本文对越南西北部Phan Si Pan地区变质地体中的一个Ngoi Chi片麻岩进行了锆石CL内部结构分析、LA-（MC）-ICP-MS锆石U-Pb定年和Hf同位素分析。CL图象和Th/U比值特征显示该片麻岩样品中的锆石主要为岩浆锆石,有少量窄的变质边。岩浆锆石...本文对越南西北部Phan Si Pan地区变质地体中的一个Ngoi Chi片麻岩进行了锆石CL内部结构分析、LA-（MC）-ICP-MS锆石U-Pb定年和Hf同位素分析。CL图象和Th/U比值特征显示该片麻岩样品中的锆石主要为岩浆锆石,有少量窄的变质边。岩浆锆石的年龄为-2.9 Ga,表明该样品是越南西北部Phan Si Pan地区的基底岩石。它们的εHf（t）值为–4.70±0.92,二阶段Hf模式年龄为-3.5 Ga,表明其为更古老的（〉3.5 Ga）冥太古代地壳物质部分熔融作用形成。变质边部锆石给出了-1.8 Ga的年龄,表明变质作用发生在古元古代早期,Phan Si Pan地区在这一时期可能经历了一次重要的构造热事件。展开更多
免疫应答受多种因素影响和调节,从而维持机体内环境的稳定。巨噬细胞、树突状细胞等抗原提呈细胞表达的吲哚胺2,3-二氧化酶(Indoleam ine 2,3-d ioxygenase,IDO)清除局部微环境中的色氨酸,诱导T淋巴细胞的凋亡,通过调节性T细胞的作用抑...免疫应答受多种因素影响和调节,从而维持机体内环境的稳定。巨噬细胞、树突状细胞等抗原提呈细胞表达的吲哚胺2,3-二氧化酶(Indoleam ine 2,3-d ioxygenase,IDO)清除局部微环境中的色氨酸,诱导T淋巴细胞的凋亡,通过调节性T细胞的作用抑制T细胞的克隆性增生,参于细胞免疫的调节;在机体维持正常的妊娠以及自身免疫性疾病、器官移植排斥反应、肿瘤等疾病的发生发展中起着重要作用。调控IDO的活性可能是寻找防治免疫相关性疾病药物的新途径。展开更多
Poly(amidoamine)(PAMAM) dendrimer has a large number of terminal groups which can be functionalized by different kinds of ligands.A novel open-tubular CEC(OT-CEC) column in which BSA was bonded to inner wall of capill...Poly(amidoamine)(PAMAM) dendrimer has a large number of terminal groups which can be functionalized by different kinds of ligands.A novel open-tubular CEC(OT-CEC) column in which BSA was bonded to inner wall of capillary as stationary phase through different generations of PAMAM dendrimer was developed.The obtained columns were characterized via labelling BSA with fluorescein isothiocyanate(FITC).Under the optimized condition,the resolution of D,L-Trp was gradually improved with the increase of PAMAM generation.By OT-CEC column modified with BSA-G3.0-PAMAM,the baseline separation of D,L-Trp can be obtained.展开更多
目的观察盐酸沙格雷酯对大鼠细胞色素P4502D1/2(CYP2D1/2)的底物右美沙芬药动学的影响。方法♂SD大鼠,随机分成2组,对照组按右美沙芬组10 mg·kg-1灌胃给药,盐酸沙格雷酯组按右美沙芬和盐酸沙格雷酯均10 mg·kg-1同时灌胃给药,...目的观察盐酸沙格雷酯对大鼠细胞色素P4502D1/2(CYP2D1/2)的底物右美沙芬药动学的影响。方法♂SD大鼠,随机分成2组,对照组按右美沙芬组10 mg·kg-1灌胃给药,盐酸沙格雷酯组按右美沙芬和盐酸沙格雷酯均10 mg·kg-1同时灌胃给药,按不同时间从大鼠眼底静脉丛取血,血样处理后,用LC-MS/MS法测定大鼠血浆中右美沙芬的浓度,用DAS 2.0软件进行分析,求出其主要药代动力学参数。结果盐酸沙格雷酯组与对照组比较,右美沙芬的T12明显延长(2.49 h±0.93 h vs 1.47 h±0.20 h,P<0.05),Cmax明显升高(325.7μg·L-1±133.2μg·L-1vs 104.5μg·L-1±52.4μg·L-1,P<0.05),AUC0-t(785.5μg·L-1·h±451.9μg·L-1·h vs 244.8μg·L-1·h±168.3μg·L-1·h,P<0.05)和AUC0-∞(804.7μg·L-1·h±445.6μg·L-1·h vs 251.4μg·L-1·h±173.4μg·L-1·h,P<0.05)明显增大。结论盐酸沙格雷酯在大鼠体内对右美沙芬的代谢有抑制作用,能降低其消除过程。展开更多
This paper mainly consists of the classification of all crystallographic point groups of n-dimensional space with n ≤ 6 into different isomorphism classes. An isomorphism class is defined by a type of finite mathemat...This paper mainly consists of the classification of all crystallographic point groups of n-dimensional space with n ≤ 6 into different isomorphism classes. An isomorphism class is defined by a type of finite mathematic group;for instance, the different types of mathematic groups have been well defined and studied by Coxeter. This classification may be used in the investigation of several domains of crystallography such as the study of the incommensurate phases, the quasi crystals … Indeed, each mathematic substitution group characterizes an isomorphism class of crystallographic point groups (spaces E2 or E3), of point groups of super crystals (spaces E4 or E5), and of molecular symmetry groups (spaces E2 or E3). This mathematic group gives interesting information about: 1) the incommensurate phase structures and their phase transitions according to the Landau’s theory in their super spaces E4, E5, E6, ···;2) the molecular symmetry group of chemisorbed molecules in space E2 (paragraph 2) or of the molecular crystal or solution in view of studying the molecule structure or its rotations or vibrationsin space E3;3) the geometric polyhedron symmetry groups as the regular rhombohedron in space E3, the rhombotope in space E4 or the rhombotope in space E5. Then, thanks to the isomorphism classes, we shall give properties of some crystal families that we have not published up to now. This formalism may be used to study crystal families in n-dimensional space with n > 6.展开更多
基金Vietnam National University-Ho Chi Minh City(VNU-HCM)(No.C2014-18-02)资助
文摘本文对越南西北部Phan Si Pan地区变质地体中的一个Ngoi Chi片麻岩进行了锆石CL内部结构分析、LA-（MC）-ICP-MS锆石U-Pb定年和Hf同位素分析。CL图象和Th/U比值特征显示该片麻岩样品中的锆石主要为岩浆锆石,有少量窄的变质边。岩浆锆石的年龄为-2.9 Ga,表明该样品是越南西北部Phan Si Pan地区的基底岩石。它们的εHf（t）值为–4.70±0.92,二阶段Hf模式年龄为-3.5 Ga,表明其为更古老的（〉3.5 Ga）冥太古代地壳物质部分熔融作用形成。变质边部锆石给出了-1.8 Ga的年龄,表明变质作用发生在古元古代早期,Phan Si Pan地区在这一时期可能经历了一次重要的构造热事件。
文摘免疫应答受多种因素影响和调节,从而维持机体内环境的稳定。巨噬细胞、树突状细胞等抗原提呈细胞表达的吲哚胺2,3-二氧化酶(Indoleam ine 2,3-d ioxygenase,IDO)清除局部微环境中的色氨酸,诱导T淋巴细胞的凋亡,通过调节性T细胞的作用抑制T细胞的克隆性增生,参于细胞免疫的调节;在机体维持正常的妊娠以及自身免疫性疾病、器官移植排斥反应、肿瘤等疾病的发生发展中起着重要作用。调控IDO的活性可能是寻找防治免疫相关性疾病药物的新途径。
文摘Poly(amidoamine)(PAMAM) dendrimer has a large number of terminal groups which can be functionalized by different kinds of ligands.A novel open-tubular CEC(OT-CEC) column in which BSA was bonded to inner wall of capillary as stationary phase through different generations of PAMAM dendrimer was developed.The obtained columns were characterized via labelling BSA with fluorescein isothiocyanate(FITC).Under the optimized condition,the resolution of D,L-Trp was gradually improved with the increase of PAMAM generation.By OT-CEC column modified with BSA-G3.0-PAMAM,the baseline separation of D,L-Trp can be obtained.
文摘目的观察盐酸沙格雷酯对大鼠细胞色素P4502D1/2(CYP2D1/2)的底物右美沙芬药动学的影响。方法♂SD大鼠,随机分成2组,对照组按右美沙芬组10 mg·kg-1灌胃给药,盐酸沙格雷酯组按右美沙芬和盐酸沙格雷酯均10 mg·kg-1同时灌胃给药,按不同时间从大鼠眼底静脉丛取血,血样处理后,用LC-MS/MS法测定大鼠血浆中右美沙芬的浓度,用DAS 2.0软件进行分析,求出其主要药代动力学参数。结果盐酸沙格雷酯组与对照组比较,右美沙芬的T12明显延长(2.49 h±0.93 h vs 1.47 h±0.20 h,P<0.05),Cmax明显升高(325.7μg·L-1±133.2μg·L-1vs 104.5μg·L-1±52.4μg·L-1,P<0.05),AUC0-t(785.5μg·L-1·h±451.9μg·L-1·h vs 244.8μg·L-1·h±168.3μg·L-1·h,P<0.05)和AUC0-∞(804.7μg·L-1·h±445.6μg·L-1·h vs 251.4μg·L-1·h±173.4μg·L-1·h,P<0.05)明显增大。结论盐酸沙格雷酯在大鼠体内对右美沙芬的代谢有抑制作用,能降低其消除过程。
文摘This paper mainly consists of the classification of all crystallographic point groups of n-dimensional space with n ≤ 6 into different isomorphism classes. An isomorphism class is defined by a type of finite mathematic group;for instance, the different types of mathematic groups have been well defined and studied by Coxeter. This classification may be used in the investigation of several domains of crystallography such as the study of the incommensurate phases, the quasi crystals … Indeed, each mathematic substitution group characterizes an isomorphism class of crystallographic point groups (spaces E2 or E3), of point groups of super crystals (spaces E4 or E5), and of molecular symmetry groups (spaces E2 or E3). This mathematic group gives interesting information about: 1) the incommensurate phase structures and their phase transitions according to the Landau’s theory in their super spaces E4, E5, E6, ···;2) the molecular symmetry group of chemisorbed molecules in space E2 (paragraph 2) or of the molecular crystal or solution in view of studying the molecule structure or its rotations or vibrationsin space E3;3) the geometric polyhedron symmetry groups as the regular rhombohedron in space E3, the rhombotope in space E4 or the rhombotope in space E5. Then, thanks to the isomorphism classes, we shall give properties of some crystal families that we have not published up to now. This formalism may be used to study crystal families in n-dimensional space with n > 6.
