technologies for PRTM.Specifically,we will introduce and discuss the underlying radiation heat transfer mechanisms,fabrication methods of textiles,and various indoor/outdoor applications in light of their different regulation functionalities,including radiative cooling,radiative heating,and dual-mode thermoregulation.Furthermore,we will shine a light on the current hurdles,propose potential strategies,and delve into future technology trends for PRTM with an emphasis on functionalities and applications. 展开更多
关键词 personal thermal management Radiative cooling and heating Thermal comfort Dynamic thermoregulation
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Correlation of personality with individual reproductive success in shrub-nesting birds depends on their life history style
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作者 Jianchuan Li Wen Zhang +5 位作者 Ningning Sun Yujie Wang Lifang Gao Ran Feng Liqing Fan Bo Du 《Avian Research》 SCIE CSCD 2024年第1期42-49,共8页
Two questions in the research of animal personality—whether there is a correlation between a personality trait and individual reproductive success,and what is the genetic basis underlying a personality trait—remain ... Two questions in the research of animal personality—whether there is a correlation between a personality trait and individual reproductive success,and what is the genetic basis underlying a personality trait—remain unresolved.We addressed these two questions in three shrub-nesting birds,the Azure-winged Magpie(Cyanopica cyanus,AM),White-collared Blackbird(Turdus albocinctus,WB),and Brown-cheeked Laughingthrush(Trochalopteron henrici,BL).The personality type of an individual was first identified according to its response to a territorial intruder.Then,we compared the fleeing distance,breeding parameters,and differential expressed genes(DEGs) in the brain transcriptome between bold and shy breeders.In the three species,bold breeders exhibited more aggressiveness towards an intruder of their territory than did shy breeders.The reproductive success of bold breeders was significantly higher than that of shy breeders in AM but not in WB and BL.The three species shared one DEG,crabp1,which was up-regulated in bold relative to in shy individuals.By regulating the expression of corticotropin-releasing hormone,higher crabp1 gene expression can decrease cellular response to retinoic acid.Therefore,bold individuals are insensitive to external stresses and able to exhibit more aggressiveness to intruders than their shier counterparts.Aggressiveness is beneficial to bold individuals in AM but not in WB and BL because the former could evoke neighbors to make the same response of defending against intruders but the latter could not.Although a personality trait may have the same genetic basis across species,its correlation with reproductive success depends largely on the life history style of a species. 展开更多
关键词 BOLDNESS Life history style personalITY Reproductive success Transcriptome analysis
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Enhancing personalized exercise recommendation with student and exercise portraits
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作者 Wei-Wei Gao Hui-Fang Ma +2 位作者 Yan Zhao Jing Wang Quan-Hong Tian 《Journal of Electronic Science and Technology》 EI CAS CSCD 2024年第2期91-109,共19页
The exercise recommendation system is emerging as a promising application in online learning scenarios,providing personalized recommendations to assist students with explicit learning directions.Existing solutions gen... The exercise recommendation system is emerging as a promising application in online learning scenarios,providing personalized recommendations to assist students with explicit learning directions.Existing solutions generally follow a collaborative filtering paradigm,while the implicit connections between students(exercises)have been largely ignored.In this study,we aim to propose an exercise recommendation paradigm that can reveal the latent connections between student-student(exercise-exercise).Specifically,a new framework was proposed,namely personalized exercise recommendation with student and exercise portraits(PERP).It consists of three sequential and interdependent modules:Collaborative student exercise graph(CSEG)construction,joint random walk,and recommendation list optimization.Technically,CSEG is created as a unified heterogeneous graph with students’response behaviors and student(exercise)relationships.Then,a joint random walk to take full advantage of the spectral properties of nearly uncoupled Markov chains is performed on CSEG,which allows for full exploration of both similar exercises that students have finished and connections between students(exercises)with similar portraits.Finally,we propose to optimize the recommendation list to obtain different exercise suggestions.After analyses of two public datasets,the results demonstrated that PERP can satisfy novelty,accuracy,and diversity. 展开更多
关键词 Educational data mining Exercise recommend Joint random walk Nearly uncoupled Markov chains Optimization personalized learning
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Personality Trait Detection via Transfer Learning
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作者 Bashar Alshouha Jesus Serrano-Guerrero +2 位作者 Francisco Chiclana Francisco P.Romero Jose A.Olivas 《Computers, Materials & Continua》 SCIE EI 2024年第2期1933-1956,共24页
Personality recognition plays a pivotal role when developing user-centric solutions such as recommender systems or decision support systems across various domains,including education,e-commerce,or human resources.Tra-... Personality recognition plays a pivotal role when developing user-centric solutions such as recommender systems or decision support systems across various domains,including education,e-commerce,or human resources.Tra-ditional machine learning techniques have been broadly employed for personality trait identification;nevertheless,the development of new technologies based on deep learning has led to new opportunities to improve their performance.This study focuses on the capabilities of pre-trained language models such as BERT,RoBERTa,ALBERT,ELECTRA,ERNIE,or XLNet,to deal with the task of personality recognition.These models are able to capture structural features from textual content and comprehend a multitude of language facets and complex features such as hierarchical relationships or long-term dependencies.This makes them suitable to classify multi-label personality traits from reviews while mitigating computational costs.The focus of this approach centers on developing an architecture based on different layers able to capture the semantic context and structural features from texts.Moreover,it is able to fine-tune the previous models using the MyPersonality dataset,which comprises 9,917 status updates contributed by 250 Facebook users.These status updates are categorized according to the well-known Big Five personality model,setting the stage for a comprehensive exploration of personality traits.To test the proposal,a set of experiments have been performed using different metrics such as the exact match ratio,hamming loss,zero-one-loss,precision,recall,F1-score,and weighted averages.The results reveal ERNIE is the top-performing model,achieving an exact match ratio of 72.32%,an accuracy rate of 87.17%,and 84.41%of F1-score.The findings demonstrate that the tested models substantially outperform other state-of-the-art studies,enhancing the accuracy by at least 3%and confirming them as powerful tools for personality recognition.These findings represent substantial advancements in personality recognition,making them appropriate for the development of user-centric applications. 展开更多
关键词 personality trait detection pre-trained language model big five model transfer learning
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MAIPFE:An Efficient Multimodal Approach Integrating Pre-Emptive Analysis,Personalized Feature Selection,and Explainable AI
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作者 Moshe Dayan Sirapangi S.Gopikrishnan 《Computers, Materials & Continua》 SCIE EI 2024年第5期2229-2251,共23页
Medical Internet of Things(IoT)devices are becoming more and more common in healthcare.This has created a huge need for advanced predictive health modeling strategies that can make good use of the growing amount of mu... Medical Internet of Things(IoT)devices are becoming more and more common in healthcare.This has created a huge need for advanced predictive health modeling strategies that can make good use of the growing amount of multimodal data to find potential health risks early and help individuals in a personalized way.Existing methods,while useful,have limitations in predictive accuracy,delay,personalization,and user interpretability,requiring a more comprehensive and efficient approach to harness modern medical IoT devices.MAIPFE is a multimodal approach integrating pre-emptive analysis,personalized feature selection,and explainable AI for real-time health monitoring and disease detection.By using AI for early disease detection,personalized health recommendations,and transparency,healthcare will be transformed.The Multimodal Approach Integrating Pre-emptive Analysis,Personalized Feature Selection,and Explainable AI(MAIPFE)framework,which combines Firefly Optimizer,Recurrent Neural Network(RNN),Fuzzy C Means(FCM),and Explainable AI,improves disease detection precision over existing methods.Comprehensive metrics show the model’s superiority in real-time health analysis.The proposed framework outperformed existing models by 8.3%in disease detection classification precision,8.5%in accuracy,5.5%in recall,2.9%in specificity,4.5%in AUC(Area Under the Curve),and 4.9%in delay reduction.Disease prediction precision increased by 4.5%,accuracy by 3.9%,recall by 2.5%,specificity by 3.5%,AUC by 1.9%,and delay levels decreased by 9.4%.MAIPFE can revolutionize healthcare with preemptive analysis,personalized health insights,and actionable recommendations.The research shows that this innovative approach improves patient outcomes and healthcare efficiency in the real world. 展开更多
关键词 Predictive health modeling Medical Internet of Things explainable artificial intelligence personalized feature selection preemptive analysis
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Personalized Lower Limb Gait Reconstruction Modeling Based on RFA-ProMP
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作者 Chunhong Zeng Kang Lu +1 位作者 Zhiqin He Qinmu Wu 《Computers, Materials & Continua》 SCIE EI 2024年第7期1441-1456,共16页
Personalized gait curves are generated to enhance patient adaptability to gait trajectories used for passive training in the early stage of rehabilitation for hemiplegic patients.The article utilizes the random forest... Personalized gait curves are generated to enhance patient adaptability to gait trajectories used for passive training in the early stage of rehabilitation for hemiplegic patients.The article utilizes the random forest algorithm to construct a gait parameter model,which maps the relationship between parameters such as height,weight,age,gender,and gait speed,achieving prediction of key points on the gait curve.To enhance prediction accuracy,an attention mechanism is introduced into the algorithm to focus more on the main features.Meanwhile,to ensure high similarity between the reconstructed gait curve and the normal one,probabilistic motion primitives(ProMP)are used to learn the probability distribution of normal gait data and construct a gait trajectorymodel.Finally,using the specified step speed as input,select a reference gait trajectory from the learned trajectory,and reconstruct the curve of the reference trajectoryusing the gait keypoints predictedby the parametermodel toobtain the final curve.Simulation results demonstrate that the method proposed in this paper achieves 98%and 96%curve correlations when generating personalized lower limb gait curves for different patients,respectively,indicating its suitability for such tasks. 展开更多
关键词 personalized lower limb gait prediction random forest probabilistic movement primitives
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Personalized and continuous care intervention affects rehabilitation,living quality,and negative emotions of patients with breast cancer
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作者 Ling-Xia Kong Yan-Hong Zhao +1 位作者 Zhi-Lin Feng Ting-Ting Liu 《World Journal of Psychiatry》 SCIE 2024年第6期876-883,共8页
BACKGROUND Breast cancer is among the most common malignancies worldwide.With progress in treatment methods and levels,the overall survival period has been prolonged,and the demand for quality care has increased.AIM T... BACKGROUND Breast cancer is among the most common malignancies worldwide.With progress in treatment methods and levels,the overall survival period has been prolonged,and the demand for quality care has increased.AIM To investigate the effect of individualized and continuous care intervention in patients with breast cancer.METHODS Two hundred patients with breast cancer who received systemic therapy at The First Affiliated Hospital of Hebei North University(January 2021 to July 2023)were retrospectively selected as research participants.Among them,134 received routine care intervention(routing group)and 66 received personalized and continuous care(intervention group).Self-rating anxiety scale(SAS),self-rating depression scale(SDS),and Functional Assessment of Cancer Therapy-Breast(FACT-B)scores,including limb shoulder joint activity,complication rate,and care satisfaction,were compared between both groups after care.RESULTS SAS and SDS scores were lower in the intervention group than in the routing group at one and three months after care.The total FACT-B scores and five dimensions in the intervention group were higher than those in the routing group at three months of care.The range of motion of shoulder anteflexion,posterior extension,abduction,internal rotation,and external rotation in the intervention group was higher than that in the routing group one month after care.The incidence of postoperative complications was 18.18%lower in the intervention group than in the routing group(34.33%;P<0.05).Satisfaction with care was 90.91% higher in the intervention group than in the routing group(78.36%;P<0.05).CONCLUSION Personalized and continuous care can alleviate negative emotions in patients with breast cancer,quicken rehabilitation of limb function,decrease the incidence of complications,and improve living quality and care satisfaction. 展开更多
关键词 Breast cancer personalized care Continuous care Negative emotions Living quality Rehabilitation effect
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Effects of personalized oral hygiene management on oral health status of pregnant women
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作者 Xiao-Chen Men Xiao-Pei Du Ying Ji 《World Journal of Clinical Cases》 SCIE 2024年第21期4566-4573,共8页
BACKGROUND The Cariostat caries activity test(CAT)was used to evaluate the effectiveness of personalized oral hygiene management combining oral health education and professional mechanical tooth cleaning on the oral h... BACKGROUND The Cariostat caries activity test(CAT)was used to evaluate the effectiveness of personalized oral hygiene management combining oral health education and professional mechanical tooth cleaning on the oral health status of pregnant women.AIM To investigate whether personalized oral hygiene management enhances the oral health status of pregnant women.METHODS A total of 114 pregnant women who were examined at Dalian Women’s and Children’s Medical Center were divided into four groups:High-risk experimental group(n=29;CAT score≥2;received personalized oral hygiene management training),low-risk experimental group(n=29;CAT score≤1;received oral health education),high-risk control group(n=28;CAT score≥2),and low-risk control group(n=28;CAT score≤1).No hygiene intervention was provided to control groups.CAT scores at different times were compared using independent samples t-test and least significant difference t-test.RESULTS No significant difference in baseline CAT scores was observed between the experimental and control groups,either in the high-risk or low-risk groups.CAT scores were reduced significantly after 3(1.74±0.47 vs 2.50±0.38,P<0.0001)and 6 months(0.53±0.50 vs 2.45±0.42,P<0.0001)of personalized oral hygiene management intervention but not after oral health education alone(0.43±0.39 vs 0.46±0.33,P>0.05 and 0.45±0.36 vs 0.57±0.32,P>0.05,respectively).Within groups,the decrease in CAT scores was significant(2.43±0.44 vs 1.74±0.47 vs 0.53±0.50,P<0.0001)for only the high-risk experimental group.CONCLUSION Personalized oral hygiene management is effective in improving the oral health of pregnant women and can improve pregnancy outcomes and the oral health of the general population. 展开更多
关键词 Oral health care Pregnant women Decayed teeth Cariostat caries activity test Professional mechanical tooth cleaning personalized oral hygiene management
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The Dynamic System Theory of Legal Protection for Personal Information Rights Infringement
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作者 莫杨燊 NI Weis 《The Journal of Human Rights》 2024年第1期143-172,共30页
The advent of the big data era has presented unprecedented challenges to remedies for personal information infringement in areas such as damage assessment,proof of causation,determination of illegality,fault assessmen... The advent of the big data era has presented unprecedented challenges to remedies for personal information infringement in areas such as damage assessment,proof of causation,determination of illegality,fault assessment,and liability.Traditional tort law is unable to provide a robust response for these challenges,which severely hinders human rights protection in the digital society.The dynamic system theory represents a third path between fixed constitutive elements and general clauses.It both overcomes the rigidity of the“allor-nothing”legal effect evaluation mechanism of the“element-effect”model and avoids the uncertainty of the general clause model.It can effectively enhance the flexibility of the legal system in responding to social changes.In light of this,it is necessary to construct a dynamic foundational evaluation framework for personal information infringement under the guidance of the dynamic system theory.By relying on the dynamic interplay effect of various foundational evaluation elements,this framework can achieve a flexible evaluation of the constitutive elements of liability and the legal effects of liability for personal information infringement.Through this approach,the crisis of personal information infringement in the era of big data can be mitigated,and the realization of personal information rights as digital human rights can be promoted. 展开更多
关键词 personal information digital human rights dynamic system theory constitutive elements of torts LIABILITY
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On the“News Exception”in Personal Information Protection
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作者 张文亮 刘雨祺 LI Donglin 《The Journal of Human Rights》 2024年第1期89-110,共22页
Protection of personal information is a significant issue in the construction of legal systems in various countries in the information age.Introducing a balanced approach for protecting personal information is an impo... Protection of personal information is a significant issue in the construction of legal systems in various countries in the information age.Introducing a balanced approach for protecting personal information is an important goal of basic human rights protection and data legislation.Personal information protection involves comprehensive considerations among various values,and the balanced structure between personal information rights and other rights systems has become the key to legislation on personal information protection.The“news exception”is a prominent example representing the balanced structure of personal information protection.As a societal instrument,news not only pursues commercial value but also advocates freedom of expression and public value.There exists a natural tension between news and personal information protection.The“news exception”of the balanced structure has become a fundamental requirement and important connotation for constructing a system for protecting personal information.The balanced structure of the“news exception”requires a reasonable definition of the concept and purpose of news,and both the self-discipline within the news industry and the judicial intervention are necessary factors.China has preliminarily completed the top-level legislative design of personal information protection through laws such as the Civil Code of the People’s Republic of China(PRC)and the Personal Information Protection Law of the People’s Republic of China.However,the balanced mechanism of the“news exception”has not yet been fully established in China.A“news exception”based on the ideas of balance and the improvement of the institutional system is the fundamental principle for the development of China’s personal information protection system. 展开更多
关键词 personal information news exception Civil Code of the PRC
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The Impact of Big Five Personality Traits on Older Europeans’ Physical Health
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作者 Eleni Serafetinidou Christina Parpoula 《Journal of Biomedical Science and Engineering》 2024年第2期41-56,共16页
Investigating the role of Big Five personality traits in relation to various health outcomes has been extensively studied. The impact of “Big Five” on physical health is here explored for older Europeans with a focu... Investigating the role of Big Five personality traits in relation to various health outcomes has been extensively studied. The impact of “Big Five” on physical health is here explored for older Europeans with a focus on examining age groups differences. The study sample included 378,500 respondents derived from the seventh data wave of Survey of Health, Aging and Retirement in Europe (SHARE). The physical health status of older Europeans was estimated by constructing an index considering the combined effect of well-established health indicators such as the number of chronic diseases, mobility limitations, limitations with basic and instrumental activities of daily living, and self-perceived health. This index was used for an overall physical health assessment, for which the higher the score for an individual, the worst health level. Then, through a dichotomization process applied to the retrieved Principal Component Analysis scores, a two-group discrimination (good or bad health status) of SHARE participants was obtained as regards their physical health condition, allowing for further con-structing logistic regression models to assess the predictive significance of “Big Five” and their protective role for physical health. Results showed that neuroti-cism was the most significant predictor of physical health for all age groups un-der consideration, while extraversion, agreeableness and openness were not found to significantly affect the self-reported physical health levels of midlife adults aged 50 up to 64. Older adults aged 65 up to 79 were more prone to open-ness, whereas the oldest old individuals aged 80 up to 105 were mainly affected by openness and conscientiousness. . 展开更多
关键词 Big Five personality Traits Physical Health Older Europeans SHARE Principal Component Analysis
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Taxation Models and Improvement Proposals for Personal Income Tax in the Sharing Economy
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作者 Xinyao Ruan 《Proceedings of Business and Economic Studies》 2024年第3期220-226,共7页
As an innovative economic model,the sharing economy has seen rapid growth globally in recent years.It has not only brought a profound impact on traditional economies but also injected new vitality and momentum into th... As an innovative economic model,the sharing economy has seen rapid growth globally in recent years.It has not only brought a profound impact on traditional economies but also injected new vitality and momentum into the sustainable development of the social economy.However,for the sharing economy,the process of collecting personal income tax is facing several issues,such as the ambiguity of tax policies regarding personal income,challenges in identifying taxpayers,and difficulties in defining income.To achieve the fairness and efficiency of personal income tax collection in the sharing economy,this study proposes optimized regulatory mechanisms and conducts in-depth discussions on the adjustment of personal income tax policies,innovation in tax management technology,and improvement in the quality of personal income tax services. 展开更多
关键词 Sharing economy personal income tax Taxation models
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Personalized Health Monitoring Systems: Integrating Wearable and AI
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作者 Ion-Alexandru Secara Dariia Hordiiuk 《Journal of Intelligent Learning Systems and Applications》 2024年第2期44-52,共9页
The integration of wearable technologies and artificial intelligence (AI) has revolutionized healthcare, enabling advanced personal health monitoring systems. This article explores the transformative impact of wearabl... The integration of wearable technologies and artificial intelligence (AI) has revolutionized healthcare, enabling advanced personal health monitoring systems. This article explores the transformative impact of wearable technologies and AI on healthcare, highlighting the development and theoretical application of the Integrated Personal Health Monitoring System (IPHMS). By integrating data from various wearable devices, such as smartphones, Apple Watches, and Oura Rings, the IPHMS framework aims to revolutionize personal health monitoring through real-time alerts, comprehensive tracking, and personalized insights. Despite its potential, the practical implementation faces challenges, including data privacy, system interoperability, and scalability. The evolution of healthcare technology from traditional methods to AI-enhanced wearables underscores a significant advancement towards personalized care, necessitating further research and innovation to address existing limitations and fully realize the benefits of such integrated health monitoring systems. 展开更多
关键词 Wearables AI personalized Healthcare Health Monitoring Systems
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The Effect of Personalized Comprehensive Care on the Nursing Care of Severe Pneumonia Patients
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作者 Juan Li 《Journal of Clinical and Nursing Research》 2024年第1期71-77,共7页
Objective:To explore the value of receiving personalized comprehensive care for patients with severe pneumonia.Methods:73 patients with severe pneumonia who visited the clinic from February 2020 to February 2023 were ... Objective:To explore the value of receiving personalized comprehensive care for patients with severe pneumonia.Methods:73 patients with severe pneumonia who visited the clinic from February 2020 to February 2023 were included in this study.The patients were randomly grouped into Group A and Group B.Group A received personalized comprehensive care whereas Group B received conventional care.The value of care was compared.Results:The duration of mechanical ventilation time,the time taken for fever and dyspnea relief,and the hospitalization time of Group A were shorter than those in Group B(P<0.05).The blood gas indexes such as PaO_(2),PaCO_(2),and blood pH of Group A were better than those of Group B(P<0.05).The pulmonary function indexes such as peak expiratory flow(PEF),forced vital capacity(FVC),and forced expiratory volume in 1 second(FEV_(1))of Group A were better than those of Group B,P<0.05.Moreover,the patients in Group A were generally more satisfied with the care given compared to the patients in Group B(P<0.05).Conclusion:Personalized comprehensive care improves blood gas indexes,enhances lung function,accelerates the relief of symptoms,and also enhances patient satisfaction in severe pneumonia patients. 展开更多
关键词 Severe pneumonia personalized nursing Comprehensive care
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Therapeutic potential of exosome-based personalized delivery platform in chronic inflammatory diseases 被引量:2
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作者 Chenglong Wang Maochang Xu +2 位作者 Qingze Fan Chunhong Li Xiangyu Zhou 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2023年第1期27-43,共17页
In the inflammatory microenvironment,there are numerous exosomes secreted by immune cells(Macrophages,neutrophils,dendritic cells),mesenchymal stem cells(MSCs)and platelets as intercellular communicators,which partici... In the inflammatory microenvironment,there are numerous exosomes secreted by immune cells(Macrophages,neutrophils,dendritic cells),mesenchymal stem cells(MSCs)and platelets as intercellular communicators,which participate in the regulation of inflammation by modulating gene expression and releasing anti-inflammatory factors.Due to their good biocompatibility,accurate targeting,low toxicity and immunogenicity,these exosomes are able to selectively deliver therapeutic drugs to the site of inflammation through interactions between their surface-antibody or modified ligand with cell surface receptors.Therefore,the role of exosome-based biomimetic delivery strategies in inflammatory diseases has attracted increasing attention.Here we review current knowledge and techniques for exosome identification,isolation,modification and drug loading.More importantly,we highlight progress in using exosomes to treat chronic inflammatory diseases such as rheumatoid arthritis(RA),osteoarthritis(OA),atherosclerosis(AS),and inflammatory bowel disease(IBD).Finally,we also discuss their potential and challenges as anti-inflammatory drug carriers. 展开更多
关键词 EXOSOME personalized delivery platform Chronic inflammation Therapeutic potential
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The personal protective equipment(PPE)based on individual combat:A systematic review and trend analysis 被引量:1
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作者 Qian-ran Hu Xing-yu Shen +2 位作者 Xin-ming Qian Guang-yan Huang Meng-qi Yuan 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第10期195-221,共27页
With the development of ordnance technology,the survival and safety of individual combatants in hightech warfare are under serious threat,and the Personal Protective Equipment(PPE),as an important guarantee to reduce ... With the development of ordnance technology,the survival and safety of individual combatants in hightech warfare are under serious threat,and the Personal Protective Equipment(PPE),as an important guarantee to reduce casualties and maintain military combat effectiveness,is widely developed.This paper systematically reviewed various PPE based on individual combat through literature research and comprehensive discussion,and introduced in detail the latest application progress of PPE in terms of material and technology from three aspects:individual integrated protection system,traditional protection equipment,and intelligent protection equipment,respectively,and discussed in depth the functional improvement and optimization status brought by advanced technology for PPE,focusing on the achievements of individual equipment technology application.Finally,the problems and technical bottlenecks in the development of PPE were analyzed and summarized,and the development trend of PPE were pointed out.The results of the review will provide a forward-looking reference for the current development of individual PPE,and are important guidance for the design and technological innovation of advanced equipment based on the future technological battlefield. 展开更多
关键词 personal protective equipment(PPE) Individual combat Material and structure Equipment application Intelligent devices Wearable technology
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Improving Recommendation for Effective Personalization in Context-Aware Data Using Novel Neural Network 被引量:1
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作者 R.Sujatha T.Abirami 《Computer Systems Science & Engineering》 SCIE EI 2023年第8期1775-1787,共13页
The digital technologies that run based on users’content provide a platform for users to help air their opinions on various aspects of a particular subject or product.The recommendation agents play a crucial role in ... The digital technologies that run based on users’content provide a platform for users to help air their opinions on various aspects of a particular subject or product.The recommendation agents play a crucial role in personalizing the needs of individual users.Therefore,it is essential to improve the user experience.The recommender system focuses on recommending a set of items to a user to help the decision-making process and is prevalent across e-commerce and media websites.In Context-Aware Recommender Systems(CARS),several influential and contextual variables are identified to provide an effective recommendation.A substantial trade-off is applied in context to achieve the proper accuracy and coverage required for a collaborative recommendation.The CARS will generate more recommendations utilizing adapting them to a certain contextual situation of users.However,the key issue is how contextual information is used to create good and intelligent recommender systems.This paper proposes an Artificial Neural Network(ANN)to achieve contextual recommendations based on usergenerated reviews.The ability of ANNs to learn events and make decisions based on similar events makes it effective for personalized recommendations in CARS.Thus,the most appropriate contexts in which a user should choose an item or service are achieved.This work converts every label set into a Multi-Label Classification(MLC)problem to enhance recommendations.Experimental results show that the proposed ANN performs better in the Binary Relevance(BR)Instance-Based Classifier,the BR Decision Tree,and the Multi-label SVM for Trip Advisor and LDOS-CoMoDa Dataset.Furthermore,the accuracy of the proposed ANN achieves better results by 1.1%to 6.1%compared to other existing methods. 展开更多
关键词 Recommendation agents context-aware recommender systems collaborative recommendation personalization systems optimized neural network-based contextual recommendation algorithm
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Personal glucose meters coupled with signal amplification technologies for quantitative detection of non-glucose targets:Recent progress and challenges in food safety hazards analysis
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作者 Feng He Haijie Wang +7 位作者 Pengfei Du Tengfei Li Weiting Wang Tianyu Tan Yaobo Liu Yanli Ma Yuanshang Wang A.M.Abd El-Aty 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2023年第3期223-238,共16页
Ensuring food safety is paramount worldwide.Developing effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix ... Ensuring food safety is paramount worldwide.Developing effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix effects of food.Personal glucose meter(PGM),a classic point-of-care testing device,possesses unique application advantages,demonstrating promise in food safety.Currently,many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food hazards.Signal amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors,which is crucial for solving the challenges associated with the use of PGMs for food safety analysis.This review introduces the basic detection principle of a PGM-based sensing strategy,which consists of three key factors:target recognition,signal transduction,and signal output.Representative studies of existing PGM-based sensing strategies combined with various signal amplification technologies(nanomaterial-loaded multienzyme labeling,nucleic acid reaction,DNAzyme catalysis,responsive nanomaterial encapsulation,and others)in the field of food safety detection are reviewed.Future perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are discussed.Despite the need for complex sample preparation and the lack of standardization in the field,using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis. 展开更多
关键词 Food safety personal glucose meter Signal amplification Point-of-care testing Detection principle
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Personal Rockin'Computer吊椅
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《新潮电子》 2009年第4期232-232,共1页
作为现代人家居环境中最普遍也最不可缺少的家具,椅子的作用不言而喻。从传统的板凳到木椅、摇椅、沙发,大多数椅子都必须放置在地面,如果将它吊在空中会怎样呢?
关键词 personal 吊椅 家居环境 现代人 椅子
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