目的通过建立稳态流体模型,验证3.0 T MRI快速电影相位对比(fast cine PC)序列进行血流动力学测量的准确性。方法将直径为3.0mm的医用塑料管固定在水模中,塑料管的一端连接高压注射器,高压注射器以不同流速(0.5、1.0、1.5、2.0、2.5、3....目的通过建立稳态流体模型,验证3.0 T MRI快速电影相位对比(fast cine PC)序列进行血流动力学测量的准确性。方法将直径为3.0mm的医用塑料管固定在水模中,塑料管的一端连接高压注射器,高压注射器以不同流速(0.5、1.0、1.5、2.0、2.5、3.0、3.5、4.0 mL/s)向管腔内注射0.9%氯化钠溶液,管的另一端连入量筒。将流体模型中心置于头部8通道线圈中心,平行放置的医用塑料管与磁体长轴一致。应用3.0TMRI扫描仪进行fastcine PC序列扫描,扫描层面垂直于所测管腔长轴。在不同流速、不同观测者(2名)、不同流动方向(相向和相反)、不同倾斜角度(0°、20°、30°、45°)对流速进行测量。对图像进行后处理。测定感兴趣区流速,进行统计学分析。结果实际流动方向与流速编码方向相同时测得的流速值分别为6.75、13.90、21.14、28.69、36.52、42.48、50.49、57.10 cm/s;实际流动方向与流速编码方向相反时测得的流速值分别为8.09、14.76、22.53、29.79、36.61、44.75、51.08、54.94 cm/s。管腔内实际流速为42.46 cm/s时,不同倾斜角度测得的流速值分别为42.48、42.77、42.38、42.94、42.47、42.62、42.59 cm/s。测量速度与实际速度间差异无统计学意义,且呈正相关(r=0.99,P<0.000 1)。2名观察者的测量值之间差异无统计学意义(t=-0.87,P=0.41>0.05)。液体流动方向与流速编码方向相同、相反测得的流速与实际流速两两之间差异无统计学意义(F=3.51,P=0.06>0.05)。不管管腔在各个方向有无角度,测得的流速与实际流速之间差异均无统计学意义(t=2.01,P=0.09>0.05)。结论 3.0 T fast cine PC序列可以准确测量稳态流体模型流速,为人体血流动力学检测的临床应用提供了可靠的实验依据。展开更多
Objectives To reveal the relationship of brain motion and cerebrospinal fluid (CSF) flow by phase-contrast cine MRI, and to evaluate this technique in differentiating between arachnoid cysts and subarachnoid space en...Objectives To reveal the relationship of brain motion and cerebrospinal fluid (CSF) flow by phase-contrast cine MRI, and to evaluate this technique in differentiating between arachnoid cysts and subarachnoid space enlargement. Methods Using a phase-contrast cine MRI pulse sequence, we measured brain motion and CSF flow during the cardiac cycle in 10 healthy volunteers and 10 patients with MRI-suspected arachnoid cyst or subarachnoid space enlargement. CSF stroke volume curve was illustrated according to flow quantification, and time-signal intensity curve was traced. The two curves were compared. Results This study showed that brain motion was due to the volume difference between arterial and venous blood flow during a cardiac cycle, and thus drives CSF pulsation. Arachnoid cysts and subarachnoid space enlargement carried different curve patterns, demonstrating that phase-contrast MRI and flow quantification can be a useful and reliable technique for non-invasive evaluation of brain motion and CSF flow. Conclusion Arachnoid cysts can be successfully differentiated using phase-contrast cine MRI from subarachnoid space enlargement.展开更多
Background: The hepatic hemodynamics is an essential parameter in surgical planning as well as in various disease processes. The transit time ultrasound(TTUS) perivascular flow probe technology is widely used in clini...Background: The hepatic hemodynamics is an essential parameter in surgical planning as well as in various disease processes. The transit time ultrasound(TTUS) perivascular flow probe technology is widely used in clinical practice to evaluate the hepatic inflow, yet invasive. The phase-contrast-MRI(PC-MRI) is not invasive and potentially applicable in assessing the hepatic blood flow. In the present study, we compared the hepatic inflow rates using the PC-MRI and the TTUS probe, and evaluated their predictive value of post-hepatectomy adverse events. Methods: Eighteen large white pigs were anaesthetized for PC-MRI and approximately 75% hepatic resection was performed under a unified protocol. The blood flow was measured in the hepatic artery(Qha), the portal vein(Qpv), and the aorta above the celiac trunk(Qca) using PC-MRI, and was compared to the TTUS probe. The Bland-Altman method was conducted and a partial least squares regression(PLS) model was implemented. Results: The mean Qpv measured in PC-MRI was 0.55 ± 0.12 L/min, and in the TTUS probe was 0.74 ± 0.17 L/min. Qca was 1.40 ± 0.47 L/min in the PC-MRI and 2.00 ± 0.60 L/min in the TTUS probe. Qha was 0.17 ± 0.10 L/min in the PC-MRI, and 0.13 ± 0.06 L/min in the TTUS probe. The Bland-Altman method revealed that the estimated bias of Qca in the PC-MRI was 32%(95% CI:-49% to 15%); Qha 17%(95% CI:-15% to 51%); and Qpv 40%(95% CI:-62% to 18%). The TTUS probe had a higher weight in predicting adverse outcomes after 75% resection compared to the PC-MRI( β= 0.35 and 0.43 vs β = 0.22 and 0.07, for tissue changes and premature death, respectively). Conclusions: There is a tendency of the PC-MRI to underestimate the flow measured by the TTUS probes. The TTUS probe measures are more predictive of relevant post-hepatectomy outcomes.展开更多
文摘目的通过建立稳态流体模型,验证3.0 T MRI快速电影相位对比(fast cine PC)序列进行血流动力学测量的准确性。方法将直径为3.0mm的医用塑料管固定在水模中,塑料管的一端连接高压注射器,高压注射器以不同流速(0.5、1.0、1.5、2.0、2.5、3.0、3.5、4.0 mL/s)向管腔内注射0.9%氯化钠溶液,管的另一端连入量筒。将流体模型中心置于头部8通道线圈中心,平行放置的医用塑料管与磁体长轴一致。应用3.0TMRI扫描仪进行fastcine PC序列扫描,扫描层面垂直于所测管腔长轴。在不同流速、不同观测者(2名)、不同流动方向(相向和相反)、不同倾斜角度(0°、20°、30°、45°)对流速进行测量。对图像进行后处理。测定感兴趣区流速,进行统计学分析。结果实际流动方向与流速编码方向相同时测得的流速值分别为6.75、13.90、21.14、28.69、36.52、42.48、50.49、57.10 cm/s;实际流动方向与流速编码方向相反时测得的流速值分别为8.09、14.76、22.53、29.79、36.61、44.75、51.08、54.94 cm/s。管腔内实际流速为42.46 cm/s时,不同倾斜角度测得的流速值分别为42.48、42.77、42.38、42.94、42.47、42.62、42.59 cm/s。测量速度与实际速度间差异无统计学意义,且呈正相关(r=0.99,P<0.000 1)。2名观察者的测量值之间差异无统计学意义(t=-0.87,P=0.41>0.05)。液体流动方向与流速编码方向相同、相反测得的流速与实际流速两两之间差异无统计学意义(F=3.51,P=0.06>0.05)。不管管腔在各个方向有无角度,测得的流速与实际流速之间差异均无统计学意义(t=2.01,P=0.09>0.05)。结论 3.0 T fast cine PC序列可以准确测量稳态流体模型流速,为人体血流动力学检测的临床应用提供了可靠的实验依据。
文摘Objectives To reveal the relationship of brain motion and cerebrospinal fluid (CSF) flow by phase-contrast cine MRI, and to evaluate this technique in differentiating between arachnoid cysts and subarachnoid space enlargement. Methods Using a phase-contrast cine MRI pulse sequence, we measured brain motion and CSF flow during the cardiac cycle in 10 healthy volunteers and 10 patients with MRI-suspected arachnoid cyst or subarachnoid space enlargement. CSF stroke volume curve was illustrated according to flow quantification, and time-signal intensity curve was traced. The two curves were compared. Results This study showed that brain motion was due to the volume difference between arterial and venous blood flow during a cardiac cycle, and thus drives CSF pulsation. Arachnoid cysts and subarachnoid space enlargement carried different curve patterns, demonstrating that phase-contrast MRI and flow quantification can be a useful and reliable technique for non-invasive evaluation of brain motion and CSF flow. Conclusion Arachnoid cysts can be successfully differentiated using phase-contrast cine MRI from subarachnoid space enlargement.
基金supported mainly by the “Agence de la Biomedecine” through its program of Research(AOR 2009)BM,AC,BP,WM,VCI and VE acknowledged funding of project ANR-13-TECS-0006 by the Agence Nationale de la Recherche
文摘Background: The hepatic hemodynamics is an essential parameter in surgical planning as well as in various disease processes. The transit time ultrasound(TTUS) perivascular flow probe technology is widely used in clinical practice to evaluate the hepatic inflow, yet invasive. The phase-contrast-MRI(PC-MRI) is not invasive and potentially applicable in assessing the hepatic blood flow. In the present study, we compared the hepatic inflow rates using the PC-MRI and the TTUS probe, and evaluated their predictive value of post-hepatectomy adverse events. Methods: Eighteen large white pigs were anaesthetized for PC-MRI and approximately 75% hepatic resection was performed under a unified protocol. The blood flow was measured in the hepatic artery(Qha), the portal vein(Qpv), and the aorta above the celiac trunk(Qca) using PC-MRI, and was compared to the TTUS probe. The Bland-Altman method was conducted and a partial least squares regression(PLS) model was implemented. Results: The mean Qpv measured in PC-MRI was 0.55 ± 0.12 L/min, and in the TTUS probe was 0.74 ± 0.17 L/min. Qca was 1.40 ± 0.47 L/min in the PC-MRI and 2.00 ± 0.60 L/min in the TTUS probe. Qha was 0.17 ± 0.10 L/min in the PC-MRI, and 0.13 ± 0.06 L/min in the TTUS probe. The Bland-Altman method revealed that the estimated bias of Qca in the PC-MRI was 32%(95% CI:-49% to 15%); Qha 17%(95% CI:-15% to 51%); and Qpv 40%(95% CI:-62% to 18%). The TTUS probe had a higher weight in predicting adverse outcomes after 75% resection compared to the PC-MRI( β= 0.35 and 0.43 vs β = 0.22 and 0.07, for tissue changes and premature death, respectively). Conclusions: There is a tendency of the PC-MRI to underestimate the flow measured by the TTUS probes. The TTUS probe measures are more predictive of relevant post-hepatectomy outcomes.
