Quick Single Run Capillary Zone Electrophoresis Determination of Active Ingredients and Preservatives in Pharmaceutical Products

The paper deals with the development of a rapid and efficient Capillary Zone Electrophoresis (CZE) method for Quality Control analysis of pharmaceutical preparations containing antihistamines, decongestants, anticholinergic remedies and preservatives. Active ingredients of interest are: ChlorPheniramine Maleate (CPM), DiPhenhydramine Hydrochloride (DPH), Ephedrine hydrochloride (E), Isopropamide Iodide (II), Pheniramine Maleate (PM), Lidocaine hydrochloride (L), Tetracaine hydrochloride (T), Clopamide Hydrochloride (CH), DiHydroErgochristine (DHE), PhenylEphrine hydrochloride (PE) and Acetaminophen (A). Preservatives studied are: MethylParaben (MeP), EthylParaben (EtP), PropylParaben (PrP), ButylParaben (BuP), p-HydroxyBenzoic Acid (p-HBA). All these analytes were separated in a single run using 60 mM tetraborate buffer solution (TBS) pH = 9.2 as a BackGround Electrolyte (BGE) by using an uncoated fused silica capillary of I.D. = 50 mm and applying a voltage of 25 kV in the first part of the electropheretic run (up to 5.8 min) and 30 kV for the remaining time. The hydrodynamic pressurization of the inlet vial was 20 psi at 7.2 min. up to the end of analysis. Total separation time was of 7.5 min. The method was then successfully validated and applied to the simultaneous determination of active ingredients and preservatives. Good repeatability, linearity, and sensitivity were demonstrated. Precision of migration time (tm) was RSD% < 0.53% and of corrected peak area (Ac) was RSD% < 6.15%. The linearity evaluation gave 0.9928 2 1.000. LOD and LOQ, accuracy (recovery) and ruggedness were evaluated for each analyte demonstrating the good reliability of the method. Analyses of some pharmaceutical real samples were performed.

A Study on Theoretical Model and Applied Evaluation of Land Use Performance of High-tech Zone in Urban Fringe: A Case Study in Haidian District, Beijing

High-tech industrial zone is an important carrier for constructing innovative cities. It also plays an important role in implementing the national independent innovative strategy. How-ever, most of the high-tech industrial zones have many problems in their development process, such as efficiency of land use, weakness of oriented function and lack of land intensive. To solve these problems, the authors of this paper introduced the concept of land use performance and established the theoretical model to assess the land use performance of high-tech industrial zones. The model consists of the following three-dimensional parts: land use benefit, land use efficiency and innovative function. Based on this theory model, an index system which was composed of three secondary indictors, eight tertiary indictors and 37 fourth-grade indictors was set up to evaluate the land use performance of high-tech zone. To avoid the defects of plus model and function model, the authors brought out a three-dimensional evaluation model to examine the index of the land use performance of the high-tech industrial parks, which equals to the evaluation indicator system of land use performance of high-tech zone based on the above research. The authors examined the land use performance of five different high-tech industrial parks in Haidian District, Beijing City. The results indicated that the indicator system per-forms better in the aspect of evaluating land use benefit, land use efficiency and function of the high-tech industrial zone compared with other models.

The Role of China's High-Tech Zones in Its Regional Economic Development

National high-tech industrial development zones represent a major strategy of the Chinese government in developing high-tech industries and spurring regional economic growth. The effect of this policy is yet to be proven. Based on the panel data of 283 Chinese cities between 1984 and 2012, this paper investigates the effect of high-tech zones on regional economic development. Empirical results suggest that first, national hightech zones have remarkably enhanced regional GDP and per capita GDP growth, and this conclusion still holds true after multiple rounds of robustness test; second, the economic effect of national high-tech zones is subject to diminishing marginal return and compared with higher-tier cities, lower-tier cities benefited more from the creation of national hightech zones. This paper concludes that national high-tech zones where special policies are experimented and offered not only drive economic development but, if properly distributed across regions, may help reduce regional economic disparities as well. The results of this study provide important implications for the future distribution of national high-tech zones and the creation of other relevant policies.

Spatial Pattern Evolution and Industrial Characteristics of Economic and Technological Development Zones and High-tech Industrial Zones in China

Economic and technological development zone and high-tech industrial zone are important types of development zone in China,and there are differences in their connotation and goal setting.In this paper,basic data of national and provincial economic and technological development zones and high-tech industrial zones in China were collected and arranged.Kernel density analysis and other GIS spatial analysis techniques were used to analyze the evolution laws of spatial patterns of economic and technological development zones and high-tech industrial zones in cities from 2006 to 2018.First,the agglomeration intensity was compared by measuring the degree of regional agglomeration and dispersion on the two time nodes.Next,kernel density method was used to explore the evolution of the two in the spatial layout and location,and analyze development commonness and difference of economic and technological development zones and high-tech industrial zones.Finally,the trend and reason of spatial evolution of development zones with different leading industries were explored.Research results show that:①the agglomeration degree of layout of high-tech industrial zones is stronger than that of economic and technological development zones,and there are similarities and differences in distribution trend of spatial patterns of the two types of development zones;②the distribution of labor-intensive,capital-intensive and technology-intensive development zones is concentrated at smaller scales and dispersed at larger ones;③although there are differences between the economic and technological development zones and the high-tech industrial zones in the goal,support,structure and function,management system and so on,their spatial development presents a trend of convergence.In the future,when enhancing urban-rural planning and public administration,governments should combine the trend of industrial transformation and upgrading,and optimize spatial layout of development zones by adjusting industrial structure,layout,transportation and land use.

Rapid and Sensitive CZE Method for Quality Control Analysis of Pharmaceuticals Containing Pseudoephedrine, Triprolidine and Paracetamol

A rapid and sensitive CZE (Capillary Zone Electrophoresis) method for pharmaceutical analysis was developed and fully validated. The active compounds: Pseudoephedrine hydrochloride (PSE), Triprolidine hydrochloride (TRI) and Paracetamol (PAR) were separated and quantitatively determined using the tris-borate 30 mM buffer at pH = 9.0 as a Background Electrolyte (BGE). The electrophoretic separation was carried out at 25 kV in an unmodified fused silica capillary of I.D. = 50 μm with a “bubble-cell” for UV detection at 210 nm and 25&deg;C. The separation was reached in about 3 min. After calibration the method was applied for analysis of three commercially available pharmaceutical preparations. The repeatability (RSD%) of migration time (tm) was ranging between 0.47% and 0.90% and of peak areas (A) between 0.63% and 3.64%. The Limit of Detection (LOD) values was of 0.19 μg/mL, 0.31 μg/mL and 0.08 μg/mL for respectively PSE, TRI and PAR. The results obtained in this study showed that the proposed method was useful in routinely analysis of pharmaceuticals.

The Impact of the Establishment of National High-tech Zones on Total Factor Productivity of Chinese Enterprises

The National High-tech Zone(NHTZs)is an important strategic platform for cultivating high-tech industries and realizing high-quality economic development in China.Based on the combined data from 2006 to 2014 of the industrial enterprise database,the customs database,and the China Development Zones Audit and Announcement Catalogue(abbreviated asthe Catalogue),this paper systematically investigates the influence of the construction of NHTZs on enterprise’s total factor productivity(TFP).Results show that NHTZs have a positive impact on the TFP of enterprises in the zone,and this conclusion is still valid after considering endogeneity problems.Furthermore,the above productivity effects of NHTZs are heterogeneous in terms of enterprise ownership,external environment and establishment time,and NHTZs have greater stimulation effects on enterprise productivity after comparing with other types of functional zones.An investigation of the specific mechanisms at play shows that NHTZs promote the TFP of enterprises in the zone through the release of preferential policies,strengthening the“technology spillover effects”of imported intermediate goods,enhancing enterprise’s innovation ability and attracting talent.In addition,based on the decomposition of industry productivity,this paper also investigates the impact of NHTZs on changes in industry productivity and finds that NHTZs promote the overall productivity of specific industries mainly by stimulating the productivity improvement of incumbent enterprises and expanding the market share of high-productivity enterprises.Moreover,the preferential policies of NHTZs do not significantly stimulate high-productivity enterprises to enter the zones,nor do they cause low-productivity enterprises to exit.This research is helpful in objectively evaluating the economic effects of the NHTZs in China and in providing a theoretical basis for its further adjustment.

A Study of the Industrial Development in Huazhong Agricultural High-tech Industrial Development Zone

This paper illustrates the current situation and problems concerning the industrial structure in Huazhong Agricultural High-tech Industrial Development Zone,and analyzes the internal contradictions that exist in industry: small-scale land operation has become an inherent obstacle to the industrial development in Agricultural High-tech Zone; farmers are always in a passive position in industrial restructuring optimization; government's policy failures and rent-seeking behaviors have hindered industrial development; the research,popularization and application of agricultural science and technology is not suited to industrial development requirements. Finally,this paper makes the corresponding recommendations for industrial development in Huazhong Agricultural High-tech Industrial Development Zone.

Comprehensive Control Measures and Effect Evaluation of Groundwater Over-exploitation Areas in High-tech Zone,Jining in 2020

Groundwater over-exploitation is a major problem in groundwater development, utilization and protection. At present, the area of shallow groundwater over-exploitation in the High-tech Zone is 76 km^(2). In this study, the system and mechanism construction, engineering measure construction, and control effect of national comprehensive control project of groundwater over-exploitation areas in the High-tech Zone in 2020 were evaluated, and the comprehensive control of groundwater over-exploitation in the High-tech Zone in the year was summarized to provide effective basis for the continuous implementation of comprehensive control of groundwater over-exploitation. At the same time, the water-saving and exploitation reduction effect and generalizability of different measures were studied to provide useful reference for other over-exploitation areas.

Economic Development Strategies and Optimization of High-tech Development Zones from the Perspective of"Four-transform and Three-famous":Taking Nanchang High-tech Development Zone as an Example

In recent years,high-tech development zones(hi-tech zones)have always occupied a very important position in the strategy of promoting China's innovative development.The combination of the"four-transform and three-famous"coordinated economic development strategy pioneered by Zhejiang Province in 2015 and the coordinated economic development of high-tech zones is particularly important for modern China at a critical time for innovative economic development.In this article,based on the research on the coordination mechanism of economic activities and development of Nanchang High-tech Zone,the development course of high-tech zones in China is elaborated,the early economic models in high-tech zones of Nanchang and China are analyzed,the existing problems in the structure of economic development of high-tech zones are analyzed in depth,the main driving factors for promoting the economic development of high-tech zones are studied from the aspects of capital,space,industry,economic model,etc.,and corresponding development strategies for high-tech development zones in China are proposed.

Evolution of Industrial Competitiveness Based on Evaluation of Urban Competitiveness of Dongguan City:A Case Study of Songshan Lake High-tech Zone

Based on the theoretical system of urban competitiveness,the evaluation model of urban competitiveness from the perspective of competition and cooperation was established.According to the significance index and explanatory index,the urban competitiveness was divided into urban comprehensive competitiveness(UC),urban internal node competitiveness(NC)and external competitiveness of urban network(EC).The scores and rankings of UC,NC and EC in 2006,2010 and 2015 were obtained by conducting the comprehensive evaluation of the urban competitiveness of Dongguan City with integrated usage of the principal component analysis and Technique for Order Preference by Similarity to an Ideal Solution and the data of other 20 cities in Guangdong province,Hong Kong and Macao.The research showed that the competitiveness of Dongguan City has been greatly improved during the decade of 2006–2015,and the regional cities in Guangdong Province had significant differences,which are reflected in the two dimensions of urban internal node competitiveness(NC)and external competitiveness of urban network(EC).Based on this,this study further analyzed Dongguan’s urban competitiveness from two dimensions of NC and EC,and took Dongguan Songshan Lake High-tech Zone as an example to study how to promote Dongguan’s urban competitiveness from the industrial level.

High-tech Industrial Development Zones in Nanjing,Suzhou,Changzhou and Wuxi

Nanjing High-tech Industrial Devel-opment Zone It is a state-level high-tech in-dustrial development zone approved by theState Council, with an area of 16.5 sq km,comprising seven sq km of industrial area,five sq km of Taiwan invested area, three sqkm of university teaching and scientificresearch area and 1.5 sq km of compositeservice area. The development zone is 13.5 kmfrom the city center, with convenient trafficconditions, three state highways and a pro-

Characteristics and Development Modes of Standardization forChina's National High-Tech Zones:A Review

Indigenous innovation focused on the development of technical standards has become the core of China's innovation policy,since China released the "Outline of the National Program for Longand Medium-Term Scientific and Technological Development (2006-2020)" in 2006.Meanwhile,standardization issues are greatly emphasized by high-tech zones which serve as the major carriers of national economic growth as well as innovation clusters in the context of fast-growing international standardization.By means of the effective guide of the government,the standardization of high-tech zones in China now presents a wide range of operating modes.Specifically,they can be divided predominantly into the government promotion mode,the alliance collaboration mode,the research-standard-industry linkage mode,and the talent training mode,in terms of the main body of work and influence factors.

High-tech Industrial Zones Take Lead in Industrial Innovation

China’s 56 leading high-tech industrial zones have led the country’s industrial innovation, playing an important role in the nation’s social and economic development, a government statement said on Jan 1.

氧氟沙星片剂与针剂中有效成分的毛细管区带电泳快速测定

建立了一种简单、快速的毛细管区带电泳法，用于测定氧氟沙星片剂与针剂中的有效成分。背景电解液的组成为１０ ｍｍｏ／Ｌ ＫＨ２ＰＯ４与１２ｍｍｏｌ／Ｌ ＣｕＳＯ４的混合溶液，其ｐＨ值为３．６，检测波长为２９０ｎｍ。同时研究了背景电解液中Ｃｕ２＋的加入对氧氟沙星的有效电泳淌度以及检测灵敏度的影响。结果表明Ｃｕ２＋的加入可以有效地改善氧氟沙星的峰型，提高检测灵敏度。对所建立方法的线性、灵敏度、精密度、回收率等进行了考察，结果表明该法适于测定氧氟沙星片剂与针剂中的有效成分的含量。

毛细管电泳氨类手性药物对映体拆分机理研究

Using capillary zone electrophoresis,the enantiomers resolution of 13 pharmaceuticals including non-amide,primary amine,the secondary amine and the tertiary amine was studied with highly sulfated – α(β,γ)-cyclodextrins(HS-α(β,γ)-CD) as chiral selector,It was found a good resolution effect for the amide chiral pharmaceuticals,especially for tertiary amine.Through the primary analysis of chiral resolution mechanism,it was believed there be the static gravitational action in addition to space matches and hydrogen bonding between highly sulfated cyclodextrins and the amine drugs.With mobility shift method,Determination of binding constants between chlorpheniramine,hydrochloride isoprenaline,naphthylethylamine and HS-β-CD showed that the binding constant order of chlorpheniramine > hydrochloride isoprenaline > naphthylethylamine,and that highly sulfonated cyclodextrins and the tertiary amine the strongest action force.

校企合作建设制药实践教学基地的研究与实践

在本科教学中,实践教学的重要性已越来越受到重视,但是如何加强实践教学,各校的做法都不相同。本文在分析了武汉工程大学化药学院制药工程专业实践教学基地建设现状的基础上,提出了实践教学基地建设的措施,讨论了实践教学基地在实践教学中的作用,以及管理机制的建设与创新。

关于制药车间百级灌装区背景环境级别设置的分析

从工艺和净化两方面分析了欧盟GMP洁净级别划分中B级的设置,认为B级静态条件下洁净度定为百级是没有必要的,静态条件下洁净度万级就可以满足欧盟GMP和ISO14644中A区沉降菌小于1个/(4h)的要求。建议在修订我国GMP时可向国际标准靠拢,即B区静态级别不定,只定动态万级或为高于万级的某级。

基于Pearson关联模型的山东省海洋生物医药业发展路径分析

21世纪以来,海洋生物医药业作为我国战略性新兴产业,对山东省实现产业结构升级起着重要作用。文章从国内外海洋生物医药业发展现状入手,对山东省海洋生物医药业现状进行研究,分析其发展的优势和存在的问题;从社会、资金、科研、环境等4个层面选取6个影响因素,运用Pearson关联模型进行实证分析;根据分析结论,提出实现山东省海洋生物医药业可持续发展的相关政策建议。

典型医化园区废气和环境空气中挥发性有机物污染特征

对典型医化园区中的挥发性有机物(VOCs)污染特征进行研究,采用便携式气相色谱质谱法监测园区及周边14个点位的环境空气,大气预浓缩气相色谱质谱法监测10个点位排气筒中废气。结果表明,废气中非甲烷总烃为1. 77～218 mg/m3,环境空气中甲苯、二氯甲烷、丙酮、乙酸乙酯、四氢呋喃的质量浓度分别为0. 048～0. 833,0. 022～3. 07,0. 011～0. 312,0. 004～0. 754和0. 004～0. 529 mg/m3;废气和环境空气中均检出含量较高的芳香烃、卤代烃、酯类、酮类等化合物,以及园区特征的氟苯类和噻吩类化合物。园区环境空气明显受到工业源VOCs污染,分布趋势为生产越密集区域VOCs值越高,经过园区后沿着风向逐渐降低,园区下风向11 km处可测到园区特征氟苯类物质。