CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role...CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.展开更多
This paper addresses the challenges in the teaching of electrical and electronic technology in higher vocational colleges and proposes specific countermeasures to improve teaching quality and effectiveness.The counter...This paper addresses the challenges in the teaching of electrical and electronic technology in higher vocational colleges and proposes specific countermeasures to improve teaching quality and effectiveness.The countermeasures include optimizing teaching content,emphasizing practical application and innovation,innovating teaching methods,introducing modern instructional approaches,strengthening the teaching team,enhancing teacher quality and practical expertise,upgrading experimental equipment and facilities,enriching curriculum resources,and incorporating digital teaching materials.These measures aim to cultivate high-quality skilled talents,promote social and economic development,and enhance national competitiveness.By adjusting the course structure,incorporating real-world industry cases,and fostering collaboration with enterprises,students can better understand and apply electrical and electronic technology.The introduction of project-based teaching,flipped classrooms,and multimedia technology can enhance student engagement and facilitate independent learning.Furthermore,the improvement of experimental resources and the establishment of online teaching platforms can enhance students’practical skills and provide a variety of learning resources.These measures contribute to the overall improvement of electrical and electronic technology teaching in higher vocational colleges.展开更多
This study demonstrated the feasibility of implementing of MBR in pharmaceutical wastewater independently, and concluded different applications of MBR in industries. Membrane bioreactor (MBR) technology was a new wast...This study demonstrated the feasibility of implementing of MBR in pharmaceutical wastewater independently, and concluded different applications of MBR in industries. Membrane bioreactor (MBR) technology was a new wastewater treatment technology with a combination of membrane separation technology and biological treatment technology, which had unique advantages on pharmaceutical wastewater treatment. The modified membrane rector design provided a significantly lower concentration of NH3-N, Phosphorous, Total Nitrogen and COD around the membranes, and subsequently a more sustainable membrane performance due to much lower overall fouling rates. In this paper, the classification and structure of biological waste water treatment by using MBR technology were summed up along with some examples of MBR in industrial wastewater treatment, which was emphatically analyzed and discussed. Finally, the prospect of MBR in industrial wastewater treatment was described. The industrial wastewater was a high-strength wastewater which had characteristics of complicated constituents, high organics concentration, highly toxic.展开更多
Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of myco- sessince. It is highly effective in the treatment of determatomycoses. The chemical and pharmaceutical analysis of ...Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of myco- sessince. It is highly effective in the treatment of determatomycoses. The chemical and pharmaceutical analysis of the drug requires effective analytical methods for quality control and pharmacodynamic and pharmacokinetic studies. Ever since it was introduced as an effective antifungal agent, many methods have been developed and validated for its assay in pharmaceuticals and biological materials. This article reviews the various methods reported during the last 25 years.展开更多
Today the ASEAN Pharmaceutical manufacturing companies are still focusing on their local countries,with the exception of a fewlarge regionals who are already and increasingly looking and capable to export to the outsi...Today the ASEAN Pharmaceutical manufacturing companies are still focusing on their local countries,with the exception of a fewlarge regionals who are already and increasingly looking and capable to export to the outside markets such as Europe.This means that the majority of companies producing medicinal products to higher regulatory standards have less international experience/exposure in handling the GMP requirements demanded by PIC/s[1].In addition most of their processes are manual with legacy practices,and mostly the data and controls are in paper with a very high amount of data made with pen and paper on numerous human reviews of documentation mainly to assess the data is complete but not for accuracy of the data at the time that action could be taken—data integrity on paper has been shownto be highly questionable.展开更多
Pharmaceutical technology innovation process needs a lot of human, material and financial support, so the government must give full play to its financial support function. Specifically, the government should improve t...Pharmaceutical technology innovation process needs a lot of human, material and financial support, so the government must give full play to its financial support function. Specifically, the government should improve the fund investment mechanism of the pharmaceutical industry, improve the financial investment management system of pharmaceutical technology innovation, strengthen the function and mechanism of the capital market, improve the risk investment system, focus on cultivating a good credit environment, and increase the support of national policy-based financial institutions. Through direct investment, financial subsidies, tax incentives and low-interest financing and other means, vigorously promote the improvement of pharmaceutical innovation capacity.展开更多
Over the past few years,China’s extensive domestic power has been continually enhanced,and the economy,science,and technology are constantly evolving.Thus,people’s living standards have also been significantly impro...Over the past few years,China’s extensive domestic power has been continually enhanced,and the economy,science,and technology are constantly evolving.Thus,people’s living standards have also been significantly improved.In contemporary culture,individuals are increasingly demanding high-quality,safe lives and,on the one side,all regular necessities such as life-related,drug safety is a must attach huge significance.However,the state’s investment in medical care is not particularly large due to the late start of China’s medical industry.As a result,the pharmaceutical equipment of pharmaceutical companies in China still has many problems and there are potential hidden dangers in drug safety.The pharmaceutical companies in China are innovating on this basis.In technology,research and discussion,many problems appear and related solutions are proposed.展开更多
During the construction process of the construction project,the construction technology management work can improve the overall quality of the project construction.In the context of increasingly fierce competition in ...During the construction process of the construction project,the construction technology management work can improve the overall quality of the project construction.In the context of increasingly fierce competition in the construction market,construction enterprises should strengthen the management of construction technology,enhance their technical level and market competitiveness,and promote the development of the construction market[1].The paper mainly analyzes the optimization methods of build-Keywords:ing construction technology management.展开更多
English for science and technology is a branch of English texts,and the translation of petroleum technology is an important part of it.The translation of scientific and technological texts is different from the previo...English for science and technology is a branch of English texts,and the translation of petroleum technology is an important part of it.The translation of scientific and technological texts is different from the previous literary translation.This paper mainly analyses vocabularies of petroleum technology English,and gives corresponding translation methods to improve the translation quality.展开更多
Carbonate reservoirs worldwide are complex in structure,diverse in form,and highly heterogeneous.Based on these characteristics,the reservoir stimulation technologies and fluid flow characteristics of carbonate reserv...Carbonate reservoirs worldwide are complex in structure,diverse in form,and highly heterogeneous.Based on these characteristics,the reservoir stimulation technologies and fluid flow characteristics of carbonate reservoirs are briefly described in this study.The development methods and EOR technologies of carbonate reservoirs are systematically summarized,the relevant mechanisms are analyzed,and the application status of oil fields is catalogued.The challenges in the development of carbonate reservoirs are discussed,and future research directions are explored.In the current development processes of carbonate reservoirs,water flooding and gas flooding remain the primary means but are often prone to channeling problems.Chemical flooding is an effective method of tertiary oil recovery,but the harsh formation conditions require high-performance chemical agents.The application of emerging technologies can enhance the oil recovery efficiency and environmental friendliness to a certain extent,which is welcome in hard-to-recover areas such as heavy oil reservoirs,but the economic cost is often high.In future research on EOR technologies,flow field control and flow channel plugging will be the potential directions of traditional development methods,and the application of nanoparticles will revolutionize the chemical EOR methods.On the basis of diversified reservoir stimulation,combined with a variety of modern data processing schemes,multichannel EOR technologies are being developed to realize the systematic,intelligent,and cost-effective development of carbonate reservoirs.展开更多
The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,...The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,making the identification and quantification of specific ingredients still a challenge.Herein,we developed a quality control(QC)system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry(mini-MS).It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time.Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata(Fuzi)during decoction were used as examples,and the scientific principle of Fuzi compatibility was also investigated.Finally,the system was verified to work stably at the hourly level for pilot-scale extraction.This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.展开更多
Piezoelectric material,as one of the great potential materials,had attracted lots of attention all over the world due to its distinguish advantages.In this paper,the development of piezoelectric-based technology for a...Piezoelectric material,as one of the great potential materials,had attracted lots of attention all over the world due to its distinguish advantages.In this paper,the development of piezoelectric-based technology for application in the field of civil structural health monitoring(CSHM),was summarized and discussed.Based on the different identification mechanisms,the piezoelectric transducer-based technology can be divided into two main approaches as the active or passive sensing and detection methods.This paper summarized the development of these two approaches and discussed their applications in the area of civil structural health monitoring,such as structural and concrete engineering,bridge engineering,pipeline engineering,protection engineering for geological hazards and earthquake disasters,and so on.In addition,the electrical mechanical impedance(EMI)technique,as one of the active identification methods,was also detailly presented.Finally,its great potential for the piezoelectric-based technique was presented based on the detail discussion,especially in the areas of civil structural health monitoring.展开更多
[Objectives]This study was conducted to establish simple, efficient, stable, standardized and practical identification methods for sugarcane resistance to white leaf disease(SCWL), and promote the breeding for sugarca...[Objectives]This study was conducted to establish simple, efficient, stable, standardized and practical identification methods for sugarcane resistance to white leaf disease(SCWL), and promote the breeding for sugarcane resistance to SCWL. [Methods]The identification technology of sugarcane resistance to SCWL was systematically studied and explored from the aspects of sugarcane material treatment and planting, inoculation liquid preparation, inoculation method, disease investigation, grading standard formulation, etc., and two sets of simple, efficient, stable, standardized and practical accurate identification methods for sugarcane resistance to SCWL were created for the first time, namely, the seed cane coating inoculation method and the stem-cutting inoculation method at the growth stage. The seed cane coating inoculation method includes the steps of directly screening SCWL phytoplasma, extracting juice from cane and adding 10 times of sterile water to prepare an inoculation liquid, spraying seed cane on plastic film to keep moisture, planting the inoculated materials in barrels in an insect-proof greenhouse for cultivation, investigating the incidence rate 30 d after inoculation, and evaluating the disease resistance according to the 1-5 level standard. The method of stem-cutting inoculation includes the steps of directly screening sugarcane stems carrying SCWL phytoplasma and adding 10 times of sterile water to prepare an inoculation liquid, cultivating the identification materials in an insect-proof greenhouse, dropping 100 μl of the inoculation liquid into each root incision with a pipette gun at the age of 6 months, investigating the incidence rate 20 d after planting, and evaluating the disease resistance according to the 1-5 level standard. [Results] The two methods are similar to the natural transmission method. After inoculation, SCML occurred significantly, with high sensitivity and good reproducibility. The results of resistance identification were consistent with those of natural disease in the field. Through the two inoculation methods and field natural disease investigation, the resistance of 10 main cultivars to SCML was identified, which was true and reliable. [Conclusions] This study can provide standard varieties for identification of SCML resistance in the future.展开更多
This paper presents a comprehensive overview of various advanced technologies employed in the treatment of volatile organic compounds(VOCs),which are crucial pollutants in industrial emissions.The study explores diffe...This paper presents a comprehensive overview of various advanced technologies employed in the treatment of volatile organic compounds(VOCs),which are crucial pollutants in industrial emissions.The study explores different methods,including direct combustion,thermal combustion,catalytic combustion,low-temperature plasma purification,photocatalytic purification,membrane separation,and adsorption methods.Each technology is critically analyzed for its operational principles,efficiency,and applicability under different conditions.Special attention is given to adsorption concentration and catalytic combustion parallel method,highlighting its efficiency in treating low-concentration,high-volume VOC emissions.The paper also delves into the advantages and limitations of each method,providing insights into their effectiveness in various industrial scenarios.The study aims to offer a detailed guide for selecting appropriate VOC treatment technologies,contributing to enhanced environmental protection and sustainable industrial practices.展开更多
Objective To study the policies of integrating medical resources and centralized drug procurement in China from 2018 to 2020,and to provide a reference for large pharmaceutical commercial companies to select partners....Objective To study the policies of integrating medical resources and centralized drug procurement in China from 2018 to 2020,and to provide a reference for large pharmaceutical commercial companies to select partners.Methods Analytic hierarchy process(AHP)and fuzzy synthesis evaluation method were used to establish the index evaluation system and assign values to each index.Results and Conclusion According to the questionnaire survey data,the weight of each evaluation index was determined,and the evaluation results were obtained by using the fuzzy synthesis evaluation method.The selection of production enterprises by large pharmaceutical commercial companies includes five first-level indicators and 11 second-level indicators.They can provide a favorable reference for the selection of production enterprises by large pharmaceutical commercial companies against the background of complex pharmaceutical industry.展开更多
Objective To study the identification method that aims at the research and development target and makes the limited resources be optimized.With the frequent occurrence of potential drug safety hazards and the vigorous...Objective To study the identification method that aims at the research and development target and makes the limited resources be optimized.With the frequent occurrence of potential drug safety hazards and the vigorous development of biomedicine,China’s pharmaceutical cold chain is facing huge opportunities and challenges.Under this background,it’s vital to promote the research and development of Chinese pharmaceutical cold chain technology.Methods First,China’s pharmaceutical cold chain patents were sorted out through the literature research method and patent analysis method,de-noises and cleans the data,uses the international patent classification(IPC)numbers as the pharmaceutical cold chain technology.Then,the IPC number co-occurrence matrix was constructed.Third,UCINET was used to visualize,draw the IPC number co-occurrence network.After that,K-cores analysis was applied to initially screen the core technology so as to build a comprehensive evaluation index system to evaluate the core technologies.Finally,Condorcet voting method was used to integrate the evaluation results to identify the core technologies.Results and Conclusion Based on this method,it can provide theoretical guidance for the development and decision-making of Chinese pharmaceutical cold chain enterprises,helping them break through technical barriers and improving the efficiency of Chinese pharmaceutical cold chain logistics.展开更多
文摘CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.
基金The Project of China Vocational Education Association(Project number:ZJS2022YB024)。
文摘This paper addresses the challenges in the teaching of electrical and electronic technology in higher vocational colleges and proposes specific countermeasures to improve teaching quality and effectiveness.The countermeasures include optimizing teaching content,emphasizing practical application and innovation,innovating teaching methods,introducing modern instructional approaches,strengthening the teaching team,enhancing teacher quality and practical expertise,upgrading experimental equipment and facilities,enriching curriculum resources,and incorporating digital teaching materials.These measures aim to cultivate high-quality skilled talents,promote social and economic development,and enhance national competitiveness.By adjusting the course structure,incorporating real-world industry cases,and fostering collaboration with enterprises,students can better understand and apply electrical and electronic technology.The introduction of project-based teaching,flipped classrooms,and multimedia technology can enhance student engagement and facilitate independent learning.Furthermore,the improvement of experimental resources and the establishment of online teaching platforms can enhance students’practical skills and provide a variety of learning resources.These measures contribute to the overall improvement of electrical and electronic technology teaching in higher vocational colleges.
文摘This study demonstrated the feasibility of implementing of MBR in pharmaceutical wastewater independently, and concluded different applications of MBR in industries. Membrane bioreactor (MBR) technology was a new wastewater treatment technology with a combination of membrane separation technology and biological treatment technology, which had unique advantages on pharmaceutical wastewater treatment. The modified membrane rector design provided a significantly lower concentration of NH3-N, Phosphorous, Total Nitrogen and COD around the membranes, and subsequently a more sustainable membrane performance due to much lower overall fouling rates. In this paper, the classification and structure of biological waste water treatment by using MBR technology were summed up along with some examples of MBR in industrial wastewater treatment, which was emphatically analyzed and discussed. Finally, the prospect of MBR in industrial wastewater treatment was described. The industrial wastewater was a high-strength wastewater which had characteristics of complicated constituents, high organics concentration, highly toxic.
文摘Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of myco- sessince. It is highly effective in the treatment of determatomycoses. The chemical and pharmaceutical analysis of the drug requires effective analytical methods for quality control and pharmacodynamic and pharmacokinetic studies. Ever since it was introduced as an effective antifungal agent, many methods have been developed and validated for its assay in pharmaceuticals and biological materials. This article reviews the various methods reported during the last 25 years.
文摘Today the ASEAN Pharmaceutical manufacturing companies are still focusing on their local countries,with the exception of a fewlarge regionals who are already and increasingly looking and capable to export to the outside markets such as Europe.This means that the majority of companies producing medicinal products to higher regulatory standards have less international experience/exposure in handling the GMP requirements demanded by PIC/s[1].In addition most of their processes are manual with legacy practices,and mostly the data and controls are in paper with a very high amount of data made with pen and paper on numerous human reviews of documentation mainly to assess the data is complete but not for accuracy of the data at the time that action could be taken—data integrity on paper has been shownto be highly questionable.
文摘Pharmaceutical technology innovation process needs a lot of human, material and financial support, so the government must give full play to its financial support function. Specifically, the government should improve the fund investment mechanism of the pharmaceutical industry, improve the financial investment management system of pharmaceutical technology innovation, strengthen the function and mechanism of the capital market, improve the risk investment system, focus on cultivating a good credit environment, and increase the support of national policy-based financial institutions. Through direct investment, financial subsidies, tax incentives and low-interest financing and other means, vigorously promote the improvement of pharmaceutical innovation capacity.
文摘Over the past few years,China’s extensive domestic power has been continually enhanced,and the economy,science,and technology are constantly evolving.Thus,people’s living standards have also been significantly improved.In contemporary culture,individuals are increasingly demanding high-quality,safe lives and,on the one side,all regular necessities such as life-related,drug safety is a must attach huge significance.However,the state’s investment in medical care is not particularly large due to the late start of China’s medical industry.As a result,the pharmaceutical equipment of pharmaceutical companies in China still has many problems and there are potential hidden dangers in drug safety.The pharmaceutical companies in China are innovating on this basis.In technology,research and discussion,many problems appear and related solutions are proposed.
文摘During the construction process of the construction project,the construction technology management work can improve the overall quality of the project construction.In the context of increasingly fierce competition in the construction market,construction enterprises should strengthen the management of construction technology,enhance their technical level and market competitiveness,and promote the development of the construction market[1].The paper mainly analyzes the optimization methods of build-Keywords:ing construction technology management.
文摘English for science and technology is a branch of English texts,and the translation of petroleum technology is an important part of it.The translation of scientific and technological texts is different from the previous literary translation.This paper mainly analyses vocabularies of petroleum technology English,and gives corresponding translation methods to improve the translation quality.
基金supported by the Innovation Project for Graduates in UPC(Grant YCX2019016)the National Natural Science Foundation of China(Nos.51774306 and 51974346)+1 种基金the Science and Technology Support Plan for Youth Innovation of University in Shandong Province under Grant 2019KJH002the Major Scientific and Technological Projects of CNPC under Grant ZD2019-183-008。
文摘Carbonate reservoirs worldwide are complex in structure,diverse in form,and highly heterogeneous.Based on these characteristics,the reservoir stimulation technologies and fluid flow characteristics of carbonate reservoirs are briefly described in this study.The development methods and EOR technologies of carbonate reservoirs are systematically summarized,the relevant mechanisms are analyzed,and the application status of oil fields is catalogued.The challenges in the development of carbonate reservoirs are discussed,and future research directions are explored.In the current development processes of carbonate reservoirs,water flooding and gas flooding remain the primary means but are often prone to channeling problems.Chemical flooding is an effective method of tertiary oil recovery,but the harsh formation conditions require high-performance chemical agents.The application of emerging technologies can enhance the oil recovery efficiency and environmental friendliness to a certain extent,which is welcome in hard-to-recover areas such as heavy oil reservoirs,but the economic cost is often high.In future research on EOR technologies,flow field control and flow channel plugging will be the potential directions of traditional development methods,and the application of nanoparticles will revolutionize the chemical EOR methods.On the basis of diversified reservoir stimulation,combined with a variety of modern data processing schemes,multichannel EOR technologies are being developed to realize the systematic,intelligent,and cost-effective development of carbonate reservoirs.
基金supported by Ministry of Science and Technology of the People's Republic of China(Grant No.:2022YFC3502300)Beijing Natural Science Foundation(Grant No.:L222150)+2 种基金the National Natural Science Foundation of China(Grant No.:82072247)the second batch of“Ten thousand plan”National High Level Talents Special Support Plan(Grant No.:W02020052)Beijing University of Chinese Medicine(Grant Nos.:XJYS21005,JY21024,MSGZF-202001,2022-syjs-05,and 2022-syjs-10).
文摘The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,making the identification and quantification of specific ingredients still a challenge.Herein,we developed a quality control(QC)system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry(mini-MS).It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time.Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata(Fuzi)during decoction were used as examples,and the scientific principle of Fuzi compatibility was also investigated.Finally,the system was verified to work stably at the hourly level for pilot-scale extraction.This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.
基金the National Natural Science Funding of China(No.51878628,51708520).
文摘Piezoelectric material,as one of the great potential materials,had attracted lots of attention all over the world due to its distinguish advantages.In this paper,the development of piezoelectric-based technology for application in the field of civil structural health monitoring(CSHM),was summarized and discussed.Based on the different identification mechanisms,the piezoelectric transducer-based technology can be divided into two main approaches as the active or passive sensing and detection methods.This paper summarized the development of these two approaches and discussed their applications in the area of civil structural health monitoring,such as structural and concrete engineering,bridge engineering,pipeline engineering,protection engineering for geological hazards and earthquake disasters,and so on.In addition,the electrical mechanical impedance(EMI)technique,as one of the active identification methods,was also detailly presented.Finally,its great potential for the piezoelectric-based technique was presented based on the detail discussion,especially in the areas of civil structural health monitoring.
基金Supported by National Natural Science Foundation of China (31760504)China Agriculture Research System of MOF and MARA(CARS-170303)+1 种基金Yunling Industry and Technology Leading Talent Training Program (2018LJRC56)Special Fund for the Construction of Modern Agricultural Industry Technology System in Yunnan Province。
文摘[Objectives]This study was conducted to establish simple, efficient, stable, standardized and practical identification methods for sugarcane resistance to white leaf disease(SCWL), and promote the breeding for sugarcane resistance to SCWL. [Methods]The identification technology of sugarcane resistance to SCWL was systematically studied and explored from the aspects of sugarcane material treatment and planting, inoculation liquid preparation, inoculation method, disease investigation, grading standard formulation, etc., and two sets of simple, efficient, stable, standardized and practical accurate identification methods for sugarcane resistance to SCWL were created for the first time, namely, the seed cane coating inoculation method and the stem-cutting inoculation method at the growth stage. The seed cane coating inoculation method includes the steps of directly screening SCWL phytoplasma, extracting juice from cane and adding 10 times of sterile water to prepare an inoculation liquid, spraying seed cane on plastic film to keep moisture, planting the inoculated materials in barrels in an insect-proof greenhouse for cultivation, investigating the incidence rate 30 d after inoculation, and evaluating the disease resistance according to the 1-5 level standard. The method of stem-cutting inoculation includes the steps of directly screening sugarcane stems carrying SCWL phytoplasma and adding 10 times of sterile water to prepare an inoculation liquid, cultivating the identification materials in an insect-proof greenhouse, dropping 100 μl of the inoculation liquid into each root incision with a pipette gun at the age of 6 months, investigating the incidence rate 20 d after planting, and evaluating the disease resistance according to the 1-5 level standard. [Results] The two methods are similar to the natural transmission method. After inoculation, SCML occurred significantly, with high sensitivity and good reproducibility. The results of resistance identification were consistent with those of natural disease in the field. Through the two inoculation methods and field natural disease investigation, the resistance of 10 main cultivars to SCML was identified, which was true and reliable. [Conclusions] This study can provide standard varieties for identification of SCML resistance in the future.
文摘This paper presents a comprehensive overview of various advanced technologies employed in the treatment of volatile organic compounds(VOCs),which are crucial pollutants in industrial emissions.The study explores different methods,including direct combustion,thermal combustion,catalytic combustion,low-temperature plasma purification,photocatalytic purification,membrane separation,and adsorption methods.Each technology is critically analyzed for its operational principles,efficiency,and applicability under different conditions.Special attention is given to adsorption concentration and catalytic combustion parallel method,highlighting its efficiency in treating low-concentration,high-volume VOC emissions.The paper also delves into the advantages and limitations of each method,providing insights into their effectiveness in various industrial scenarios.The study aims to offer a detailed guide for selecting appropriate VOC treatment technologies,contributing to enhanced environmental protection and sustainable industrial practices.
基金2021 Scientific Research of Liaoning Provincial Department of Education Fund(No.LJKZ0298)Key projects of Shenyang Philosophy and Social Science Planning Fund(No.SZ202001L).
文摘Objective To study the policies of integrating medical resources and centralized drug procurement in China from 2018 to 2020,and to provide a reference for large pharmaceutical commercial companies to select partners.Methods Analytic hierarchy process(AHP)and fuzzy synthesis evaluation method were used to establish the index evaluation system and assign values to each index.Results and Conclusion According to the questionnaire survey data,the weight of each evaluation index was determined,and the evaluation results were obtained by using the fuzzy synthesis evaluation method.The selection of production enterprises by large pharmaceutical commercial companies includes five first-level indicators and 11 second-level indicators.They can provide a favorable reference for the selection of production enterprises by large pharmaceutical commercial companies against the background of complex pharmaceutical industry.
基金Source of the project:project supported by Liaoning Provincial Social Science Foundation-Research on Patent Legal Issues of Liaoning Traditional Chinese Medicine Manufacturing Industry Going Global Based on Technological Innovation(L18BFX011).
文摘Objective To study the identification method that aims at the research and development target and makes the limited resources be optimized.With the frequent occurrence of potential drug safety hazards and the vigorous development of biomedicine,China’s pharmaceutical cold chain is facing huge opportunities and challenges.Under this background,it’s vital to promote the research and development of Chinese pharmaceutical cold chain technology.Methods First,China’s pharmaceutical cold chain patents were sorted out through the literature research method and patent analysis method,de-noises and cleans the data,uses the international patent classification(IPC)numbers as the pharmaceutical cold chain technology.Then,the IPC number co-occurrence matrix was constructed.Third,UCINET was used to visualize,draw the IPC number co-occurrence network.After that,K-cores analysis was applied to initially screen the core technology so as to build a comprehensive evaluation index system to evaluate the core technologies.Finally,Condorcet voting method was used to integrate the evaluation results to identify the core technologies.Results and Conclusion Based on this method,it can provide theoretical guidance for the development and decision-making of Chinese pharmaceutical cold chain enterprises,helping them break through technical barriers and improving the efficiency of Chinese pharmaceutical cold chain logistics.