Parkinson’s disease(PD)is a neurodegenerative disordercharacterized by motor retardation,myotonia,quiescent tremor,and postural gait abnormality,as well as nonmotor symptoms such asanxiety and depression.Biofeedback ...Parkinson’s disease(PD)is a neurodegenerative disordercharacterized by motor retardation,myotonia,quiescent tremor,and postural gait abnormality,as well as nonmotor symptoms such asanxiety and depression.Biofeedback improves motor and nonmotorfunctions of patients by regulating abnormal electroencephalogram(EEG),electrocardiogram(ECG),photoplethysmography(PPG),electromyography(EMG),respiration(RSP),or other physiologicalsignals.Given that multimodal signals are closely related to PDstates,the clinical effect of multimodal biofeedback on patientswith PD is worth exploring.Twenty-one patients with PD in Beijing Rehabilitation Hospital were enrolled and divided into threegroups:multimodal(EEG,ECG,PPG,and RSP feedback signal),EEG(EEG feedback signal),and sham(random feedback signal),and they received biofeedback training five times in two weeks.The combined clinical scale and multimodal signal analysis resultsrevealed that the EEG group significantly improved motor symptomsand increased Berg balance scale scores by regulatingβband activity;the multimodal group significantly improved nonmotorsymptoms and reduced Hamilton rating scale for depression scores by improvingθband activity.Our preliminary results revealed thatmultimodal biofeedback can improve the clinical symptoms of PD,but the regulation effect on motor symptoms is weaker than that ofEEG biofeedback.展开更多
文摘目的:探讨定量脑电图分析在阿尔茨海默病(Alzheimer’s disease,AD)中的应用价值。方法:我们纳入AD患者和认知功能正常老年人各26人。利用20导联的静息态脑电图检测受试者脑电波形。采用各频段功率值和加权相位延迟指数(weighted phase lag index,wPLI)分析各组人群中脑电波变化的差异性。结果:在AD组中,θ频段的功率显著高于对照组。另外,两组中功能连接的差异主要存在于低频段的δ和θ中。δ频段中AD病人的相位同步性减低,而在θ频段中AD病人的相位同步性明显强于对照组。结论:定量脑电图分析中显示,阿尔茨海默病病人脑内频率慢化和功能失连接的现象。
基金This work was supported by the STI 2030-Major Projects(Grant No.2022ZD0208500)the National Natural Science Foundation of China(Grant Nos.U20A20191,82071912,12104049,82202291)+2 种基金the Key Research and Development Program(Grant No.2022YFC3602603)the Fundamental Research Funds for the Central Universities(Grant No.2021CX11011)the National Key Research and Development Program of China(Grant No.2020YFC2007305).
文摘Parkinson’s disease(PD)is a neurodegenerative disordercharacterized by motor retardation,myotonia,quiescent tremor,and postural gait abnormality,as well as nonmotor symptoms such asanxiety and depression.Biofeedback improves motor and nonmotorfunctions of patients by regulating abnormal electroencephalogram(EEG),electrocardiogram(ECG),photoplethysmography(PPG),electromyography(EMG),respiration(RSP),or other physiologicalsignals.Given that multimodal signals are closely related to PDstates,the clinical effect of multimodal biofeedback on patientswith PD is worth exploring.Twenty-one patients with PD in Beijing Rehabilitation Hospital were enrolled and divided into threegroups:multimodal(EEG,ECG,PPG,and RSP feedback signal),EEG(EEG feedback signal),and sham(random feedback signal),and they received biofeedback training five times in two weeks.The combined clinical scale and multimodal signal analysis resultsrevealed that the EEG group significantly improved motor symptomsand increased Berg balance scale scores by regulatingβband activity;the multimodal group significantly improved nonmotorsymptoms and reduced Hamilton rating scale for depression scores by improvingθband activity.Our preliminary results revealed thatmultimodal biofeedback can improve the clinical symptoms of PD,but the regulation effect on motor symptoms is weaker than that ofEEG biofeedback.
