Vein visualization enhancement by dual-wavelength phase-locked denoising technology

Visual near-infrared imaging equipment has broad applications in various fields such as venipuncture,facial injections,and safety verification due to its noncontact,compact,and portable design.Currently,most studies utilize near-infrared single-wavelength for image acquisition of veins.However,many substances in the skin,including water,protein,and melanin can create significant background noise,which hinders accurate detection.In this paper,we developed a dual-wavelength imaging system with phase-locked denoising technology to acquire vein image.The signals in the effective region are compared by using the absorption valley and peak of hemoglobin at 700nm and 940nm,respectively.The phase-locked denoising algorithm is applied to decrease the noise and interference of complex surroundings from the images.The imaging results of the vein are successfully extracted in complex noise environment.It is demonstrated that the denoising effect on hand veins imaging can be improved with 57.3%by using our dual-wavelength phase-locked denoising technology.Consequently,this work proposes a novel approach for venous imaging with dual-wavelengths and phase-locked denoising algorithm to extract venous imaging results in complex noisy environment better.

Gigahertz frequency hopping in an optical phase-locked loop for Raman lasers

Raman lasers are essential in atomic physics,and the development of portable devices has posed requirements for time-division multiplexing of Raman lasers.We demonstrate an innovative gigahertz frequency hopping approach of a slave Raman laser within an optical phase-locked loop(OPLL),which finds practical application in an atomic gravimeter,where the OPLL frequently switches between near-resonance lasers and significantly detuned Raman lasers.The method merges the advantages of rapid and extensive frequency hopping with the OPLL’s inherent low phase noise,and exhibits a versatile range of applications in compact laser systems,promising advancements in portable instruments.

Sliding-mode Observer-based Grid Voltage-observation Method with Frequency-fixed Dual SOGI and Cross-compensated Phase-locked Loop

Conventional sliding-mode observer(SMO)-based grid-voltage observation methods often require a low-pass filter(LPF)to remove high-frequency sliding-mode noise.However,a complicated phase-and amplitude-compensation method,which is highly sensitive to the DC-offset,is required.A frequency-adaptive dual second-order generalized integrator(SOGI)can be used to replace the LPF,eliminating the compensation link and the effects of the DC-offset;however,strong coupling is introduced between the front-end SOGI block and back-end phase-locked loop(PLL)block,thereby reducing the dynamic performance.To solve this problem,this study proposes an SMO-based grid-voltage observation method with a frequency-fixed dual SOGI and cross-compensated PLL that can eliminate the frequency coupling between the front-end SOGI block and back-end PLL blocks,thereby increasing its dynamic performance.In this study,the phase and amplitude are compensated simultaneously using the proposed cross-compensation method,achieving an accurate observation of the grid voltage under off-nominal frequencies.An analysis of the small-signal model theoretically verified that the proposed method has good dynamic performance.Finally,the superiority of the proposed method is verified through comparative experiments.

Quantifying the agreement and accuracy characteristics of four satellite-based LULC products for cropland classification in China

Various land use and land cover(LULC)products have been produced over the past decade with the development of remote sensing technology.Despite the differences in LULC classification schemes,there is a lack of research on assessing the accuracy of their application to croplands in a unified framework.Thus,this study evaluated the spatial and area accuracies of cropland classification for four commonly used global LULC products(i.e.,MCD12Q1V6,GlobCover2009,FROM-GLC and GlobeLand30)based on the harmonised FAO criterion,and quantified the relationships between four factors(i.e.,slope,elevation,field size and crop system)and cropland classification agreement.The validation results indicated that MCD12Q1 and GlobeLand30 performed well in cropland classification regarding spatial consistency,with overall accuracies of 94.90 and 93.52%,respectively.The FROMGLC showed the worst performance,with an overall accuracy of 83.17%.Overlaying the cropland generated by the four global LULC products,we found the proportions of complete agreement and disagreement were 15.51 and 44.72% for the cropland classification,respectively.High consistency was mainly observed in the Northeast China Plain,the Huang-Huai-Hai Plain and the northern part of the Middle-lower Yangtze Plain,China.In contrast,low consistency was detected primarily on the eastern edge of the northern and semiarid region,the Yunnan-Guizhou Plateau and southern China.Field size was the most important factor for mapping cropland.For area accuracy,compared with China Statistical Yearbook data at the provincial scale,the accuracies of different products in descending order were:GlobeLand30,FROM-GLC,MCD12Q1,and GlobCover2009.The cropland classification schemes mainly caused large area deviations among the four products,and they also resulted in the different ranks of spatial accuracy and area accuracy among the four products.Our results can provide valuable suggestions for selecting cropland products at the national or provincial scale and help cropland mapping and reconstruction,which is essential for food security and crop management,so they can also contribute to achieving the Sustainable Development Goals issued by the United Nations.

Influence of initial check, information exchange, final accuracy check, reaction information nursing on the psychology of elderly with lung cancer

BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and safety.Elderly patients usually have poor self-care and are more likely to show a series of psychological problems.AIM To investigate the effectiveness of the initial check,information exchange,final accuracy check,reaction(IIFAR)information care model on the mental health status of elderly patients with lung cancer.METHODS This study is a single-centre study.We randomly recruited 60 elderly patients with lung cancer who attended our hospital from January 2021 to January 2022.These elderly patients with lung cancer were randomly divided into two groups,with the control group taking the conventional propaganda and education and the observation group taking the IIFAR information care model based on the conventional care protocol.The differences in psychological distress,anxiety and depression,life quality,fatigue,and the locus of control in psychology were compared between these two groups,and the causes of psychological distress were analyzed.RESULTS After the intervention,Distress Thermometer,Hospital Anxiety and Depression Scale(HADS)for anxiety and the HADS for depression,Revised Piper’s Fatigue Scale,and Chance Health Locus of Control scores were lower in the observation group compared to the pre-intervention period in the same group and were significantly lower in the observation group compared to those of the control group(P<0.05).After the intervention,Quality of Life Questionnaire Core 30(QLQ-C30),Internal Health Locus of Control,and Powerful Others Health Locus of Control scores were significantly higher in the observation and the control groups compared to the pre-intervention period in their same group,and QLQ-C30 scores were significantly higher in the observation group compared to those of the control group(P<0.05).CONCLUSION The IIFAR information care model can help elderly patients with lung cancer by reducing their anxiety and depression,psychological distress,and fatigue,improving their tendencies on the locus of control in psychology,and enhancing their life qualities.

Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

BACKGROUND Helicobacter pylori(H.pylori)infection has been well-established as a significant risk factor for several gastrointestinal disorders.The urea breath test(UBT)has emerged as a leading non-invasive method for detecting H.pylori.Despite numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent limitations.These findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of H.pylori infection.AIM To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for H.pylori infection in adult patients with dyspepsia.METHODS We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April 2022.Our search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference standard.We used the QUADAS-2 tool to assess the methodo-logical quality of the studies.We utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence intervals.We conducted subgroup analyses based on urea dosing,time after urea administration,and assessment technique.To investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess heterogeneity.Finally,we visually inspected a funnel plot and used Egger’s test to evaluate publication bias.endorsing both as reliable diagnostic tools in clinical practice.CONCLUSION In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic approach.Additionally,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enhance diagnostic precision.Nevertheless,it is crucial for researchers and clinicians to evaluate the strengths and limitations of our findings before implementing them in practice.

Diagnostic Accuracy of Computerized Bowel Sound Analysis with Non-Invasive Devices for Irritable Bowel Syndrome:A Systematic Review and Meta-Analysis

Objective To assess the diagnostic accuracy of bowel sound analysis for irritable bowel syndrome(IBS)with a systematic review and meta-analysis.Methods We searched MEDLINE,Embase,the Cochrane Library,Web of Science,and IEEE Xplore databases until September 2023.Cross-sectional and case-control studies on diagnostic accuracy of bowel sound analysis for IBS were identified.We estimated the pooled sensitivity,specificity,positive likelihood ratio,negative likeli-hood ratio,and diagnostic odds ratio with a 95% confidence interval(CI),and plotted a summary receiver operat-ing characteristic curve and evaluated the area under the curve.Results Four studies were included.The pooled diagnostic sensitivity,specificity,positive likelihood ratio,nega-tive likelihood ratio,and diagnostic odds ratio were 0.94(95%CI,0.87‒0.97),0.89(95%CI,0.81‒0.94),8.43(95%CI,4.81‒14.78),0.07(95%CI,0.03‒0.15),and 118.86(95%CI,44.18‒319.75),respectively,with an area under the curve of 0.97(95%CI,0.95‒0.98).Conclusions Computerized bowel sound analysis is a promising tool for IBS.However,limited high-quality data make the results'validity and applicability questionable.There is a need for more diagnostic test accuracy studies and better wearable devices for monitoring and analysis of IBS.

Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains

BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood glucose.Due to its increased usage in clinics,the number of studies investigating its accuracy has increased.However,its accuracy has not been investigated in highland populations in China.AIM To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(T2D)who had migrated within 3 mo from highlands to plains.METHODS Overall,68 patients with T2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 d.Throughout the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(Super GL,China),and blood glucose levels were read from the scanning probe during fasting and 2 h after all three meals.Moreover,the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled to<5 min.The accuracy of the FGM system was evaluated according to the CGM guidelines.Subsequently,the factors influencing the mean absolute relative difference(MARD)of this system were analyzed by a multiple linear regression method.RESULTS Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).The aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and B.According to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when the largest amplitude of glycemic excursion(LAGE)was<5.80 mmol/L but negatively correlated with blood glucose when the LAGE was≥5.80 mmol/L.CONCLUSION The FreeStyle Libre FGM system has good accuracy in patients with T2D who had recently migrated from highlands to plains.This system might be ideal for avoiding the effects of high hematocrit on blood glucose monitoring in populations that recently migrated to plains.MARD is mainly influenced by glucose levels and fluctuations,and the accuracy of the system is higher when the blood glucose fluctuation is small.In case of higher blood glucose level fluctuations,deviation in the scanned glucose levels is the highest at extremely low blood glucose levels.

Clinical study on improving the diagnostic accuracy of adult elbow joint cartilage injury by multisequence magnetic resonance imaging

BACKGROUND Due to frequent and high-risk sports activities,the elbow joint is susceptible to injury,especially to cartilage tissue,which can cause pain,limited movement and even loss of joint function.AIM To evaluate magnetic resonance imaging(MRI)multisequence imaging for improving the diagnostic accuracy of adult elbow cartilage injury.METHODS A total of 60 patients diagnosed with elbow cartilage injury in our hospital from January 2020 to December 2021 were enrolled in this retrospective study.We analyzed the accuracy of conventional MRI sequences(T1-weighted imaging,T2-weighted imaging,proton density weighted imaging,and T2 star weighted image)and Three-Dimensional Coronary Imaging by Spiral Scanning(3D-CISS)in the diagnosis of elbow cartilage injury.Arthroscopy was used as the gold standard to evaluate the diagnostic effect of single and combination sequences in different injury degrees and the consistency with arthroscopy.RESULTS The diagnostic accuracy of 3D-CISS sequence was 89.34%±4.98%,the sensitivity was 90%,and the specificity was 88.33%,which showed the best performance among all sequences(P<0.05).The combined application of the whole sequence had the highest accuracy in all sequence combinations,the accuracy of mild injury was 91.30%,the accuracy of moderate injury was 96.15%,and the accuracy of severe injury was 93.33%(P<0.05).Compared with arthroscopy,the combination of all MRI sequences had the highest consistency of 91.67%,and the kappa value reached 0.890(P<0.001).CONCLUSION Combination of 3D-CISS and each sequence had significant advantages in improving MRI diagnostic accuracy of elbow cartilage injuries in adults.Multisequence MRI is recommended to ensure the best diagnosis and treatment.

Numerical Investigation of Thermal Behavior of CNC Machine Tool and Its Effects on Dimensional Accuracy of Machined Parts

The dimensional accuracy of machined parts is strongly influenced by the thermal behavior of machine tools (MT). Minimizing this influence represents a key objective for any modern manufacturing industry. Thermally induced positioning error compensation remains the most effective and practical method in this context. However, the efficiency of the compensation process depends on the quality of the model used to predict the thermal errors. The model should consistently reflect the relationships between temperature distribution in the MT structure and thermally induced positioning errors. A judicious choice of the number and location of temperature sensitive points to represent heat distribution is a key factor for robust thermal error modeling. Therefore, in this paper, the temperature sensitive points are selected following a structured thermomechanical analysis carried out to evaluate the effects of various temperature gradients on MT structure deformation intensity. The MT thermal behavior is first modeled using finite element method and validated by various experimentally measured temperature fields using temperature sensors and thermal imaging. MT Thermal behavior validation shows a maximum error of less than 10% when comparing the numerical estimations with the experimental results even under changing operation conditions. The numerical model is used through several series of simulations carried out using varied working condition to explore possible relationships between temperature distribution and thermal deformation characteristics to select the most appropriate temperature sensitive points that will be considered for building an empirical prediction model for thermal errors as function of MT thermal state. Validation tests achieved using an artificial neural network based simplified model confirmed the efficiency of the proposed temperature sensitive points allowing the prediction of the thermally induced errors with an accuracy greater than 90%.

Further Analysis of Machine Tool Dimensional Accuracy and Thermal Stability under Varying Floor Temperature

Machining is as old as humanity, and changes in temperature in both the machine’s internal and external environments can be of great concern as they affect the machine’s thermal stability and, thus, the machine’s dimensional accuracy. This paper is a continuation of our earlier work, which aimed to analyze the effect of the internal temperature of a machine tool as the machine is put into operation and vary the external temperature, the machine floor temperature. Some experiments are carried out under controlled conditions to study how machine tool components get heated up and how this heating up affects the machine’s accuracy due to thermally induced deviations. Additionally, another angle is added by varying the machine floor temperature. The parameters mentioned above are explored in line with the overall thermal stability of the machine tool and its dimensional accuracy. A Robodrill CNC machine tool is used. The CNC was first soaked with thermal energy by gradually raising the machine floor temperature to a certain level before putting the machine in operation. The machine was monitored, and analytical methods were deplored to evaluate thermal stability. Secondly, the machine was run idle for some time under raised floor temperature before it was put into operation. Data was also collected and analyzed. It is observed that machine thermal stability can be achieved in several ways depending on how the above parameters are joggled. This paper, in conclusion, reinforces the idea of machine tool warm-up process in conjunction with a carefully analyzed and established machine floor temperature variation for the approximation of the machine tool’s thermally stability to map the long-time behavior of the machine tool.

Study on the Accuracy of Serum Prealbumin Level in Predicting the Prognosis of Patients with Critical Respiratory Illness

Objective: To analyze the accuracy of serum prealbumin levels in predicting the prognosis of patients with critical respiratory illness. Methods: Fifty patients with critical respiratory illness admitted to our hospital from October 2022 to September 2023 were selected and divided into an observation group and a control group after condition assessment, with 25 cases in each group. The results of cholinesterase (ChE), prealbumin (PALB), albumin (ALB), aspartate aminotransferase (AST), total protein (TP), and forced expiratory volume (FEV1)/Predicted (Pred) of the two groups were measured. Results: The ChE levels of the observation group were lower than those of the control group, while the PALB and ALB levels of the observation group were higher than those of the control group (P < 0.05). The AST, TP, and FEV1 /Pred levels of the observation group were higher than those in the control group (P < 0.05). Conclusion: Serum PALB levels can be used as the main indicator for prognosis in critically ill respiratory patients.

Fourier Spectrometer based on Wide-range and Phase-locked Michelson Interferometer with Femtosecond Laser Excitation

A wide-range and phase-locked Michelson interferometer technique is described. This technique combined with femtosecond laser is used to measure the spectrum of the rare-earth ion Nd：YVO4, which presents very high signal to noise ratio of interferometric intensity output and higher spectral resolution than traditional grating spectrophotometer.

11.6-GHz 0.18-μm monolithic CMOS phase-locked loop

A design of a ll. 6-GHz phase-locked loop （PLL） fabricated in 49-GHz 0. 18-μm CMOS （complementary metal-oxide-semiconductor transistor） technology is described. An analog multiplier phase detector （PD）, a one-pole passive low pass filter and a three-stage ring oscillator with variable negativeresistance loads build up the monolithic phase-locked loop. The measured rms jitter of output signal via onwafer testing is 2. 2 ps under the stimulation of 2^31 - 1 bit-long pseudo random bit sequence （PRBS） at the bit rate of 11.6 GHz. And the tracking range is 250 MHz. The phase noise in the locked condition is measured to be - 107 dBc/Hz at 10 MHz offset, and that of the ring VCO at the central frequency is -99 dBc/Hz at 10 MHz offset. The circuit area of the proposed PLL is only 0. 47mm×0.72mm and the direct current （DC） power dissipation is 164 mW under a 1.8-V supply.

An improved arctangent algorithm based on phase-locked loop for heterodyne detection system

We present an ameliorated arctangent algorithm based on phase-locked loop for digital Doppler signal processing,utilized within the heterodyne detection system. We define the error gain factor given by the approximation of Taylor expansion by means of a comparison of the measured values and true values. Exact expressions are derived for the amplitude error of two in-phase & quadrature signals and the frequency error of the acousto-optic modulator. Numerical simulation results and experimental results make it clear that the dynamic instability of the intermediate frequency signals leads to cumulative errors, which will spiral upward. An improved arctangent algorithm for the heterodyne detection is proposed to eliminate the cumulative errors and harmonic components. Depending on the narrow-band filter, our experiments were performed to realize the detectable displacement of 20 nm at a detection distance of 20 m. The aim of this paper is the demonstration of the optimized arctangent algorithm as a powerful approach to the demodulation algorithm, which will advance the signal-to-noise ratio and measurement accuracy of the heterodyne detection system.

CMOS analog and mixed-signal phase-locked loops: An overview

CMOS analog and mixed-signal phase-locked loops(PLL)are widely used in varies of the system-on-chips(SoC)as the clock generator or frequency synthesizer.This paper presents an overview of the AMS-PLL,including:1)a brief introduction of the basics of the charge-pump based PLL,which is the most widely used AMS-PLL architecture due to its simplicity and robustness;2)a summary of the design issues of the basic CPPLL architecture;3)a systematic introduction of the techniques for the performance enhancement of the CPPLL;4)a brief overview of ultra-low-jitter AMS-PLL architectures which can achieve lower jitter(<100 fs)with lower power consumption compared with the CPPLL,including the injection-locked PLL(ILPLL),subsampling(SSPLL)and sampling PLL(SPLL);5)a discussion about the consideration of the AMS-PLL architecture selection,which could help designers meet their performance requirements.

Design of radiation hard phase-locked loop at 2.5 GHz using SOS-CMOS

A radiation hard phase-locked loop （PLL） is designed at 2.5 GHz using silicon on sapphire complementary metal-oxide-semiconductor process. Radiation hardness is achieved through improving circuit design without sacrificing real estate. Stability is guaranteed by a fully self-bias architecture. The lock time of PLL is minimized by maximizing the loop bandwidth. Frequency tuning range of voltage controlled oscillator is significantly enhanced by a novel load configuration. In addition, multiple bias stages, asynchronous frequency divider, and silicon on sapphire process jointly make the proposed PLL more radiation hard. Layout of this PLL is simulated by Cadence Spectre RF under both single event effect and total induced dose effect. Simulation results demonstrate excellent stability, lock time 〈 600 ns, frequency tuning range [1.57 GHz, 3.46 GHz], and jitter 〈 12 ps. Through comparison with PLLs in literatures, the PLL is especially superior in terms of lock time and frequency tuning range performances.

Tunable characteristic of phase-locked quantum cascade laser arrays

A multimode interference(MMI)structure is designed to simplify the fabrication of quantum cascade laser(QCL)phase-locked arrays.The MMI geometry is optimized with a sufficient output channel distance to accommodate conventional photolithography and wet etching process by which power amplifier array is fabricated without using the complicated two-step etching-regrowth or dry etching technique.The far-field pattern with periodically modulated peaks reveals that the beams from the arrays are phase-locked.Furthermore,the frequency tuning performance of the MMI-based phase-locked arrays is studied using the Littrow-configuration external cavity structure.A wavelength tuning range of more than 60 cm^(−1) is demonstrated,which will eventually realize the high power,frequency tunable,large-scale phase-locked arrays,and their application in spectroscopy.

A 5.12-GHz LC-based phase-locked loop for silicon pixel readouts of high-energy physics

There is an urgent need for high-quality and high-frequency clock generators for high-energy physics experiments.The transmission data rate exceeds 10 Gbps for a single channel in future readout electronics of silicon pixel detectors.Others,such as time measurement detectors,require a high time resolution based on the time-to-digital readout architecture.A phase-locked loop(PLL)is an essential and broadly used circuit in these applications.This study presents an application-specific integrated circuit of a low-jitter,low-power LC-tank that is PLL fabricated using 55-nm CMOS technology.It includes a 3rd-order frequency synthesis loop with a programmable bandwidth,a divide-by-2 pre-scaler,standard low-voltage differential signaling interfaces,and a current mode logic(CML)driver for clock transmissions.All the d-flip-flop dividers and phase-frequency detectors are protected from single-event upsets using the triple modular redundancy technique.The proposed VCO uses low-pass filters to suppress the noise from bias circuits.The tested LC-PLL covers a frequency locking range between 4.74 GHz and 5.92 GHz with two sub-bands.The jitter measurements of the frequency-halved clock(2.56 GHz)are less than 460 fs and 0.8 ps for the random and deterministic jitters,respectively,and a total of 7.5 ps peak-to-peak with a bit error rate of 10^(-12).The random and total jitter values for frequencies of 426 MHz and 20 MHz are less than 1.8 ps and 65 ps,respectively.The LC-PLL consumed 27 mW for the core and 73.8 mW in total.The measured results nearly coincided with the simulations and validated the analyses and tests.

A LOW POWER TIME-TO-DIGITAL CONVERTER FOR ALL-DIGITAL PHASE-LOCKED LOOP

Time-to-Digital Converter (TDC) is a key block used as the phase/frequency detector in an All-Digital Phase-Locked Loop (ADPLL). Usually, it occupies a large proportion of ADPLL's total power consumption up to about 30% to 40%. In this paper, the detailed power consumption of different components in the TDC is analyzed. A Power Management Block (PMB) is presented for the TDC to reduce its power consumption. A 24-bits TDC core with the proposed PMB is implemented in HJTC 0.18 μm CMOS technology. Simulation results show that up to 84% power reduction is achieved using our proposed technique.