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Effect of Fusariosis on the Metabolism of Phenolics Compounds of Date Palm Leaflets, Resistant and Sensitive to the Disease
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作者 Saida Ouafi Nicole Bounaga 《Journal of Food Science and Engineering》 2012年第4期213-217,共5页
Because of socio-economic importance of date palm in North Africa, the scientific community has always followed the progression of parasitic disease that affects it. The study was performed on population of thirty pal... Because of socio-economic importance of date palm in North Africa, the scientific community has always followed the progression of parasitic disease that affects it. The study was performed on population of thirty palm trees belonging to three cultivars of the oases of south-west Algeria TOUAT Gourara. The analytical protocol consists of a hot hydrochloric acid hydrolysis of I g of leaf material dried and ground. Structural analysis of compounds present in extracts was conducted by chromatographic and spectrophotometric techniques. Through the analysis of all HPLC profiles of phenolic acids, we have established three chemotypes: resistant with the highest heights, sensitive, with the lowest height, finally low sensitivity or tolerant with intermediate heights. The increased synthesis of C-glycoflavones, within diseased palms, can be seen as the first sign of plant response to fungal attack, or even as a defense mechanism so these flavonoids correspond to "pre-inhibitines". It has not been found qualitative differences between different cultivars studied. The merits of our work show a negative correlation between flavonoid content and the level of lignification in the date palm, suggests that the process of lignification is more rapid in resistant cultivars. We can say that there is a constitutive resistance. 展开更多
关键词 Date palm tree fusariose CHEMOTYPE RESISTANT phenolic compounds.
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Hollow ZIF-67-derived Co@N-doped carbon nanotubes boosting the hydrogenation of phenolic compounds to alcohols
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作者 Zhihao Guo Jiuxuan Zhang +3 位作者 Lanlan Chen Chaoqun Fan Hong Jiang Rizhi Chen 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第2期157-166,共10页
The selective hydrogenation of highly toxic phenolic compounds to generate alcohols with thermal stability,environmental friendliness,and non-toxicity is of great importance.Herein,a series of Co-based catalysts,named... The selective hydrogenation of highly toxic phenolic compounds to generate alcohols with thermal stability,environmental friendliness,and non-toxicity is of great importance.Herein,a series of Co-based catalysts,named Co@NCNTs,were designed and constructed by direct pyrolysis of hollow ZIF-67(HZIF-67)under H_(2)/Ar atmosphere.The evolution of the catalyst surface from the shell layer assembled by ZIF-67-derived particles to the in situ-grown hollow nitrogen-doped carbon nanotubes(NCNTs)with certain length and density is achieved by adjusting the pyrolysis atmosphere and temperature.Due to the synergistic effects of in situ-formed hollow NCNTs,well-dispersed Co nanoparticles,and intact carbon matrix,the as-prepared Co@NCNTs-0.10-450 catalyst exhibits superior catalytic performance in the hydrogenation of phenolic compounds to alcohols.The turnover frequency value of Co@NCNTs-0.10-450is 3.52 h^(-1),5.9 times higher than that of Co@NCNTs-0.40-450 and 4.5 times higher than that of Co@NCNTs-0.10-550,exceeding most previously reported non-noble metal catalysts.Our findings provide new insights into the development of non-precious metal,efficient,and cost-effective metal-organic framework-derived catalysts for the hydrogenation of phenolic compounds to alcohols. 展开更多
关键词 Phenolic compounds Hollow ZIF-67 pyrolysis Nitrogen-doped carbon nanotubes Reduction Multiphase reaction Catalysis
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Screening for Antioxidant Phenolic Compounds from Polygonum capitatum
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作者 Yan LIN 《Medicinal Plant》 2024年第4期1-3,10,共4页
[Objectives]To discover antioxidant natural products from the famous Hmong medicinal plant Polygonum capitatum.[Methods]The antioxidant activities of the isolated components were evaluated by ABTS and DPPH assays.[Res... [Objectives]To discover antioxidant natural products from the famous Hmong medicinal plant Polygonum capitatum.[Methods]The antioxidant activities of the isolated components were evaluated by ABTS and DPPH assays.[Results]A total of 27 free phenolics were isolated form P.capitatum.Then the in vitro antioxidant potential of these components was evaluated according to the DPPH and ABTS radical scavenging assays.Among them,five compounds(13,14,17,23,and 25)showed most significant ABTS radical-scavenging activity(IC 50 values of 3.81-15.09μg/mL).And 12 components(1,2,6,7,9,12,13,14,16,17,23,and 25)showed notable radical scavenging activity against DPPH(inhibition rates>88%).[Conclusions]Most of the above bioactive compounds were reported for the first time. 展开更多
关键词 Polygonum capitatum Phenolic compounds Antioxidant activity
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Mechanism of action of Balanophora involucrata polyphenolic compounds in the treatment of myocardial injury based on network pharmacology and molecular docking techniques
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作者 Shipeng Duan Ting Gao +4 位作者 Feifei Li Xuehan Li Haojun Shen Fang Wang Xiaoshu Zhang 《Journal of Polyphenols》 2024年第2期45-55,共11页
The objective of this work was to investigate the mechanism of action of Balanophora involucrata polyphenolic compounds in the treatment of myocardial injury.In the present study,Balanophora involucrata was extracted ... The objective of this work was to investigate the mechanism of action of Balanophora involucrata polyphenolic compounds in the treatment of myocardial injury.In the present study,Balanophora involucrata was extracted by refluxing 75%of ethanol.The obtained extract was extracted with petroleum ether,ethyl acetate and n-butanol respectively.And the ethyl acetate layer was separated.The extract was prepared by silica gel column chromatography,sephadex LH-20 elution and thin layer chromatography.After that,the Swiss target prediction database was utilized to obtain the targets of Balanophora involucrata,and the Genecards,OMIM and TTD databases were used to predict and screen the targets of Balanophora involucrata for the treatment of myocardial injury.The active ingredient-target network was constructed using Cytoscape software,and the PPI network was mapped using String database and Cytoscape software.GO bioprocess enrichment analysis and KEGG pathway enrichment analysis were performed by Metascape software to predict the mechanism of action.Molecular docking was performed in Discovery Studio 2016 client software to verify the binding of Balanophora involucrata polyphenols to key targets.In this study,six polyphenolic compounds were isolated from Balanophora involucrata.By GO enrichment analysis,1614 biological processes(BP),127 cellular compositions(CC),and 215 molecular functions(MF)were obtained;a total of 155 cross-targets were involved in the KEGG enrichment analysis.The PPI network showed that quercetin was the main active component of polyphenolic compounds against myocardial injury and that AKT1,EGFR,STAT3,SRC,ESR1,MMP9,HSP90AA1 and other related signals were associated with myocardial injury treatment.Finally,the multi-component-multi-target-multi-pathway action of Balanophora involucrata was concluded,which provided new ideas and methods for further research on the mechanism of action of Balanophora involucrata in myocardial injury. 展开更多
关键词 Balanophora involucrata myocardial injury phenolic compounds network pharmacology molecular docking
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Effective anti-inflammatory phenolic compounds from dandelion:identification and mechanistic insights using UHPLC-ESI-MS/MS,fluorescence quenching and anisotropy,molecular docking and dynamics simulation 被引量:1
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作者 Hui Zou Tingting Ben +2 位作者 Ping Wu Geoffrey I.N.Waterhouse Yilun Chen 《Food Science and Human Wellness》 SCIE CSCD 2023年第6期2184-2194,共11页
This novel study identifi es the effective anti-inflammatory phenolic compounds in dandelion and provides mechanistic insights into their interactions with receptor proteins(toll-like receptor 4,TLR4;co-receptor myelo... This novel study identifi es the effective anti-inflammatory phenolic compounds in dandelion and provides mechanistic insights into their interactions with receptor proteins(toll-like receptor 4,TLR4;co-receptor myeloid differentiation protein-2,MD-2)using UHPLC-ESI-MS/MS,lipopolysaccharide(LPS)-stimulated THP-1 cell line,fluorescence quenching and anisotropy,molecular docking(single ligand and multi-ligand docking)and molecular dynamics simulation.A 50%aqueous methanol extract had a greater anti-inflammatory effect and higher chicoric acid content,compared with the 100%water and 100%methanol extracts.Chicoric acid,chlorogenic acid,methylophiopogonone A,caffeic acid,gallic acid monohydrate and 4’-O-demethylbroussonin A had relatively high binding energies and contents in all extracts.Chicoric acid competed with chlorogenic acid,4’-O-demethylbroussonin A and quercetin for MD-2.Among dandelion’s phenolics,chicoric acid most effectively hindered TLR4-MD-2 complex formation,with a quenching constant of 0.62×10^(6) L/mol for MD-2 or TLR4 at 320 K,and binding energies of-6.87 and-5.97 kcal/mol,respectively,for MD-2 and TLR4. 展开更多
关键词 Dandelion extracts Phenolic compounds binding affinity TLR4-MD-2 antagonist Anti-inflammatory agent
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Effect of pressure cooking on phenolic compounds of quinoa 被引量:1
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作者 Qianwei Ma Zhixiang Li +2 位作者 Thanutchaporn Kumrungsee Wenda Huang Ruge Cao 《Grain & Oil Science and Technology》 CAS 2023年第3期127-134,共8页
Due to good nutritional properties and potential health benefits,quinoa has gained an increasing attention.The study aimed to analyze the effect of pressure cooking on the composition,antioxidant activity,antibacteria... Due to good nutritional properties and potential health benefits,quinoa has gained an increasing attention.The study aimed to analyze the effect of pressure cooking on the composition,antioxidant activity,antibacterial activity and bioavailability of phenolic compounds in four types of quinoa,and to evaluate the correlation between phenolics and its biological activities by correlation analysis.The results showed that different varieties of quinoa contained different phenolic components and their biological activities were different.Pressure cooking could significantly increase(P<0.05)the phenolic contents of quinoa,and decrease in vitro digestibility of protein.The antioxidant activity,antibacterial activity and bioavailability of quinoa were also enhanced which were positively related with phenolic contents.HPLC analysis indicated that at least twelve phenolic compounds were found in quinoa,and hyperoside,sinapic acid,rutin and ferulic acid occupied a majority of them.Correlation analysis suggested that hyperoside,quercetin,sinapic acid,ferulic acid and gallic acid made the key contribution to antioxidant and antibacterial activities of phenolic compounds of quinoa.The results provided valuable information for quinoa processing with phenolics as functional ingredient. 展开更多
关键词 QUINOA Pressure cooking Phenolic compounds Bioactivity CORRELATION
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Effects of different thermal processing methods on bioactive components,phenolic compounds,and antioxidant activities of Qingke(highland hull-less barley)
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作者 Qingyue Hong Guangjing Chen +2 位作者 Zhirong Wang Xuhui Chen Jianquan Kan 《Food Science and Human Wellness》 SCIE CSCD 2023年第1期119-129,共11页
Qingke(highland hull-less barley)is a grain replete with substantial nutrients and bioactive ingredients.In this study,we evaluated the effects of boiling(BO),steaming(ST),microwave baking(MB),far-infrared baking(FB),... Qingke(highland hull-less barley)is a grain replete with substantial nutrients and bioactive ingredients.In this study,we evaluated the effects of boiling(BO),steaming(ST),microwave baking(MB),far-infrared baking(FB),steam explosion(SE),and deep frying(DF)on bioactive components,phenolic compounds,and antioxidant activities of Qingke compared with the effects of traditional roast(TR).Results showed that the soluble dietary fiber,beta-glucan and water-extractable pentosans of Qingke in dry heat processes of TR,SE,MB and FB had a higher content compared with other thermal methods and had a better antioxidant activity of hydroxyl radical scavenging and a better reduction capacity,while those in wet heat processes of BO and ST had a better antioxidant activity of ABTS radical scavenging and a better Fe^(2+) chelating ability.DF-and SE-Qingke had a higher content of tocopherol,phenolic,and flavonoid.Overall,6 free phenolic compounds and 12 bound phenolic compounds of Qingke were identified,and free phenolic compounds suffered more damage during thermal processing.Principal component analysis showed that SE had more advantages in retaining and improving the main biological active ingredients of Qingke,and it may be the best method for treating Qingke. 展开更多
关键词 Qingke(highland hull-less barley) Thermal processing Antioxidant activity Phenolic compounds Bioactive components
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In Vitro and in Silico Insights on the Biological Activities, Phenolic Compounds Composition of Hypericum perforatum L. Hairy Root Cultures
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作者 Oliver Tusevski Marija Todorovska +2 位作者 Jasmina Petreska Stanoeva Marina Stefova Sonja Gadzovska Simic 《Phyton-International Journal of Experimental Botany》 SCIE 2023年第3期921-941,共21页
Three Hypericum perforatum hairy root lines(HR B,HR F and HR H)along with non-transformed roots were analyzed for phenolic compounds composition and in vitro enzyme inhibitory properties.In silico molecular modeling w... Three Hypericum perforatum hairy root lines(HR B,HR F and HR H)along with non-transformed roots were analyzed for phenolic compounds composition and in vitro enzyme inhibitory properties.In silico molecular modeling was performed to predict the interactions of the most representative phenolic compounds in HR clones with enzymes related to depression,neurodegeneration and diabetes.Chromatographic analyses revealed that HR clones represent an efficient source of quinic acid and hydroxybenzoic acids,epicatechin and procyanidin derivatives,quercetin and kaempferol glycosides,as well numerous xanthones.In vitro antidepressant activity of HR extracts through monoamine oxidase A(MAO-A)inhibition was attributed to the production of oxygenated and prenylated xanthones.The neuroprotective potential of HR extracts was related to the accumulation of quercetin 6-C-glucoside,epicatechin,procyanidins andγ-mangostin isomers as potential inhibitors of acetylcholinesterase(AChE)and butyrylcholinesterase(BChE).Vanillic acid and prenylated xanthones in HR clones as promising inhibitors of tyrosinase additionally contributed to the neuroprotective activity.Five preeminent xanthones in HR(γ-mangostin,mangiferin,garcinone C,garcinone E and 1,3,7-trihydroxy-6-metoxy-8-prenyl xanthone)along with the flavonol quercetin 6-C-glucoside effectively inhibitedα-amylase andα-glucosidase indicating the antidiabetic properties of HR extracts.Transgenic roots of H.perforatum can be exploited for the preparation of novel phytoproducts with multi-biological activities. 展开更多
关键词 Biological activities hairy roots Hypericum perforatum molecular docking phenolic compounds
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Dual Role of Plant Phenolic Compounds as Antioxidants and Prooxidants
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作者 Channa B. Rajashekar 《American Journal of Plant Sciences》 CAS 2023年第1期15-28,共14页
Natural phenolic compounds are secondary metabolites found in a wide range of plants including food crops. As many of them are known to be antioxidants and can prevent several chronic and degenerative diseases in huma... Natural phenolic compounds are secondary metabolites found in a wide range of plants including food crops. As many of them are known to be antioxidants and can prevent several chronic and degenerative diseases in humans, they are a part of a healthy diet. However, these antioxidants can act as prooxidants under high phenolic concentration, high pH, or in the presence of transition metal ions such as Cu<sup>2+</sup> or Fe<sup>3+</sup>, producing reactive oxygen species (ROS) including hydroxyl radicals resulting in oxidative stress and cell toxicity. While this can lead to pathogenesis including the development of various types of cancers, elevated levels of ROS are beneficial to kill malignant cells and foodborne pathogens to improve food safety. Thus, the dual nature of phenolic compounds allows them to act as antioxidants and prooxidants. Similarly, depending on the level of prooxidant activity, ROS can induce either pathogenesis or serve as a potential agent to kill malignant cells and foodborne pathogens. 展开更多
关键词 ANTICANCER ANTIMICROBIAL ANTIOXIDANTS Food Safety Phenolic compounds Prooxidants
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Effect of wall-disruption on nutrient composition and in vitro digestion of camellia and lotus bee pollens 被引量:1
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作者 Yuan Yuan Shun Zhong +3 位作者 Zeyuan Deng Guangyan Li Jinwu Zhang Hongyan Li 《Food Science and Human Wellness》 SCIE CSCD 2024年第3期1567-1577,共11页
The nutrient digestion,absorption and biological activity of bee pollen may be limited due to the complex pollen wall.Here,the effect of superfine grinding technology on the release of nutrients from bee pollen were i... The nutrient digestion,absorption and biological activity of bee pollen may be limited due to the complex pollen wall.Here,the effect of superfine grinding technology on the release of nutrients from bee pollen were investigated,and their antioxidant activities and in vitro digestion were explored in this study.Results showed that the content of nutrients in bee pollen increased after wall disruption.Among them,fat content increased by 22.55%-8.31%,protein content increased by 0.54%-4.91%,starch content increased by 36.31%-48.64%,soluble sugar content increased by 20.57%-29.67%,total phenolic acid content increased by 11.73%-86.98%and total flavonoids content increased by 14.29%-24.79%.At the same time,the antioxidant activity increased by 14.84%-46.00%.Furthermore,the active components such as phenolic compounds in the wall-disruption bee pollen were more readily to be released during the in vitro digestion,and easier to be absorbed because of their higher bioaccessibility.Antioxidant activities during in vitro digestion were also improved in walldisruption bee pollen.These findings provide evidence that bee pollen wall disruption was suggested,thus,it is more conducive to exerting the value of bee pollen in functional foods. 展开更多
关键词 Bee pollen NUTRIENTS Wall disruption Phenolic compounds In vitro digestion
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Effect of Rosmarinus officinalis and Origanum majorana extracts on stability of sunflower oil during storage and repeated heating
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作者 Ali Sahunie 《Oil Crop Science》 CSCD 2024年第1期29-37,共9页
Both rosemary(Rosmarinus officinalis)and marjoram(Origanum majorana)are abundant in phenolic compounds,exhibiting exceptional antioxidant activity.This study aims to assess the impact of rosemary and marjoram extracts... Both rosemary(Rosmarinus officinalis)and marjoram(Origanum majorana)are abundant in phenolic compounds,exhibiting exceptional antioxidant activity.This study aims to assess the impact of rosemary and marjoram extracts on the stability of sunflower oil during storage and repeated heating.Sunflower oil supplemented with herbal extracts or butylated hydroxytoluene(BHA)at a concentration of 200 ppm was stored for six months under light and dark conditions at room temperature.Peroxide value(PV),p-anisidine value(An-V),and total oxidation(TOTOX)value were measured to monitor lipid oxidation progression.A significant difference(P<0.05)was observed between light and dark storage for all studied samples regarding oxidation parameters.The ethanolic extract of rosemary exhibited higher antioxidant activity compared to BHA and other extracts.Furthermore,sunflower oil supplemented with the ethanolic extract of rosemary underwent weekly treatment at 100℃for 30 min over four consecutive weeks.Although all oxidation indicators increased during repeated heating,the addition of rosemary and marjoram extracts as well as BHA significantly reduced these indicators.These findings demonstrate that both rosemary extracts and marjoram extracts can serve as natural antioxidants in edible oils. 展开更多
关键词 Phenolic compounds BHA Marjoram extract Rosemary extract Sunflower oil
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Comparisons between Phenolic Compounds and Antioxidation of Momordica charantia L. in Different Varieties
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作者 黄龙 邓媛元 +4 位作者 张名位 张雁 魏振承 张瑞芬 唐小俊 《Agricultural Science & Technology》 CAS 2012年第6期1263-1269,共7页
[Objective] The aim was to compare contents of free and bound polyphenol and antioxidation of balsam pear in different varieties. [Method] Fourteen varieties of balsam pear were chosen to analyze total contents of fre... [Objective] The aim was to compare contents of free and bound polyphenol and antioxidation of balsam pear in different varieties. [Method] Fourteen varieties of balsam pear were chosen to analyze total contents of free or bound phenol and components of free phenol. FRAP (Freeic reducing/antioxidant power), DPPH (1,1diphenyl-2-picrylhydrazy), and ABTS +· (2, 2’-azinobis-3-ethylbenzothiazoline-6-sulphonic acid diammonium salt) were used to measure antioxidation and analyze relationship between polyphenol content and antioxidation. [Result] Among the fourteen varieties of balsam pear, free, bound and total phenols were 157.58 -382.92, 6.46 -54 and 175.27 -413.79 mg GAE/100 g DW; coefficients of variance were 23.50% , 61.04% and 21.58%, respectively; free phenol accounted for 91.34% of total phenol and bound phenol accounted for 8.66% ; contents of total flavone for the fourteen varieties were from 8.97 to 18.22 mg CE/100 g DW and the coefficient was at 22.80%; vanillic aldehyde acid, epicatechin and rutin differed in contents among different varieties, which changed in 1.83-9.29, 35.17-114.52 and 0.91-4.53 mg/100 g DW and the coefficients were 43.85%, 26.97% and 33.09%; FRAP antioxidation was at 272.16 -713.32 mg TE/100 g DW and coefficient at 27.67% ; IC 50 of DPPH and ABTS +· clearance were 11.43-34.14 and 21.57-119.71 mg GAE/100 g DW and coefficients were at 35.10% and 63.75% , accordingly; content of total phenol was of extremely positive correlation with FRAP (P0.01) and of extremely negative correlation with IC 50 of DPPH and ABTS + · clearance (P0.01). [Conclusion] Contents of phenolic compounds and antioxidation are of significant genotype differences; and phenolic substance and antioxidation are mainly in free form and phenolic substance is the major basis for antioxidation. 展开更多
关键词 Momordica charantia L. Phenolic compounds ANTIOXIDATION
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Differences in Phenolic Compounds and Related Enzyme Activities between 2 Eucalyptus Species
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作者 姚瑞玲 项东云 +1 位作者 陈健波 梁小春 《Agricultural Science & Technology》 CAS 2010年第7期6-8,共3页
[Objective] The aim was to provide theoretical basis for speeding up the popularization of Eucalyptus dunnii.[Method] Differences in phenolic compounds and related enzyme activities between hard rooting E.dunnii and e... [Objective] The aim was to provide theoretical basis for speeding up the popularization of Eucalyptus dunnii.[Method] Differences in phenolic compounds and related enzyme activities between hard rooting E.dunnii and easily rooting E.urophylla×E.grandis clone (U9) were studied.[Result] There were significant differences in contents of phenolic compounds and activities of indole acetic acid oxidase (IAAO),andperoxidase (POD) and polyphenol oxidase (PPO) between the two Eucalyptus species.Compared with U9,contents of phenolic compounds and POD activity of E.dunnii cuttings were relatively high,while activities of IAAO and PPO were relatively low.[Conclusion] More phenolic compounds and the differences in related enzyme activities might be the major factors to result in hard rooting of E.dunnii cuttings. 展开更多
关键词 Eucalyptus dunnii Phenolic compound Enzyme activity
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In silico prospective analysis of the medicinal plants activity on the CagA oncoprotein from Helicobacter pylori
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作者 Rafaela Viana Vieira Gabrielle Caroline Peiter +2 位作者 Fabrício Freire de Melo Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira 《World Journal of Clinical Oncology》 2024年第5期653-663,共11页
BACKGROUND Colonization with Helicobacter pylori(H.pylori)has a strong correlation with gastric cancer,and the virulence factor CagA is implicated in carcinogenesis.Studies have been conducted using medicinal plants w... BACKGROUND Colonization with Helicobacter pylori(H.pylori)has a strong correlation with gastric cancer,and the virulence factor CagA is implicated in carcinogenesis.Studies have been conducted using medicinal plants with the aim of eliminating the pathogen;however,the possibility of blocking H.pylori-induced cell differentiation to prevent the onset and/or progression of tumors has not been addressed.This type of study is expensive and time-consuming,requiring in vitro and/or in vivo tests,which can be solved using bioinformatics.Therefore,prospective computational analyses were conducted to assess the feasibility of interaction between phenolic compounds from medicinal plants and the CagA oncoprotein.AIM To perform a computational prospecting of the interactions between phenolic compounds from medicinal plants and the CagA oncoprotein of H.pylori.METHODS In this in silico study,the structures of the phenolic compounds(ligands)kaempferol,myricetin,quercetin,ponciretin(flavonoids),and chlorogenic acid(phenolic acid)were selected from the PubChem database.These phenolic compounds were chosen based on previous studies that suggested medicinal plants as non-drug treatments to eliminate H.pylori infection.The three-dimensional structure model of the CagA oncoprotein of H.pylori(receptor)was obtained through molecular modeling using computational tools from the I-Tasser platform,employing the threading methodology.The primary sequence of CagA was sourced from GenBank(BAK52797.1).A screening was conducted to identify binding sites in the structure of the CagA oncoprotein that could potentially interact with the ligands,utilizing the GRaSP online platform.Both the ligands and receptor were prepared for molecular docking using AutoDock Tools 4(ADT)software,and the simulations were carried out using a combination of ADT and AutoDock Vina v.1.2.0 software.Two sets of simulations were performed:One involving the central region of CagA with phenolic compounds,and another involving the carboxy-terminus region of CagA with phenolic compounds.The receptor-ligand complexes were then analyzed using PyMol and BIOVIA Discovery Studio software.RESULTS The structure model obtained for the CagA oncoprotein exhibited high quality(C-score=0.09)and was validated using parameters from the MolProbity platform.The GRaSP online platform identified 24 residues(phenylalanine and leucine)as potential binding sites on the CagA oncoprotein.Molecular docking simulations were conducted with the three-dimensional model of the CagA oncoprotein.No complexes were observed in the simulations between the carboxy-terminus region of CagA and the phenolic compounds;however,all phenolic compounds interacted with the central region of the oncoprotein.Phenolic compounds and CagA exhibited significant affinity energy(-7.9 to-9.1 kcal/mol):CagA/kaempferol formed 28 chemical bonds,CagA/myricetin formed 18 chemical bonds,CagA/quercetin formed 16 chemical bonds,CagA/ponciretin formed 13 chemical bonds,and CagA/chlorogenic acid formed 17 chemical bonds.Although none of the phenolic compounds directly bound to the amino acid residues of the K-Xn-R-X-R membrane binding motif,all of them bound to residues,mostly positively or negatively charged,located near this region.CONCLUSION In silico,the tested phenolic compounds formed stable complexes with CagA.Therefore,they could be tested in vitro and/or in vivo to validate the findings,and to assess interference in CagA/cellular target interactions and in the oncogenic differentiation of gastric cells. 展开更多
关键词 CagA oncoprotein Phenolic compounds Helicobacter pylori In silico analyses Medicinal plants Prospective analysis
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Phytochemical Analysis and Antioxidant Activity of Aqueous and Hydroethanolic Extracts from Three Anticancerous Fabaceae of Northern Cameroon Pharmacopoeia
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作者 Halmata Mohamadou Landry Lienou Lienou +5 位作者 Richard Simo Tagne Herve Pabamé Kada Elisee Libert Enyengue Embolo Grace Kembaou Nganwa Jean Louis Oyono Essame Piere Michel Dongmo Jazet 《Journal of Biosciences and Medicines》 2024年第6期19-32,共14页
Background: Cancer continues to pose a significant threat to our society, representing one of the most pressing health concerns worldwide. This study aimed to evaluate the chemical composition and the antioxidant acti... Background: Cancer continues to pose a significant threat to our society, representing one of the most pressing health concerns worldwide. This study aimed to evaluate the chemical composition and the antioxidant activity of aqueous and hydroethanolic extracts from Acacia nilotica (An), Bauhinia reticulate (Br), and Tamarindus indica (Ti) of Fabaceae family, traditionally used in Northern Cameroon for cancer treatment. Methods: The phytochemical screening of the three plants was conducted using conventional colorimetric methods, followed by the measurement of total phenol content, flavonoids, and tannins. The antiradical and antioxidant activities of both plant extracts were assessed through FRAP, ABTS, and DPPH methods. A principal components analysis was employed to correlate the quantities of the evaluated secondary metabolites with the activities. Results: Both types of extracts from the three plants contain alkaloids, saponins, flavonoids, phenolic compounds, tannins, glycosides, terpenoids, coumarins, anthocyanins, and anthraquinones. The aqueous extracts of Br and An are significantly richer (p Conclusion: The three Fabaceae plants from northern Cameroon, prepared in different solvents, can be utilized for their antiradical properties in cancer treatment. 展开更多
关键词 Cancer ANTIOXIDANT FABACEAE Phenolic compounds Aqueous Extract Hydroethanolic Extract
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Comprehensive analysis of phenolic composition and antioxidant mechanisms in Gymnema sylvestre extracts using LC-MS and column chromatography
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作者 Shengjie Hao Yuxin Du +2 位作者 Jianglong He Qian Li Guilin Chen 《Asian Journal of Traditional Medicines》 2024年第4期211-222,共12页
Recent studies have highlighted the potential of plant extracts as therapeutic agents for managing oxidative stress and related disorders.This study aims to elucidate the phenolic composition and antioxidant propertie... Recent studies have highlighted the potential of plant extracts as therapeutic agents for managing oxidative stress and related disorders.This study aims to elucidate the phenolic composition and antioxidant properties of Gymnema sylvestre extracts.Ethanolic reflux extraction followed by column chromatography was employed to isolate phenolic compounds.The total phenolic and flavonoid contents were quantified using the Folin–Ciocalteu and aluminum chloride colorimetric methods,respectively.Antioxidant activities were assessed by DPPH,ABTS scavenging assays and the ferric reducing antioxidant power(FRAP)assay.High-Performance Liquid Chromatography(HPLC)with a C18 column and Thermo TSQ Quantum Access Max(LC-MS)were used to determine the levels of gymnemic acid and identify other potential phenolic compounds.The analysis revealed significant antioxidant activities in the fractions.Fraction A showed the highest DPPH and ABTS scavenging activities,and Fraction C demonstrated the highest ferric reducing power.LC-MS analysis identified several phenolic compounds,indicating that these are major contributors to the antioxidant efficacy of the extract.This study provides a detailed phenolic profile and confirms the strong antioxidant potential of Gymnema sylvestre leaf extract,supporting its therapeutic use and further investigation. 展开更多
关键词 Gymnema sylvestre ANTIOXIDANTS column chromatography phenolic compounds LC-MS
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Adsorption of phenolic compounds from aqueous solutions by aminated hypercrosslinked polymers 被引量:9
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作者 JIANG Zhen-mao LI Ai-min +2 位作者 CAI Jian-guo WANG Chun ZHANG Quan-xin 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2007年第2期135-140,共6页
Two novel polymers (NJ-1 and N J-2) were synthesized by chemically modified a hypercrosslinked polymer NJ-0 with dimethylamine and trimethylamine, respectively. The comparison of the adsorption properties of the thr... Two novel polymers (NJ-1 and N J-2) were synthesized by chemically modified a hypercrosslinked polymer NJ-0 with dimethylamine and trimethylamine, respectively. The comparison of the adsorption properties of the three polymers toward phenol, resorcin and phloroglucin was made. The study focused on the static equilibrium adsorption behaviors and the adsorption thermodynamics. Freundlich equation was found to fit the adsorption results well. The effect of amino groups introduced onto the surface of the resin and the structure of phenolic compounds on the adsorption were also studied. The hydrogen-bonding interaction and electrostatic interaction could happen between the amino groups and the adsorbates. The adsorption impetus increased as quantity of hydroxyl groups increased, but the adsorption capacity decreased due to the drop of the matching degree of the aperture of resins and the diameter of adsorbate molecules. 展开更多
关键词 hypercrosslinked polymer phenolic compounds amino groups modified static adsorption
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Phenolic compounds as natural feed additives in poultry and swine diets:a review 被引量:8
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作者 Shad Mahfuz Qinghui Shang Xiangshu Piao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2021年第3期841-858,共18页
Due to ban on using antibiotics in feed industry,awareness of using natural feed additives have led to a great demand.The interest of plants phenolic compounds as a potential natural antioxidant source has been consid... Due to ban on using antibiotics in feed industry,awareness of using natural feed additives have led to a great demand.The interest of plants phenolic compounds as a potential natural antioxidant source has been considered in research community due to their predictable potential role as feed additives in poultry and swine production.However,the mode of action for their functional role and dosage recommendation in animal diets are still remain indistinct.Taking into account,the present review study highlights an outline about the mode of action of phenolic compound and their experimental uses in poultry and swine focusing on the growth performance,antioxidant function,immune function,antimicrobial role and overall health status,justified with the past findings till to date.Finally,the present review study concluded that supplementation of phenolic compounds as natural feed additives may have a role on the antioxidant,immunity,antimicrobial and overall production performance in poultry and swine. 展开更多
关键词 Antioxidant role Immune response Phenolic compounds Production performance POULTRY SWINE
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Phenolic compounds and its antioxidant activities in ethanolic extracts from seven cultivars of Chinese jujube 被引量:20
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作者 Huan-xia Zhao Hai-sheng Zhang Shu-fang Yang 《Food Science and Human Wellness》 SCIE 2014年第3期183-190,共8页
Phenolic compounds and its antioxidant activity of extracts from seven cultivars of Chinese jujubes were investigated by high performance liquid chromatography(HPLC)with standards and different antioxidant evaluation ... Phenolic compounds and its antioxidant activity of extracts from seven cultivars of Chinese jujubes were investigated by high performance liquid chromatography(HPLC)with standards and different antioxidant evaluation methods,such as phosphomolybdenum assay,superoxide radical scavenging activity(SRSA),hydroxyl radical scavenging activity(HRSA),antihemolytic activity and inhibition of lipid peroxidation in rat liver homogenate,respectively.The results showed the components of the extracts are comprised of total phenols and flavonoids,and its content ranges from 454.3 to 1298.9(GAE mg/100 g dry weight).Phlorizin,catechin,gallic acid,chlorogenic acid,caffeic acid were the predominant phenolic compounds.All the extracts had significant antioxidant activities either in vitro or in vivo.Correlation analysis indicated that the antioxidant capacities of Chinese jujube extracts demonstrated a good positive relationship with some phenolic acids,which was higher in Xiao and Goutou.The results indicated that Xiao and Goutou could be attributed to a potential source of natural antioxidants for food applications. 展开更多
关键词 Chinese jujube Phenolic compounds FLAVONOIDS Antioxidant activity PHLORIZIN
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Thermodynamic study of adsorption of phenolic compounds onto Amberlite XAD-4 polymeric adsorbents and its acetylized derivative MX-4 被引量:4
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作者 LIAi-min ZHANGQuan-xing +2 位作者 CHENJin-longJm-long FEIZheng-hao LONGChao1 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2002年第4期457-463,共7页
Adsorption equilibrium isotherms of phenolic compounds, phenol, p cresol, p chlorophenol and p nitrophenol, from aqueous solutions by Amberlite XAD 4 polymeric adsorbent and its acetylized derivative M... Adsorption equilibrium isotherms of phenolic compounds, phenol, p cresol, p chlorophenol and p nitrophenol, from aqueous solutions by Amberlite XAD 4 polymeric adsorbent and its acetylized derivative MX 4 within temperature range of 283 323K were obtained and fitted to the Freundlich isotherms. The capacities of equilibrium adsorption for all four phenolic compounds from their aqueous solutions increased around 20% on the acetylized resin, which may be contributed to the specific surface area and the partial polarity on the network. Estimations of the isosteric enthalpy, free energy, and entropy for the adsorption process were reported. 展开更多
关键词 macroporous polymeric adsorbent phenolic compound adsorption thermodynamic temperature effect
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